FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3610, 364 aa 1>>>pF1KE3610 364 - 364 aa - 364 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2118+/-0.000349; mu= 16.4876+/- 0.022 mean_var=60.2327+/-11.806, 0's: 0 Z-trim(113.7): 64 B-trim: 1136 in 1/54 Lambda= 0.165256 statistics sampled from 23042 (23109) to 23042 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.271), width: 16 Scan time: 7.900 The best scores are: opt bits E(85289) NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 2512 607.4 1.6e-173 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 524 133.4 8e-31 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 522 132.9 1.2e-30 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 502 128.1 2.1e-29 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 460 118.1 2.9e-26 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 460 118.1 2.9e-26 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 460 118.2 3.4e-26 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 460 118.2 3.4e-26 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 460 118.2 3.4e-26 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 460 118.2 3.4e-26 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 444 114.4 5.8e-25 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 421 108.8 1.3e-23 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 423 109.4 1.6e-23 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 421 108.9 2.1e-23 XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 421 108.9 2.2e-23 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 421 108.9 2.3e-23 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 410 106.3 1.6e-22 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 410 106.3 1.6e-22 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 410 106.3 1.6e-22 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 384 100.1 1.1e-20 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 380 99.1 1.9e-20 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 380 99.1 1.9e-20 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 380 99.1 2.2e-20 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 380 99.2 2.4e-20 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 367 96.0 1.7e-19 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 351 92.2 2.3e-18 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 350 92.0 3e-18 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 334 88.0 2.1e-17 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 338 89.1 2.2e-17 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 334 88.1 3.3e-17 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 333 87.9 4.6e-17 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 325 86.0 1.7e-16 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 316 83.8 7.1e-16 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 305 81.2 4e-15 NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 298 79.5 1.3e-14 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 289 77.4 5.9e-14 XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 273 73.5 6.4e-13 NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 273 73.6 8.1e-13 XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 273 73.6 8.1e-13 NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 273 73.6 8.1e-13 NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 273 73.6 8.1e-13 NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 273 73.6 8.1e-13 XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 273 73.6 8.1e-13 NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 273 73.6 8.1e-13 XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 273 73.6 8.1e-13 XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 273 73.6 8.1e-13 XP_011541610 (OMIM: 601918) PREDICTED: growth/diff ( 454) 273 73.6 9.8e-13 NP_005251 (OMIM: 601918) growth/differentiation fa ( 454) 273 73.6 9.8e-13 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 270 72.9 1.5e-12 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 270 72.9 1.5e-12 >>NP_065685 (OMIM: 606522,613702,613703,613704) growth/d (364 aa) initn: 2512 init1: 2512 opt: 2512 Z-score: 3236.0 bits: 607.4 E(85289): 1.6e-173 Smith-Waterman score: 2512; 99.7% identity (99.7% similar) in 364 aa overlap (1-364:1-364) 10 20 30 40 50 60 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKERE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 FNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSRVNFQPEDTCARLRCSLHASLLVVTLNP :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: NP_065 FNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDE 310 320 330 340 350 360 pF1KE3 CGCG :::: NP_065 CGCG >>NP_001483 (OMIM: 187500,208530,217095,602880,613854) e (372 aa) initn: 595 init1: 222 opt: 524 Z-score: 674.4 bits: 133.4 E(85289): 8e-31 Smith-Waterman score: 701; 36.8% identity (62.6% similar) in 356 aa overlap (29-363:39-371) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGL-DKAPSPQKFQPVPYILKKIFQD .:: ::: :. . ...::: .. ..:. NP_001 CGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPPVMWRLFRR 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 REAAATT--------GVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASS----CL :. : ::. . :.:.:::: ::..: .::.: : . :. .: : NP_001 RDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRG---APTRASEPASAAGHCP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 QKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGK . . :.:::.. :. . :.: : .. . .:: : ..: . : :: NP_001 EWTVVFDLSAVEPAERPSRARLELRFAAAA--AAAPEGGWELSVAQAGQGAGAD---PGP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 MFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSRVNFQPEDTCARL ... . :: :. .:: .: : : .: : . .. . .:::: NP_001 VLLRQLVPALGPPVRAELLGAA--WARNASWPRSLRLALALRP--------RAPAACARL 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 RCSLHASLLVVTLNPDQCHP-SRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIA .::::.:::.: ::: .: :: : :: . . :. ..:...::..:::.:.:: NP_001 A---EASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIA 240 250 260 270 280 290 300 310 320 330 pF1KE3 PKGFMANYCHGECPFSLTISLNSS----NYAFMQALMHAVDP---EIPQAVCIPTKLSPI :.::.::::.:.: . ...: ... :.: ..:::::. : ..: :.:..:::: NP_001 PRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLP--CCVPARLSPI 290 300 310 320 330 340 340 350 360 pF1KE3 SMLYQDNNDNVILRHYEDMVVDECGCG :.:. ::.:::.::.::::::::::: NP_001 SVLFFDNSDNVVLRQYEDMVVDECGCR 350 360 370 >>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa) initn: 485 init1: 462 opt: 522 Z-score: 671.4 bits: 132.9 E(85289): 1.2e-30 Smith-Waterman score: 567; 31.1% identity (61.7% similar) in 360 aa overlap (26-363:54-395) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF : .:...:: . :.:.. :: . .. NP_001 LVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLY 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE3 QDREAAATTGVSRDLCYVKELGVRGNVLR-FLPDQGFFLYPKKISQASSCLQKLLYFNLS :. .. : ... . :.:..: : .... ... ..:. . ..:::: NP_001 --RRHSGQPGSPAPDHRLERAASRANTVRSFHHEESL----EELPETSGKTTRRFFFNLS 90 100 110 120 130 120 130 140 150 160 pF1KE3 AIKEREQLTLAQLGL------D-LGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMF .: .: .: :.: . : :: :: .. .. .. . .: . .. : ... NP_001 SIPTEEFITSAELQVFREQMQDALGNNSSFHH----RINIYEIIKPATANSKFPVT-RLL 140 150 160 170 180 190 170 180 190 200 210 pF1KE3 VLRSVPWPQGAVHFNLLDVAKD---WNDNPRKNFGLFLEILVKEDRD---------SRVN : : :.: ... .::. :. . . : :. .:. :... :: NP_001 DTRLV--NQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE3 FQPEDTCARLRCSLHASLLVVTLNPDQCHP--SRKRRAAIPVPKLSCKNLCHRHQLFINF : : . ...: :::. . . :: .:..: : . :. :.:: :...: NP_001 HQDEHSWSQIR-----PLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDF 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 RDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTK :.::. ::.:: :. : :::::::: :. :::.:.:..:.:...:. .::.: :.::. NP_001 SDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTE 310 320 330 340 350 360 340 350 360 pF1KE3 LSPISMLYQDNNDNVILRHYEDMVVDECGCG :: ::::: :.:..:.:..:.::::. ::: NP_001 LSAISMLYLDENEKVVLKNYQDMVVEGCGCR 370 380 390 >>XP_011527625 (OMIM: 112261,112600,235200) PREDICTED: b (240 aa) initn: 485 init1: 462 opt: 502 Z-score: 649.0 bits: 128.1 E(85289): 2.1e-29 Smith-Waterman score: 502; 39.2% identity (67.5% similar) in 194 aa overlap (181-363:51-239) 160 170 180 190 200 210 pF1KE3 QEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDR :.. .. :. . . : :. .:. :.. XP_011 IKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEK 30 40 50 60 70 80 220 230 240 250 pF1KE3 D---------SRVNFQPEDTCARLRCSLHASLLVVTLNPDQCHP--SRKRRAAIPVPKLS . :: : : . ...: :::. . . :: .:..: : . XP_011 QGVSKRHVRISRSLHQDEHSWSQIR-----PLLVTFGHDGKGHPLHKREKRQAKHKQRKR 90 100 110 120 130 260 270 280 290 300 310 pF1KE3 CKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHA :. :.:: :...: :.::. ::.:: :. : :::::::: :. :::.:.:..:.:... XP_011 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNS 140 150 160 170 180 190 320 330 340 350 360 pF1KE3 VDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG :. .::.: :.::.:: ::::: :.:..:.:..:.::::. ::: XP_011 VNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 200 210 220 230 240 >>XP_016877093 (OMIM: 112262,600625,607932) PREDICTED: b (345 aa) initn: 494 init1: 445 opt: 460 Z-score: 592.4 bits: 118.1 E(85289): 2.9e-26 Smith-Waterman score: 534; 31.5% identity (60.7% similar) in 356 aa overlap (33-363:2-344) 10 20 30 40 50 60 pF1KE3 RFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF--QDREA .:: . :.:.: .: .. .. :. : XP_016 MFGLRRRPQPSKSAVIPDYMRDLYRLQSGEE 10 20 30 70 80 90 100 110 120 pF1KE3 AATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKERE : : : .. . :.:..: . . . :. :. ..: ::::.: : : XP_016 EEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNLSSIPENE 40 50 60 70 80 130 140 150 160 170 pF1KE3 QLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWP .. :.: : : ::. .. : . .. .. :..: . ...: .: . XP_016 VISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKPPA--EVVPGHLITRLLDTRLVH 90 100 110 120 130 140 180 190 200 210 220 pF1KE3 QGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ-PEDTC--A ....... .::. :. . . :.:: .:. ... . :.. . :. . : XP_016 HNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWA 150 160 170 180 190 200 230 240 250 260 270 pF1KE3 RLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQLFINFRDLG .:: :::. . . : .:: : :: :: :.::.:...: :.: XP_016 QLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVG 210 220 230 240 250 280 290 300 310 320 330 pF1KE3 WHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPI :. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: :.::.:: : XP_016 WNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAI 260 270 280 290 300 310 340 350 360 pF1KE3 SMLYQDNNDNVILRHYEDMVVDECGCG :::: :. :.:.:..:..:::. ::: XP_016 SMLYLDEYDKVVLKNYQEMVVEGCGCR 320 330 340 >>XP_016877094 (OMIM: 112262,600625,607932) PREDICTED: b (345 aa) initn: 494 init1: 445 opt: 460 Z-score: 592.4 bits: 118.1 E(85289): 2.9e-26 Smith-Waterman score: 534; 31.5% identity (60.7% similar) in 356 aa overlap (33-363:2-344) 10 20 30 40 50 60 pF1KE3 RFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF--QDREA .:: . :.:.: .: .. .. :. : XP_016 MFGLRRRPQPSKSAVIPDYMRDLYRLQSGEE 10 20 30 70 80 90 100 110 120 pF1KE3 AATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKERE : : : .. . :.:..: . . . :. :. ..: ::::.: : : XP_016 EEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNLSSIPENE 40 50 60 70 80 130 140 150 160 170 pF1KE3 QLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWP .. :.: : : ::. .. : . .. .. :..: . ...: .: . XP_016 VISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKPPA--EVVPGHLITRLLDTRLVH 90 100 110 120 130 140 180 190 200 210 220 pF1KE3 QGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ-PEDTC--A ....... .::. :. . . :.:: .:. ... . :.. . :. . : XP_016 HNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWA 150 160 170 180 190 200 230 240 250 260 270 pF1KE3 RLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQLFINFRDLG .:: :::. . . : .:: : :: :: :.::.:...: :.: XP_016 QLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVG 210 220 230 240 250 280 290 300 310 320 330 pF1KE3 WHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPI :. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: :.::.:: : XP_016 WNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAI 260 270 280 290 300 310 340 350 360 pF1KE3 SMLYQDNNDNVILRHYEDMVVDECGCG :::: :. :.:.:..:..:::. ::: XP_016 SMLYLDEYDKVVLKNYQEMVVEGCGCR 320 330 340 >>NP_570911 (OMIM: 112262,600625,607932) bone morphogene (408 aa) initn: 494 init1: 445 opt: 460 Z-score: 591.3 bits: 118.2 E(85289): 3.4e-26 Smith-Waterman score: 551; 31.8% identity (61.1% similar) in 365 aa overlap (26-363:58-407) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF : ..::..:: . :.:.: .: .. .. NP_570 PETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLY 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE3 --QDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNL :. : : : : .. . :.:..: . . . :. :. ..: ::: NP_570 RLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNL 90 100 110 120 130 140 120 130 140 150 160 pF1KE3 SAIKEREQLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMF- :.: : : .. :.: : : ::. .. : . .. .. :..: . ::... NP_570 SSIPENEVISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKP----PAEVVPGHLIT 150 160 170 180 190 170 180 190 200 210 pF1KE3 -VLRSVPWPQGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ .: . ....... .::. :. . . :.:: .:. ... . :.. . NP_570 RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRS 200 210 220 230 240 250 220 230 240 250 260 pF1KE3 -PEDTC--ARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQ :. . :.:: :::. . . : .:: : :: :: :.::. NP_570 LPQGSGNWAQLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHS 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE3 LFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAV :...: :.::. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: NP_570 LYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKAC 320 330 340 350 360 370 330 340 350 360 pF1KE3 CIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG :.::.:: ::::: :. :.:.:..:..:::. ::: NP_570 CVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 380 390 400 >>NP_001193 (OMIM: 112262,600625,607932) bone morphogene (408 aa) initn: 494 init1: 445 opt: 460 Z-score: 591.3 bits: 118.2 E(85289): 3.4e-26 Smith-Waterman score: 551; 31.8% identity (61.1% similar) in 365 aa overlap (26-363:58-407) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF : ..::..:: . :.:.: .: .. .. NP_001 PETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLY 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE3 --QDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNL :. : : : : .. . :.:..: . . . :. :. ..: ::: NP_001 RLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNL 90 100 110 120 130 140 120 130 140 150 160 pF1KE3 SAIKEREQLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMF- :.: : : .. :.: : : ::. .. : . .. .. :..: . ::... NP_001 SSIPENEVISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKP----PAEVVPGHLIT 150 160 170 180 190 170 180 190 200 210 pF1KE3 -VLRSVPWPQGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ .: . ....... .::. :. . . :.:: .:. ... . :.. . NP_001 RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRS 200 210 220 230 240 250 220 230 240 250 260 pF1KE3 -PEDTC--ARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQ :. . :.:: :::. . . : .:: : :: :: :.::. NP_001 LPQGSGNWAQLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHS 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE3 LFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAV :...: :.::. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: NP_001 LYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKAC 320 330 340 350 360 370 330 340 350 360 pF1KE3 CIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG :.::.:: ::::: :. :.:.:..:..:::. ::: NP_001 CVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 380 390 400 >>XP_005268072 (OMIM: 112262,600625,607932) PREDICTED: b (408 aa) initn: 494 init1: 445 opt: 460 Z-score: 591.3 bits: 118.2 E(85289): 3.4e-26 Smith-Waterman score: 551; 31.8% identity (61.1% similar) in 365 aa overlap (26-363:58-407) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF : ..::..:: . :.:.: .: .. .. XP_005 PETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLY 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE3 --QDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNL :. : : : : .. . :.:..: . . . :. :. ..: ::: XP_005 RLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNL 90 100 110 120 130 140 120 130 140 150 160 pF1KE3 SAIKEREQLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMF- :.: : : .. :.: : : ::. .. : . .. .. :..: . ::... XP_005 SSIPENEVISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKP----PAEVVPGHLIT 150 160 170 180 190 170 180 190 200 210 pF1KE3 -VLRSVPWPQGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ .: . ....... .::. :. . . :.:: .:. ... . :.. . XP_005 RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRS 200 210 220 230 240 250 220 230 240 250 260 pF1KE3 -PEDTC--ARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQ :. . :.:: :::. . . : .:: : :: :: :.::. XP_005 LPQGSGNWAQLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHS 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE3 LFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAV :...: :.::. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: XP_005 LYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKAC 320 330 340 350 360 370 330 340 350 360 pF1KE3 CIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG :.::.:: ::::: :. :.:.:..:..:::. ::: XP_005 CVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 380 390 400 >>XP_016877092 (OMIM: 112262,600625,607932) PREDICTED: b (408 aa) initn: 494 init1: 445 opt: 460 Z-score: 591.3 bits: 118.2 E(85289): 3.4e-26 Smith-Waterman score: 551; 31.8% identity (61.1% similar) in 365 aa overlap (26-363:58-407) 10 20 30 40 50 pF1KE3 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIF : ..::..:: . :.:.: .: .. .. XP_016 PETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLY 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE3 --QDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNL :. : : : : .. . :.:..: . . . :. :. ..: ::: XP_016 RLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAF--RFL-FNL 90 100 110 120 130 140 120 130 140 150 160 pF1KE3 SAIKEREQLTLAQLGL-----DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMF- :.: : : .. :.: : : ::. .. : . .. .. :..: . ::... XP_016 SSIPENEVISSAELRLFREQVDQGPD--WERGFH-RINIYEVMKP----PAEVVPGHLIT 150 160 170 180 190 170 180 190 200 210 pF1KE3 -VLRSVPWPQGAVHFNLLDVAKD---WNDNPRKNFGLFLEIL------VKEDRDSRVNFQ .: . ....... .::. :. . . :.:: .:. ... . :.. . XP_016 RLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRS 200 210 220 230 240 250 220 230 240 250 260 pF1KE3 -PEDTC--ARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC-----KNL-CHRHQ :. . :.:: :::. . . : .:: : :: :: :.::. XP_016 LPQGSGNWAQLR-----PLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHS 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE3 LFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAV :...: :.::. ::.:: :..: ::::.::: :. :::.:.:..:.:...:. ::.: XP_016 LYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKAC 320 330 340 350 360 370 330 340 350 360 pF1KE3 CIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG :.::.:: ::::: :. :.:.:..:..:::. ::: XP_016 CVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 380 390 400 364 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:28:10 2016 done: Sun Nov 6 22:28:12 2016 Total Scan time: 7.900 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]