Result of FASTA (omim) for
pFN21AE1350
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1350, 1187 aa
1>>>pF1KE1350 1187 - 1187 aa - 1187 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.0241+/-0.000625; mu= -33.2576+/- 0.036
mean_var=797.9104+/-180.527, 0's: 0 Z-trim(115.6): 1046 B-trim: 2087 in 2/53
Lambda= 0.045404
statistics sampled from 24662 (26230) to 24662 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.308), width: 16
Scan time: 13.110
The best scores are: opt bits E(85289)
XP_011526547 (OMIM: 176941,611521) PREDICTED: non- (1187) 8226 556.5 3.5e-157
NP_003322 (OMIM: 176941,611521) non-receptor tyros (1187) 8226 556.5 3.5e-157
XP_011526549 (OMIM: 176941,611521) PREDICTED: non- (1088) 7514 509.9 3.6e-143
XP_011526548 (OMIM: 176941,611521) PREDICTED: non- (1088) 7514 509.9 3.6e-143
XP_011526551 (OMIM: 176941,611521) PREDICTED: non- ( 745) 5041 347.7 1.6e-94
XP_011526554 (OMIM: 176941,611521) PREDICTED: non- ( 606) 4117 287.1 2.3e-76
XP_011526553 (OMIM: 176941,611521) PREDICTED: non- ( 606) 3840 269.0 6.6e-71
XP_016856701 (OMIM: 147795) PREDICTED: tyrosine-pr (1153) 2135 157.5 4.4e-37
NP_001308786 (OMIM: 147795) tyrosine-protein kinas (1153) 2135 157.5 4.4e-37
NP_001308782 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_001308783 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_001308785 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_001308784 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_002218 (OMIM: 147795) tyrosine-protein kinase J (1154) 2135 157.5 4.4e-37
NP_001308781 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_001307852 (OMIM: 147795) tyrosine-protein kinas (1154) 2135 157.5 4.4e-37
NP_000206 (OMIM: 600173,600802) tyrosine-protein k (1124) 1313 103.7 6.9e-21
XP_005259953 (OMIM: 600173,600802) PREDICTED: tyro (1167) 1313 103.7 7.1e-21
XP_011526292 (OMIM: 600173,600802) PREDICTED: tyro ( 866) 792 69.5 1.1e-10
NP_001309128 (OMIM: 133100,147796,254450,263300,60 ( 727) 785 68.9 1.3e-10
NP_001309127 (OMIM: 133100,147796,254450,263300,60 ( 727) 785 68.9 1.3e-10
NP_001309133 (OMIM: 133100,147796,254450,263300,60 ( 983) 785 69.1 1.6e-10
NP_001309124 (OMIM: 133100,147796,254450,263300,60 (1132) 785 69.1 1.8e-10
NP_004963 (OMIM: 133100,147796,254450,263300,60088 (1132) 785 69.1 1.8e-10
NP_001309125 (OMIM: 133100,147796,254450,263300,60 (1132) 785 69.1 1.8e-10
NP_001309123 (OMIM: 133100,147796,254450,263300,60 (1132) 785 69.1 1.8e-10
XP_011510623 (OMIM: 606994) PREDICTED: activated C ( 979) 489 49.7 0.00011
NP_005772 (OMIM: 606994) activated CDC42 kinase 1 (1038) 489 49.7 0.00012
NP_001294975 (OMIM: 606994) activated CDC42 kinase (1040) 489 49.7 0.00012
XP_016860999 (OMIM: 606994) PREDICTED: activated C (1055) 489 49.7 0.00012
XP_005269327 (OMIM: 606994) PREDICTED: activated C (1055) 489 49.7 0.00012
XP_011510622 (OMIM: 606994) PREDICTED: activated C (1055) 489 49.7 0.00012
XP_016860998 (OMIM: 606994) PREDICTED: activated C (1069) 489 49.7 0.00012
XP_016860997 (OMIM: 606994) PREDICTED: activated C (1072) 489 49.7 0.00012
XP_011510620 (OMIM: 606994) PREDICTED: activated C (1085) 489 49.7 0.00012
NP_001010938 (OMIM: 606994) activated CDC42 kinase (1086) 489 49.7 0.00012
XP_005269325 (OMIM: 606994) PREDICTED: activated C (1118) 489 49.7 0.00012
XP_011510619 (OMIM: 606994) PREDICTED: activated C (1219) 489 49.8 0.00013
NP_001167639 (OMIM: 600085) tyrosine-protein kinas ( 612) 468 48.1 0.0002
NP_001128524 (OMIM: 600085) tyrosine-protein kinas ( 612) 468 48.1 0.0002
NP_001167638 (OMIM: 600085) tyrosine-protein kinas ( 635) 468 48.1 0.00021
XP_005252204 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 468 48.1 0.00021
XP_011517248 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 468 48.1 0.00021
NP_003168 (OMIM: 600085) tyrosine-protein kinase S ( 635) 468 48.1 0.00021
NP_001070 (OMIM: 176947,269840,617006) tyrosine-pr ( 619) 467 48.0 0.00022
XP_016859071 (OMIM: 600543,615515) PREDICTED: rece (1116) 475 48.8 0.00023
XP_016860359 (OMIM: 176947,269840,617006) PREDICTE ( 707) 467 48.1 0.00024
XP_016860358 (OMIM: 176947,269840,617006) PREDICTE ( 730) 467 48.1 0.00024
XP_016869174 (OMIM: 600758) PREDICTED: focal adhes ( 948) 471 48.5 0.00025
XP_016860356 (OMIM: 176947,269840,617006) PREDICTE ( 742) 467 48.1 0.00025
>>XP_011526547 (OMIM: 176941,611521) PREDICTED: non-rece (1187 aa)
initn: 8226 init1: 8226 opt: 8226 Z-score: 2942.9 bits: 556.5 E(85289): 3.5e-157
Smith-Waterman score: 8226; 99.9% identity (100.0% similar) in 1187 aa overlap (1-1187:1-1187)
10 20 30 40 50 60
pF1KE1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_011 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180
pF1KE1 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
1150 1160 1170 1180
>>NP_003322 (OMIM: 176941,611521) non-receptor tyrosine- (1187 aa)
initn: 8226 init1: 8226 opt: 8226 Z-score: 2942.9 bits: 556.5 E(85289): 3.5e-157
Smith-Waterman score: 8226; 99.9% identity (100.0% similar) in 1187 aa overlap (1-1187:1-1187)
10 20 30 40 50 60
pF1KE1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_003 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180
pF1KE1 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
:::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
1150 1160 1170 1180
>>XP_011526549 (OMIM: 176941,611521) PREDICTED: non-rece (1088 aa)
initn: 7514 init1: 7514 opt: 7514 Z-score: 2691.4 bits: 509.9 E(85289): 3.6e-143
Smith-Waterman score: 7514; 99.9% identity (100.0% similar) in 1088 aa overlap (100-1187:1-1088)
70 80 90 100 110 120
pF1KE1 CFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPG
::::::::::::::::::::::::::::::
XP_011 MLYFRIRFYFRNWHGMNPREPAVYRCGPPG
10 20 30
130 140 150 160 170 180
pF1KE1 TEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFL
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 HLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 LSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAA
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 GPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRP
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE1 REPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTAD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE1 SSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQ
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE1 RSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRR
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE1 CCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLR
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE1 VEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTH
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE1 LAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE1 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGAN
640 650 660 670 680 690
790 800 810 820 830 840
pF1KE1 SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCL
700 710 720 730 740 750
850 860 870 880 890 900
pF1KE1 TYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFG
760 770 780 790 800 810
910 920 930 940 950 960
pF1KE1 KVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQ
820 830 840 850 860 870
970 980 990 1000 1010 1020
pF1KE1 GEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNV
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_011 GEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNV
880 890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KE1 LLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
940 950 960 970 980 990
1090 1100 1110 1120 1130 1140
pF1KE1 TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMK
1000 1010 1020 1030 1040 1050
1150 1160 1170 1180
pF1KE1 NCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
::::::::::::::::::::::::::::::::::::::
XP_011 NCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
1060 1070 1080
>>XP_011526548 (OMIM: 176941,611521) PREDICTED: non-rece (1088 aa)
initn: 7514 init1: 7514 opt: 7514 Z-score: 2691.4 bits: 509.9 E(85289): 3.6e-143
Smith-Waterman score: 7514; 99.9% identity (100.0% similar) in 1088 aa overlap (100-1187:1-1088)
70 80 90 100 110 120
pF1KE1 CFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPG
::::::::::::::::::::::::::::::
XP_011 MLYFRIRFYFRNWHGMNPREPAVYRCGPPG
10 20 30
130 140 150 160 170 180
pF1KE1 TEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFL
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 HLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGR
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 LSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAA
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE1 GPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRP
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE1 REPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTAD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE1 SSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQ
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE1 RSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRR
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE1 CCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLR
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE1 VEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTH
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE1 LAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE1 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGAN
640 650 660 670 680 690
790 800 810 820 830 840
pF1KE1 SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCL
700 710 720 730 740 750
850 860 870 880 890 900
pF1KE1 TYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFG
760 770 780 790 800 810
910 920 930 940 950 960
pF1KE1 KVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQ
820 830 840 850 860 870
970 980 990 1000 1010 1020
pF1KE1 GEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNV
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_011 GEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNV
880 890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KE1 LLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
940 950 960 970 980 990
1090 1100 1110 1120 1130 1140
pF1KE1 TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMK
1000 1010 1020 1030 1040 1050
1150 1160 1170 1180
pF1KE1 NCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
::::::::::::::::::::::::::::::::::::::
XP_011 NCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
1060 1070 1080
>>XP_011526551 (OMIM: 176941,611521) PREDICTED: non-rece (745 aa)
initn: 5041 init1: 5041 opt: 5041 Z-score: 1818.0 bits: 347.7 E(85289): 1.6e-94
Smith-Waterman score: 5041; 99.9% identity (100.0% similar) in 732 aa overlap (456-1187:14-745)
430 440 450 460 470 480
pF1KE1 LTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
::::::::::::::::::::::::::::::
XP_011 MLPPLQAAACAGNLEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
10 20 30 40
490 500 510 520 530 540
pF1KE1 TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCF
50 60 70 80 90 100
550 560 570 580 590 600
pF1KE1 SLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYE
110 120 130 140 150 160
610 620 630 640 650 660
pF1KE1 GRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
170 180 190 200 210 220
670 680 690 700 710 720
pF1KE1 SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL
230 240 250 260 270 280
730 740 750 760 770 780
pF1KE1 ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLP
290 300 310 320 330 340
790 800 810 820 830 840
pF1KE1 GGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLT
350 360 370 380 390 400
850 860 870 880 890 900
pF1KE1 SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGE
410 420 430 440 450 460
910 920 930 940 950 960
pF1KE1 GHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGC
470 480 490 500 510 520
970 980 990 1000 1010 1020
pF1KE1 CEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
XP_011 CEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLA
530 540 550 560 570 580
1030 1040 1050 1060 1070 1080
pF1KE1 ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVW
590 600 610 620 630 640
1090 1100 1110 1120 1130 1140
pF1KE1 SFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVY
650 660 670 680 690 700
1150 1160 1170 1180
pF1KE1 HLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
::::::::::::::::::::::::::::::::::::::::::
XP_011 HLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
710 720 730 740
>>XP_011526554 (OMIM: 176941,611521) PREDICTED: non-rece (606 aa)
initn: 4117 init1: 4117 opt: 4117 Z-score: 1492.1 bits: 287.1 E(85289): 2.3e-76
Smith-Waterman score: 4117; 100.0% identity (100.0% similar) in 591 aa overlap (1-591:1-591)
10 20 30 40 50 60
pF1KE1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQGPWAGATSG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
XP_011 AQSAGP
>>XP_011526553 (OMIM: 176941,611521) PREDICTED: non-rece (606 aa)
initn: 3840 init1: 3840 opt: 3840 Z-score: 1394.0 bits: 269.0 E(85289): 6.6e-71
Smith-Waterman score: 3840; 99.8% identity (100.0% similar) in 557 aa overlap (631-1187:50-606)
610 620 630 640 650 660
pF1KE1 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
::::::::::::::::::::::::::::::
XP_011 SSSCGGLGPAPGHSTSASSASTGLTRRRSPRDRGQELRVVLKVLDPSHHDIALAFYETAS
20 30 40 50 60 70
670 680 690 700 710 720
pF1KE1 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
80 90 100 110 120 130
730 740 750 760 770 780
pF1KE1 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
140 150 160 170 180 190
790 800 810 820 830 840
pF1KE1 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
200 210 220 230 240 250
850 860 870 880 890 900
pF1KE1 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
260 270 280 290 300 310
910 920 930 940 950 960
pF1KE1 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
320 330 340 350 360 370
970 980 990 1000 1010 1020
pF1KE1 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_011 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
380 390 400 410 420 430
1030 1040 1050 1060 1070 1080
pF1KE1 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
440 450 460 470 480 490
1090 1100 1110 1120 1130 1140
pF1KE1 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
500 510 520 530 540 550
1150 1160 1170 1180
pF1KE1 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
560 570 580 590 600
>>XP_016856701 (OMIM: 147795) PREDICTED: tyrosine-protei (1153 aa)
initn: 2164 init1: 1125 opt: 2135 Z-score: 786.8 bits: 157.5 E(85289): 4.4e-37
Smith-Waterman score: 3367; 46.9% identity (72.7% similar) in 1141 aa overlap (41-1166:46-1145)
20 30 40 50 60 70
pF1KE1 GSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPC
:: . .. . ::::.::. :. :.: :
XP_016 CAKMRSSKKTEVNLEAPEPGVEVIFYLSDREP-LRLGSGEYTAEELCIRAAQACRISPLC
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE1 FNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGT
:::::.: ....: ::. . . :: :..:.:::: :::: : : .:.: .:
XP_016 HNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQ
80 90 100 110 120 130
140 150 160 170 180
pF1KE1 EASSDQTA--QGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAF
. . .. .. ::: .:.:::: ::....:. .: . . .::.. : ..:: ::::
XP_016 KNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE1 LHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ--
: . : :. . . : :. : :.: ::... . :::.. :::.:. :::. ::..:.
XP_016 LAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNK
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE1 ---PGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDP
. .: . . :::::::: :. ..:.: . : : ..:.: ..... :
XP_016 TICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSML--LISSENEMNWFHSN-----DG
260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVG
: . .::.:::. :::: . :. :. . .: :: . ..
XP_016 G-----NVLYYEVMVTGNLGIQWRHKPNVVSVEK---------EKNKLKRKKLENKHKKD
310 320 330 340 350
370 380 390 400 410 420
pF1KE1 QPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGY
. .. :: : : : .:::.:.:: :::..:::: .::.: :. :::::::::::
XP_016 EEKNKIREE-WNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGY
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE1 FRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPE---DGLYLIHWSTSHP
::::::. :::: .:::: .: .:..: :::. .. ::: : .:.:...:: .
XP_016 FRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDF
420 430 440 450 460 470
490 500 510 520 530
pF1KE1 YRLILTVA--QRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLL
...::. ..:.. .: :. ....: :: : : . :.: :::::. .: . :. .:
XP_016 DNILMTVTCFEKSEV-QGAQK-QFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQIL
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE1 RAGDDCFSLRRCCLPQPGETSNLIIM-RGARASPRTLNLSQLSFHRVDQKEITQLSHLGQ
:. . : :.::: :.: : :::.. . :. . .::::: :. .:...: :::.
XP_016 RTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGR
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE1 GTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYE
::::..: : : :: .: : .. ....:.::::::::.::.:::.:
XP_016 GTRTHIYSGTL------------MDYKDD--EGTSEEKKIKVILKVLDPSHRDISLAFFE
600 610 620 630
660 670 680 690 700 710
pF1KE1 TASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQ
.::.: :::: :.....::::: ::::: :.:: ::::....:. . ::. ::.:
XP_016 AASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQ
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE1 LASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP
:::::::::.:.::::::: .:.:::: :. .:::::::::. . .:::.: .::::
XP_016 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE1 WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS
:.::::. . : ::.: :::.::.:: :::..:: ::.... :::.::. . : ::
XP_016 WIAPECVEDSKN-LSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE1 CPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYL
: .:: : ..:..:.:.::: ::.:.::...:. .: :... . . ::: :.::.:
XP_016 CKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN-PDIVSEKKPATEVDPTHFEKRFL
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE1 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE
:.:::::::::::: : ::: .:.:::.::::.:: . : .: . :.::.:::.::::
XP_016 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHE
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE1 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMAYLH
.:.:::: : ..: ....:.::..: :::..:::... :.: : : .: :::.:: ::
XP_016 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLG
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE1 SQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKE
:..:.::::::::::..... ::::::::.::. .::: :..: :::::::::::: .
XP_016 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE1 YKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLP
::: :::::::::::.::::.:::..:: . ::..:: ..::::: ::.. :..:.:::
XP_016 SKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLP
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180
pF1KE1 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
: .:: :::.::..::: . : : .:.:::
XP_016 CPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
1120 1130 1140 1150
>>NP_001308786 (OMIM: 147795) tyrosine-protein kinase JA (1153 aa)
initn: 2164 init1: 1125 opt: 2135 Z-score: 786.8 bits: 157.5 E(85289): 4.4e-37
Smith-Waterman score: 3367; 46.9% identity (72.7% similar) in 1141 aa overlap (41-1166:46-1145)
20 30 40 50 60 70
pF1KE1 GSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPC
:: . .. . ::::.::. :. :.: :
NP_001 CAKMRSSKKTEVNLEAPEPGVEVIFYLSDREP-LRLGSGEYTAEELCIRAAQACRISPLC
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE1 FNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGT
:::::.: ....: ::. . . :: :..:.:::: :::: : : .:.: .:
NP_001 HNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQ
80 90 100 110 120 130
140 150 160 170 180
pF1KE1 EASSDQTA--QGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAF
. . .. .. ::: .:.:::: ::....:. .: . . .::.. : ..:: ::::
NP_001 KNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE1 LHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ--
: . : :. . . : :. : :.: ::... . :::.. :::.:. :::. ::..:.
NP_001 LAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNK
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE1 ---PGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDP
. .: . . :::::::: :. ..:.: . : : ..:.: ..... :
NP_001 TICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSML--LISSENEMNWFHSN-----DG
260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVG
: . .::.:::. :::: . :. :. . .: :: . ..
NP_001 G-----NVLYYEVMVTGNLGIQWRHKPNVVSVEK---------EKNKLKRKKLENKHKKD
310 320 330 340 350
370 380 390 400 410 420
pF1KE1 QPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGY
. .. :: : : : .:::.:.:: :::..:::: .::.: :. :::::::::::
NP_001 EEKNKIREE-WNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGY
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE1 FRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPE---DGLYLIHWSTSHP
::::::. :::: .:::: .: .:..: :::. .. ::: : .:.:...:: .
NP_001 FRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDF
420 430 440 450 460 470
490 500 510 520 530
pF1KE1 YRLILTVA--QRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLL
...::. ..:.. .: :. ....: :: : : . :.: :::::. .: . :. .:
NP_001 DNILMTVTCFEKSEV-QGAQK-QFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQIL
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE1 RAGDDCFSLRRCCLPQPGETSNLIIM-RGARASPRTLNLSQLSFHRVDQKEITQLSHLGQ
:. . : :.::: :.: : :::.. . :. . .::::: :. .:...: :::.
NP_001 RTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGR
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE1 GTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYE
::::..: : : :: .: : .. ....:.::::::::.::.:::.:
NP_001 GTRTHIYSGTL------------MDYKDD--EGTSEEKKIKVILKVLDPSHRDISLAFFE
600 610 620 630
660 670 680 690 700 710
pF1KE1 TASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQ
.::.: :::: :.....::::: ::::: :.:: ::::....:. . ::. ::.:
NP_001 AASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQ
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE1 LASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP
:::::::::.:.::::::: .:.:::: :. .:::::::::. . .:::.: .::::
NP_001 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE1 WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS
:.::::. . : ::.: :::.::.:: :::..:: ::.... :::.::. . : ::
NP_001 WIAPECVEDSKN-LSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE1 CPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYL
: .:: : ..:..:.:.::: ::.:.::...:. .: :... . . ::: :.::.:
NP_001 CKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN-PDIVSEKKPATEVDPTHFEKRFL
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE1 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE
:.:::::::::::: : ::: .:.:::.::::.:: . : .: . :.::.:::.::::
NP_001 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHE
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE1 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMAYLH
.:.:::: : ..: ....:.::..: :::..:::... :.: : : .: :::.:: ::
NP_001 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLG
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE1 SQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKE
:..:.::::::::::..... ::::::::.::. .::: :..: :::::::::::: .
NP_001 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE1 YKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLP
::: :::::::::::.::::.:::..:: . ::..:: ..::::: ::.. :..:.:::
NP_001 SKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLP
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180
pF1KE1 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
: .:: :::.::..::: . : : .:.:::
NP_001 CPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
1120 1130 1140 1150
>>NP_001308782 (OMIM: 147795) tyrosine-protein kinase JA (1154 aa)
initn: 2309 init1: 1125 opt: 2135 Z-score: 786.8 bits: 157.5 E(85289): 4.4e-37
Smith-Waterman score: 3375; 46.9% identity (72.6% similar) in 1141 aa overlap (41-1166:46-1146)
20 30 40 50 60 70
pF1KE1 GSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPC
:: . .. . ::::.::. :. :.: :
NP_001 CAKMRSSKKTEVNLEAPEPGVEVIFYLSDREP-LRLGSGEYTAEELCIRAAQACRISPLC
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE1 FNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGT
:::::.: ....: ::. . . :: :..:.:::: :::: : : .:.: .:
NP_001 HNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQ
80 90 100 110 120 130
140 150 160 170 180
pF1KE1 EASSDQTA--QGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAF
. . .. .. ::: .:.:::: ::....:. .: . . .::.. : ..:: ::::
NP_001 KNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAV
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE1 LHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ--
: . : :. . . : :. : :.: ::... . :::.. :::.:. :::. ::..:.
NP_001 LAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNK
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE1 ---PGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDP
. .: . . :::::::: :. ..:.: . : : ..:.: ..... :
NP_001 TICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSML--LISSENEMNWFHSN-----DG
260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVG
: . .::.:::. :::: . :. :. . .: :: . ..
NP_001 G-----NVLYYEVMVTGNLGIQWRHKPNVVSVEK---------EKNKLKRKKLENKHKKD
310 320 330 340 350
370 380 390 400 410 420
pF1KE1 QPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGY
. .. :: : : : .:::.:.:: :::..:::: .::.: :. :::::::::::
NP_001 EEKNKIREE-WNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGY
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE1 FRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPE---DGLYLIHWSTSHP
::::::. :::: .:::: .: .:..: :::. .. ::: : .:.:...:: .
NP_001 FRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDF
420 430 440 450 460 470
490 500 510 520 530
pF1KE1 YRLILTVA--QRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLL
...::. ..:. .: :. ....: :: : : . :.: :::::. .: . :. .:
NP_001 DNILMTVTCFEKSEQVQGAQK-QFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQIL
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE1 RAGDDCFSLRRCCLPQPGETSNLIIM-RGARASPRTLNLSQLSFHRVDQKEITQLSHLGQ
:. . : :.::: :.: : :::.. . :. . .::::: :. .:...: :::.
NP_001 RTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGR
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE1 GTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYE
::::..: : : :: .: : .. ....:.::::::::.::.:::.:
NP_001 GTRTHIYSGTL------------MDYKDD--EGTSEEKKIKVILKVLDPSHRDISLAFFE
600 610 620 630
660 670 680 690 700 710
pF1KE1 TASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQ
.::.: :::: :.....::::: ::::: :.:: ::::....:. . ::. ::.:
NP_001 AASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQ
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE1 LASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP
:::::::::.:.::::::: .:.:::: :. .:::::::::. . .:::.: .::::
NP_001 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE1 WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS
:.::::. . : ::.: :::.::.:: :::..:: ::.... :::.::. . : ::
NP_001 WIAPECVEDSKN-LSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE1 CPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYL
: .:: : ..:..:.:.::: ::.:.::...:. .: :... . . ::: :.::.:
NP_001 CKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN-PDIVSEKKPATEVDPTHFEKRFL
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE1 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE
:.:::::::::::: : ::: .:.:::.::::.:: . : .: . :.::.:::.::::
NP_001 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHE
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE1 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMAYLH
.:.:::: : ..: ....:.::..: :::..:::... :.: : : .: :::.:: ::
NP_001 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLG
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE1 SQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKE
:..:.::::::::::..... ::::::::.::. .::: :..: :::::::::::: .
NP_001 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE1 YKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLP
::: :::::::::::.::::.:::..:: . ::..:: ..::::: ::.. :..:.:::
NP_001 SKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLP
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180
pF1KE1 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
: .:: :::.::..::: . : : .:.:::
NP_001 CPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
1120 1130 1140 1150
1187 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 22:58:38 2016 done: Sun Nov 6 22:58:40 2016
Total Scan time: 13.110 Total Display time: 0.330
Function used was FASTA [36.3.4 Apr, 2011]