FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4531, 594 aa 1>>>pF1KE4531 594 - 594 aa - 594 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7434+/-0.00039; mu= 4.9300+/- 0.024 mean_var=231.0322+/-48.365, 0's: 0 Z-trim(120.3): 137 B-trim: 2048 in 1/54 Lambda= 0.084380 statistics sampled from 35154 (35328) to 35154 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.414), width: 16 Scan time: 12.210 The best scores are: opt bits E(85289) NP_058544 (OMIM: 605263) SHC-transforming protein ( 594) 3976 497.1 6.6e-140 XP_011517087 (OMIM: 605263) PREDICTED: SHC-transfo ( 598) 3958 495.0 3e-139 XP_011517088 (OMIM: 605263) PREDICTED: SHC-transfo ( 452) 2778 351.2 4.3e-96 XP_016870299 (OMIM: 605263) PREDICTED: SHC-transfo ( 307) 1798 231.8 2.7e-60 XP_011508194 (OMIM: 600560) PREDICTED: SHC-transfo ( 593) 1398 183.3 2e-45 XP_016870298 (OMIM: 605263) PREDICTED: SHC-transfo ( 359) 1193 158.2 4.4e-38 NP_001123512 (OMIM: 600560) SHC-transforming prote ( 584) 1197 158.8 4.5e-38 NP_892113 (OMIM: 600560) SHC-transforming protein ( 583) 1190 158.0 8.1e-38 XP_005245506 (OMIM: 600560) PREDICTED: SHC-transfo ( 598) 1190 158.0 8.3e-38 NP_003020 (OMIM: 600560) SHC-transforming protein ( 474) 1181 156.8 1.5e-37 NP_001123513 (OMIM: 600560) SHC-transforming prote ( 473) 1174 156.0 2.7e-37 XP_005245508 (OMIM: 600560) PREDICTED: SHC-transfo ( 488) 1174 156.0 2.8e-37 NP_001189788 (OMIM: 600560) SHC-transforming prote ( 428) 1129 150.4 1.1e-35 XP_011508200 (OMIM: 600560) PREDICTED: SHC-transfo ( 432) 1068 143.0 1.9e-33 NP_036567 (OMIM: 605217) SHC-transforming protein ( 582) 1027 138.1 7.6e-32 XP_011526195 (OMIM: 605217) PREDICTED: SHC-transfo ( 594) 1027 138.2 7.8e-32 XP_011526197 (OMIM: 605217) PREDICTED: SHC-transfo ( 537) 1019 137.1 1.4e-31 XP_011526196 (OMIM: 605217) PREDICTED: SHC-transfo ( 549) 1019 137.2 1.4e-31 XP_011508195 (OMIM: 600560) PREDICTED: SHC-transfo ( 592) 943 127.9 9.3e-29 XP_011526198 (OMIM: 605217) PREDICTED: SHC-transfo ( 437) 912 124.0 1e-27 XP_016882056 (OMIM: 605217) PREDICTED: SHC-transfo ( 437) 912 124.0 1e-27 XP_011508196 (OMIM: 600560) PREDICTED: SHC-transfo ( 575) 671 94.8 8.4e-19 XP_011508199 (OMIM: 600560) PREDICTED: SHC-transfo ( 465) 655 92.8 2.8e-18 XP_016857571 (OMIM: 600560) PREDICTED: SHC-transfo ( 565) 526 77.1 1.7e-13 XP_016857570 (OMIM: 600560) PREDICTED: SHC-transfo ( 566) 526 77.1 1.7e-13 XP_016857572 (OMIM: 600560) PREDICTED: SHC-transfo ( 455) 510 75.1 5.6e-13 >>NP_058544 (OMIM: 605263) SHC-transforming protein 3 [H (594 aa) initn: 3976 init1: 3976 opt: 3976 Z-score: 2632.7 bits: 497.1 E(85289): 6.6e-140 Smith-Waterman score: 3976; 99.5% identity (99.8% similar) in 594 aa overlap (1-594:1-594) 10 20 30 40 50 60 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_058 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: NP_058 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_058 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 AKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ :::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_058 AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 550 560 570 580 590 >>XP_011517087 (OMIM: 605263) PREDICTED: SHC-transformin (598 aa) initn: 2699 init1: 2699 opt: 3958 Z-score: 2620.8 bits: 495.0 E(85289): 3e-139 Smith-Waterman score: 3958; 98.8% identity (99.2% similar) in 598 aa overlap (1-594:1-598) 10 20 30 40 50 60 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: XP_011 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQG----SSDIYSTPEGKLHVA ::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_011 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGERQGSSDIYSTPEGKLHVA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 PTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVE 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 CISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGM 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 HNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_011 HNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 550 560 570 580 590 >>XP_011517088 (OMIM: 605263) PREDICTED: SHC-transformin (452 aa) initn: 1519 init1: 1519 opt: 2778 Z-score: 1846.1 bits: 351.2 E(85289): 4.3e-96 Smith-Waterman score: 2778; 98.6% identity (99.0% similar) in 417 aa overlap (182-594:36-452) 160 170 180 190 200 210 pF1KE4 GVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSS :::::::::::::::::::::::::::::: XP_011 KSPRGFPIPRTWPRLREAVWSGRWTLRKKGREAISRVCEAVPGAKGAFKKRKPPSKMLSS 10 20 30 40 50 60 220 230 240 250 260 270 pF1KE4 ILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 ILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVA 70 80 90 100 110 120 280 290 300 310 320 330 pF1KE4 KDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTE 130 140 150 160 170 180 340 350 360 370 380 390 pF1KE4 EEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGE 190 200 210 220 230 240 400 410 420 430 440 pF1KE4 DWQQTPLRQG----SSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPR :::::::::: :::::::::::::::::::::::::::::::::::::::::::::: XP_011 DWQQTPLRQGERQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPR 250 260 270 280 290 300 450 460 470 480 490 500 pF1KE4 KDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRK 310 320 330 340 350 360 510 520 530 540 550 560 pF1KE4 EAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLI ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 EAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLI 370 380 390 400 410 420 570 580 590 pF1KE4 NHHLESSLPIVSAGSELCLQQPVERKQ ::::::::::::::::::::::::::: XP_011 NHHLESSLPIVSAGSELCLQQPVERKQ 430 440 450 >>XP_016870299 (OMIM: 605263) PREDICTED: SHC-transformin (307 aa) initn: 1798 init1: 1798 opt: 1798 Z-score: 1203.6 bits: 231.8 E(85289): 2.7e-60 Smith-Waterman score: 1798; 99.3% identity (99.6% similar) in 278 aa overlap (1-278:1-278) 10 20 30 40 50 60 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA ::::::::::::::::::::::::::::::.::::::: XP_016 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRGSRWSGGMTFAGRRAPFNPLQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL XP_016 LSHFGML >>XP_011508194 (OMIM: 600560) PREDICTED: SHC-transformin (593 aa) initn: 1613 init1: 927 opt: 1398 Z-score: 936.7 bits: 183.3 E(85289): 2e-45 Smith-Waterman score: 1666; 48.1% identity (67.8% similar) in 628 aa overlap (3-593:6-592) 10 20 30 40 50 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP :. ::: .::.:..:... :..:.. . .: : : : : XP_011 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS : .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : : XP_011 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL 60 70 80 90 100 120 130 140 150 160 pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL .:.. :. :. : : : : :: : .:.:.::::.:.:.:. XP_011 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF ::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.: XP_011 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC ::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.::: XP_011 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC 230 240 250 260 270 280 290 300 310 320 330 pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHD---------RMQSLD-EPWT ::::: .:::::::..:::::::::::::. : :. . :: :: ..: : XP_011 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDSHSFTVLSLRMAGFDGSAWD 290 300 310 320 330 340 340 350 360 370 380 pF1KE4 EEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF ::: . :: :::..:.: :: :: .: ::. . :: .:. : . :: ::: :. XP_011 EEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATL 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE4 --GEDWQQTP-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVS :. : .:. : :. . :.:::.:.. : : . XP_011 PVGQPVGGDPEVRKQMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPA 410 420 430 440 450 450 460 470 480 490 500 pF1KE4 SAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWY :.:: ::::::::::::. : : ...: :.:..: :. XP_011 INGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWF 460 470 480 490 510 520 530 540 550 560 pF1KE4 QGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVF .:..::.:::.::. .::::::.:::.::..::::...:: ::::::::::...:::. : XP_011 HGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF 500 510 520 530 540 550 570 580 590 pF1KE4 DSISHLINHHLESSLPIVSAGSELCLQQPVERKQ .:.::::..:... :::.::::::::::::::: XP_011 ESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 560 570 580 590 >>XP_016870298 (OMIM: 605263) PREDICTED: SHC-transformin (359 aa) initn: 1211 init1: 1187 opt: 1193 Z-score: 804.7 bits: 158.2 E(85289): 4.4e-38 Smith-Waterman score: 1193; 87.9% identity (92.6% similar) in 215 aa overlap (1-210:1-215) 10 20 30 40 50 60 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 TR---EAISRVCEAVP-GAKGAFKK-RKPPSKMLSSILGKSNLQFAGMSISLTISTASLN :: :..... : : . ... :: :: .: XP_016 TRVHLEGLAKLSSQVTSGFQHSINALRKQKSKRISYPQDLAQAERSCVEWKMDIEEEGQV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 LRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIG XP_016 WSHPEWFLLLPRCPGFSHGLCWVLPWVLWMHPACWKFCALCFHPFVVVMTVYLSPVPSSA 250 260 270 280 290 300 >>NP_001123512 (OMIM: 600560) SHC-transforming protein 1 (584 aa) initn: 1524 init1: 960 opt: 1197 Z-score: 804.5 bits: 158.8 E(85289): 4.5e-38 Smith-Waterman score: 1694; 48.8% identity (68.8% similar) in 619 aa overlap (3-593:6-583) 10 20 30 40 50 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP :. ::: .::.:..:... :..:.. . .: : : : : NP_001 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS : .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : : NP_001 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL 60 70 80 90 100 120 130 140 150 160 pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL .:.. :. :. : : : : :: : .:.:.::::.:.:.:. NP_001 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF ::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.: NP_001 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC ::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.::: NP_001 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC 230 240 250 260 270 280 290 300 310 320 330 pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH ::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . :: NP_001 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT :::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :. NP_001 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD 350 360 370 380 390 400 400 410 420 430 440 pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD : .:. : :. . :.:::.:.. : : . :.:: : NP_001 PEVRKQMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D 410 420 430 440 450 450 460 470 480 490 500 pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA :::::::::::. : : ...: :.:..: :..:..::.:: NP_001 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA 460 470 480 490 510 520 530 540 550 560 pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH :.::. .::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::.. NP_001 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISY 500 510 520 530 540 550 570 580 590 pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ :... :::.::::::::::::::: NP_001 HMDNHLPIISAGSELCLQQPVERKL 560 570 580 >>NP_892113 (OMIM: 600560) SHC-transforming protein 1 is (583 aa) initn: 1441 init1: 960 opt: 1190 Z-score: 799.9 bits: 158.0 E(85289): 8.1e-38 Smith-Waterman score: 1687; 48.8% identity (68.8% similar) in 619 aa overlap (3-593:6-582) 10 20 30 40 50 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP :. ::: .::.:..:... :..:.. . .: : : : : NP_892 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS : .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : : NP_892 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL 60 70 80 90 100 120 130 140 150 160 pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL .:.. :. :. : : : : :: : .:.:.::::.:.:.:. NP_892 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF ::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.: NP_892 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC ::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.::: NP_892 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC 230 240 250 260 270 280 290 300 310 320 330 pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH ::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . :: NP_892 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT :::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :. NP_892 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD 350 360 370 380 390 400 400 410 420 430 440 pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD : .:. : .: . :.:::.:.. : : . :.:: : NP_892 PEVRKQMPPPPPCPGRELF-----DDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D 410 420 430 440 450 450 460 470 480 490 500 pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA :::::::::::. : : ...: :.:..: :..:..::.:: NP_892 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA 460 470 480 490 510 520 530 540 550 560 pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH :.::. .::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::.. NP_892 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISY 500 510 520 530 540 550 570 580 590 pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ :... :::.::::::::::::::: NP_892 HMDNHLPIISAGSELCLQQPVERKL 560 570 580 >>XP_005245506 (OMIM: 600560) PREDICTED: SHC-transformin (598 aa) initn: 1239 init1: 960 opt: 1190 Z-score: 799.8 bits: 158.0 E(85289): 8.3e-38 Smith-Waterman score: 1485; 47.0% identity (67.1% similar) in 583 aa overlap (3-557:6-546) 10 20 30 40 50 pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP :. ::: .::.:..:... :..:.. . .: : : : : XP_005 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS : .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : : XP_005 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL 60 70 80 90 100 120 130 140 150 160 pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL .:.. :. :. : : : : :: : .:.:.::::.:.:.:. XP_005 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF ::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.: XP_005 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC ::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.::: XP_005 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC 230 240 250 260 270 280 290 300 310 320 330 pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH ::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . :: XP_005 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT :::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :. XP_005 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD 350 360 370 380 390 400 400 410 420 430 440 pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD : .:. : .: . :.:::.:.. : : . :.:: : XP_005 PEVRKQMPPPPPCPGRELF-----DDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D 410 420 430 440 450 450 460 470 480 490 500 pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA :::::::::::. : : ...: :.:..: :..:..::.:: XP_005 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA 460 470 480 490 510 520 530 540 550 560 pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH :.::. .::::::.:::.::..::::...:: ::::::::::.... . XP_005 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVSVAEVWVRGGKKEGTV 500 510 520 530 540 550 570 580 590 pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ XP_005 PYSVSLFLPSLLCRHSRWAAVYGPLLLFKVSGIFLQRLIP 560 570 580 590 >>NP_003020 (OMIM: 600560) SHC-transforming protein 1 is (474 aa) initn: 1550 init1: 960 opt: 1181 Z-score: 795.2 bits: 156.8 E(85289): 1.5e-37 Smith-Waterman score: 1631; 56.1% identity (75.5% similar) in 469 aa overlap (136-593:33-473) 110 120 130 140 150 160 pF1KE4 AAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEV .: :: : .:.:.::::.:.:.:.::.:: NP_003 KLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEV 10 20 30 40 50 60 170 180 190 200 210 220 pF1KE4 LRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSI :.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:::: : NP_003 LQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPI 70 80 90 100 110 120 230 240 250 260 270 280 pF1KE4 SLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILEC .::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.:::::::: NP_003 TLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILEC 130 140 150 160 170 180 290 300 310 320 330 340 pF1KE4 CDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDHPYYNS .:::::::..:::::::::::::. : :. . :::: ..: : ::: . :: :::. NP_003 PEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYND 190 200 210 220 230 240 350 360 370 380 390 400 pF1KE4 IPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQTP-LRQ .:.: :: :: .: ::. . :: .:. : . :: ::: :. :. : .:. NP_003 FPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGDPEVRK 250 260 270 280 290 410 420 430 440 450 pF1KE4 GSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKDLFDMK : :. . :.:::.:.. : : . :.:: :::::: NP_003 QMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-DLFDMK 300 310 320 330 340 350 460 470 480 490 500 510 pF1KE4 PFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLE ::::::. : : ...: :.:..: :..:..::.:::.::. NP_003 PFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQ 360 370 380 390 520 530 540 550 560 570 pF1KE4 KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESS .::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::..:... NP_003 LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNH 400 410 420 430 440 450 580 590 pF1KE4 LPIVSAGSELCLQQPVERKQ :::.::::::::::::::: NP_003 LPIISAGSELCLQQPVERKL 460 470 594 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:12:20 2016 done: Sun Nov 6 00:12:22 2016 Total Scan time: 12.210 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]