Result of FASTA (omim) for
pFN21AE6444
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6444, 510 aa
1>>>pF1KE6444 510 - 510 aa - 510 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5827+/-0.000338; mu= 14.3091+/- 0.021
mean_var=191.2857+/-40.018, 0's: 0 Z-trim(120.9): 225 B-trim: 7 in 2/56
Lambda= 0.092733
statistics sampled from 36348 (36657) to 36348 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.753), E-opt: 0.2 (0.43), width: 16
Scan time: 9.380
The best scores are: opt bits E(85289)
NP_112178 (OMIM: 609607,613573) nectin-4 precursor ( 510) 3411 469.0 1.5e-131
XP_011508323 (OMIM: 609607,613573) PREDICTED: nect ( 511) 3399 467.4 4.5e-131
XP_011508325 (OMIM: 609607,613573) PREDICTED: nect ( 460) 2927 404.2 4.3e-112
XP_005245565 (OMIM: 609607,613573) PREDICTED: nect ( 485) 2777 384.1 4.9e-106
XP_011508324 (OMIM: 609607,613573) PREDICTED: nect ( 486) 2765 382.5 1.5e-105
XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 is ( 510) 721 109.1 3.2e-23
NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Ho ( 487) 712 107.9 7.2e-23
XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 is ( 541) 697 105.9 3.1e-22
NP_056295 (OMIM: 607147) nectin-3 isoform 1 precur ( 549) 690 105.0 5.9e-22
XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 is ( 526) 681 103.8 1.3e-21
NP_001230215 (OMIM: 607147) nectin-3 isoform 2 pre ( 366) 674 102.6 2e-21
XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 is ( 534) 666 101.8 5.4e-21
XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 is ( 580) 666 101.8 5.7e-21
NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 ( 458) 555 86.8 1.5e-16
NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 ( 517) 542 85.2 5.2e-16
NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 ( 352) 514 81.2 5.5e-15
NP_001129242 (OMIM: 173850) poliovirus receptor is ( 392) 474 75.9 2.4e-13
NP_006496 (OMIM: 173850) poliovirus receptor isofo ( 417) 474 75.9 2.5e-13
NP_001129240 (OMIM: 173850) poliovirus receptor is ( 372) 463 74.4 6.5e-13
NP_001129241 (OMIM: 173850) poliovirus receptor is ( 364) 457 73.6 1.1e-12
NP_001036189 (OMIM: 600798) nectin-2 isoform delta ( 538) 401 66.3 2.6e-10
XP_016861616 (OMIM: 607147) PREDICTED: nectin-3 is ( 337) 388 64.3 6.4e-10
XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 is ( 369) 369 61.8 3.9e-09
NP_002847 (OMIM: 600798) nectin-2 isoform alpha pr ( 479) 370 62.1 4.2e-09
NP_001091987 (OMIM: 605686) cell adhesion molecule ( 414) 343 58.4 4.7e-08
NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 314 54.5 6.8e-07
NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 314 54.6 7.1e-07
XP_016872950 (OMIM: 605686) PREDICTED: cell adhesi ( 267) 288 50.8 5.9e-06
XP_016858441 (OMIM: 608869,615112) PREDICTED: leuc ( 553) 289 51.3 8.4e-06
XP_016861625 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 290 51.7 9.8e-06
XP_011531881 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 290 51.7 9.8e-06
XP_016861624 (OMIM: 608868) PREDICTED: leucine-ric ( 867) 290 51.7 1e-05
XP_011531880 (OMIM: 608868) PREDICTED: leucine-ric (1045) 290 51.8 1.1e-05
XP_016861623 (OMIM: 608868) PREDICTED: leucine-ric (1068) 290 51.8 1.1e-05
NP_056356 (OMIM: 608868) leucine-rich repeats and (1093) 290 51.9 1.2e-05
NP_001299615 (OMIM: 608869,615112) leucine-rich re ( 962) 289 51.7 1.2e-05
NP_055628 (OMIM: 608869,615112) leucine-rich repea (1065) 289 51.7 1.3e-05
XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369) 275 49.2 2.4e-05
NP_660339 (OMIM: 609744) cell adhesion molecule 4 ( 388) 275 49.3 2.5e-05
XP_011536195 (OMIM: 608870) PREDICTED: leucine-ric (1041) 266 48.6 0.0001
NP_001129523 (OMIM: 608870) leucine-rich repeats a (1059) 266 48.6 0.00011
NP_700356 (OMIM: 608870) leucine-rich repeats and (1119) 266 48.7 0.00011
XP_005271426 (OMIM: 608869,615112) PREDICTED: leuc ( 958) 251 46.6 0.0004
NP_005520 (OMIM: 142461,224410,255800) basement me (4391) 259 48.5 0.00048
NP_001278789 (OMIM: 142461,224410,255800) basement (4392) 259 48.5 0.00048
XP_016856611 (OMIM: 142461,224410,255800) PREDICTE (4438) 259 48.5 0.00048
XP_016856610 (OMIM: 142461,224410,255800) PREDICTE (4439) 259 48.5 0.00048
XP_016856609 (OMIM: 142461,224410,255800) PREDICTE (4456) 259 48.5 0.00049
XP_011539620 (OMIM: 142461,224410,255800) PREDICTE (4574) 259 48.5 0.00049
NP_001275739 (OMIM: 614133) HEPACAM family member ( 455) 230 43.3 0.0018
>>NP_112178 (OMIM: 609607,613573) nectin-4 precursor [Ho (510 aa)
initn: 3411 init1: 3411 opt: 3411 Z-score: 2482.8 bits: 469.0 E(85289): 1.5e-131
Smith-Waterman score: 3411; 100.0% identity (100.0% similar) in 510 aa overlap (1-510:1-510)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
430 440 450 460 470 480
490 500 510
pF1KE6 AMNHFVQENGTLRAKPTGNGIYINGRGHLV
::::::::::::::::::::::::::::::
NP_112 AMNHFVQENGTLRAKPTGNGIYINGRGHLV
490 500 510
>>XP_011508323 (OMIM: 609607,613573) PREDICTED: nectin-4 (511 aa)
initn: 2321 init1: 2321 opt: 3399 Z-score: 2474.1 bits: 467.4 E(85289): 4.5e-131
Smith-Waterman score: 3399; 99.8% identity (99.8% similar) in 511 aa overlap (1-510:1-511)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
250 260 270 280 290 300
310 320 330 340 350
pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
430 440 450 460 470 480
480 490 500 510
pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV
:::::::::::::::::::::::::::::::
XP_011 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV
490 500 510
>>XP_011508325 (OMIM: 609607,613573) PREDICTED: nectin-4 (460 aa)
initn: 2979 init1: 2321 opt: 2927 Z-score: 2133.4 bits: 404.2 E(85289): 4.3e-112
Smith-Waterman score: 2927; 99.1% identity (99.3% similar) in 441 aa overlap (1-440:1-441)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
250 260 270 280 290 300
310 320 330 340 350
pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
::::::::::::::::: . :
XP_011 AEGHPDSLKDNSSCSVMVRPPAPPVSPPLSSGPCPGPRYE
430 440 450 460
>>XP_005245565 (OMIM: 609607,613573) PREDICTED: nectin-4 (485 aa)
initn: 2857 init1: 2777 opt: 2777 Z-score: 2024.7 bits: 384.1 E(85289): 4.9e-106
Smith-Waterman score: 3181; 95.1% identity (95.1% similar) in 510 aa overlap (1-510:1-485)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQ---------
370 380 390 400 410
430 440 450 460 470 480
pF1KE6 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
::::::::::::::::::::::::::::::::::::::::::::
XP_005 ----------------SEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
420 430 440 450
490 500 510
pF1KE6 AMNHFVQENGTLRAKPTGNGIYINGRGHLV
::::::::::::::::::::::::::::::
XP_005 AMNHFVQENGTLRAKPTGNGIYINGRGHLV
460 470 480
>>XP_011508324 (OMIM: 609607,613573) PREDICTED: nectin-4 (486 aa)
initn: 2817 init1: 2321 opt: 2765 Z-score: 2016.0 bits: 382.5 E(85289): 1.5e-105
Smith-Waterman score: 3169; 94.9% identity (94.9% similar) in 511 aa overlap (1-510:1-486)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
250 260 270 280 290 300
310 320 330 340 350
pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQ--------
370 380 390 400 410
420 430 440 450 460 470
pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
:::::::::::::::::::::::::::::::::::::::::::
XP_011 -----------------SEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
420 430 440 450
480 490 500 510
pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV
:::::::::::::::::::::::::::::::
XP_011 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV
460 470 480
>>XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 isofor (510 aa)
initn: 261 init1: 110 opt: 721 Z-score: 537.9 bits: 109.1 E(85289): 3.2e-23
Smith-Waterman score: 721; 34.5% identity (65.0% similar) in 371 aa overlap (12-376:36-396)
10 20 30
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPA--GELETSDV
: ::::. : :. : : : . .
XP_016 RPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPH
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 VTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVE
::.: :....: :. . .: . :..: .. :...: .:. : .::. :. :.:::
XP_016 VTAVWGKNVSLKCLI--EVNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 QPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-A
: :... :.: .: :.: :.. ::: :. :. . ::: : :: :: .
XP_016 FKNYSLN--DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 LEEGQGLTLAASC-TAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMN
: .: . :.:: : .: :.:. . :. .. :. . ...:.. :...: :.:
XP_016 LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE6 GQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPP
:. .::::.::.: .: : . :: ... :.:: : : : : .::.:. ::: ....::
XP_016 GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPP
250 260 270 280 290
280 290 300 310 320 330
pF1KE6 PSYN-WTRLDGPLPSGVRVDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDP
: . :.:::: :.:. .. .:: : ::: ..::.:.:.:.: ...:..: .. . :
XP_016 PFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDV
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE6 QEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRE
::.. .... .:.:.. ::.. . :.:.: : .:
XP_016 PF---KQTSSIAVAGAVIGAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPL
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE6 NSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIE
XP_016 YEERSPPLPQKDLFQPEHLPLQTQFKEREVGNLQHSNGLNSRSFDYEDENPVGEDGIQQM
420 430 440 450 460 470
>>NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Homo s (487 aa)
initn: 326 init1: 110 opt: 712 Z-score: 531.6 bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 712; 34.7% identity (65.6% similar) in 363 aa overlap (20-376:21-373)
10 20 30 40 50
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTG--RCPAGELETSDVVTVVLGQDAKLPCFYRGD
:: ::.: : :: . . ::.: :....: :. .
NP_001 MAEGWRWCFVRRTPGLLRGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLI--E
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 SGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNA
.: . :..: .. :...: .:. : .::. :. :.::: : :... :.:
NP_001 VNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 VQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEG
.: :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: :
NP_001 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 SPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQR
.:. . :. .. :. . ...:.. :...: :.: :. .::::.::.: .: :
NP_001 KPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 ITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVR
. :: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:.
NP_001 YSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 VDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVV
.. .:: : ::: ..::.:.:.:.: ...:..: .. . : ::.. .... .:.
NP_001 ASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPF---KQTSSIAVAGAVI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 GVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPE
:.. ::.. . :.:.: : .:
NP_001 GAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEH
360 370 380 390 400 410
>>XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 isofor (541 aa)
initn: 261 init1: 110 opt: 697 Z-score: 520.2 bits: 105.9 E(85289): 3.1e-22
Smith-Waterman score: 697; 34.3% identity (66.0% similar) in 350 aa overlap (31-376:88-427)
10 20 30 40 50 60
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
:: . . ::.: :....: :. . .:
XP_016 GDCFSCKTIDCPPFILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLI--EVNE
60 70 80 90 100 110
70 80 90 100 110 120
pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
. :..: .. :...: .:. : .::. :. :.::: : :... :.: .
XP_016 TITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNIGFS
120 130 140 150 160 170
130 140 150 160 170
pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEGSPA
: :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: :.:.
XP_016 DSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPV
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE6 PSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITH
. :. .. :. . ...:.. :...: :.: :. .::::.::.: .: : .
XP_016 AHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSF
240 250 260 270 280 290
240 250 260 270 280 290
pF1KE6 ILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVRVDG
:: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:. ..
XP_016 ILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASD
300 310 320 330 340 350
300 310 320 330 340 350
pF1KE6 DTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVI
.:: : ::: ..::.:.:.:.: ...:..: .. . : ::.. .... .:.:..
XP_016 NTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPF---KQTSSIAVAGAVIGAV
360 370 380 390 400
360 370 380 390 400 410
pF1KE6 AALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESV
::.. . :.:.: : .:
XP_016 LALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPL
410 420 430 440 450 460
>>NP_056295 (OMIM: 607147) nectin-3 isoform 1 precursor (549 aa)
initn: 153 init1: 153 opt: 690 Z-score: 515.1 bits: 105.0 E(85289): 5.9e-22
Smith-Waterman score: 692; 30.5% identity (60.1% similar) in 486 aa overlap (12-455:36-505)
10 20 30
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPA--GELETSDV
: ::::. : :. : : : . .
NP_056 RPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPH
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 VTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVE
::.: :....: :. . .: . :..: .. :...: .:. : .::. :. :.:::
NP_056 VTAVWGKNVSLKCLI--EVNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 QPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-A
: :... :.: .: :.: :.. ::: :. :. . ::: : :: :: .
NP_056 FKNYSLN--DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 LEEGQGLTLAASC-TAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMN
: .: . :.:: : .: :.:. . :. .. :. . ...:.. :...: :.:
NP_056 LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE6 GQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPP
:. .::::.::.: .: : . :: ... :.:: : : : : .::.:. ::: ....::
NP_056 GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPP
250 260 270 280 290
280 290 300 310 320 330
pF1KE6 PSYN-WTRLDGPLPSGVRVDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDP
: . :.:::: :.:. .. .:: : ::: ..::.:.:.:.: ...:..: .. . ::
NP_056 PFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDP
300 310 320 330 340 350
340 350 360
pF1KE6 QEDSGKQV------------DLVS------------ASV-------VVVGVIAALLFCLL
. : ::.. :.. ....:... :: .:
NP_056 PTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVL
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE6 VVVVVLMSRYHRRKA---QQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAE
: :.. . :.::.. . ....: . .:..: :.. . : : :. :: . .
NP_056 VSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELD--SYPD-SVKKENK
420 430 440 450 460 470
430 440 450 460 470
pF1KE6 GHPDSL--KDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK
. ..: :: . :::: ..... .. ..:
NP_056 NPVNNLIRKD------YLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDEN
480 490 500 510 520
480 490 500 510
pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV
NP_056 EDDLVSHVDGSVISRREWYV
530 540
>>XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 isofor (526 aa)
initn: 258 init1: 153 opt: 681 Z-score: 508.8 bits: 103.8 E(85289): 1.3e-21
Smith-Waterman score: 683; 30.5% identity (60.5% similar) in 478 aa overlap (20-455:21-482)
10 20 30 40 50
pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTG--RCPAGELETSDVVTVVLGQDAKLPCFYRGD
:: ::.: : :: . . ::.: :....: :. .
XP_016 MAEGWRWCFVRRTPGLLRGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLI--E
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 SGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNA
.: . :..: .. :...: .:. : .::. :. :.::: : :... :.:
XP_016 VNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 VQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEG
.: :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: :
XP_016 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 SPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQR
.:. . :. .. :. . ...:.. :...: :.: :. .::::.::.: .: :
XP_016 KPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 ITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVR
. :: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:.
XP_016 YSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLL
240 250 260 270 280 290
300 310 320 330 340
pF1KE6 VDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQV----------
.. .:: : ::: ..::.:.:.:.: ...:..: .. . :: . :
XP_016 ASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTAD
300 310 320 330 340 350
350 360 370
pF1KE6 --DLVS------------ASV-------VVVGVIAALLFCLLVVVVVLMSRYHRRKA---
::.. :.. ....:... :: .:: :.. . :.::..
XP_016 IEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRG
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE6 QQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSL--KDNSSCSVMS
. ....: . .:..: :.. . : : :. :: . .. ..: :: .
XP_016 DYFAKNYIPPSDMQKESQIDVLQQDELD--SYPD-SVKKENKNPVNNLIRKD------YL
420 430 440 450 460
440 450 460 470 480 490
pF1KE6 EEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPT
:::: ..... .. ..:
XP_016 EEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREW
470 480 490 500 510 520
510 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:21:52 2016 done: Tue Nov 8 13:21:54 2016
Total Scan time: 9.380 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]