FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6134, 143 aa 1>>>pF1KE6134 143 - 143 aa - 143 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6112+/-0.000388; mu= 14.8093+/- 0.024 mean_var=51.8852+/-10.546, 0's: 0 Z-trim(111.9): 12 B-trim: 650 in 1/52 Lambda= 0.178054 statistics sampled from 20568 (20575) to 20568 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.241), width: 16 Scan time: 3.550 The best scores are: opt bits E(85289) NP_001851 (OMIM: 603088) probable low affinity cop ( 143) 931 246.7 9.7e-66 XP_011516518 (OMIM: 603088) PREDICTED: probable lo ( 141) 919 243.6 8.1e-65 XP_016869756 (OMIM: 603088) PREDICTED: probable lo ( 199) 920 243.9 9e-65 NP_001850 (OMIM: 603085) high affinity copper upta ( 190) 223 64.9 6.8e-11 >>NP_001851 (OMIM: 603088) probable low affinity copper (143 aa) initn: 931 init1: 931 opt: 931 Z-score: 1301.2 bits: 246.7 E(85289): 9.7e-66 Smith-Waterman score: 931; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE6 MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTW 70 80 90 100 110 120 130 140 pF1KE6 IFLGVVLGSAVGYYLAYPLLSTA ::::::::::::::::::::::: NP_001 IFLGVVLGSAVGYYLAYPLLSTA 130 140 >>XP_011516518 (OMIM: 603088) PREDICTED: probable low af (141 aa) initn: 919 init1: 919 opt: 919 Z-score: 1284.7 bits: 243.6 E(85289): 8.1e-65 Smith-Waterman score: 919; 100.0% identity (100.0% similar) in 141 aa overlap (3-143:1-141) 10 20 30 40 50 60 pF1KE6 MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPT 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 SISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTW 60 70 80 90 100 110 130 140 pF1KE6 IFLGVVLGSAVGYYLAYPLLSTA ::::::::::::::::::::::: XP_011 IFLGVVLGSAVGYYLAYPLLSTA 120 130 140 >>XP_016869756 (OMIM: 603088) PREDICTED: probable low af (199 aa) initn: 920 init1: 920 opt: 920 Z-score: 1283.9 bits: 243.9 E(85289): 9e-65 Smith-Waterman score: 920; 99.3% identity (100.0% similar) in 142 aa overlap (2-143:58-199) 10 20 30 pF1KE6 MAMHFIFSDTAVLLFDFWSVHSPAGMALSVL .::::::::::::::::::::::::::::: XP_016 MAQLPDKMAANQICLPFHPHTDVCLHRNSFSMHFIFSDTAVLLFDFWSVHSPAGMALSVL 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE6 VLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYL 90 100 110 120 130 140 100 110 120 130 140 pF1KE6 CHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA 150 160 170 180 190 >>NP_001850 (OMIM: 603085) high affinity copper uptake p (190 aa) initn: 210 init1: 118 opt: 223 Z-score: 316.5 bits: 64.9 E(85289): 6.8e-11 Smith-Waterman score: 228; 33.6% identity (65.0% similar) in 143 aa overlap (1-135:43-174) 10 20 pF1KE6 MAMHFIFSDTAV-LLFDFWSVHSPAGMALS : : : :. : :::. ... . :: . NP_001 DSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGA 20 30 40 50 60 70 30 40 50 60 70 80 pF1KE6 VLVLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGDSAGSD--SFPV ....:::..:::.:... .:: .:: . ..:. . :: ..:.. ::: NP_001 FVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFP- 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE6 GRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLST :. :...:.:::::.::.:: :.:: .. ..:. :...::.: NP_001 ----------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAV 140 150 160 170 180 pF1KE6 A NP_001 VVDITEHCH 190 143 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 09:45:33 2016 done: Tue Nov 8 09:45:34 2016 Total Scan time: 3.550 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]