FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1414, 224 aa 1>>>pF1KE1414 224 - 224 aa - 224 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8209+/-0.000305; mu= 17.2220+/- 0.019 mean_var=69.6822+/-13.854, 0's: 0 Z-trim(118.0): 11 B-trim: 2 in 1/55 Lambda= 0.153643 statistics sampled from 30505 (30510) to 30505 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.358), width: 16 Scan time: 6.530 The best scores are: opt bits E(85289) NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224) 1590 360.8 1.1e-99 NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220) 780 181.2 1.2e-45 NP_000353 (OMIM: 136900,188826) metalloproteinase ( 211) 706 164.8 9.9e-41 NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207) 502 119.6 4e-27 >>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4 (224 aa) initn: 1590 init1: 1590 opt: 1590 Z-score: 1910.9 bits: 360.8 E(85289): 1.1e-99 Smith-Waterman score: 1590; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224) 10 20 30 40 50 60 pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD 130 140 150 160 170 180 190 200 210 220 pF1KE1 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP :::::::::::::::::::::::::::::::::::::::::::: NP_003 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 190 200 210 220 >>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2 (220 aa) initn: 812 init1: 564 opt: 780 Z-score: 940.6 bits: 181.2 E(85289): 1.2e-45 Smith-Waterman score: 780; 50.0% identity (80.2% similar) in 212 aa overlap (14-224:14-220) 10 20 30 40 50 60 pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA :: : .:::: ..::::.:.:::: .:.. .::::: ::: : . NP_003 MGAAARTLRLALGLLLLATLLRP---ADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDS 10 20 30 40 50 70 80 90 100 110 pF1KE1 SADP-ADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ . : .. : ..::::::::::: : ::...::: .:..:::.:.....:.::..:. NP_003 GNDIYGNPIKRIQYEIKQIKMFKGPE--KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT . .:::. : ::..: ::. :: .:..::::.:...: :.:: : .:: ::.:.:::: NP_003 AEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP ::. :... :.::. ..:.:. ::.:.:::: : ..::.:: .: NP_003 DWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP 180 190 200 210 220 >>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi (211 aa) initn: 688 init1: 392 opt: 706 Z-score: 852.2 bits: 164.8 E(85289): 9.9e-41 Smith-Waterman score: 706; 47.4% identity (73.5% similar) in 215 aa overlap (11-224:4-211) 10 20 30 40 50 pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLG-EACSCAPAHPQQHICHSALVIRAKISSEKVVP :. :. ::. : :::.:.:.:::. .:.: .:::::. ..:.: NP_000 MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVK 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 ASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ . : : : : :::.::..:: :. ::::.: . ::::.:::.: . ::::::. NP_000 EG--PFGT---LVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGR 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT : :::.. :::..: :..:.: ::..::..:::.:.:.: .:: .:: ... :::::: NP_000 VY-DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWT 110 120 130 140 150 160 180 190 200 210 220 pF1KE1 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP : : . :::..::.:... : :::::: : : ... ..: NP_000 DMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP 170 180 190 200 210 >>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1 (207 aa) initn: 408 init1: 152 opt: 502 Z-score: 608.0 bits: 119.6 E(85289): 4e-27 Smith-Waterman score: 502; 37.4% identity (67.5% similar) in 206 aa overlap (7-207:6-199) 10 20 30 40 50 60 pF1KE1 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA : : .::: : :. : ..::.:.: ::: .:.: ::::::. . : NP_003 MAPFEPLASGILLL--LWLIAP---SRACTCVPPHPQTAFCNSDLVIRAKFVGTPEV-- 10 20 30 40 50 70 80 90 100 110 pF1KE1 SADPADTEKMLRYEIKQIKMFKGFEKV---KDVQYIYTPFDSSLCGVKLEA-NSQKQYLL .: . :::::. ::.:::. . :....::: :.:: .. : ....:. NP_003 ----NQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLI 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 TGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCG-CQITTCYTVPCTISAPNE .:. :.:: . : :... ::..:::.::..... : ..: : . : ..:: ... .. NP_003 AGK-LQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTH 110 120 130 140 150 160 180 190 200 210 220 pF1KE1 CLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP ::::: ::. . :.:..: .:. . : :.: NP_003 CLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA 170 180 190 200 224 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:32:08 2016 done: Mon Nov 7 15:32:09 2016 Total Scan time: 6.530 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]