FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1552, 560 aa 1>>>pF1KE1552 560 - 560 aa - 560 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9800+/-0.000501; mu= 10.9112+/- 0.031 mean_var=216.2884+/-41.915, 0's: 0 Z-trim(115.9): 489 B-trim: 130 in 2/53 Lambda= 0.087208 statistics sampled from 26046 (26640) to 26046 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.312), width: 16 Scan time: 9.120 The best scores are: opt bits E(85289) NP_004123 (OMIM: 188050,603924,616535) hyaluronan- ( 560) 4060 524.6 3.1e-148 NP_001171131 (OMIM: 188050,603924,616535) hyaluron ( 534) 3893 503.6 6.4e-142 NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 1148 158.4 6.7e-38 NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 1100 152.3 4.4e-36 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 536 81.0 6.6e-15 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 538 81.4 6.6e-15 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 538 81.4 6.6e-15 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 536 81.2 8e-15 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 536 81.2 8e-15 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 538 81.6 8.3e-15 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 538 81.6 8.4e-15 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 538 81.6 8.4e-15 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 530 80.3 1.2e-14 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 530 80.4 1.4e-14 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 530 80.4 1.4e-14 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 530 80.4 1.4e-14 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 530 80.5 1.5e-14 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 532 81.0 1.6e-14 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 532 81.0 1.6e-14 NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 529 80.7 2.3e-14 NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 529 80.7 2.5e-14 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 516 78.6 4.3e-14 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 516 78.6 4.6e-14 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 516 78.6 4.6e-14 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 516 79.0 6.8e-14 NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 508 77.4 6.8e-14 XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 511 78.1 7.9e-14 XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 511 78.2 8.5e-14 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 510 78.0 8.5e-14 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 511 78.2 8.6e-14 XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 511 78.2 8.6e-14 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 510 78.0 8.9e-14 NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 504 76.8 9.3e-14 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 509 77.9 9.6e-14 NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 500 76.3 1.3e-13 NP_000496 (OMIM: 234000,610618,610619) coagulation ( 615) 505 77.4 1.4e-13 NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 495 75.7 2.1e-13 XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 492 75.2 2.5e-13 XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 492 75.4 2.9e-13 NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 494 75.9 3.2e-13 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 489 74.9 3.4e-13 NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 492 75.6 3.5e-13 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 494 76.0 3.6e-13 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 495 76.2 3.7e-13 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 489 75.0 3.8e-13 NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 489 75.0 3.9e-13 NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 489 75.1 4.1e-13 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 495 76.5 4.8e-13 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 495 76.5 4.9e-13 XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 487 74.9 5e-13 >>NP_004123 (OMIM: 188050,603924,616535) hyaluronan-bind (560 aa) initn: 4060 init1: 4060 opt: 4060 Z-score: 2782.3 bits: 524.6 E(85289): 3.1e-148 Smith-Waterman score: 4060; 100.0% identity (100.0% similar) in 560 aa overlap (1-560:1-560) 10 20 30 40 50 60 pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY 490 500 510 520 530 540 550 560 pF1KE1 TQVTKFLNWIKATIKSESGF :::::::::::::::::::: NP_004 TQVTKFLNWIKATIKSESGF 550 560 >>NP_001171131 (OMIM: 188050,603924,616535) hyaluronan-b (534 aa) initn: 3893 init1: 3893 opt: 3893 Z-score: 2668.9 bits: 503.6 E(85289): 6.4e-142 Smith-Waterman score: 3893; 100.0% identity (100.0% similar) in 534 aa overlap (27-560:1-534) 10 20 30 40 50 60 pF1KE1 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT :::::::::::::::::::::::::::::::::: NP_001 MSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT 10 20 30 70 80 90 100 110 120 pF1KE1 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY 460 470 480 490 500 510 550 560 pF1KE1 TQVTKFLNWIKATIKSESGF :::::::::::::::::::: NP_001 TQVTKFLNWIKATIKSESGF 520 530 >>NP_001519 (OMIM: 604552) hepatocyte growth factor acti (655 aa) initn: 787 init1: 203 opt: 1148 Z-score: 801.5 bits: 158.4 E(85289): 6.7e-38 Smith-Waterman score: 1148; 36.6% identity (61.8% similar) in 503 aa overlap (75-555:162-646) 50 60 70 80 90 100 pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP ::: .:: .::.: ... ::: NP_001 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA 140 150 160 170 180 190 110 120 130 140 150 pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC :.:. : . : :. : . :. .: : . : . : . .: NP_001 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC 200 210 220 230 240 160 170 180 190 200 210 pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH .:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ... NP_001 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV .:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: . NP_001 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE1 SACSAQDVAY--PEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQAS :: . . :. : : :: ..::. . . .. :: :: .: :.::: :. NP_001 EACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAA 370 380 390 400 410 420 340 350 360 370 380 pF1KE1 LQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLKKEEFHEQ . . ::.:.:.: :::..:::: . : ..::::.. ... : NP_001 IYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQ 430 440 450 460 470 390 400 410 420 430 440 pF1KE1 SFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS-FPSGSE .: .:: . :. :. . : :..:..:: .:: .:..:. .:::. :: ::.: . NP_001 TFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHK 480 490 500 510 520 530 450 460 470 480 490 500 pF1KE1 CHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDT :.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: .. . :. NP_001 CQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKS-DA 540 550 560 570 580 590 510 520 530 540 550 560 pF1KE1 CQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF :::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :. NP_001 CQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVA 600 610 620 630 640 650 NP_001 PS >>NP_001284368 (OMIM: 604552) hepatocyte growth factor a (662 aa) initn: 718 init1: 237 opt: 1100 Z-score: 768.8 bits: 152.3 E(85289): 4.4e-36 Smith-Waterman score: 1137; 36.3% identity (61.8% similar) in 510 aa overlap (75-555:162-653) 50 60 70 80 90 100 pF1KE1 SYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDC--LVHGSTFTCSCLAP ::: .:: .::.: ... ::: NP_001 WCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRA 140 150 160 170 180 190 110 120 130 140 150 pF1KE1 FSGNKCQKVQNTCKDNP------CGRGQCLITQSPPYYRCVCKHPYTGPS-CSQVV-PVC :.:. : . : :. : . :. .: : . : . : . .: NP_001 FTGKDCG--TEKCFDETRYEYLEGGDRWARVRQGH-VEQCEC---FGGRTWCEGTRHTAC 200 210 220 230 240 160 170 180 190 200 210 pF1KE1 RPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDD-CYVGDGYSYRGKMNRTVNQH .:: ::.:: . .:::: : :..:.: :. :..:.: .::: . ... NP_001 LSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE1 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV .:: ::: :: :: . . : :.: : .::::: ::.:::.. : .. ..:::: . NP_001 SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRL 310 320 330 340 350 360 280 290 300 310 320 pF1KE1 SACSAQ-----DVAYPEESP----TEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAG ::. . ... . :: : : :: ..::. . . .. :: :: .: : NP_001 EACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPG 370 380 390 400 410 420 330 340 350 360 370 380 pF1KE1 KHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHC-TDIKTRH-LKVVLGDQDLK .::: :.. . ::.:.:.: :::..:::: . : ..::::.. .. NP_001 SHPWLAAIYIG---------DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFN 430 440 450 460 470 390 400 410 420 430 440 pF1KE1 KEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPD-GS . :.: .:: . :. :. . : :..:..:: .:: .:..:. .:::. :: NP_001 RTTDVTQTFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGS 480 490 500 510 520 530 450 460 470 480 490 pF1KE1 -FPSGSECHISGWG-VTETGKG-SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNL ::.: .:.:.::: . :. .: : .: .: : :.:. :.: ..: :. .:.::: . NP_001 TFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYF 540 550 560 570 580 590 500 510 520 530 540 550 pF1KE1 QKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIK . . :.:::::::::.:::.:. :.:::.::: ::. .:::::.:.....::. :. NP_001 DCKS-DACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR 600 610 620 630 640 650 560 pF1KE1 SESGF NP_001 PPRRLVAPS 660 >>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa) initn: 497 init1: 114 opt: 536 Z-score: 388.6 bits: 81.0 E(85289): 6.6e-15 Smith-Waterman score: 569; 41.3% identity (64.2% similar) in 254 aa overlap (313-557:89-324) 290 300 310 320 330 340 pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP :: :: : .. ::::::: NP_115 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF--------- 60 70 80 90 100 350 360 370 380 390 pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS :: :.:::..: : :..:::::. :. . . .: .: . : :::: .: NP_115 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS 110 120 130 140 150 160 400 410 420 430 440 450 pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET .:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.:: NP_115 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED 170 180 190 200 210 220 460 470 480 490 500 510 pF1KE1 GKG--SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTC : : : : : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.: NP_115 GAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVC 230 240 250 260 270 280 520 530 540 550 560 pF1KE1 EKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF .. . . : .:.:. :.. .:::::.::.::.::. .. . NP_115 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 290 300 310 320 >>NP_001305325 (OMIM: 229000,612423) plasma kallikrein i (436 aa) initn: 395 init1: 158 opt: 538 Z-score: 388.6 bits: 81.4 E(85289): 6.6e-15 Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:140-428) 230 240 250 260 270 280 pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV .:: ::.... : : . NP_001 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI 110 120 130 140 150 290 300 310 320 330 340 pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS :: .. . : .: . : . . : . :: :: .:. :. :::.::: .: NP_001 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT---- 160 170 180 190 200 210 350 360 370 380 390 pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI : :.:::.:: :::::::: : .. : . .:. .:. :. : ...: NP_001 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI 220 230 240 250 260 400 410 420 430 440 450 pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW . ...:. . ..::::.::. :.. ... : .:::. . : ..: ..:: NP_001 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG : . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.::::: NP_001 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG 330 340 350 360 370 520 530 540 550 560 pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF ::.:...: . . ::.::: :..: :::::.:.....:: .: .: NP_001 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA 380 390 400 410 420 430 >>XP_016863673 (OMIM: 229000,612423) PREDICTED: plasma k (436 aa) initn: 395 init1: 158 opt: 538 Z-score: 388.6 bits: 81.4 E(85289): 6.6e-15 Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:140-428) 230 240 250 260 270 280 pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV .:: ::.... : : . XP_016 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI 110 120 130 140 150 290 300 310 320 330 340 pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS :: .. . : .: . : . . : . :: :: .:. :. :::.::: .: XP_016 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT---- 160 170 180 190 200 210 350 360 370 380 390 pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI : :.:::.:: :::::::: : .. : . .:. .:. :. : ...: XP_016 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI 220 230 240 250 260 400 410 420 430 440 450 pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW . ...:. . ..::::.::. :.. ... : .:::. . : ..: ..:: XP_016 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG : . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.::::: XP_016 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG 330 340 350 360 370 520 530 540 550 560 pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF ::.:...: . . ::.::: :..: :::::.:.....:: .: .: XP_016 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA 380 390 400 410 420 430 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 504 init1: 158 opt: 536 Z-score: 387.1 bits: 81.2 E(85289): 8e-15 Smith-Waterman score: 569; 40.7% identity (64.8% similar) in 253 aa overlap (313-557:216-450) 290 300 310 320 330 340 pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP :: :: : .. ::::::: NP_001 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF--------- 190 200 210 220 230 350 360 370 380 390 pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS :: :.:::..: : :..:::::. :. . . .: .: . : :::: .: NP_001 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS 240 250 260 270 280 290 400 410 420 430 440 450 pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET .:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.:: NP_001 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED 300 310 320 330 340 460 470 480 490 500 510 pF1KE1 GKGSRQLLD-AKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCE : . .:. : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.:. NP_001 GGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVCQ 350 360 370 380 390 400 520 530 540 550 560 pF1KE1 KDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF . . . : .:.:. :.. .:::::.::.::.::. .. . NP_001 ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 410 420 430 440 450 >>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa) initn: 497 init1: 114 opt: 536 Z-score: 387.1 bits: 81.2 E(85289): 8e-15 Smith-Waterman score: 569; 41.3% identity (64.2% similar) in 254 aa overlap (313-557:216-451) 290 300 310 320 330 340 pF1KE1 YPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP :: :: : .. ::::::: NP_076 HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQF--------- 190 200 210 220 230 350 360 370 380 390 pF1KE1 QG-HFCGGALIHPCWVLTAAHCT-DIKT-RHLKVVLGDQDLKKEEFHEQSFRVEKIFKYS :: :.:::..: : :..:::::. :. . . .: .: . : :::: .: NP_076 QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNP--APSHLVEKIVYHS 240 250 260 270 280 290 400 410 420 430 440 450 pF1KE1 HYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDG--SFPSGSECHISGWGVTET .:. . :::::.:: : .. ..... ::::.. .::.:. : ::::.:: NP_076 KYKPKRL--GNDIALMKLA---GPLTF-NEMIQPVCLPNSEENFPDGKVCWTSGWGATED 300 310 320 330 340 460 470 480 490 500 510 pF1KE1 GKG--SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTC : : : : : : ::.: .:: :..: .:. ::.::: : : :.:::::::::.: NP_076 GAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTG-GVDSCQGDSGGPLVC 350 360 370 380 390 400 520 530 540 550 560 pF1KE1 EKDGTYYVYGIVSWGLECGK--RPGVYTQVTKFLNWIKATIKSESGF .. . . : .:.:. :.. .:::::.::.::.::. .. . NP_076 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 410 420 430 440 450 >>NP_000883 (OMIM: 229000,612423) plasma kallikrein isof (638 aa) initn: 395 init1: 158 opt: 538 Z-score: 386.8 bits: 81.6 E(85289): 8.3e-15 Smith-Waterman score: 550; 33.1% identity (60.9% similar) in 320 aa overlap (252-559:342-630) 230 240 250 260 270 280 pF1KE1 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDV .:: ::.... : : . NP_000 VKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDG-----------SPTRI 320 330 340 350 360 290 300 310 320 330 340 pF1KE1 AYPEESPTEPSTKLPGFDSCGKTEIAERKIK-RIYGGFKSTAGKHPWQASLQSSLPLTIS :: .. . : .: . : . . : . :: :: .:. :. :::.::: .: NP_000 AYGTQGSSGYSLRL---CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT---- 370 380 390 400 410 350 360 370 380 390 pF1KE1 MPQGHFCGGALIHPCWVLTAAHCTD---IKT--RHLKVVLGDQDLKKEEFHEQSFRVEKI : :.:::.:: :::::::: : .. : . .:. .:. :. : ...: NP_000 -AQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQ---IKEI 420 430 440 450 460 400 410 420 430 440 450 pF1KE1 FKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSG--SECHISGW . ...:. . ..::::.::. :.. ... : .:::. . : ..: ..:: NP_000 IIHQNYKVSE--GNHDIALIKLQAPLN-----YTEFQKPICLPSKGDTSTIYTNCWVTGW 470 480 490 500 510 520 460 470 480 490 500 510 pF1KE1 GVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGG : . : :. . : ... :..: :..: :. : . :.::: .. :.:.:.::::: NP_000 GFSKEKGEIQNILQKVNIPLVTNEECQKRY-QDYKITQRMVCAG-YKEGGKDACKGDSGG 530 540 550 560 570 580 520 530 540 550 560 pF1KE1 PLTCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATIKSESGF ::.:...: . . ::.::: :..: :::::.:.....:: .: .: NP_000 PLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA 590 600 610 620 630 560 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:27:01 2016 done: Sun Nov 6 22:27:02 2016 Total Scan time: 9.120 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]