Result of FASTA (omim) for
pFN21AE1324
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1324, 814 aa
1>>>pF1KE1324 814 - 814 aa - 814 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.0272+/-0.000389; mu= 0.2082+/- 0.024
mean_var=322.2426+/-64.847, 0's: 0 Z-trim(123.2): 233 B-trim: 169 in 1/59
Lambda= 0.071447
statistics sampled from 42462 (42723) to 42462 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.501), width: 16
Scan time: 15.570
The best scores are: opt bits E(85289)
NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 5828 614.9 4.3e-175
NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 5656 597.2 9.5e-170
NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 5531 584.3 7.2e-166
NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 5508 582.0 3.8e-165
NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 5498 581.0 7.8e-165
NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 5496 580.7 8.8e-165
NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 5293 559.8 1.7e-158
NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 5261 556.5 1.6e-157
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 3989 425.3 4.2e-118
XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 1850 204.9 1.2e-51
NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 1844 204.3 1.8e-51
NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 1844 204.3 1.8e-51
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 1821 201.9 8.6e-51
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 1821 201.9 8.6e-51
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 1820 201.8 9.3e-51
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 1821 202.0 1e-50
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 1820 201.9 1.1e-50
XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 1779 197.6 1.9e-49
XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 1755 195.1 1e-48
XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 1755 195.1 1e-48
XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 1751 194.7 1.4e-48
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 1737 193.3 4.1e-48
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 1737 193.3 4.2e-48
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 1671 186.4 4.1e-46
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 1647 184.0 2.2e-45
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 1582 177.3 2.4e-43
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 1538 172.7 5.5e-42
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 1538 172.8 5.6e-42
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 1538 172.8 5.6e-42
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1386 157.0 2.5e-37
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1386 157.0 2.5e-37
XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 1332 151.4 1.2e-35
XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 1247 142.6 4.9e-33
XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 1247 142.7 5.2e-33
XP_011542670 (OMIM: 606188) PREDICTED: disintegrin ( 728) 1247 142.7 5.5e-33
XP_006716337 (OMIM: 606188) PREDICTED: disintegrin ( 728) 1247 142.7 5.5e-33
XP_016868464 (OMIM: 606188) PREDICTED: disintegrin ( 732) 1247 142.7 5.6e-33
XP_005273437 (OMIM: 606188) PREDICTED: disintegrin ( 736) 1247 142.7 5.6e-33
XP_016868463 (OMIM: 606188) PREDICTED: disintegrin ( 741) 1247 142.7 5.6e-33
XP_011542669 (OMIM: 606188) PREDICTED: disintegrin ( 746) 1247 142.7 5.6e-33
NP_001291280 (OMIM: 606188) disintegrin and metall ( 754) 1247 142.7 5.7e-33
XP_006716336 (OMIM: 606188) PREDICTED: disintegrin ( 767) 1247 142.7 5.8e-33
NP_055080 (OMIM: 606188) disintegrin and metallopr ( 775) 1247 142.7 5.8e-33
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 1232 141.0 1.2e-32
XP_016868465 (OMIM: 606188) PREDICTED: disintegrin ( 715) 1230 140.9 1.8e-32
NP_002381 (OMIM: 155120) disintegrin and metallopr ( 769) 1216 139.5 5.3e-32
XP_005257430 (OMIM: 155120) PREDICTED: disintegrin ( 774) 1216 139.5 5.3e-32
XP_016867828 (OMIM: 603709) PREDICTED: disintegrin ( 887) 1208 138.8 1e-31
NP_001157961 (OMIM: 602267) disintegrin and metall ( 742) 1206 138.5 1.1e-31
XP_016867826 (OMIM: 603709) PREDICTED: disintegrin ( 907) 1208 138.8 1.1e-31
>>NP_003806 (OMIM: 605548) disintegrin and metalloprotei (814 aa)
initn: 5828 init1: 5828 opt: 5828 Z-score: 3264.4 bits: 614.9 E(85289): 4.3e-175
Smith-Waterman score: 5828; 99.8% identity (99.8% similar) in 814 aa overlap (1-814:1-814)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQGR
730 740 750 760 770 780
790 800 810
pF1KE1 CPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
::::::::::::::::::::::::::::::::::
NP_003 CPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
790 800 810
>>NP_001248393 (OMIM: 605548) disintegrin and metallopro (824 aa)
initn: 5814 init1: 5643 opt: 5656 Z-score: 3168.5 bits: 597.2 E(85289): 9.5e-170
Smith-Waterman score: 5798; 98.5% identity (98.5% similar) in 824 aa overlap (1-814:1-824)
10 20 30 40 50
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNI----------GGTEEQQAESEKAPREPLEPQVLQ
:::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 MRLALLWALGLLGAGSPLPSWPLPNIVLSWGVLGPAGGTEEQQAESEKAPREPLEPQVLQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 DDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 GHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 DLHLPGHTCALSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 DLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRA
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 HLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHEL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 GHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 FERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE1 CQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQ
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE1 CQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE1 LLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE1 LLGAQECRSKCHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVM
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVM
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE1 LGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPR
730 740 750 760 770 780
780 790 800 810
pF1KE1 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
790 800 810 820
>>NP_997078 (OMIM: 605548) disintegrin and metalloprotei (838 aa)
initn: 5488 init1: 5488 opt: 5531 Z-score: 3098.8 bits: 584.3 E(85289): 7.2e-166
Smith-Waterman score: 5770; 96.9% identity (96.9% similar) in 838 aa overlap (1-814:1-838)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK---------------------
:::::::::::::::::::::::::::::::::::::::
NP_997 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPTRPLPADPVVR
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE1 ---SQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 SPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
790 800 810 820 830
>>NP_997079 (OMIM: 605548) disintegrin and metalloprotei (862 aa)
initn: 5525 init1: 5478 opt: 5508 Z-score: 3085.9 bits: 582.0 E(85289): 3.8e-165
Smith-Waterman score: 5607; 94.1% identity (94.1% similar) in 846 aa overlap (1-798:1-846)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK---------------------
:::::::::::::::::::::::::::::::::::::::
NP_997 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK
730 740 750 760 770 780
760 770 780 790
pF1KE1 ---------------------------SQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG
:::::::::::::::::::::::::::::::::
NP_997 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG
790 800 810 820 830 840
800 810
pF1KE1 IPPLVVPSRPAPPPPTVSSLYL
::::::
NP_997 IPPLVVPSRPAPPPPTVSSLYL
850 860
>>NP_997080 (OMIM: 605548) disintegrin and metalloprotei (863 aa)
initn: 5517 init1: 5411 opt: 5498 Z-score: 3080.3 bits: 581.0 E(85289): 7.8e-165
Smith-Waterman score: 5600; 94.0% identity (94.0% similar) in 846 aa overlap (1-797:1-846)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK---------------------
:::::::::::::::::::::::::::::::::::::::
NP_997 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS
730 740 750 760 770 780
760 770 780 790
pF1KE1 ----------------------------SQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA
::::::::::::::::::::::::::::::::
NP_997 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA
790 800 810 820 830 840
800 810
pF1KE1 GIPPLVVPSRPAPPPPTVSSLYL
::::::
NP_997 GIPPLVVPSRPAPPPPTVSSLYL
850 860
>>NP_997077 (OMIM: 605548) disintegrin and metalloprotei (839 aa)
initn: 5517 init1: 5411 opt: 5496 Z-score: 3079.3 bits: 580.7 E(85289): 8.8e-165
Smith-Waterman score: 5768; 96.8% identity (96.8% similar) in 839 aa overlap (1-814:1-839)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK---------------------
:::::::::::::::::::::::::::::::::::::::
NP_997 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE1 ----SQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 KRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
790 800 810 820 830
>>NP_001248394 (OMIM: 605548) disintegrin and metallopro (796 aa)
initn: 5296 init1: 5256 opt: 5293 Z-score: 2966.5 bits: 559.8 E(85289): 1.7e-158
Smith-Waterman score: 5301; 93.2% identity (94.8% similar) in 808 aa overlap (1-807:1-796)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750 760 770
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQG-
:::::::::::::::: . : . :: : : :. .... : :. :::
NP_001 LHQRLCQLKGPTCQYRLVLS--ASRPPLPGRCRLTLCPRDSSLRGQPSPH------PQGS
730 740 750 760 770
780 790 800 810
pF1KE1 RCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
.: :: : :: .. :.. :
NP_001 HC----LPTPRAGAHRVTCPAQGLESRP
780 790
>>NP_997074 (OMIM: 605548) disintegrin and metalloprotei (772 aa)
initn: 5248 init1: 5248 opt: 5261 Z-score: 2948.9 bits: 556.5 E(85289): 1.6e-157
Smith-Waterman score: 5261; 96.2% identity (97.0% similar) in 773 aa overlap (1-767:1-772)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
670 680 690 700 710 720
730 740 750 760 770
pF1KE1 LHQRLCQLKGPTCQYRAAQSGPSERPG-----PPQRALLARGT-KSQGPAKPPPPRKPLP
::::::::::::::: . .. :: .: : :: : : .:: . :
NP_997 LHQRLCQLKGPTCQY-SLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP
730 740 750 760 770
780 790 800 810
pF1KE1 ADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL
>>NP_001248395 (OMIM: 605548) disintegrin and metallopro (633 aa)
initn: 4160 init1: 3989 opt: 3989 Z-score: 2241.4 bits: 425.3 E(85289): 4.2e-118
Smith-Waterman score: 4127; 91.7% identity (93.4% similar) in 640 aa overlap (1-640:1-624)
10 20 30 40 50 60
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
:::::::::::::::::::::::::: .. . .: . : : . : : :
NP_001 MRLALLWALGLLGAGSPLPSWPLPNIVSACNVEAP-QVALRSSRQSQRRPRGSPWS----
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
:. .: .: . . :::::::::::::::::::::::::::::::::
NP_001 -----PRSFRTISQLASKRCF------RELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
60 70 80 90 100
130 140 150 160 170 180
pF1KE1 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE1 LSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE1 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE1 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE1 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE1 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE1 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE1 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE1 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
::::::::::::::::::::::::::::::::::::::::
NP_001 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVSSLGGQDQV
590 600 610 620 630
670 680 690 700 710 720
pF1KE1 CHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
>>XP_011527669 (OMIM: 607114) PREDICTED: disintegrin and (812 aa)
initn: 1243 init1: 570 opt: 1850 Z-score: 1048.4 bits: 204.9 E(85289): 1.2e-51
Smith-Waterman score: 1889; 40.1% identity (61.8% similar) in 800 aa overlap (21-795:23-797)
10 20 30 40 50
pF1KE1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---I
::.:. : . . : .:. :. . : : .
XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 SLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLE
::.. .: :. . :: .:. .::: .:. :.:: . : ::: :: . .
XP_011 SLEE--PVSKPDMGLVALEAEGQELLLELEKNQLLAPGY-IETHYGPDGQPVVLAPNHTD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 NCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQD
.: :::::::. ::: .:::::. ::..:. . :: :. .: :.. :. :
XP_011 HCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LHLPGHTCALSWRESVHTQTPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYR
: : ::. :. . : : . : ::.. : .:: :::::. ..:
XP_011 LTWKG-TCG--HRDPGNKAGMTSLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHR
180 190 200 210 220
240 250 260 270 280 290
pF1KE1 DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRA
...: .: :::: .: ..: :...:::.:::.::.:: ... . .:: ::.:::.
XP_011 NLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 HLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHEL
: . :::::::.:: .:.: :::.: ...: . ::::. ::: .:.:...:::.
XP_011 -LWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEI
290 300 310 320 330 340
360 370 380 390 400
pF1KE1 GHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDF-LPGLNFSNCSRRALEKALLDGMGSC
::::::.:: : : . : . :.: :.: .: . :: :::: :. . : :.:
XP_011 GHSLGLSHDPDG--CCVEAAAESGGCVMAAATGHPFPRV-FSACSRRQLRAFFRKGGGAC
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE1 LFERL-PSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCC
: . :.:: :.::: ::: ::.:::: ..: : :: . .:.:::::::: : ::
XP_011 LSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCC
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE1 QNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA
: :.:.: :: . ::::::::: : ::.::::: : :: ::: :.. : : : .
XP_011 VRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE1 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT
::::.:::::..:: :.:..:. :.: :.::.. : .. :. :::.::.:::: :.
XP_011 QQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKP
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE1 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHR
. ::. . :. ..: :..: . : : : :. :. ::: ::: .:: ..:
XP_011 S-LLAPHMVPVDSTVHLDGQEVTCRGA-LALPSAQLDLLGLGLVEPGTQCGPRMVCQSRR
590 600 610 620 630 640
650 660 670 680 690
pF1KE1 CQRVDLLGAQECRSKCHGHGVSDSNRHCYCEEGWAPPDCTTQLKATSSLTTG--------
:.. . :.: . ::.::: .::..:.: ::::: : . .:. .:
XP_011 CRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCD-KPGFGGSMDSGPVQAENHD
650 660 670 680 690
700 710 720 730 740 750
pF1KE1 -LLLSLLVLLVLVML-GASY-WYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALL
.::..:. ..: .: ::. : :: : . :. : :::.. :: . :
XP_011 TFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD--GPHRDHPL
700 710 720 730 740 750
760 770 780 790 800 810
pF1KE1 ARGTKSQGPAKPPPPRKPLPADPQG-RCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLY
: : .: : ::.. . ::. : .. :
XP_011 --GGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
760 770 780 790 800 810
pF1KE1 L
814 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:56:31 2016 done: Sun Nov 6 22:56:33 2016
Total Scan time: 15.570 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]