FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3633, 822 aa 1>>>pF1KE3633 822 - 822 aa - 822 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6166+/-0.000359; mu= 19.4394+/- 0.023 mean_var=74.1074+/-14.722, 0's: 0 Z-trim(113.8): 38 B-trim: 7 in 1/50 Lambda= 0.148985 statistics sampled from 23228 (23266) to 23228 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.273), width: 16 Scan time: 13.120 The best scores are: opt bits E(85289) NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822) 5447 1180.6 0 NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 230 59.2 7.1e-08 NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 230 59.2 7.1e-08 XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 230 59.2 7.1e-08 NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 230 59.2 7.2e-08 NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 230 59.2 8e-08 XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 229 59.0 8.7e-08 XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 229 59.0 8.8e-08 XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 229 59.0 8.9e-08 NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 229 59.0 1.1e-07 NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 229 59.0 1.1e-07 XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 229 59.0 1.1e-07 NP_003579 (OMIM: 300304,300354) cullin-4B isoform ( 913) 229 59.0 1.1e-07 XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 229 59.0 1.1e-07 XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455) 198 52.2 6.1e-06 XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06 NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens] ( 776) 198 52.3 9.6e-06 XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06 XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06 XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06 XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06 NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614) 182 48.8 8.5e-05 NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682) 182 48.9 9.3e-05 NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745) 182 48.9 0.0001 XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745) 182 48.9 0.0001 NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo ( 745) 182 48.9 0.0001 NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758) 182 48.9 0.0001 NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764) 182 48.9 0.0001 XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011 XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011 XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011 >>NP_037498 (OMIM: 606946) anaphase-promoting complex su (822 aa) initn: 5447 init1: 5447 opt: 5447 Z-score: 6321.2 bits: 1180.6 E(85289): 0 Smith-Waterman score: 5447; 100.0% identity (100.0% similar) in 822 aa overlap (1-822:1-822) 10 20 30 40 50 60 pF1KE3 MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF 730 740 750 760 770 780 790 800 810 820 pF1KE3 VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS :::::::::::::::::::::::::::::::::::::::::: NP_037 VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS 790 800 810 820 >>NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo sap (659 aa) initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08 Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545) 470 480 490 500 510 520 pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR :. : : .: . .::.: :.. :: : NP_003 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ :: : : . : . :: . : : : :.::: :. : ...... ... .. NP_003 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS 370 380 390 400 410 590 600 610 620 630 640 pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM :. . . ::. .:: . .... .. :.. : .. : :.:. ::: ... NP_003 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL 420 430 440 450 460 470 650 660 670 680 690 700 pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG--- .:. . :. :...::.:.. ....::.. :. . . ::: .. : : NP_003 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR 480 490 500 510 520 530 710 720 730 740 750 760 pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT :: . : : NP_003 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID 540 550 560 570 580 590 >>NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [Homo (659 aa) initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08 Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545) 470 480 490 500 510 520 pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR :. : : .: . .::.: :.. :: : NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ :: : : . : . :: . : : : :.::: :. : ...... ... .. NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS 370 380 390 400 410 590 600 610 620 630 640 pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM :. . . ::. .:: . .... .. :.. : .. : :.:. ::: ... NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL 420 430 440 450 460 470 650 660 670 680 690 700 pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG--- .:. . :. :...::.:.. ....::.. :. . . ::: .. : : NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR 480 490 500 510 520 530 710 720 730 740 750 760 pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT :: . : : NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID 540 550 560 570 580 590 >>XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A isofo (659 aa) initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08 Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545) 470 480 490 500 510 520 pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR :. : : .: . .::.: :.. :: : XP_011 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ :: : : . : . :: . : : : :.::: :. : ...... ... .. XP_011 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS 370 380 390 400 410 590 600 610 620 630 640 pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM :. . . ::. .:: . .... .. :.. : .. : :.:. ::: ... XP_011 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL 420 430 440 450 460 470 650 660 670 680 690 700 pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG--- .:. . :. :...::.:.. ....::.. :. . . ::: .. : : XP_011 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR 480 490 500 510 520 530 710 720 730 740 750 760 pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT :: . : : XP_011 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID 540 550 560 570 580 590 >>NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [Homo (667 aa) initn: 199 init1: 137 opt: 230 Z-score: 262.3 bits: 59.2 E(85289): 7.2e-08 Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:339-553) 470 480 490 500 510 520 pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR :. : : .: . .::.: :.. :: : NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ :: : : . : . :: . : : : :.::: :. : ...... ... .. NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS 370 380 390 400 410 420 590 600 610 620 630 640 pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM :. . . ::. .:: . .... .. :.. : .. : :.:. ::: ... NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL 430 440 450 460 470 480 650 660 670 680 690 700 pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG--- .:. . :. :...::.:.. ....::.. :. . . ::: .. : : NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR 490 500 510 520 530 540 710 720 730 740 750 760 pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT :: . : : NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID 550 560 570 580 590 600 >>NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [Homo (759 aa) initn: 237 init1: 137 opt: 230 Z-score: 261.5 bits: 59.2 E(85289): 8e-08 Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:431-645) 470 480 490 500 510 520 pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR :. : : .: . .::.: :.. :: : NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 410 420 430 440 450 460 530 540 550 560 570 580 pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ :: : : . : . :: . : : : :.::: :. : ...... ... .. NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS 470 480 490 500 510 590 600 610 620 630 640 pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM :. . . ::. .:: . .... .. :.. : .. : :.:. ::: ... NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL 520 530 540 550 560 570 650 660 670 680 690 700 pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG--- .:. . :. :...::.:.. ....::.. :. . . ::: .. : : NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR 580 590 600 610 620 630 710 720 730 740 750 760 pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT :: . : : NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID 640 650 660 670 680 690 >>XP_011529703 (OMIM: 300304,300354) PREDICTED: cullin-4 (701 aa) initn: 214 init1: 214 opt: 229 Z-score: 260.8 bits: 59.0 E(85289): 8.7e-08 Smith-Waterman score: 229; 28.7% identity (56.0% similar) in 216 aa overlap (501-711:376-587) 480 490 500 510 520 530 pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ :. .. ::: ::.: :.. :: ::: XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG 350 360 370 380 390 400 540 550 560 570 580 590 pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG : : . : . :: . : : : :.::: :. : :. .. : ... : . XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM--IQFKQVKYMQNQNVPGN 410 420 430 440 450 460 600 610 620 630 640 pF1KE3 VYAV--ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDV . . ::. .:: . ....: .. : . : .. : :.:. ::: .. . XP_011 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKA 470 480 490 500 510 520 650 660 670 680 690 700 pF1KE3 ELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VL :. . . :. :...::.:.. ..:::...:. . . ::: .. : : :: XP_011 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVL 530 540 550 560 570 580 710 720 730 740 750 760 pF1KE3 REEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL ..: : XP_011 AKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAA 590 600 610 620 630 640 >>XP_011529702 (OMIM: 300304,300354) PREDICTED: cullin-4 (717 aa) initn: 217 init1: 155 opt: 229 Z-score: 260.7 bits: 59.0 E(85289): 8.8e-08 Smith-Waterman score: 229; 28.0% identity (56.1% similar) in 214 aa overlap (501-711:394-603) 480 490 500 510 520 530 pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ :. .. ::: ::.: :.. :: ::: XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG 370 380 390 400 410 420 540 550 560 570 580 590 pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG : : . : . :: . : : : :.::: :. : .... ... . . . XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELT 430 440 450 460 470 480 600 610 620 630 640 650 pF1KE3 VYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVEL : ::. .:: . ....: .. : . : .. : :.:. ::: .. .:. XP_011 VN--ILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 490 500 510 520 530 540 660 670 680 690 700 pF1KE3 ADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VLRE . . :. :...::.:.. ..:::...:. . . ::: .. : : :: . XP_011 KEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVLAK 550 560 570 580 590 710 720 730 740 750 760 pF1KE3 EPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLES .: : XP_011 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV 600 610 620 630 640 650 >>XP_011529701 (OMIM: 300304,300354) PREDICTED: cullin-4 (719 aa) initn: 214 init1: 214 opt: 229 Z-score: 260.6 bits: 59.0 E(85289): 8.9e-08 Smith-Waterman score: 229; 28.7% identity (56.0% similar) in 216 aa overlap (501-711:394-605) 480 490 500 510 520 530 pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ :. .. ::: ::.: :.. :: ::: XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG 370 380 390 400 410 420 540 550 560 570 580 590 pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG : : . : . :: . : : : :.::: :. : :. .. : ... : . XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM--IQFKQVKYMQNQNVPGN 430 440 450 460 470 480 600 610 620 630 640 pF1KE3 VYAV--ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDV . . ::. .:: . ....: .. : . : .. : :.:. ::: .. . XP_011 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKA 490 500 510 520 530 540 650 660 670 680 690 700 pF1KE3 ELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VL :. . . :. :...::.:.. ..:::...:. . . ::: .. : : :: XP_011 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVL 550 560 570 580 590 710 720 730 740 750 760 pF1KE3 REEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL ..: : XP_011 AKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAA 600 610 620 630 640 650 >>NP_001073341 (OMIM: 300304,300354) cullin-4B isoform 2 (895 aa) initn: 217 init1: 155 opt: 229 Z-score: 259.2 bits: 59.0 E(85289): 1.1e-07 Smith-Waterman score: 229; 28.0% identity (56.1% similar) in 214 aa overlap (501-711:572-781) 480 490 500 510 520 530 pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ :. .. ::: ::.: :.. :: ::: NP_001 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG : : . : . :: . : : : :.::: :. : .... ... . . . NP_001 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELT 610 620 630 640 650 660 600 610 620 630 640 650 pF1KE3 VYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVEL : ::. .:: . ....: .. : . : .. : :.:. ::: .. .:. NP_001 VN--ILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 670 680 690 700 710 660 670 680 690 700 pF1KE3 ADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VLRE . . :. :...::.:.. ..:::...:. . . ::: .. : : :: . NP_001 KEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVLAK 720 730 740 750 760 770 710 720 730 740 750 760 pF1KE3 EPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLES .: : NP_001 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV 780 790 800 810 820 830 822 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:24:28 2016 done: Sat Nov 5 22:24:30 2016 Total Scan time: 13.120 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]