FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6406, 458 aa 1>>>pF1KE6406 458 - 458 aa - 458 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1572+/-0.000426; mu= 18.0307+/- 0.026 mean_var=67.1936+/-13.044, 0's: 0 Z-trim(109.8): 51 B-trim: 0 in 0/53 Lambda= 0.156462 statistics sampled from 18008 (18055) to 18008 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.212), width: 16 Scan time: 6.550 The best scores are: opt bits E(85289) XP_005271345 (OMIM: 611339) PREDICTED: cysteine pr ( 458) 3101 709.5 4.6e-204 NP_116241 (OMIM: 611339) cysteine protease ATG4C [ ( 458) 3101 709.5 4.6e-204 NP_835739 (OMIM: 611339) cysteine protease ATG4C [ ( 458) 3101 709.5 4.6e-204 XP_011540615 (OMIM: 611339) PREDICTED: cysteine pr ( 423) 2749 630.1 3.6e-180 XP_016858090 (OMIM: 611339) PREDICTED: cysteine pr ( 418) 2478 568.9 9.2e-162 XP_016858089 (OMIM: 611339) PREDICTED: cysteine pr ( 418) 2478 568.9 9.2e-162 NP_001268433 (OMIM: 611340) cysteine protease ATG4 ( 411) 941 221.9 2.5e-57 NP_116274 (OMIM: 611340) cysteine protease ATG4D i ( 474) 941 222.0 2.8e-57 XP_006722990 (OMIM: 611340) PREDICTED: cysteine pr ( 360) 615 148.3 3.2e-35 NP_001308219 (OMIM: 300663) cysteine protease ATG4 ( 226) 348 87.9 3e-17 NP_001308217 (OMIM: 300663) cysteine protease ATG4 ( 321) 349 88.2 3.5e-17 XP_011529144 (OMIM: 300663) PREDICTED: cysteine pr ( 321) 349 88.2 3.5e-17 NP_001308216 (OMIM: 300663) cysteine protease ATG4 ( 321) 349 88.2 3.5e-17 NP_840055 (OMIM: 300663) cysteine protease ATG4A i ( 321) 349 88.2 3.5e-17 NP_443168 (OMIM: 300663) cysteine protease ATG4A i ( 398) 349 88.3 4.1e-17 XP_016859129 (OMIM: 611338) PREDICTED: cysteine pr ( 319) 329 83.7 7.9e-16 XP_005247053 (OMIM: 611338) PREDICTED: cysteine pr ( 319) 329 83.7 7.9e-16 XP_005247052 (OMIM: 611338) PREDICTED: cysteine pr ( 341) 328 83.5 9.7e-16 XP_016859128 (OMIM: 611338) PREDICTED: cysteine pr ( 341) 328 83.5 9.7e-16 NP_847896 (OMIM: 611338) cysteine protease ATG4B i ( 380) 245 64.8 4.6e-10 NP_037457 (OMIM: 611338) cysteine protease ATG4B i ( 393) 245 64.8 4.7e-10 XP_005247050 (OMIM: 611338) PREDICTED: cysteine pr ( 405) 245 64.8 4.9e-10 XP_005247049 (OMIM: 611338) PREDICTED: cysteine pr ( 415) 245 64.8 5e-10 XP_016859127 (OMIM: 611338) PREDICTED: cysteine pr ( 457) 245 64.9 5.4e-10 XP_016859126 (OMIM: 611338) PREDICTED: cysteine pr ( 479) 245 64.9 5.6e-10 NP_840054 (OMIM: 300663) cysteine protease ATG4A i ( 336) 236 62.7 1.7e-09 XP_011529143 (OMIM: 300663) PREDICTED: cysteine pr ( 340) 236 62.7 1.7e-09 NP_001308218 (OMIM: 300663) cysteine protease ATG4 ( 259) 160 45.5 0.0002 >>XP_005271345 (OMIM: 611339) PREDICTED: cysteine protea (458 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN 370 380 390 400 410 420 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL :::::::::::::::::::::::::::::::::::::: XP_005 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 430 440 450 >>NP_116241 (OMIM: 611339) cysteine protease ATG4C [Homo (458 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN 370 380 390 400 410 420 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL :::::::::::::::::::::::::::::::::::::: NP_116 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 430 440 450 >>NP_835739 (OMIM: 611339) cysteine protease ATG4C [Homo (458 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_835 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN 370 380 390 400 410 420 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL :::::::::::::::::::::::::::::::::::::: NP_835 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 430 440 450 >>XP_011540615 (OMIM: 611339) PREDICTED: cysteine protea (423 aa) initn: 2749 init1: 2749 opt: 2749 Z-score: 3355.7 bits: 630.1 E(85289): 3.6e-180 Smith-Waterman score: 2749; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN ::::::::::::::::::::::::::::::::::::::::::: XP_011 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKNQIMIKAAIINIHVQDF 370 380 390 400 410 420 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL XP_011 MWT >>XP_016858090 (OMIM: 611339) PREDICTED: cysteine protea (418 aa) initn: 2468 init1: 2468 opt: 2478 Z-score: 3025.1 bits: 568.9 E(85289): 9.2e-162 Smith-Waterman score: 2722; 91.3% identity (91.3% similar) in 458 aa overlap (1-458:1-418) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN ::: ::::::::::::::::: XP_016 PLE----------------------------------------MLKFSSKEKYPLFTFVN 370 380 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL :::::::::::::::::::::::::::::::::::::: XP_016 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 390 400 410 >>XP_016858089 (OMIM: 611339) PREDICTED: cysteine protea (418 aa) initn: 2468 init1: 2468 opt: 2478 Z-score: 3025.1 bits: 568.9 E(85289): 9.2e-162 Smith-Waterman score: 2722; 91.3% identity (91.3% similar) in 458 aa overlap (1-458:1-418) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN ::: ::::::::::::::::: XP_016 PLE----------------------------------------MLKFSSKEKYPLFTFVN 370 380 430 440 450 pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL :::::::::::::::::::::::::::::::::::::: XP_016 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 390 400 410 >>NP_001268433 (OMIM: 611340) cysteine protease ATG4D is (411 aa) initn: 1273 init1: 530 opt: 941 Z-score: 1150.2 bits: 221.9 E(85289): 2.5e-57 Smith-Waterman score: 1264; 45.1% identity (68.9% similar) in 437 aa overlap (27-458:17-411) 10 20 30 40 50 60 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP ::.:..: ::. : . : :. :.:. : NP_001 MQVLHLAGRCPYVSPGWVVKSRTSFSKISSIHLCGRRYRFEGE------- 10 20 30 40 70 80 90 100 110 120 pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL :....:..::.::.:::::..:: . :. ::.:::::: ::.:::.: NP_001 -------------GDIQRFQRDFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMML 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE ::::.:::: : ::: ..... . : : . ... : .. : . NP_001 AQGLLLHFLPRDWTWAEGMGL--GPPELSGSASPSRY--------HGPARWMPPRWA--- 100 110 120 130 190 200 210 220 230 240 pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI . :...: ::.:.:::.: : : ::::.:.: :..:::::::::::..:::: NP_001 -----QGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKAGDWYGPSLVAHI 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE :::::: :. ...::.::::::..:: . .. . .:. :.:.:::::::::: NP_001 LRKAVESCS--DVTRLVVYVSQDCTVYKADVA--RLVARPDPTAEWKSVVILVPVRLGGE 200 210 220 230 240 310 320 330 340 350 360 pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF : :. :: .: : :.::.::::..: :: :.::: :.:.:::::: :::: :: NP_001 TLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADF 250 260 270 280 290 300 370 380 390 400 410 pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSK-EKYPLFTFV :::.::: ::.::.: :::::::.::: . ..:. :.:..:. :: :.::.::.. NP_001 PLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSELTRVLSSSSATERYPMFTLA 310 320 330 340 350 360 420 430 440 450 pF1KE6 NGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFSTEEFVLL .::..:... . .. . : . : :: :.:.::.: NP_001 EGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPSSEDFVFL 370 380 390 400 410 >>NP_116274 (OMIM: 611340) cysteine protease ATG4D isofo (474 aa) initn: 1302 init1: 530 opt: 941 Z-score: 1149.3 bits: 222.0 E(85289): 2.8e-57 Smith-Waterman score: 1371; 46.2% identity (70.5% similar) in 457 aa overlap (7-458:60-474) 10 20 30 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFS :::::.:.::..::::.::.::.:..: :: NP_116 GPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE6 RNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFP . : . : :. :.:. : :....:..::.::.:::::..:: NP_116 KISSIHLCGRRYRFEGE--------------------GDIQRFQRDFVSRLWLTYRRDFP 90 100 110 120 100 110 120 130 140 150 pF1KE6 QIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKK . :. ::.:::::: ::.:::.:::::.:::: : ::: ..... . NP_116 PLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPE----------- 130 140 150 160 170 160 170 180 190 200 210 pF1KE6 FTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQ . .: : : .. :. . .. . :...: ::.:.:::.: : : ::::. NP_116 ----LSGSASPSR-YHGPARWMPPRWAQGAP--ELEQERRHRQIVSWFADHPRAPFGLHR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 LIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQS :.: :..:::::::::::..:::::::::: :. ...::.::::::..:: . NP_116 LVELGQSSGKKAGDWYGPSLVAHILRKAVESCS--DVTRLVVYVSQDCTVYKADVA--RL 240 250 260 270 280 280 290 300 310 320 330 pF1KE6 ASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGF .. . .:. :.:.:::::::::: : :. :: .: : :.::.::::..: :: :. NP_116 VARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGY 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE6 QDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKR ::: :.:.:::::: :::: :::::.::: ::.::.: :::::::.::: . ..:. NP_116 QDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFET 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 ASEEITKMLKFSSK-EKYPLFTFVNGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFS :.:..:. :: :.::.::...::..:... . .. . : . : :: : NP_116 LCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPS 410 420 430 440 450 460 pF1KE6 TEEFVLL .:.::.: NP_116 SEDFVFL 470 >>XP_006722990 (OMIM: 611340) PREDICTED: cysteine protea (360 aa) initn: 1071 init1: 530 opt: 615 Z-score: 753.3 bits: 148.3 E(85289): 3.2e-35 Smith-Waterman score: 790; 35.4% identity (52.5% similar) in 457 aa overlap (7-458:60-360) 10 20 30 pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFS :::::.:.::..::::.::.::.:..: :: XP_006 GPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE6 RNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFP . : . : :. :.:. : :....:..::.::.:::::..:: XP_006 KISSIHLCGRRYRFEGE--------------------GDIQRFQRDFVSRLWLTYRRDFP 90 100 110 120 100 110 120 130 140 150 pF1KE6 QIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKK . :. ::.:::::: ::.:::.:::::.:::: :. XP_006 PLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRV------------------------ 130 140 150 160 160 170 180 190 200 210 pF1KE6 FTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQ :. : XP_006 ----------------------------YKAD---------------------------- 220 230 240 250 260 270 pF1KE6 LIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQS ::... :: :: XP_006 --------------------VARLV------AR-PD------------------------ 170 280 290 300 310 320 330 pF1KE6 ASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGF .:. :.:.:::::::::: : :. :: .: : :.::.::::..: :: :. XP_006 -----PTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGY 180 190 200 210 220 230 340 350 360 370 380 390 pF1KE6 QDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKR ::: :.:.:::::: :::: :::::.::: ::.::.: :::::::.::: . ..:. XP_006 QDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFET 240 250 260 270 280 290 400 410 420 430 440 450 pF1KE6 ASEEITKMLKFSSK-EKYPLFTFVNGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFS :.:..:. :: :.::.::...::..:... . .. . : . : :: : XP_006 LCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPS 300 310 320 330 340 350 pF1KE6 TEEFVLL .:.::.: XP_006 SEDFVFL 360 >>NP_001308219 (OMIM: 300663) cysteine protease ATG4A is (226 aa) initn: 328 init1: 215 opt: 348 Z-score: 430.5 bits: 87.9 E(85289): 3e-17 Smith-Waterman score: 348; 32.7% identity (62.3% similar) in 199 aa overlap (268-454:30-219) 240 250 260 270 280 290 pF1KE6 AHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRL .: . ..:: . .. . : ....::.:: NP_001 MDNTVVIEDIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRL 10 20 30 40 50 300 310 320 330 340 350 pF1KE6 GGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDV-- : .. : :.. : ... .: .::::...::: :: : ::..::: :.:::. NP_001 GINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEE 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE6 --SIKDFPLETFHC-PSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEK ...: .:::: ::..:.. ..::: ..::.:.. .:: . : . ::. NP_001 NGTVND---QTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEIL---KEN 120 130 140 150 160 170 420 430 440 450 pF1KE6 YPLFTFVNGHSRDYD-FTS------TTTNEEDLFSEDEKKQLKRFSTEEFVLL .: .:. : . :. :::. : . : .::..:. :: NP_001 LRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFI---DSTEQLEEFDLEEDFEILSV 180 190 200 210 220 458 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:57:56 2016 done: Tue Nov 8 12:57:57 2016 Total Scan time: 6.550 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]