FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3625, 454 aa 1>>>pF1KE3625 454 - 454 aa - 454 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3990+/-0.000572; mu= 17.7713+/- 0.035 mean_var=122.8732+/-26.513, 0's: 0 Z-trim(109.5): 350 B-trim: 225 in 2/51 Lambda= 0.115703 statistics sampled from 17273 (17699) to 17273 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.556), E-opt: 0.2 (0.208), width: 16 Scan time: 8.840 The best scores are: opt bits E(85289) NP_036296 (OMIM: 609071) F-box/WD repeat-containin ( 454) 3081 526.6 5.4e-149 XP_005251967 (OMIM: 609071) PREDICTED: F-box/WD re ( 454) 3081 526.6 5.4e-149 XP_011516820 (OMIM: 609071) PREDICTED: F-box/WD re ( 486) 3081 526.6 5.6e-149 XP_006717112 (OMIM: 609071) PREDICTED: F-box/WD re ( 486) 3081 526.6 5.6e-149 XP_016870105 (OMIM: 609071) PREDICTED: F-box/WD re ( 325) 2215 381.8 1.4e-105 XP_016870106 (OMIM: 609071) PREDICTED: F-box/WD re ( 325) 2215 381.8 1.4e-105 XP_005251970 (OMIM: 609071) PREDICTED: F-box/WD re ( 325) 2215 381.8 1.4e-105 XP_016870104 (OMIM: 609071) PREDICTED: F-box/WD re ( 389) 1532 267.9 3.4e-71 XP_006717114 (OMIM: 609071) PREDICTED: F-box/WD re ( 421) 1532 268.0 3.5e-71 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 306 63.4 1.7e-09 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 306 63.5 1.8e-09 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 306 63.5 1.8e-09 XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 306 63.6 1.9e-09 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 306 63.6 1.9e-09 NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 306 63.6 2e-09 XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 306 63.6 2e-09 XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 306 63.6 2e-09 XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 306 63.6 2e-09 XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 306 63.6 2e-09 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 247 53.3 1.1e-06 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 247 53.3 1.1e-06 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 247 53.3 1.1e-06 XP_016880191 (OMIM: 601545,607432) PREDICTED: plat ( 345) 242 52.5 2.1e-06 NP_000421 (OMIM: 601545,607432) platelet-activatin ( 410) 242 52.6 2.3e-06 XP_016880190 (OMIM: 601545,607432) PREDICTED: plat ( 410) 242 52.6 2.3e-06 XP_016880189 (OMIM: 601545,607432) PREDICTED: plat ( 410) 242 52.6 2.3e-06 XP_016880188 (OMIM: 601545,607432) PREDICTED: plat ( 410) 242 52.6 2.3e-06 XP_011522203 (OMIM: 601545,607432) PREDICTED: plat ( 428) 242 52.6 2.4e-06 XP_011522204 (OMIM: 601545,607432) PREDICTED: plat ( 428) 242 52.6 2.4e-06 XP_011522205 (OMIM: 601545,607432) PREDICTED: plat ( 428) 242 52.6 2.4e-06 NP_001188493 (OMIM: 605961) pleiotropic regulator ( 505) 237 51.9 4.7e-06 NP_002660 (OMIM: 605961) pleiotropic regulator 1 i ( 514) 237 51.9 4.7e-06 NP_115708 (OMIM: 616850) WD repeat domain-containi ( 315) 216 48.1 4e-05 NP_001093207 (OMIM: 616850) WD repeat domain-conta ( 315) 216 48.1 4e-05 NP_006089 (OMIM: 176981) receptor of activated pro ( 317) 216 48.1 4e-05 NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 204 46.0 0.00013 NP_001151 (OMIM: 602233) apoptotic protease-activa (1194) 211 48.0 0.00016 NP_863658 (OMIM: 602233) apoptotic protease-activa (1205) 211 48.0 0.00016 NP_037361 (OMIM: 602233) apoptotic protease-activa (1237) 211 48.0 0.00017 XP_016856548 (OMIM: 139380,613065,616973) PREDICTE ( 340) 204 46.2 0.00017 XP_016856550 (OMIM: 139380,613065,616973) PREDICTE ( 340) 204 46.2 0.00017 NP_002065 (OMIM: 139380,613065,616973) guanine nuc ( 340) 204 46.2 0.00017 XP_016856549 (OMIM: 139380,613065,616973) PREDICTE ( 340) 204 46.2 0.00017 NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 204 46.2 0.00017 NP_863651 (OMIM: 602233) apoptotic protease-activa (1248) 211 48.0 0.00017 XP_011516374 (OMIM: 603873) PREDICTED: phospholipa ( 524) 206 46.7 0.00017 XP_016870808 (OMIM: 603873) PREDICTED: phospholipa ( 534) 206 46.7 0.00017 NP_001308475 (OMIM: 603873) phospholipase A-2-acti ( 772) 206 46.9 0.00022 NP_001026859 (OMIM: 603873) phospholipase A-2-acti ( 795) 206 47.0 0.00022 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 200 45.4 0.00023 >>NP_036296 (OMIM: 609071) F-box/WD repeat-containing pr (454 aa) initn: 3081 init1: 3081 opt: 3081 Z-score: 2795.9 bits: 526.6 E(85289): 5.4e-149 Smith-Waterman score: 3081; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454) 10 20 30 40 50 60 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA 370 380 390 400 410 420 430 440 450 pF1KE3 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG :::::::::::::::::::::::::::::::::: NP_036 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 430 440 450 >>XP_005251967 (OMIM: 609071) PREDICTED: F-box/WD repeat (454 aa) initn: 3081 init1: 3081 opt: 3081 Z-score: 2795.9 bits: 526.6 E(85289): 5.4e-149 Smith-Waterman score: 3081; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454) 10 20 30 40 50 60 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA 370 380 390 400 410 420 430 440 450 pF1KE3 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG :::::::::::::::::::::::::::::::::: XP_005 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 430 440 450 >>XP_011516820 (OMIM: 609071) PREDICTED: F-box/WD repeat (486 aa) initn: 3081 init1: 3081 opt: 3081 Z-score: 2795.6 bits: 526.6 E(85289): 5.6e-149 Smith-Waterman score: 3081; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:33-486) 10 20 30 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLD :::::::::::::::::::::::::::::: XP_011 CDEVVYEVQSAILRHNCGYAMKTGKFFHNLMERKDFETWLDNISVTFLSLTDLQKNETLD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 VYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVAC 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW 430 440 450 460 470 480 pF1KE3 KEHG :::: XP_011 KEHG >>XP_006717112 (OMIM: 609071) PREDICTED: F-box/WD repeat (486 aa) initn: 3081 init1: 3081 opt: 3081 Z-score: 2795.6 bits: 526.6 E(85289): 5.6e-149 Smith-Waterman score: 3081; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:33-486) 10 20 30 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLD :::::::::::::::::::::::::::::: XP_006 CDEVVYEVQSAILRHNCGYAMKTGKFFHNLMERKDFETWLDNISVTFLSLTDLQKNETLD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 VYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVAC 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW 430 440 450 460 470 480 pF1KE3 KEHG :::: XP_006 KEHG >>XP_016870105 (OMIM: 609071) PREDICTED: F-box/WD repeat (325 aa) initn: 2215 init1: 2215 opt: 2215 Z-score: 2016.3 bits: 381.8 E(85289): 1.4e-105 Smith-Waterman score: 2215; 100.0% identity (100.0% similar) in 325 aa overlap (130-454:1-325) 100 110 120 130 140 150 pF1KE3 TACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDG :::::::::::::::::::::::::::::: XP_016 MKQLEDHEAFETSSLIGHSARVYALYYKDG 10 20 30 160 170 180 190 200 210 pF1KE3 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 280 290 300 310 320 >>XP_016870106 (OMIM: 609071) PREDICTED: F-box/WD repeat (325 aa) initn: 2215 init1: 2215 opt: 2215 Z-score: 2016.3 bits: 381.8 E(85289): 1.4e-105 Smith-Waterman score: 2215; 100.0% identity (100.0% similar) in 325 aa overlap (130-454:1-325) 100 110 120 130 140 150 pF1KE3 TACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDG :::::::::::::::::::::::::::::: XP_016 MKQLEDHEAFETSSLIGHSARVYALYYKDG 10 20 30 160 170 180 190 200 210 pF1KE3 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 280 290 300 310 320 >>XP_005251970 (OMIM: 609071) PREDICTED: F-box/WD repeat (325 aa) initn: 2215 init1: 2215 opt: 2215 Z-score: 2016.3 bits: 381.8 E(85289): 1.4e-105 Smith-Waterman score: 2215; 100.0% identity (100.0% similar) in 325 aa overlap (130-454:1-325) 100 110 120 130 140 150 pF1KE3 TACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDG :::::::::::::::::::::::::::::: XP_005 MKQLEDHEAFETSSLIGHSARVYALYYKDG 10 20 30 160 170 180 190 200 210 pF1KE3 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGART 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYI 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLIS 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 280 290 300 310 320 >>XP_016870104 (OMIM: 609071) PREDICTED: F-box/WD repeat (389 aa) initn: 2606 init1: 1531 opt: 1532 Z-score: 1399.3 bits: 267.9 E(85289): 3.4e-71 Smith-Waterman score: 2480; 85.7% identity (85.7% similar) in 454 aa overlap (1-454:1-389) 10 20 30 40 50 60 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC ::::::::::::::::::::::::::::::::::::::::::: XP_016 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCT----------------- 130 140 150 160 190 200 210 220 230 240 pF1KE3 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI :::::::::::: XP_016 ------------------------------------------------VFSVDYNDELDI 170 250 260 270 280 290 300 pF1KE3 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE3 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE3 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA 300 310 320 330 340 350 430 440 450 pF1KE3 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG :::::::::::::::::::::::::::::::::: XP_016 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 360 370 380 >>XP_006717114 (OMIM: 609071) PREDICTED: F-box/WD repeat (421 aa) initn: 2606 init1: 1531 opt: 1532 Z-score: 1398.9 bits: 268.0 E(85289): 3.5e-71 Smith-Waterman score: 2480; 85.7% identity (85.7% similar) in 454 aa overlap (1-454:33-421) 10 20 30 pF1KE3 MERKDFETWLDNISVTFLSLTDLQKNETLD :::::::::::::::::::::::::::::: XP_006 CDEVVYEVQSAILRHNCGYAMKTGKFFHNLMERKDFETWLDNISVTFLSLTDLQKNETLD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSAR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 VYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVAC ::::::::::::: XP_006 VYALYYKDGLLCT----------------------------------------------- 190 220 230 240 250 260 270 pF1KE3 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW :::::::::::::::::::::::::::::::::::::::::: XP_006 ------------------VFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEW 200 210 220 230 280 290 300 310 320 330 pF1KE3 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQP 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE3 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIM 300 310 320 330 340 350 400 410 420 430 440 450 pF1KE3 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW 360 370 380 390 400 410 pF1KE3 KEHG :::: XP_006 KEHG 420 >>XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD repeat (540 aa) initn: 616 init1: 179 opt: 306 Z-score: 291.6 bits: 63.4 E(85289): 1.7e-09 Smith-Waterman score: 381; 26.4% identity (55.7% similar) in 318 aa overlap (59-361:116-410) 30 40 50 60 70 80 pF1KE3 LDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWN ::: ::..:.:..:.:. :: . . : XP_011 LDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW- 90 100 110 120 130 140 90 100 110 120 130 pF1KE3 KVISACTEVWQTACKNLGWQIDDSVQ---------DALH--WKKVYLKAILRMKQLEDHE .... . .:. ::. : ::. .. .: ::..:.. . . : XP_011 RILAEDNLLWREKCKEEG--IDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGE 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 AFETSSLIGHSARVYA-LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF . : ::. .: . : . . . .:::: . :.:.. ::.:. . :: . . .. XP_011 LKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWA .. ...:: : :. :. .: . . :::..: . ... .:::: : :..:: XP_011 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 LSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKC . .: ::..: ::. : .: .. : .. .: . .:.: : : XP_011 IETGQCLHVLMGHVAAV------RC-----VQYDGRRVVSGAYDFMVKVWDPETET---C 330 340 350 360 320 330 340 350 360 370 pF1KE3 LKTLSVSEDRSICLQPRLHFDGKYIVCSSA-LGLYQWDFASYDILRVIKTPEIANLALLG :.::. .: :: ::: ..: .: .. :: . . .... XP_011 LHTLQGHTNRVYSLQ----FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 FGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTG XP_011 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 430 440 450 460 470 480 454 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:45:58 2016 done: Sun Nov 6 22:45:59 2016 Total Scan time: 8.840 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]