FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4581, 805 aa 1>>>pF1KE4581 805 - 805 aa - 805 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0204+/-0.000402; mu= 22.8196+/- 0.025 mean_var=73.8392+/-15.230, 0's: 0 Z-trim(112.3): 47 B-trim: 35 in 1/49 Lambda= 0.149256 statistics sampled from 21163 (21210) to 21163 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.249), width: 16 Scan time: 10.400 The best scores are: opt bits E(85289) NP_001278 (OMIM: 166600,602727,611490) H(+)/Cl(-) ( 805) 5294 1150.0 0 XP_011520656 (OMIM: 166600,602727,611490) PREDICTE ( 747) 4900 1065.1 0 NP_001107803 (OMIM: 166600,602727,611490) H(+)/Cl( ( 781) 4817 1047.2 0 NP_001277 (OMIM: 602726) chloride transport protei ( 869) 1146 256.8 3e-67 NP_001243888 (OMIM: 602726) chloride transport pro ( 847) 1095 245.8 5.9e-64 NP_000076 (OMIM: 602023,607364,613090) chloride ch ( 687) 566 131.8 9.8e-30 NP_001036169 (OMIM: 602024,613090) chloride channe ( 686) 539 126.0 5.5e-28 NP_004061 (OMIM: 602024,613090) chloride channel p ( 687) 539 126.0 5.5e-28 NP_001244068 (OMIM: 602024,613090) chloride channe ( 644) 530 124.0 2e-27 NP_000075 (OMIM: 300008,300009,300554,308990,31046 ( 746) 478 112.9 5.3e-24 NP_001269092 (OMIM: 300008,300009,300554,308990,31 ( 766) 478 112.9 5.4e-24 NP_001121370 (OMIM: 300008,300009,300554,308990,31 ( 816) 478 112.9 5.7e-24 NP_001121371 (OMIM: 300008,300009,300554,308990,31 ( 816) 478 112.9 5.7e-24 XP_016884747 (OMIM: 300008,300009,300554,308990,31 ( 820) 478 112.9 5.7e-24 XP_016884746 (OMIM: 300008,300009,300554,308990,31 ( 820) 478 112.9 5.7e-24 XP_011510703 (OMIM: 600570,607628,615651) PREDICTE ( 835) 478 112.9 5.8e-24 XP_006713552 (OMIM: 600570,607628,615651) PREDICTE ( 863) 478 113.0 5.9e-24 NP_001164560 (OMIM: 600570,607628,615651) chloride ( 869) 478 113.0 5.9e-24 NP_004357 (OMIM: 600570,607628,615651) chloride ch ( 898) 478 113.0 6.1e-24 NP_001230303 (OMIM: 600580) H(+)/Cl(-) exchange tr ( 791) 464 109.9 4.5e-23 NP_001820 (OMIM: 600580) H(+)/Cl(-) exchange trans ( 818) 464 109.9 4.6e-23 XP_011529888 (OMIM: 600580) PREDICTED: H(+)/Cl(-) ( 831) 464 109.9 4.6e-23 XP_005262783 (OMIM: 600580) PREDICTED: H(+)/Cl(-) ( 839) 464 109.9 4.7e-23 NP_776297 (OMIM: 600580) H(+)/Cl(-) exchange trans ( 866) 464 109.9 4.8e-23 NP_001164559 (OMIM: 600570,607628,615651) chloride ( 854) 461 109.3 7.4e-23 NP_001243873 (OMIM: 300114,302910) H(+)/Cl(-) exch ( 666) 452 107.3 2.4e-22 NP_001821 (OMIM: 300114,302910) H(+)/Cl(-) exchang ( 760) 452 107.3 2.6e-22 XP_016867229 (OMIM: 118425,160800,255700) PREDICTE ( 838) 404 97.0 3.6e-19 XP_016867228 (OMIM: 118425,160800,255700) PREDICTE ( 846) 402 96.6 4.9e-19 NP_000074 (OMIM: 118425,160800,255700) chloride ch ( 988) 384 92.8 8.1e-18 NP_001159417 (OMIM: 602023,607364,613090) chloride ( 517) 376 90.8 1.6e-17 NP_001164558 (OMIM: 600570,607628,615651) chloride ( 881) 358 87.1 3.6e-16 NP_001230301 (OMIM: 600580) H(+)/Cl(-) exchange tr ( 791) 305 75.7 9e-13 XP_006713553 (OMIM: 600570,607628,615651) PREDICTE ( 512) 270 68.0 1.2e-10 XP_011514084 (OMIM: 118425,160800,255700) PREDICTE ( 570) 269 67.8 1.5e-10 >>NP_001278 (OMIM: 166600,602727,611490) H(+)/Cl(-) exch (805 aa) initn: 5294 init1: 5294 opt: 5294 Z-score: 6156.1 bits: 1150.0 E(85289): 0 Smith-Waterman score: 5294; 100.0% identity (100.0% similar) in 805 aa overlap (1-805:1-805) 10 20 30 40 50 60 pF1KE4 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 730 740 750 760 770 780 790 800 pF1KE4 LVTRKDLARYRLGKRGLEELSLAQT ::::::::::::::::::::::::: NP_001 LVTRKDLARYRLGKRGLEELSLAQT 790 800 >>XP_011520656 (OMIM: 166600,602727,611490) PREDICTED: H (747 aa) initn: 4900 init1: 4900 opt: 4900 Z-score: 5698.0 bits: 1065.1 E(85289): 0 Smith-Waterman score: 4900; 100.0% identity (100.0% similar) in 747 aa overlap (59-805:1-747) 30 40 50 60 70 80 pF1KE4 RPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEK :::::::::::::::::::::::::::::: XP_011 MSSVELDDELLDPDMDPPHPFPKEIPHNEK 10 20 30 90 100 110 120 130 140 pF1KE4 LLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 ENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQ 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 IKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTS 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 LKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIF 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 FASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVL 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 GAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSY 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE4 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLT 400 410 420 430 440 450 510 520 530 540 550 560 pF1KE4 VSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTV 460 470 480 490 500 510 570 580 590 600 610 620 pF1KE4 IMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAR 520 530 540 550 560 570 630 640 650 660 670 680 pF1KE4 EVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLL 580 590 600 610 620 630 690 700 710 720 730 740 pF1KE4 KHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTV 640 650 660 670 680 690 750 760 770 780 790 800 pF1KE4 PQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT 700 710 720 730 740 >>NP_001107803 (OMIM: 166600,602727,611490) H(+)/Cl(-) e (781 aa) initn: 5122 init1: 4817 opt: 4817 Z-score: 5601.1 bits: 1047.2 E(85289): 0 Smith-Waterman score: 5078; 97.0% identity (97.0% similar) in 805 aa overlap (1-805:1-781) 10 20 30 40 50 60 pF1KE4 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ------------- 10 20 30 40 70 80 90 100 110 120 pF1KE4 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----------DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE4 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE4 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE4 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE4 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE4 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 700 710 720 730 740 750 790 800 pF1KE4 LVTRKDLARYRLGKRGLEELSLAQT ::::::::::::::::::::::::: NP_001 LVTRKDLARYRLGKRGLEELSLAQT 760 770 780 >>NP_001277 (OMIM: 602726) chloride transport protein 6 (869 aa) initn: 1701 init1: 704 opt: 1146 Z-score: 1328.4 bits: 256.8 E(85289): 3e-67 Smith-Waterman score: 1815; 43.3% identity (71.3% similar) in 732 aa overlap (86-784:40-756) 60 70 80 90 100 110 pF1KE4 VGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRIN .: : ::::::: :. .:: . .. NP_001 CCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMD 10 20 30 40 50 60 120 130 140 150 160 170 pF1KE4 HTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFS . : : .:.. ::. ::::. :.:. :. .. ::. :.. .... ..:: :..: NP_001 NKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALS 70 80 90 100 110 120 180 190 200 210 220 230 pF1KE4 LLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVI :: .: .::...:..: .:::::::::::..::.:::::.: .:::.::. :: ::. NP_001 LLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVL 130 140 150 160 170 180 240 250 260 270 280 290 pF1KE4 LSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAA .::.::: :::::::::::::..::. : .: ::.. : ::: : .::::::::::: NP_001 FSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAA 190 200 210 220 230 240 300 310 320 330 340 350 pF1KE4 GVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLS-IYHGNMWDLSS ::.::::::.::.:::::::.::::: :::...: :: .:::::: : : :. ... NP_001 GVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQL 250 260 270 280 290 300 360 370 380 390 400 pF1KE4 PGLINFGRF---DSEKMAY--TIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIH- :::.:::.: ::.: . : .. :..:::.::.:::.:: :: :. .:.: .: NP_001 PGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHP 310 320 330 340 350 360 410 420 430 440 450 pF1KE4 RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL----QGGSMSYPLQL----------- .: : .:.:..::. ::..:.:: . .:. . : :. :. ::. NP_001 KPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTF 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE4 FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAG :: . ::.::. ::: :.....:::. :...:.::.:: ..::.:::::::..: .: NP_001 FCPNDTYNDMATLFFNPQESAILQLFHQD-GTFSPVTLALFFVLYFLLACWTYGISVPSG 430 440 450 460 470 480 520 530 540 550 560 570 pF1KE4 VFIPSLLIGAAWGRLFGISL-SYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMM .:.:::: :::.::: . : ::. . :.. : .::.:::: :::.::::.:::::.. NP_001 LFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFALIGAAAFLGGVVRMTISLTVILI 490 500 510 520 530 540 580 590 600 610 620 630 pF1KE4 EATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVM :.:...:::.:::..::.:: .:: : .:.::.:. :..::.:.::. : .: : ..: NP_001 ESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIM 550 560 570 580 590 600 640 650 660 670 680 690 pF1KE4 STPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHK .: . . .. .:..: :. :..:::: . .. ..: : :. : . : . NP_001 EPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSS 610 620 630 640 650 660 700 710 720 730 740 pF1KE4 VFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVSQDERECTMDLSEFM-----NPS ... :.. ..: : .... .:: .. . . :....: :: . : .: NP_001 ILT-RAG----EQRKRSQSMK-SYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPY 670 680 690 700 710 750 760 770 780 790 800 pF1KE4 PYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSL : :... . . :: : .. :.. :.:.: :..: NP_001 PNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVTLLVRGVCYSESQSSASQPRLSY 720 730 740 750 760 770 pF1KE4 AQT NP_001 AEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRH 780 790 800 810 820 830 >-- initn: 258 init1: 231 opt: 238 Z-score: 271.7 bits: 61.3 E(85289): 2.1e-08 Smith-Waterman score: 238; 37.6% identity (72.0% similar) in 93 aa overlap (703-795:769-861) 680 690 700 710 720 730 pF1KE4 ARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERE : :: .. . :::.: :... .. . . NP_001 LTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPR 740 750 760 770 780 790 740 750 760 770 780 790 pF1KE4 CTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL .:.. .:::::.:: .. . .::.:::..::::: ::. ...::..::..:. : NP_001 MIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFL 800 810 820 830 840 850 800 pF1KE4 GKRGLEELSLAQT : NP_001 QARLRQHYQTI 860 >>NP_001243888 (OMIM: 602726) chloride transport protein (847 aa) initn: 1743 init1: 704 opt: 1095 Z-score: 1269.2 bits: 245.8 E(85289): 5.9e-64 Smith-Waterman score: 1764; 43.4% identity (71.8% similar) in 705 aa overlap (113-784:45-734) 90 100 110 120 130 140 pF1KE4 IPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVAC : .. : : .:.. ::. ::::. NP_001 CCCCGERETRTPEELTILGETQEEEDEILPRKDYEKGRRYEAVKWMVVFAIGVCTGLVGL 20 30 40 50 60 70 150 160 170 180 190 200 pF1KE4 FIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAA :.:. :. .. ::. :.. .... ..:: :..::: .: .::...:..: .:::::: NP_001 FVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAA 80 90 100 110 120 130 210 220 230 240 250 260 pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGIS :::::..::.:::::.: .:::.::. :: ::..::.::: :::::::::::::..::. NP_001 GSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLP 140 150 160 170 180 190 270 280 290 300 310 320 pF1KE4 QGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQF : .: ::.. : ::: : .:::::::::::::.::::::.::.:::::::.::::: NP_001 QFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQG 200 210 220 230 240 250 330 340 350 360 370 pF1KE4 LTWRIFFASMISTFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMAY--TIHEIP :::...: :: .:::::: : : :. ... :::.:::.: ::.: . : .. NP_001 LTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLG 260 270 280 290 300 310 380 390 400 410 420 430 pF1KE4 VFIAMGVVGGVLGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYS :..:::.::.:::.:: :: :. .:.: .: .: : .:.:..::. ::..:.:: . NP_001 FFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMV 320 330 340 350 360 370 440 450 460 470 pF1KE4 SRDCQPL----QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFH .:. . : :. :. ::. :: . ::.::. ::: :.....::: NP_001 LGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFH 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE4 DPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL-SYLTGA . :...:.::.:: ..::.:::::::..: .:.:.:::: :::.::: . : ::. . NP_001 QD-GTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLG 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE4 AIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFI :.. : .::.:::: :::.::::.:::::..:.:...:::.:::..::.:: .:: : NP_001 HIYS--GTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFN 500 510 520 530 540 550 600 610 620 630 640 650 pF1KE4 EGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNH .:.::.:. :..::.:.::. : .: : ..: .: . . .. .:..: :. : NP_001 KGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--H 560 570 580 590 600 660 670 680 690 700 710 pF1KE4 NGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP-- ..:::: . .. ..: : :. : . : ..... .. ::. : .... .:: NP_001 HAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGE----QRK-RSQSMK-SYPSS 610 620 630 640 650 660 720 730 740 750 760 pF1KE4 RFPPIQSIHVSQDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHL .. . . :....: :: . : .: : :... . . :: : .. : NP_001 ELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGL 670 680 690 700 710 720 770 780 790 800 pF1KE4 VVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT .. :.:.: :..: NP_001 IL---RSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIV 730 740 750 760 770 >-- initn: 258 init1: 231 opt: 238 Z-score: 271.9 bits: 61.3 E(85289): 2.1e-08 Smith-Waterman score: 238; 37.6% identity (72.0% similar) in 93 aa overlap (703-795:747-839) 680 690 700 710 720 730 pF1KE4 ARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERE : :: .. . :::.: :... .. . . NP_001 LTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPR 720 730 740 750 760 770 740 750 760 770 780 790 pF1KE4 CTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL .:.. .:::::.:: .. . .::.:::..::::: ::. ...::..::..:. : NP_001 MIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFL 780 790 800 810 820 830 800 pF1KE4 GKRGLEELSLAQT : NP_001 QARLRQHYQTI 840 >>NP_000076 (OMIM: 602023,607364,613090) chloride channe (687 aa) initn: 315 init1: 134 opt: 566 Z-score: 654.8 bits: 131.8 E(85289): 9.8e-30 Smith-Waterman score: 620; 25.0% identity (56.5% similar) in 687 aa overlap (127-789:50-675) 100 110 120 130 140 150 pF1KE4 LDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKY : . .:.: .::.: .:..::. NP_000 ELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVES------ 20 30 40 50 60 70 160 170 180 190 200 210 pF1KE4 RVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNG :.... . : : . : :.. .:.: .: . : : ..:::::..: .: : NP_000 -VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAG 80 90 100 110 120 130 220 230 240 250 260 270 pF1KE4 VKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF : . . .:.. :: :. ... : : .:: ::..: . ..:: ... :.:.. . NP_000 VVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEP- 140 150 160 170 180 190 280 290 300 310 320 330 pF1KE4 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI . ... ... :.::.::...:.:: .:::::.: .: .. . :: :::. NP_000 ------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATC 200 210 220 230 240 340 350 360 370 380 390 pF1KE4 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN ..: . . :....... ..: .: : : . . . :: :.:.: . :.::... NP_000 GAFMFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVALGGLCGILGSAYL 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE4 ALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLF . . : :: . . . : .. ::.... : . . .. .:. .: NP_000 FCQRIFFGF-IRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHL- 310 320 330 340 350 460 470 480 490 500 pF1KE4 CADGEYNSMAAAFFNTPEKSVVSLFHDPPGS----YNPL-----TLGLFTLVYFFLACWT :. ... . :... . :: :.: ::..: .. :.. . NP_000 --DSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILA 360 370 380 390 400 410 510 520 530 540 550 pF1KE4 YGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD-------PGKYALMGAAAQLG . . :: :.: .. ::: ::::: .::.. .: : :: ::: :::: .. NP_000 TTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAA-FS 420 430 440 450 460 470 560 570 580 590 600 610 pF1KE4 GIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH-- : : :.: ... .:.:.......:.......:. ... ..:: . ....:.: NP_000 GAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI 480 490 500 510 520 530 620 630 640 650 660 670 pF1KE4 WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARL . :: . ... :. .: : . . .: :. :... .:.:: .:. : NP_000 LGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVV--TSTDVAKYPLVE---STESQIL 540 550 560 570 580 590 680 690 700 710 720 730 pF1KE4 QGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTM :.. :.::. :: . : . : ...: . NP_000 VGIVRRAQLVQALKAEP-----------------------PSWAP--------GHQQCLQ 600 610 740 750 760 770 780 790 pF1KE4 DLSEFMNPS-PYTVP--QEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRL :. :. : :. :.:: .. .::. :.: : . : .:...:: :. .. . NP_000 DILAAGCPTEPVTLKLSPETSLHEAHNLFELLNL-HSLFVTSRGRAVGCVSWVEMKKAIS 620 630 640 650 660 670 800 pF1KE4 GKRGLEELSLAQT NP_000 NLTNPPAPK 680 >>NP_001036169 (OMIM: 602024,613090) chloride channel pr (686 aa) initn: 313 init1: 130 opt: 539 Z-score: 623.4 bits: 126.0 E(85289): 5.5e-28 Smith-Waterman score: 554; 25.1% identity (56.0% similar) in 705 aa overlap (114-789:39-674) 90 100 110 120 130 140 pF1KE4 PHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACF ... .:: : : . .:.: .::. NP_001 EGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGE--DWYFLMTLGVLMALVSYA 10 20 30 40 50 60 150 160 170 180 190 200 pF1KE4 IDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAA ..... : :.... . : : . : :.. .:.: .: . : : .. NP_001 MNFAI----GC---VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG 70 80 90 100 110 210 220 230 240 250 260 pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAG :::::..: .: :: . . .:.. :: :. ... : : .:: ::..: . .::: NP_001 GSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAY 120 130 140 150 160 170 270 280 290 300 310 320 pF1KE4 ISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWN ... :.:.. . . ... ... :.::.::...:.:: .:::::.: .: .. NP_001 LGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFS 180 190 200 210 220 230 330 340 350 360 370 380 pF1KE4 QFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIA :: :::. ..: . . :....... ..: .: : : . . . :: :.: NP_001 VRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVA 240 250 260 270 280 390 400 410 420 430 pF1KE4 MGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQVIEAVLVAAVTATVAFVLI .: . :::. : . .:.... :: .: ... ..:.:..: . . NP_001 LGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHF 290 300 310 320 330 340 440 450 460 470 480 pF1KE4 YSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPL--- .:: ::. :. :: :.. .. . . : .. : :.: NP_001 LASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTI 350 360 370 380 390 490 500 510 520 530 540 pF1KE4 --TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD--- ::..: .. :.. . . . :: :.: ...::: :::.: .:. .: . NP_001 FGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVT 400 410 420 430 440 450 550 560 570 580 590 pF1KE4 ----PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIE :: ::: :::: ..: : :.: ... .: :.......:.......:. ... NP_001 NPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQP 460 470 480 490 500 510 600 610 620 630 640 650 pF1KE4 GLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASN ..:: : ....:.: . :: . ... :. .: : . . .: :. :... NP_001 SFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVV--TSTD 520 530 540 550 560 570 660 670 680 690 700 710 pF1KE4 HNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP- . .:.:: .. ::..: :.::: .. .. : NP_001 VTEYPLVESTE-------------SQILV-------------GIVQRAQLVQALQAEPPS 580 590 600 720 730 740 750 760 770 pF1KE4 RFPPIQSIHVSQD--ERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDN : : : . :: : : . : :. .:..: .. .::. :.:. : :. . NP_001 RAPGHQCL---QDILARGCPTE------PVTLTLFSETTLHQAQNLFKLLNLQSLFVT-S 610 620 630 640 650 780 790 800 pF1KE4 RNQVVGLVTRKDLARYRLGKRGLEELSLAQT :...:: :. .. . NP_001 RGRAVGCVSWVEMKKAISNLTNPPAPK 660 670 680 >>NP_004061 (OMIM: 602024,613090) chloride channel prote (687 aa) initn: 313 init1: 130 opt: 539 Z-score: 623.4 bits: 126.0 E(85289): 5.5e-28 Smith-Waterman score: 556; 24.7% identity (56.3% similar) in 705 aa overlap (114-789:39-675) 90 100 110 120 130 140 pF1KE4 PHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACF ... .:: : : . .:.: .::. NP_004 EGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGE--DWYFLMTLGVLMALVSYA 10 20 30 40 50 60 150 160 170 180 190 200 pF1KE4 IDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAAFVLVGSVIVAFIEPVAA ..... : :.... . : : . : :.. .:.: .: . : : .. NP_004 MNFAI----GC---VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG 70 80 90 100 110 210 220 230 240 250 260 pF1KE4 GSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LAVGKEGPMIHSGSVIAAG :::::..: .: :: . . .:.. :: :. ... : : .:: ::..: . .::: NP_004 GSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAY 120 130 140 150 160 170 270 280 290 300 310 320 pF1KE4 ISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWN ... :.:.. . . ... ... :.::.::...:.:: .:::::.: .: .. NP_004 LGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFS 180 190 200 210 220 230 330 340 350 360 370 380 pF1KE4 QFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIA :: :::. ..: . . :....... ..: .: : : . . . :: :.: NP_004 VRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF-RVD---VPFDLPEIFFFVA 240 250 260 270 280 390 400 410 420 430 pF1KE4 MGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQVIEAVLVAAVTATVAFVLI .: . :::. : . .:.... :: .: ... ..:.:..: . . NP_004 LGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHF 290 300 310 320 330 340 440 450 460 470 480 pF1KE4 YSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPL--- .:: ::. :. :: :.. .. . . : .. : :.: NP_004 LASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTI 350 360 370 380 390 490 500 510 520 530 540 pF1KE4 --TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD--- ::..: .. :.. . . . :: :.: ...::: :::.: .:. .: . NP_004 FGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVT 400 410 420 430 440 450 550 560 570 580 590 pF1KE4 ----PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIE :: ::: :::: ..: : :.: ... .: :.......:.......:. ... NP_004 NPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQP 460 470 480 490 500 510 600 610 620 630 640 650 pF1KE4 GLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASN ..:: : ....:.: . :: . ... :. .: : . . .: :. :... NP_004 SFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVV--TSTD 520 530 540 550 560 570 660 670 680 690 700 710 pF1KE4 HNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPR . .:.:: .:. : :.. :.::. :. . NP_004 VTEYPLVE---STESQILVGIVQRAQLVQALQAE-------------------------- 580 590 600 720 730 740 750 760 770 pF1KE4 FPPIQSIHVSQDERECTMDLSEFMNPS-PYTVP--QEASLPRVFKLFRALGLRHLVVVDN :: . . ...: .:. :. : :. .:..: .. .::. :.:. : :. . NP_004 -PPSR----APGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVT-S 610 620 630 640 650 660 780 790 800 pF1KE4 RNQVVGLVTRKDLARYRLGKRGLEELSLAQT :...:: :. .. . NP_004 RGRAVGCVSWVEMKKAISNLTNPPAPK 670 680 >>NP_001244068 (OMIM: 602024,613090) chloride channel pr (644 aa) initn: 310 init1: 130 opt: 530 Z-score: 613.3 bits: 124.0 E(85289): 2e-27 Smith-Waterman score: 534; 25.2% identity (57.4% similar) in 664 aa overlap (157-789:30-632) 130 140 150 160 170 180 pF1KE4 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKG---GLSFSLLLWATLN :.:.:... . .: : .. .:. ::. NP_001 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLM--TLG 10 20 30 40 50 190 200 210 220 230 240 pF1KE4 AAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG-- . ..::. .. : :. :::::..: .: :: . . .:.. :: :. ... : NP_001 VLMALVSYAMNFAIGCVVRGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGST 60 70 80 90 100 110 250 260 270 280 290 300 pF1KE4 LAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAF : .:: ::..: . .::: ... :.:.. . . ... ... :.::.::...: NP_001 LFLGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVF 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE4 GAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFG .:: .:::::.: .: .. :: :::. ..: . . :....... ..: .: NP_001 AAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRL-LAVFNSEQETITSLYKTSF- 180 190 200 210 220 370 380 390 400 410 pF1KE4 RFDSEKMAYTIHEIPVFIAMGVVGGVLG-AVFNALNYWLTMFRI-RY------IHRPCLQ : : . . . :: :.:.: . :::. : . .:.... :: .: . NP_001 RVD---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYS 230 240 250 260 270 280 420 430 440 450 460 470 pF1KE4 VIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQ-LFCADGEYNSMAAAFFNTPEK .. ..:.:..: . . .:: ::. :. :: :.. .. . . : NP_001 ALATLLLASITYPPGVGHFLASRL-------SMKQHLDSLF--DNHSWALMTQNSSPPWP 290 300 310 320 330 480 490 500 510 520 pF1KE4 SVVSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRL .. : :.: ::..: .. :.. . . . :: :.: ...::: ::: NP_001 EELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRL 340 350 360 370 380 390 530 540 550 560 570 580 pF1KE4 FGISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYG .: .:. .: . :: ::: :::: ..: : :.: ... .: :...... NP_001 LGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHA 400 410 420 430 440 450 590 600 610 620 630 pF1KE4 FPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCL .:.......:. ... ..:: : ....:.: . :: . ... :. .: : NP_001 LPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTL 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE4 RRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSN . . .: :. :... . .:.:: .:. : :.. :.::. :. . NP_001 AKDTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQAE------- 520 530 540 550 560 700 710 720 730 740 750 pF1KE4 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPS-PYTVP--QEASLP :: .. ...: .:. :. : :. .:..: NP_001 --------------------PPSRA----PGHQQCLQDILARGCPTEPVTLTLFSETTLH 570 580 590 760 770 780 790 800 pF1KE4 RVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT .. .::. :.:. : :. .:...:: :. .. . NP_001 QAQNLFKLLNLQSLFVT-SRGRAVGCVSWVEMKKAISNLTNPPAPK 600 610 620 630 640 >>NP_000075 (OMIM: 300008,300009,300554,308990,310468) H (746 aa) initn: 889 init1: 219 opt: 478 Z-score: 551.9 bits: 112.9 E(85289): 5.3e-24 Smith-Waterman score: 901; 31.2% identity (58.5% similar) in 727 aa overlap (127-790:58-731) 100 110 120 130 140 150 pF1KE4 LDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKY :.. :::.:.: .: .::: .. .. :: NP_000 RDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKE 30 40 50 60 70 80 160 170 180 pF1KE4 RVIKGNI-------------------DKF------------TEKGGLS-----FSLLLWA . :.. :: :..:... : .::: NP_000 GICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWA 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE4 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG : :.... .: . : : :::::.:: .:.: : . :::::. ..:.: . NP_000 LL---FAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSS 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE4 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA ::..:::::..: .. .. : . :. .: . ....:. .::.::::::.: NP_000 GLSLGKEGPLVH--------VACCCGNILCHCFN--KYRKNEAKRREVLSAAAAAGVSVA 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF ::::.::::::::: . .. :: :::.....::: . . :: : .. . NP_000 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPF--GN-----SRLVLFY 260 270 280 290 300 370 380 390 400 410 pF1KE4 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVL .: . . . :. :: .:. ::. ::.: : : . . . :::... NP_000 VEFHTP---WHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLV 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 VAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAA-FFNTPEKSVVSLF :.:.:: .:: :. . . : .: .:: : .: . : . : . . NP_000 VTAITAILAFPNEYTRMSTSEL----IS---ELFNDCGLLDSSKLCDYENRFNTSKGGEL 370 380 390 400 410 480 490 500 510 520 530 pF1KE4 HDPP---GSYNPL-TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSY : : : :. . :.: .. . .. .:.:. . .:.::::. .:: :::.:... NP_000 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 420 430 440 450 460 470 540 550 560 570 580 pF1KE4 L-------TGAAIW----AD---PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYG : : : :: :: ::..:::: :::..:::.::.:::.: :... : NP_000 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 480 490 500 510 520 530 590 600 610 620 630 pF1KE4 FPIMLVLMTAKIVGDVFI-EGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVM----STPV :.: . ::.: :.:.. ::.:: ::.:.. :::. . .:. : .:: . :. NP_000 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPL 540 550 560 570 580 590 640 650 660 670 680 690 pF1KE4 TCLRRREKVGV--IVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF . .... : . ..:.: ...::::: . ..: :: :..:: .::. ... NP_000 LTVLTQDSMTVEDVETIISET--TYSGFPVVV-SRESQ--RLVGFVLRRDLIISIEN--- 600 610 620 630 640 700 710 720 730 740 750 pF1KE4 VERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEAS ..... :.:. . : . : .:: :. : .... ::.:: . . NP_000 ARKKQDGVVSTSIIY--FTEHSPPLPPYTPP---------TLKLRNILDLSPFTVTDLTP 650 660 670 680 690 760 770 780 790 800 pF1KE4 LPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT . : .:: ::::. .:. : ....:..:.::. .. NP_000 MEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDVLKHIAQMANQDPDSILFN 700 710 720 730 740 805 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:18:20 2016 done: Mon Nov 7 15:18:22 2016 Total Scan time: 10.400 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]