FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3942, 433 aa 1>>>pF1KE3942 433 - 433 aa - 433 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4927+/-0.00037; mu= 18.4136+/- 0.023 mean_var=123.1467+/-26.800, 0's: 0 Z-trim(116.8): 99 B-trim: 2147 in 2/53 Lambda= 0.115575 statistics sampled from 28060 (28171) to 28060 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.33), width: 16 Scan time: 9.170 The best scores are: opt bits E(85289) NP_114404 (OMIM: 606130) RING finger protein 26 [H ( 433) 2846 485.9 8.8e-137 XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 514) 188 42.8 0.0026 NP_001135763 (OMIM: 607559) E3 ubiquitin-protein l ( 530) 188 42.8 0.0026 XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 530) 188 42.8 0.0026 XP_016878581 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 531) 188 42.8 0.0026 XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 539) 188 42.8 0.0026 XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 552) 188 42.8 0.0027 NP_001135762 (OMIM: 607559) E3 ubiquitin-protein l ( 552) 188 42.8 0.0027 XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 188 42.8 0.0027 XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 188 42.8 0.0027 NP_001135761 (OMIM: 607559) E3 ubiquitin-protein l ( 554) 188 42.8 0.0027 XP_005255275 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 555) 188 42.8 0.0027 NP_056061 (OMIM: 607559) E3 ubiquitin-protein liga ( 576) 188 42.8 0.0028 XP_005255274 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 577) 188 42.8 0.0028 XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 339) 184 41.9 0.0031 XP_016870773 (OMIM: 610933,614436) PREDICTED: E3 u ( 460) 183 41.9 0.0042 XP_016876421 (OMIM: 606138) PREDICTED: cell growth ( 272) 179 40.9 0.0048 XP_016876420 (OMIM: 606138) PREDICTED: cell growth ( 272) 179 40.9 0.0048 XP_011534664 (OMIM: 606138) PREDICTED: cell growth ( 272) 179 40.9 0.0048 NP_006559 (OMIM: 606138) cell growth regulator wit ( 332) 179 41.0 0.0055 NP_647478 (OMIM: 605737) baculoviral IAP repeat-co ( 298) 177 40.6 0.0065 XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 u ( 690) 178 41.2 0.0098 NP_001177652 (OMIM: 610933,614436) E3 ubiquitin-pr ( 696) 178 41.2 0.0099 >>NP_114404 (OMIM: 606130) RING finger protein 26 [Homo (433 aa) initn: 2846 init1: 2846 opt: 2846 Z-score: 2576.6 bits: 485.9 E(85289): 8.8e-137 Smith-Waterman score: 2846; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433) 10 20 30 40 50 60 pF1KE3 MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVYNLPHTVLTSLLHLGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVYNLPHTVLTSLLHLGRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGHLASHGALRSREILHRGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGHLASHGALRSREILHRGVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQNLFSLVLALWDAVTGPLWRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 NVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQNLFSLVLALWDAVTGPLWRM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TDVVAAFLAHISSSAVAMAILLWTPCQLALELLASAARLLASFVLVNLTGLVLLACVLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TDVVAAFLAHISSSAVAMAILLWTPCQLALELLASAARLLASFVLVNLTGLVLLACVLAV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 PNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 PPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPL 370 380 390 400 410 420 430 pF1KE3 CRRGILQTLNVYL ::::::::::::: NP_114 CRRGILQTLNVYL 430 >>XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (514 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.6 bits: 42.8 E(85289): 0.0026 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:215-287) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_016 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 190 200 210 220 230 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_016 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 240 250 260 270 280 290 XP_016 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 300 310 320 330 340 350 >>NP_001135763 (OMIM: 607559) E3 ubiquitin-protein ligas (530 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.4 bits: 42.8 E(85289): 0.0026 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:253-325) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. NP_001 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: NP_001 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 NP_001 ALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITY 340 350 360 370 380 390 >>XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (530 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.4 bits: 42.8 E(85289): 0.0026 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:253-325) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_005 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_005 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 XP_005 ALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITY 340 350 360 370 380 390 >>XP_016878581 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (531 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.4 bits: 42.8 E(85289): 0.0026 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:254-326) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_016 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_016 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 XP_016 ALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITY 340 350 360 370 380 390 >>XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (539 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.3 bits: 42.8 E(85289): 0.0026 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:216-288) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_011 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 190 200 210 220 230 240 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_011 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 250 260 270 280 290 XP_011 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 300 310 320 330 340 350 >>XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (552 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:253-325) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_005 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_005 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 XP_005 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 340 350 360 370 380 390 >>NP_001135762 (OMIM: 607559) E3 ubiquitin-protein ligas (552 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:253-325) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. NP_001 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: NP_001 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 NP_001 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 340 350 360 370 380 390 >>XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (553 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:254-326) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_016 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_016 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 XP_016 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 340 350 360 370 380 390 >>XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (553 aa) initn: 154 init1: 154 opt: 188 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 188; 35.8% identity (67.9% similar) in 81 aa overlap (350-427:254-326) 320 330 340 350 360 370 pF1KE3 VRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKK . : : :..: ..: ..... .. XP_005 AFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDD-----ENSDNSNE 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 CVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQTLNVYL ::.: .. . .:.::::::::: .:.. : :. . :::.:: :..:: XP_005 CVVCLSDLRDTLILPCRHLCLCTSCADTL-RYQA--NNCPICRLPFRALLQIRAVRKKPG 280 290 300 310 320 330 XP_005 ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEA 340 350 360 370 380 390 433 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:44:18 2016 done: Sun Nov 6 08:44:19 2016 Total Scan time: 9.170 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]