FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3928, 396 aa 1>>>pF1KE3928 396 - 396 aa - 396 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0948+/-0.000397; mu= 18.4624+/- 0.025 mean_var=72.1294+/-14.620, 0's: 0 Z-trim(111.7): 151 B-trim: 1228 in 1/50 Lambda= 0.151014 statistics sampled from 20193 (20345) to 20193 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.239), width: 16 Scan time: 7.390 The best scores are: opt bits E(85289) NP_001287787 (OMIM: 613292) DENN domain-containing ( 396) 2657 588.4 1e-167 XP_016855960 (OMIM: 613292) PREDICTED: DENN domain ( 745) 2573 570.3 5.4e-162 XP_005244988 (OMIM: 613292) PREDICTED: DENN domain ( 755) 2444 542.2 1.6e-153 XP_011507549 (OMIM: 613292) PREDICTED: DENN domain ( 803) 2444 542.2 1.6e-153 NP_079096 (OMIM: 613633) DENN domain-containing pr ( 559) 1839 410.3 5.9e-114 XP_005252170 (OMIM: 613633) PREDICTED: DENN domain ( 574) 1839 410.3 6e-114 XP_011517189 (OMIM: 613633) PREDICTED: DENN domain ( 592) 1839 410.3 6.2e-114 NP_065997 (OMIM: 613633) DENN domain-containing pr (1009) 1839 410.5 9.3e-114 XP_005252168 (OMIM: 613633) PREDICTED: DENN domain (1024) 1839 410.5 9.4e-114 XP_011517188 (OMIM: 613633) PREDICTED: DENN domain (1042) 1839 410.5 9.6e-114 XP_016870437 (OMIM: 613633) PREDICTED: DENN domain (1052) 1839 410.5 9.6e-114 XP_011517185 (OMIM: 613633) PREDICTED: DENN domain (1066) 1839 410.5 9.7e-114 XP_006717258 (OMIM: 613633) PREDICTED: DENN domain (1067) 1839 410.5 9.7e-114 XP_005252166 (OMIM: 613633) PREDICTED: DENN domain (1070) 1839 410.5 9.8e-114 XP_011517184 (OMIM: 613633) PREDICTED: DENN domain (1085) 1839 410.5 9.9e-114 XP_011517187 (OMIM: 613633) PREDICTED: DENN domain (1049) 1836 409.8 1.5e-113 XP_016870436 (OMIM: 613633) PREDICTED: DENN domain (1058) 1782 398.1 5.3e-110 NP_659414 (OMIM: 613292) DENN domain-containing pr ( 426) 1693 378.4 1.8e-104 XP_016870440 (OMIM: 613633) PREDICTED: DENN domain (1020) 1694 378.9 3e-104 XP_011517186 (OMIM: 613633) PREDICTED: DENN domain (1056) 1694 378.9 3.1e-104 XP_016855959 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99 XP_006711256 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99 XP_011507551 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99 XP_006711255 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1609 360.3 9.2e-99 NP_001182144 (OMIM: 613292) DENN domain-containing ( 775) 1609 360.3 9.2e-99 XP_011507550 (OMIM: 613292) PREDICTED: DENN domain ( 788) 1609 360.3 9.4e-99 XP_011507548 (OMIM: 613292) PREDICTED: DENN domain ( 823) 1609 360.3 9.7e-99 XP_011507553 (OMIM: 613292) PREDICTED: DENN domain ( 447) 1395 313.5 6.6e-85 XP_016870439 (OMIM: 613633) PREDICTED: DENN domain (1025) 1349 303.7 1.3e-81 XP_016870438 (OMIM: 613633) PREDICTED: DENN domain (1043) 1349 303.7 1.3e-81 XP_011526620 (OMIM: 613634) PREDICTED: DENN domain ( 757) 999 227.4 9.2e-59 XP_006722969 (OMIM: 613634) PREDICTED: DENN domain ( 757) 999 227.4 9.2e-59 NP_001277260 (OMIM: 613634) DENN domain-containing ( 757) 999 227.4 9.2e-59 NP_079174 (OMIM: 613634) DENN domain-containing pr ( 801) 999 227.4 9.6e-59 XP_016855961 (OMIM: 613292) PREDICTED: DENN domain ( 491) 838 192.1 2.4e-48 XP_006711257 (OMIM: 613292) PREDICTED: DENN domain ( 469) 691 160.1 1e-38 XP_016870441 (OMIM: 613633) PREDICTED: DENN domain ( 811) 644 150.0 1.9e-35 XP_006722968 (OMIM: 613634) PREDICTED: DENN domain ( 715) 635 148.0 6.6e-35 XP_011518631 (OMIM: 140750) PREDICTED: suppression ( 717) 374 91.2 8.6e-18 XP_005253140 (OMIM: 140750) PREDICTED: suppression ( 717) 374 91.2 8.6e-18 NP_631896 (OMIM: 140750) suppression of tumorigeni ( 717) 374 91.2 8.6e-18 XP_011518628 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18 XP_011518630 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18 XP_016873676 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18 XP_011518629 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18 XP_011518627 (OMIM: 140750) PREDICTED: suppression ( 737) 374 91.2 8.8e-18 XP_011518626 (OMIM: 140750) PREDICTED: suppression ( 747) 374 91.2 8.9e-18 XP_011518625 (OMIM: 140750) PREDICTED: suppression ( 767) 374 91.2 9.1e-18 XP_016873675 (OMIM: 140750) PREDICTED: suppression ( 957) 374 91.3 1.1e-17 XP_016873673 (OMIM: 140750) PREDICTED: suppression ( 977) 374 91.3 1.1e-17 >>NP_001287787 (OMIM: 613292) DENN domain-containing pro (396 aa) initn: 2657 init1: 2657 opt: 2657 Z-score: 3132.0 bits: 588.4 E(85289): 1e-167 Smith-Waterman score: 2657; 99.7% identity (99.7% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA 310 320 330 340 350 360 370 380 390 pF1KE3 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ :::::::::::::::::::::::::::::::::::: NP_001 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ 370 380 390 >>XP_016855960 (OMIM: 613292) PREDICTED: DENN domain-con (745 aa) initn: 2597 init1: 2573 opt: 2573 Z-score: 3029.4 bits: 570.3 E(85289): 5.4e-162 Smith-Waterman score: 2573; 99.0% identity (99.5% similar) in 387 aa overlap (1-387:1-387) 10 20 30 40 50 60 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASML 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLA 310 320 330 340 350 360 370 380 390 pF1KE3 KLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ ::::::::::::::::::::::::. . XP_016 KLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKATPAVRTAYKF 370 380 390 400 410 420 >>XP_005244988 (OMIM: 613292) PREDICTED: DENN domain-con (755 aa) initn: 2466 init1: 2442 opt: 2444 Z-score: 2877.4 bits: 542.2 E(85289): 1.6e-153 Smith-Waterman score: 2444; 98.6% identity (99.5% similar) in 370 aa overlap (18-387:28-397) 10 20 30 40 50 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV .:::::::::::::::::::::::::::::::: XP_005 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 ATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_005 ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL 310 320 330 340 350 360 360 370 380 390 pF1KE3 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ ::::::::::::::::::::::::::::::::::. . XP_005 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKA 370 380 390 400 410 420 XP_005 TPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEK 430 440 450 460 470 480 >>XP_011507549 (OMIM: 613292) PREDICTED: DENN domain-con (803 aa) initn: 2442 init1: 2442 opt: 2444 Z-score: 2877.0 bits: 542.2 E(85289): 1.6e-153 Smith-Waterman score: 2444; 98.6% identity (99.5% similar) in 370 aa overlap (18-387:76-445) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDV .::::::::::::::::::::::::::::: XP_011 NDYFAQEIRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDV 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE3 ERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADY 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE3 LAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAV 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE3 DVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYC 230 240 250 260 270 280 230 240 250 260 270 280 pF1KE3 CAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKK 290 300 310 320 330 340 290 300 310 320 330 340 pF1KE3 QSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAIN :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: XP_011 QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAIN 350 360 370 380 390 400 350 360 370 380 390 pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ :::::::::::::::::::::::::::::::::::::. . XP_011 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAM 410 420 430 440 450 460 XP_011 TKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGN 470 480 490 500 510 520 >>NP_079096 (OMIM: 613633) DENN domain-containing protei (559 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.8 bits: 410.3 E(85289): 5.9e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:28-404) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVE .:.: : .::::..:::.::.. :::::: :. NP_079 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :::: NP_079 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::::: NP_079 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC :::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::::: NP_079 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ :::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.::: NP_079 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 STATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..: . NP_079 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ 310 320 330 340 350 360 350 360 370 380 390 pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ :::::::::::: ::.:.::::::::::. : . .:.::: ... NP_079 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAILNTV 370 380 390 400 410 NP_079 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAK 420 430 440 450 460 470 >>XP_005252170 (OMIM: 613633) PREDICTED: DENN domain-con (574 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.7 bits: 410.3 E(85289): 6e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF .:.: : .::::..:::.::.. :::::: XP_005 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA :. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :: XP_005 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV :: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::: XP_005 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD ::::::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::: XP_005 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL ::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.: XP_005 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET :: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::.. XP_005 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN 320 330 340 350 360 370 350 360 370 380 390 pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ : .:::::::::::: ::.:.::::::::::. : . .:.::: ... XP_005 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL 380 390 400 410 420 430 XP_005 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV 440 450 460 470 480 490 >>XP_011517189 (OMIM: 613633) PREDICTED: DENN domain-con (592 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2166.5 bits: 410.3 E(85289): 6.2e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF .:.: : .::::..:::.::.. :::::: XP_011 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA :. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :: XP_011 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV :: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::: XP_011 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD ::::::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::: XP_011 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL ::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.: XP_011 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET :: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::.. XP_011 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN 320 330 340 350 360 370 350 360 370 380 390 pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ : .:::::::::::: ::.:.::::::::::. : . .:.::: ... XP_011 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL 380 390 400 410 420 430 XP_011 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV 440 450 460 470 480 490 >>NP_065997 (OMIM: 613633) DENN domain-containing protei (1009 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.3 bits: 410.5 E(85289): 9.3e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:28-404) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVE .:.: : .::::..:::.::.. :::::: :. NP_065 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :::: NP_065 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.::::::::::: NP_065 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC :::::.::::::.::::.:: :::::::::::::::.::::::::.:::::::::::::: NP_065 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ :::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.::: NP_065 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 STATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::..: . NP_065 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ 310 320 330 340 350 360 350 360 370 380 390 pF1KE3 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ :::::::::::: ::.:.::::::::::. : . .:.::: ... NP_065 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAILNTV 370 380 390 400 410 NP_065 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAK 420 430 440 450 460 470 >>XP_005252168 (OMIM: 613633) PREDICTED: DENN domain-con (1024 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.2 bits: 410.5 E(85289): 9.4e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF .:.: : .::::..:::.::.. :::::: XP_005 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA :. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :: XP_005 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV :: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::: XP_005 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD ::::::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::: XP_005 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL ::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.: XP_005 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET :: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::.. XP_005 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN 320 330 340 350 360 370 350 360 370 380 390 pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ : .:::::::::::: ::.:.::::::::::. : . .:.::: ... XP_005 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL 380 390 400 410 420 430 XP_005 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV 440 450 460 470 480 490 >>XP_011517188 (OMIM: 613633) PREDICTED: DENN domain-con (1042 aa) initn: 1814 init1: 1606 opt: 1839 Z-score: 2163.1 bits: 410.5 E(85289): 9.6e-114 Smith-Waterman score: 1839; 70.6% identity (90.5% similar) in 378 aa overlap (16-392:43-419) 10 20 30 40 pF1KE3 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPF .:.: : .::::..:::.::.. :::::: XP_011 NETRKVCLWQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPF 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 DVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLA :. .. .::::.::::::::.::::::::::.::. :.:::::::::::.::::: :: XP_011 YVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 DYLAKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFV :: .:. ::. :: :..:.. :.: .. :.::::::: .::. ::.:::.:::::::: XP_011 DYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD ::::::::.::::::.::::.:: :::::::::::::::.::::::::.::::::::::: XP_011 AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKL ::::::::::::: ::.:.:.: .:.:::.:::::::::.::.::..::.::.:.:::.: XP_011 YCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRL 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 KKQSTATGDGVARAFLRAQAALFGYYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLET :: ::.::::::::::.::::.:: ::.::. .: ::::::::.::.: ::..:.:::.. XP_011 KKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQN 320 330 340 350 360 370 350 360 370 380 390 pF1KE3 AINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDKLQYDYPFSQ : .:::::::::::: ::.:.::::::::::. : . .:.::: ... XP_011 ATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEY-AGSDKLYHQWLSTVRKGSGAIL 380 390 400 410 420 430 XP_011 NTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLV 440 450 460 470 480 490 396 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:51:36 2016 done: Sun Nov 6 08:51:37 2016 Total Scan time: 7.390 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]