FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6231, 743 aa 1>>>pF1KB6231 743 - 743 aa - 743 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3512+/-0.000408; mu= 6.6318+/- 0.025 mean_var=180.1294+/-37.802, 0's: 0 Z-trim(117.7): 98 B-trim: 1503 in 2/56 Lambda= 0.095561 statistics sampled from 29870 (29977) to 29870 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.691), E-opt: 0.2 (0.351), width: 16 Scan time: 13.850 The best scores are: opt bits E(85289) NP_057653 (OMIM: 181450,601621) T-box transcriptio ( 743) 4919 691.1 4.4e-198 NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 3254 461.5 5.5e-129 NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 1083 162.2 6.8e-39 XP_011523461 (OMIM: 600747) PREDICTED: T-box trans ( 486) 802 123.3 2.3e-27 XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 551 88.7 5.3e-17 NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 551 88.8 6.6e-17 NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 551 88.8 6.6e-17 XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 551 88.8 7.2e-17 XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 551 88.8 7.2e-17 NP_001159692 (OMIM: 606061,611363) T-box transcrip ( 297) 529 85.6 3.3e-16 NP_001071121 (OMIM: 606061,611363) T-box transcrip ( 447) 529 85.7 4.6e-16 NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 528 85.6 5.7e-16 NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 528 85.6 5.7e-16 XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 528 85.6 5.8e-16 NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 526 85.3 6.3e-16 NP_005983 (OMIM: 187500,188400,192430,217095,60205 ( 372) 520 84.4 9.4e-16 NP_542377 (OMIM: 187500,188400,192430,217095,60205 ( 398) 520 84.4 9.9e-16 XP_016884417 (OMIM: 187500,188400,192430,217095,60 ( 448) 520 84.4 1.1e-15 XP_006724375 (OMIM: 187500,188400,192430,217095,60 ( 495) 520 84.5 1.2e-15 XP_016884415 (OMIM: 187500,188400,192430,217095,60 ( 495) 520 84.5 1.2e-15 NP_542378 (OMIM: 187500,188400,192430,217095,60205 ( 495) 520 84.5 1.2e-15 XP_016884414 (OMIM: 187500,188400,192430,217095,60 ( 545) 520 84.5 1.3e-15 NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 516 83.8 1.4e-15 XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 516 83.9 1.5e-15 XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15 XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15 NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 510 83.0 2.8e-15 XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15 XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 503 82.0 4.7e-15 XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 503 82.0 4.8e-15 XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 503 82.0 4.8e-15 XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 503 82.0 4.8e-15 XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 503 82.0 4.8e-15 NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 503 82.2 7e-15 NP_689593 (OMIM: 260660,604127) T-box transcriptio ( 496) 474 78.1 9.6e-14 NP_001317606 (OMIM: 260660,604127) T-box transcrip ( 602) 474 78.2 1.1e-13 XP_005271218 (OMIM: 260660,604127) PREDICTED: T-bo ( 635) 456 75.7 6.5e-13 XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 420 70.6 1.3e-11 NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 420 70.7 1.7e-11 NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 420 70.7 1.7e-11 XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 420 70.7 1.7e-11 XP_016866961 (OMIM: 143100,143400,604613) PREDICTE ( 449) 409 69.1 4.4e-11 NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 402 68.1 7.5e-11 NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 402 68.2 8.4e-11 XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 402 68.2 8.4e-11 NP_006584 (OMIM: 604616) T-box brain protein 1 [Ho ( 682) 404 68.6 9.9e-11 NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 398 67.7 1.4e-10 XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 405 68.9 1.6e-10 XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 405 68.9 1.7e-10 XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 405 69.0 2.3e-10 >>NP_057653 (OMIM: 181450,601621) T-box transcription fa (743 aa) initn: 4919 init1: 4919 opt: 4919 Z-score: 3677.2 bits: 691.1 E(85289): 4.4e-198 Smith-Waterman score: 4919; 100.0% identity (100.0% similar) in 743 aa overlap (1-743:1-743) 10 20 30 40 50 60 pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB6 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE 670 680 690 700 710 720 730 740 pF1KB6 LQSIQRLVSGLEAKPDRSRSASP ::::::::::::::::::::::: NP_057 LQSIQRLVSGLEAKPDRSRSASP 730 740 >>NP_005987 (OMIM: 181450,601621) T-box transcription fa (723 aa) initn: 3254 init1: 3254 opt: 3254 Z-score: 2436.8 bits: 461.5 E(85289): 5.5e-129 Smith-Waterman score: 4725; 97.3% identity (97.3% similar) in 743 aa overlap (1-743:1-723) 10 20 30 40 50 60 pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT :::::::::::::::::::::::::::::::::::::::: NP_005 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT-------------------- 190 200 210 220 250 260 270 280 290 300 pF1KB6 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB6 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB6 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB6 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB6 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE 650 660 670 680 690 700 730 740 pF1KB6 LQSIQRLVSGLEAKPDRSRSASP ::::::::::::::::::::::: NP_005 LQSIQRLVSGLEAKPDRSRSASP 710 720 >>NP_005985 (OMIM: 600747) T-box transcription factor TB (712 aa) initn: 1467 init1: 884 opt: 1083 Z-score: 819.3 bits: 162.2 E(85289): 6.8e-39 Smith-Waterman score: 2309; 56.0% identity (70.5% similar) in 770 aa overlap (5-743:1-706) 10 20 30 40 50 pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGH-QPPFFPALTLPPNGAAALSLPG- ::.:.. ...:::::: : :: ::: :. :: :::::.::: :: : :: NP_005 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPP-GALAKPLPDP 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 --ALAKPIMDQLVGAAETGIPFSSLGPQ---AHLRPLKTMEPEEEVEDDPKVHLEAKELW : : ..:::.:. :.:::. :::: ::..:::.:::::::: ::::::: NP_005 GLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 DQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVA ::::: :::::::::::::::::::: :::::::::::::::.::::::::::::::::: NP_005 DQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 GKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGN :::::::::::::::::::::::::.: :.::::::::::::::::: NP_005 GKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFT------------- 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 YSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLK :::::::::::::::::::::::::::::::.::::.:::::::::::::::: NP_005 -------ILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLK 230 240 250 260 270 300 310 320 330 340 350 pF1KB6 IDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKE-NGT-SDESSSEQAAFNCFAQ :::::::::::::::::::::::::: :.:...:. : : .:. :: :: . NP_005 IDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAR--EP 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB6 ASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPA .::.:. : :. :.. :.: : :: . . .. .. : :..:: NP_005 PTSPGAA---PSPLRLHRARAEEKSCAADSDPE--PERLSEERAGAPLGRSPAPDSASP- 340 350 360 370 380 420 430 440 450 460 470 pF1KB6 VKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEAR ..: :: :. . ::. . :: . : : :: .: . . .:.: NP_005 --TRLTEPERARE-----RRSPERGKEPAE----SGGDGPFGLRSLEKERAEARRKDEGR 390 400 410 420 430 480 490 500 510 520 pF1KB6 --ALPGKE-AFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFN----GHPLFLHPSQ : ::: ..:::.::::.:. :. : ::::.:. : :::::. :.::::::.: NP_005 KEAAEGKEQGLAPLVVQTDSASP-LGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQ 440 450 460 470 480 490 530 540 550 560 570 580 pF1KB6 FAMG-GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQG--LSGAS-AATLPF :.:: ::::.: ::: :::.:.:...: .: .:: . :.. : :.:: :: .:: NP_005 FTMGPGAFSAM---GMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPF 500 510 520 530 540 550 590 600 610 620 pF1KB6 HLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSA-----------AASSSVHRHPFL ::.::.:::::. : ::.:::::::::::::::.:: ::..:. : ::: NP_005 HLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFL 560 570 580 590 600 610 630 640 650 660 670 680 pF1KB6 NLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSG . . :::::.:::.::: .: ..:::::.: : .. :. ... :: NP_005 G--SARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSR----EPSPLP------ 620 630 640 650 660 690 700 710 720 730 740 pF1KB6 SELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP :: :. . : .:::. : :::: .:::::::::::::.. :. :: NP_005 -ELALRKVG-APSRGALSPSGSA-KEAA-NELQSIQRLVSGLESQ----RALSPGRESPK 670 680 690 700 710 >>XP_011523461 (OMIM: 600747) PREDICTED: T-box transcrip (486 aa) initn: 1016 init1: 534 opt: 802 Z-score: 612.3 bits: 123.3 E(85289): 2.3e-27 Smith-Waterman score: 1256; 49.9% identity (67.5% similar) in 523 aa overlap (245-743:1-480) 220 230 240 250 260 270 pF1KB6 DKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFP :::::::::::::::::::::::::::.:: XP_011 MHKYQPRFHIVRANDILKLPYSTFRTYVFP 10 20 30 280 290 300 310 320 330 pF1KB6 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKE-N ::.:::::::::::::::::::::::::::::::::::::::::: :.:...:. : : . XP_011 ETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERD 40 50 60 70 80 90 340 350 360 370 380 390 pF1KB6 GT-SDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDA :. :: :: . .::.:. : :. :.. :.: : :: . XP_011 GAESDASSCDPPP--AREPPTSPGAAP---SPLRLHRARAEEKSCAADSDPE--PERLSE 100 110 120 130 140 400 410 420 430 440 450 pF1KB6 AKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAE . .. .. : :..::. .: :: :. . ::. . :: . : : XP_011 ERAGAPLGRSPAPDSASPT---RLTEPERARE-----RRSPERGKEPAE----SGGDGPF 150 160 170 180 190 460 470 480 490 500 pF1KB6 ERRSPVREGTAPAKVEEAR--ALPGKE-AFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAG :: .: . . .:.: : ::: ..:::.::::.:. :. : ::::.:. : : XP_011 GLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASP-LGAGHLPGLAFSSHLHG 200 210 220 230 240 250 510 520 530 540 550 560 pF1KB6 QQFFN----GHPLFLHPSQFAMG-GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASA ::::. :.::::::.::.:: ::::.: ::: :::.:.:...: .: .:: . XP_011 QQFFGPLGAGQPLFLHPGQFTMGPGAFSAM---GMGHLLASVAGGGNGGGGGPGTAAGLD 260 270 280 290 300 570 580 590 600 610 pF1KB6 AAAQG--LSGAS-AATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSA---- :.. : :.:: :: .::::.::.:::::. : ::.:::::::::::::::.:: XP_011 AGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPAT 310 320 330 340 350 360 620 630 640 650 660 670 pF1KB6 -------AASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPL ::..:. : ::: .. :::::.:::.::: .: ..:::::.: : .. :. XP_011 SAAAAAAAAAGSLSRSPFL--GSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGG 370 380 390 400 410 420 680 690 700 710 720 730 pF1KB6 DGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSG ... :: :: :. : . .:::. : :::: .::::::::::: XP_011 NSR----EPSPLP-------ELALRKVGAPSRG-ALSPSGSA-KEAA-NELQSIQRLVSG 430 440 450 460 470 740 pF1KB6 LEAKPDRSRSASP ::.. :. :: XP_011 LESQ----RALSPGRESPK 480 >>XP_011523797 (OMIM: 147891,601719) PREDICTED: T-box tr (417 aa) initn: 832 init1: 543 opt: 551 Z-score: 426.2 bits: 88.7 E(85289): 5.3e-17 Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341) 20 30 40 50 60 70 pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA :. .: .:: : ::: : : :: XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA 50 60 70 80 90 100 80 90 100 110 120 130 pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR 110 120 130 140 150 140 150 160 170 180 190 pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR ::: .:: ..:.:.::::::: : : . ::::::::::: XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR 220 230 240 250 260 270 280 290 300 pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG .:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : . XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 260 270 280 290 300 310 310 320 330 340 350 360 pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL . : : . :. . : .. .: XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE 320 330 340 350 360 370 >>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa) initn: 853 init1: 543 opt: 551 Z-score: 424.5 bits: 88.8 E(85289): 6.6e-17 Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:17-278) 20 30 40 50 60 70 pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA :. .: .:: : ::: : : :: NP_060 MLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA 10 20 30 40 80 90 100 110 120 130 pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: NP_060 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: NP_060 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR ::: .:: ..:.:.::::::: : : . ::::::::::: NP_060 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR 160 170 180 190 260 270 280 290 300 pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG .:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : . NP_060 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL . : : . :. . : .. .: NP_060 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE 260 270 280 290 300 310 >>NP_001308049 (OMIM: 147891,601719) T-box transcription (546 aa) initn: 839 init1: 543 opt: 551 Z-score: 424.5 bits: 88.8 E(85289): 6.6e-17 Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:17-278) 20 30 40 50 60 70 pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA :. .: .:: : ::: : : :: NP_001 MLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA 10 20 30 40 80 90 100 110 120 130 pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: NP_001 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: NP_001 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR ::: .:: ..:.:.::::::: : : . ::::::::::: NP_001 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR 160 170 180 190 260 270 280 290 300 pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG .:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : . NP_001 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL . : : . :. . : .. .: NP_001 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE 260 270 280 290 300 310 >>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa) initn: 853 init1: 543 opt: 551 Z-score: 423.9 bits: 88.8 E(85289): 7.2e-17 Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341) 20 30 40 50 60 70 pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA :. .: .:: : ::: : : :: XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA 50 60 70 80 90 100 80 90 100 110 120 130 pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR 110 120 130 140 150 140 150 160 170 180 190 pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR ::: .:: ..:.:.::::::: : : . ::::::::::: XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR 220 230 240 250 260 270 280 290 300 pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG .:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : . XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 260 270 280 290 300 310 310 320 330 340 350 360 pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL . : : . :. . : .. .: XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE 320 330 340 350 360 370 >>XP_011523792 (OMIM: 147891,601719) PREDICTED: T-box tr (609 aa) initn: 839 init1: 543 opt: 551 Z-score: 423.9 bits: 88.8 E(85289): 7.2e-17 Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341) 20 30 40 50 60 70 pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA :. .: .:: : ::: : : :: XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA 50 60 70 80 90 100 80 90 100 110 120 130 pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR 110 120 130 140 150 140 150 160 170 180 190 pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR ::: .:: ..:.:.::::::: : : . ::::::::::: XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR 220 230 240 250 260 270 280 290 300 pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG .:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : . XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 260 270 280 290 300 310 310 320 330 340 350 360 pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL . : : . :. . : .. .: XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE 320 330 340 350 360 370 >>NP_001159692 (OMIM: 606061,611363) T-box transcription (297 aa) initn: 581 init1: 275 opt: 529 Z-score: 411.9 bits: 85.6 E(85289): 3.3e-16 Smith-Waterman score: 777; 45.5% identity (65.3% similar) in 303 aa overlap (19-306:9-289) 10 20 30 40 50 pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVL---GHQPPFFPALTLPPNGAAALSLP : : :: :...:.. : . :. : . NP_001 MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKP--LEQFVEK 10 20 30 40 60 70 80 90 100 110 pF1KB6 GALAKPI--MDQLVGAAETGIPFSSLGPQAHL--RPLKTMEPEEEVEDDPKV--HLEAKE .. :.:. . .: . .: : .: .. : .:: : :. :. ::.:: NP_001 SSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKE 50 60 70 80 90 100 120 130 140 150 160 pF1KB6 LWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKF--HNSR :::.::. ::::.:::::::::: ..: ::.: .::::.::::. .:. ::.. : : NP_001 LWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSS 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 WMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHAT :.::::::: .: :.:.::::: :::: ....:.:.:.::::: :.:: NP_001 WLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHG----------- 170 180 190 200 210 230 240 250 260 270 280 pF1KB6 WQGNYSFGTQTILNSMHKYQPRFHIVRAND----ILKLPYSTFRTYLFPETEFIAVTAYQ . ::::::::::: ::.. .: .:.: :::..:::: : :::::: NP_001 ---------HIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQ 220 230 240 250 260 290 300 310 320 330 340 pF1KB6 NDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAA :. ::.::::.:::::::::. NP_001 NQLITKLKIDSNPFAKGFRDSSRLTDIER 270 280 290 743 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:10:52 2016 done: Sun Nov 6 06:10:54 2016 Total Scan time: 13.850 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]