FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1340, 802 aa 1>>>pF1KE1340 802 - 802 aa - 802 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.0682+/-0.000577; mu= -22.7470+/- 0.035 mean_var=889.3169+/-199.744, 0's: 0 Z-trim(118.8): 715 B-trim: 0 in 0/60 Lambda= 0.043008 statistics sampled from 31258 (32046) to 31258 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.376), width: 16 Scan time: 14.560 The best scores are: opt bits E(85289) NP_998812 (OMIM: 134935) fibroblast growth factor ( 802) 5442 354.8 8.7e-97 XP_005265895 (OMIM: 134935) PREDICTED: fibroblast ( 802) 5442 354.8 8.7e-97 NP_002002 (OMIM: 134935) fibroblast growth factor ( 802) 5442 354.8 8.7e-97 XP_011532766 (OMIM: 134935) PREDICTED: fibroblast ( 833) 5442 354.8 8.9e-97 XP_011532767 (OMIM: 134935) PREDICTED: fibroblast ( 696) 4722 310.0 2.3e-83 NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806) 3134 211.6 1.1e-53 XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807) 3132 211.4 1.2e-53 XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807) 3122 210.8 1.9e-53 XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808) 3120 210.7 2.1e-53 XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809) 3118 210.6 2.2e-53 NP_001307587 (OMIM: 101200,101400,101600,123150,12 ( 819) 3055 206.7 3.4e-52 NP_000132 (OMIM: 101200,101400,101600,123150,12350 ( 821) 3035 205.4 8.1e-52 NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808) 3022 204.6 1.4e-51 XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809) 3020 204.5 1.5e-51 XP_016868713 (OMIM: 101600,123150,136350,147950,16 ( 818) 3018 204.4 1.7e-51 XP_016868714 (OMIM: 101600,123150,136350,147950,16 ( 818) 3018 204.4 1.7e-51 XP_016868709 (OMIM: 101600,123150,136350,147950,16 ( 851) 3018 204.4 1.7e-51 XP_016871412 (OMIM: 101200,101400,101600,123150,12 ( 749) 3016 204.2 1.7e-51 XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810) 3008 203.8 2.6e-51 XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810) 3008 203.8 2.6e-51 XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811) 3006 203.6 2.8e-51 NP_075418 (OMIM: 101200,101400,101600,123150,12350 ( 732) 3002 203.3 3.1e-51 XP_006717771 (OMIM: 101200,101400,101600,123150,12 ( 839) 2997 203.1 4.2e-51 XP_016871410 (OMIM: 101200,101400,101600,123150,12 ( 804) 2983 202.2 7.4e-51 XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729) 2961 200.8 1.8e-50 XP_016868716 (OMIM: 101600,123150,136350,147950,16 ( 762) 2961 200.8 1.9e-50 XP_016868715 (OMIM: 101600,123150,136350,147950,16 ( 764) 2959 200.7 2e-50 XP_016871411 (OMIM: 101200,101400,101600,123150,12 ( 750) 2958 200.6 2.1e-50 NP_001138390 (OMIM: 101200,101400,101600,123150,12 ( 704) 2954 200.3 2.4e-50 NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731) 2950 200.1 2.9e-50 XP_011542752 (OMIM: 101600,123150,136350,147950,16 ( 764) 2950 200.1 3e-50 NP_001167535 (OMIM: 101600,123150,136350,147950,16 ( 812) 2949 200.1 3.2e-50 NP_001167534 (OMIM: 101600,123150,136350,147950,16 ( 820) 2949 200.1 3.2e-50 XP_011542749 (OMIM: 101600,123150,136350,147950,16 ( 853) 2949 200.1 3.3e-50 XP_006717774 (OMIM: 101200,101400,101600,123150,12 ( 752) 2944 199.7 3.8e-50 NP_001138388 (OMIM: 101200,101400,101600,123150,12 ( 706) 2940 199.5 4.4e-50 XP_016871413 (OMIM: 101200,101400,101600,123150,12 ( 725) 2940 199.5 4.4e-50 NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733) 2939 199.4 4.7e-50 NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733) 2939 199.4 4.7e-50 NP_001167536 (OMIM: 101600,123150,136350,147950,16 ( 820) 2940 199.5 4.8e-50 NP_056934 (OMIM: 101600,123150,136350,147950,16625 ( 820) 2940 199.5 4.8e-50 NP_001167538 (OMIM: 101600,123150,136350,147950,16 ( 853) 2940 199.6 4.9e-50 NP_075598 (OMIM: 101600,123150,136350,147950,16625 ( 822) 2929 198.9 7.7e-50 XP_011542748 (OMIM: 101600,123150,136350,147950,16 ( 855) 2929 198.9 7.9e-50 XP_016871409 (OMIM: 101200,101400,101600,123150,12 ( 805) 2925 198.6 9e-50 NP_075259 (OMIM: 101200,101400,101600,123150,12350 ( 822) 2916 198.1 1.3e-49 XP_016868712 (OMIM: 101600,123150,136350,147950,16 ( 828) 2890 196.4 4.1e-49 XP_016868708 (OMIM: 101600,123150,136350,147950,16 ( 861) 2890 196.5 4.2e-49 XP_006717775 (OMIM: 101200,101400,101600,123150,12 ( 726) 2886 196.1 4.5e-49 XP_016871414 (OMIM: 101200,101400,101600,123150,12 ( 689) 2882 195.8 5.2e-49 >>NP_998812 (OMIM: 134935) fibroblast growth factor rece (802 aa) initn: 5442 init1: 5442 opt: 5442 Z-score: 1858.6 bits: 354.8 E(85289): 8.7e-97 Smith-Waterman score: 5442; 100.0% identity (100.0% similar) in 802 aa overlap (1-802:1-802) 10 20 30 40 50 60 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 730 740 750 760 770 780 790 800 pF1KE1 VFSHDPLPLGSSSFPFGSGVQT :::::::::::::::::::::: NP_998 VFSHDPLPLGSSSFPFGSGVQT 790 800 >>XP_005265895 (OMIM: 134935) PREDICTED: fibroblast grow (802 aa) initn: 5442 init1: 5442 opt: 5442 Z-score: 1858.6 bits: 354.8 E(85289): 8.7e-97 Smith-Waterman score: 5442; 100.0% identity (100.0% similar) in 802 aa overlap (1-802:1-802) 10 20 30 40 50 60 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 730 740 750 760 770 780 790 800 pF1KE1 VFSHDPLPLGSSSFPFGSGVQT :::::::::::::::::::::: XP_005 VFSHDPLPLGSSSFPFGSGVQT 790 800 >>NP_002002 (OMIM: 134935) fibroblast growth factor rece (802 aa) initn: 5442 init1: 5442 opt: 5442 Z-score: 1858.6 bits: 354.8 E(85289): 8.7e-97 Smith-Waterman score: 5442; 100.0% identity (100.0% similar) in 802 aa overlap (1-802:1-802) 10 20 30 40 50 60 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 730 740 750 760 770 780 790 800 pF1KE1 VFSHDPLPLGSSSFPFGSGVQT :::::::::::::::::::::: NP_002 VFSHDPLPLGSSSFPFGSGVQT 790 800 >>XP_011532766 (OMIM: 134935) PREDICTED: fibroblast grow (833 aa) initn: 5442 init1: 5442 opt: 5442 Z-score: 1858.4 bits: 354.8 E(85289): 8.9e-97 Smith-Waterman score: 5442; 100.0% identity (100.0% similar) in 802 aa overlap (1-802:32-833) 10 20 30 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVEL :::::::::::::::::::::::::::::: XP_011 DWKWSGSDQGGGGRQLVGSPAWVPESCEKEMRLLLALLGVLLSVPGPPVLSLEASEEVEL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 EPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIAS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 HPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE1 MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE1 CKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE1 YTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLY 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE1 RGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLV 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE1 SLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNAS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE1 DKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE1 DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIAD 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE1 FGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE1 PGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 730 740 750 760 770 780 760 770 780 790 800 pF1KE1 SEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT 790 800 810 820 830 >>XP_011532767 (OMIM: 134935) PREDICTED: fibroblast grow (696 aa) initn: 4722 init1: 4722 opt: 4722 Z-score: 1617.8 bits: 310.0 E(85289): 2.3e-83 Smith-Waterman score: 4722; 100.0% identity (100.0% similar) in 696 aa overlap (107-802:1-696) 80 90 100 110 120 130 pF1KE1 GRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDP :::::::::::::::::::::::::::::: XP_011 MIVLQNLTLITGDSLTSSNDDEDPKSHRDP 10 20 30 140 150 160 170 180 190 pF1KE1 SNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 IGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLP 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 ANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVE 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 VLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASG 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE1 SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGV 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE1 RLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQ 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE1 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE1 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE1 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 520 530 540 550 560 570 680 690 700 710 720 730 pF1KE1 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE1 KQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPF 640 650 660 670 680 690 800 pF1KE1 GSGVQT :::::: XP_011 GSGVQT >>NP_000133 (OMIM: 100800,109800,114500,134934,146000,14 (806 aa) initn: 2737 init1: 1760 opt: 3134 Z-score: 1084.6 bits: 211.6 E(85289): 1.1e-53 Smith-Waterman score: 3134; 63.0% identity (79.0% similar) in 795 aa overlap (5-788:8-795) 10 20 30 40 50 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLE--QQEQELTVALGQPVRL ::: .. : : :: . ..: . .:. : :::: :. . :. :.: NP_000 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQ-LVFGSGDAVEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CC---GRAERGGH-WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQ : : . : : :.:. :.:. :: ::.. . ::.: : : : .. :: NP_000 SCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFR .... . :. ::.:::: . : .. . :::::.:.::.::: ::::.:::.:: NP_000 HFSVRVTDA-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG :::::::::.: :::.:. :.::.:::::.::::.::::::::::::::.:::.::: : NP_000 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING ::: .: :::::::::::::::::::: :::.:::::. ::::::::::::::::. .:: NP_000 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNG 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 SSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLT :. : :: ::: ::::: :.. :.::: :.::. :::::::::::::::.:..::::. NP_000 SKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 VLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKL ::: :. : . :. :. :. : . . ... . : : .. . : ::.:. NP_000 VLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 SRFPLARQFSLESGSSGKSSSSLVRGVRLSSS-GPALLAGLVSLDLPLDPLWEFPRDRLV ::::: :: ::::..: .:.. ::: .::::. ::.: :.. :.:: :: ::. : ::. NP_000 SRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTL-ANVSELELPADPKWELSRARLT 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG :::::::::::::: :::.:.: : . :::::::::.:.::::.:::::::.::.:: NP_000 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE1 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV .:::::::::.::: :::::.:: ::::::::::::::::: : : : . : :.: NP_000 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE1 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN ::::::::::::.:: :.::::::::::::::::::::::::::::: ::..::::::.: NP_000 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE1 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM ::::::::::::::::::::::::::::.::::::::::::::::::::::.::.::::: NP_000 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE1 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPS :.: .: .:: .:::::::::::::::::::: ::.:: ..: .::::: : :::. NP_000 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPG 720 730 740 750 760 770 770 780 790 800 pF1KE1 GGDA-SSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT : :. ::. :..::::.:: :: NP_000 GQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 780 790 800 >>XP_006713936 (OMIM: 100800,109800,114500,134934,146000 (807 aa) initn: 2692 init1: 1773 opt: 3132 Z-score: 1083.9 bits: 211.4 E(85289): 1.2e-53 Smith-Waterman score: 3132; 62.9% identity (78.9% similar) in 796 aa overlap (5-788:8-796) 10 20 30 40 50 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLE--QQEQELTVALGQPVRL ::: .. : : :: . ..: . .:. : :::: :. . :. :.: XP_006 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQ-LVFGSGDAVEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CC---GRAERGGH-WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQ : : . : : :.:. :.:. :: ::.. . ::.: : : : .. :: XP_006 SCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFR .... . :. ::.:::: . : .. . :::::.:.::.::: ::::.:::.:: XP_006 HFSVRVTDA-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG :::::::::.: :::.:. :.::.:::::.::::.::::::::::::::.:::.::: : XP_006 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING ::: .: :::::::::::::::::::: :::.:::::. ::::::::::::::::. .:: XP_006 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNG 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 SSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLT :. : :: ::: ::::: :.. :.::: :.::. :::::::::::::::.:..::::. XP_006 SKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 VLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKL ::: :. : . :. :. :. : . . ... . : : .. . : ::.:. XP_006 VLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 SRFPLARQFSLESGSSGKSSSSLVRGVRLSSS-GPALLAGLVSLDLPLDPLWEFPRDRLV ::::: :: ::::..: .:.. ::: .::::. ::.: :.. :.:: :: ::. : ::. XP_006 SRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTL-ANVSELELPADPKWELSRARLT 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG :::::::::::::: :::.:.: : . :::::::::.:.::::.:::::::.::.:: XP_006 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE1 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV .:::::::::.::: :::::.:: ::::::::::::::::: : : : . : :.: XP_006 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE1 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN ::::::::::::.:: :.::::::::::::::::::::::::::::: ::..::::::.: XP_006 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE1 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM ::::::::::::::::::::::::::::.::::::::::::::::::::::.::.::::: XP_006 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE1 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS--EEYLDLRLTFGPYSP :.: .: .:: .:::::::::::::::::::: ::.:: ..: .::::: : ::: XP_006 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQYSP 720 730 740 750 760 770 770 780 790 800 pF1KE1 SGGDA-SSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT .: :. ::. :..::::.:: :: XP_006 GGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 780 790 800 >>XP_006713935 (OMIM: 100800,109800,114500,134934,146000 (807 aa) initn: 1955 init1: 1897 opt: 3122 Z-score: 1080.6 bits: 210.8 E(85289): 1.9e-53 Smith-Waterman score: 3122; 62.9% identity (78.9% similar) in 796 aa overlap (5-788:8-796) 10 20 30 40 50 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLE--QQEQELTVALGQPVRL ::: .. : : :: . ..: . .:. : :::: :. . :. :.: XP_006 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQ-LVFGSGDAVEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CC---GRAERGGH-WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQ : : . : : :.:. :.:. :: ::.. . ::.: : : : .. :: XP_006 SCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFR .... . :. ::.:::: . : .. . :::::.:.::.::: ::::.:::.:: XP_006 HFSVRVTDA-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG :::::::::.: :::.:. :.::.:::::.::::.::::::::::::::.:::.::: : XP_006 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING ::: .: :::::::::::::::::::: :::.:::::. ::::::::::::::::. .:: XP_006 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNG 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 SSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLT :. : :: ::: ::::: :.. :.::: :.::. :::::::::::::::.:..::::. XP_006 SKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 VLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKL ::: :. : . :. :. :. : . . ... . : : .. . : ::.:. XP_006 VLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 SRFPLARQ-FSLESGSSGKSSSSLVRGVRLSSS-GPALLAGLVSLDLPLDPLWEFPRDRL ::::: :: ::::..: .:.. ::: .::::. ::.: :.. :.:: :: ::. : :: XP_006 SRFPLKRQQVSLESNASMSSNTPLVRIARLSSGEGPTL-ANVSELELPADPKWELSRARL 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI .:::::::::::::: :::.:.: : . :::::::::.:.::::.:::::::.::.: XP_006 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE1 GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP :.:::::::::.::: :::::.:: ::::::::::::::::: : : : . : :.: XP_006 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE1 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS ::::::::::::.:: :.::::::::::::::::::::::::::::: ::..::::::. XP_006 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE1 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR :::::::::::::::::::::::::::::.::::::::::::::::::::::.::.:::: XP_006 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE1 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSP ::.: .: .:: .:::::::::::::::::::: ::.:: ..: .::::: : ::: XP_006 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 720 730 740 750 760 770 770 780 790 800 pF1KE1 SGGDA-SSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT .: :. ::. :..::::.:: :: XP_006 GGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 780 790 800 >>XP_011511724 (OMIM: 100800,109800,114500,134934,146000 (808 aa) initn: 1910 init1: 1910 opt: 3120 Z-score: 1079.9 bits: 210.7 E(85289): 2.1e-53 Smith-Waterman score: 3120; 62.9% identity (78.8% similar) in 797 aa overlap (5-788:8-797) 10 20 30 40 50 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLE--QQEQELTVALGQPVRL ::: .. : : :: . ..: . .:. : :::: :. . :. :.: XP_011 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQ-LVFGSGDAVEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CC---GRAERGGH-WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQ : : . : : :.:. :.:. :: ::.. . ::.: : : : .. :: XP_011 SCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFR .... . :. ::.:::: . : .. . :::::.:.::.::: ::::.:::.:: XP_011 HFSVRVTDA-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG :::::::::.: :::.:. :.::.:::::.::::.::::::::::::::.:::.::: : XP_011 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING ::: .: :::::::::::::::::::: :::.:::::. ::::::::::::::::. .:: XP_011 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNG 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 SSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLT :. : :: ::: ::::: :.. :.::: :.::. :::::::::::::::.:..::::. XP_011 SKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 VLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKL ::: :. : . :. :. :. : . . ... . : : .. . : ::.:. XP_011 VLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 SRFPLARQ-FSLESGSSGKSSSSLVRGVRLSSS-GPALLAGLVSLDLPLDPLWEFPRDRL ::::: :: ::::..: .:.. ::: .::::. ::.: :.. :.:: :: ::. : :: XP_011 SRFPLKRQQVSLESNASMSSNTPLVRIARLSSGEGPTL-ANVSELELPADPKWELSRARL 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI .:::::::::::::: :::.:.: : . :::::::::.:.::::.:::::::.::.: XP_011 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE1 GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP :.:::::::::.::: :::::.:: ::::::::::::::::: : : : . : :.: XP_011 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE1 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS ::::::::::::.:: :.::::::::::::::::::::::::::::: ::..::::::. XP_011 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE1 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR :::::::::::::::::::::::::::::.::::::::::::::::::::::.::.:::: XP_011 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE1 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS--EEYLDLRLTFGPYS ::.: .: .:: .:::::::::::::::::::: ::.:: ..: .::::: : :: XP_011 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQYS 720 730 740 750 760 770 770 780 790 800 pF1KE1 PSGGDA-SSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT :.: :. ::. :..::::.:: :: XP_011 PGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 780 790 800 >>XP_011511722 (OMIM: 100800,109800,114500,134934,146000 (809 aa) initn: 2626 init1: 1707 opt: 3118 Z-score: 1079.2 bits: 210.6 E(85289): 2.2e-53 Smith-Waterman score: 3118; 62.8% identity (78.7% similar) in 798 aa overlap (5-788:8-798) 10 20 30 40 50 pF1KE1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLE--QQEQELTVALGQPVRL ::: .. : : :: . ..: . .:. : :::: :. . :. :.: XP_011 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQ-LVFGSGDAVEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 CC---GRAERGGH-WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQ : : . : : :.:. :.:. :: ::.. . ::.: : : : .. :: XP_011 SCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFR .... . :. ::.:::: . : .. . :::::.:.::.::: ::::.:::.:: XP_011 HFSVRVTDA-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG :::::::::.: :::.:. :.::.:::::.::::.::::::::::::::.:::.::: : XP_011 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING ::: .: :::::::::::::::::::: :::.:::::. ::::::::::::::::. .:: XP_011 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNG 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 SSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLT :. : :: ::: ::::: :.. :.::: :.::. :::::::::::::::.:..::::. XP_011 SKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 VLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKL ::: :. : . :. :. :. : . . ... . : : .. . : ::.:. XP_011 VLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 SRFPLARQF--SLESGSSGKSSSSLVRGVRLSSS-GPALLAGLVSLDLPLDPLWEFPRDR ::::: :: ::::..: .:.. ::: .::::. ::.: :.. :.:: :: ::. : : XP_011 SRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTL-ANVSELELPADPKWELSRAR 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL :.:::::::::::::: :::.:.: : . :::::::::.:.::::.:::::::.::. XP_011 LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE1 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF ::.:::::::::.::: :::::.:: ::::::::::::::::: : : : . : :.: XP_011 IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTF 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE1 PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT ::::::::::::.:: :.::::::::::::::::::::::::::::: ::..:::::: XP_011 KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE1 SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH .:::::::::::::::::::::::::::::.::::::::::::::::::::::.::.::: XP_011 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE1 RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS--EEYLDLRLTFGPY :::.: .: .:: .:::::::::::::::::::: ::.:: ..: .::::: : : XP_011 RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQY 720 730 740 750 760 770 770 780 790 800 pF1KE1 SPSGGDA-SSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT ::.: :. ::. :..::::.:: :: XP_011 SPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 780 790 800 802 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:04:22 2016 done: Sun Nov 6 23:04:24 2016 Total Scan time: 14.560 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]