Result of FASTA (omim) for
pFN21AE3652
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3652, 366 aa
1>>>pF1KE3652 366 - 366 aa - 366 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4735+/-0.000277; mu= 13.4831+/- 0.017
mean_var=133.8508+/-27.224, 0's: 0 Z-trim(122.7): 53 B-trim: 534 in 1/53
Lambda= 0.110857
statistics sampled from 41196 (41252) to 41196 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.484), width: 16
Scan time: 9.680
The best scores are: opt bits E(85289)
NP_002182 (OMIM: 147380) inhibin alpha chain prepr ( 366) 2566 421.0 2.1e-117
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 246 50.0 9.9e-06
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 225 46.6 0.00011
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 226 46.9 0.00011
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 211 44.5 0.00058
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 207 43.9 0.00093
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 196 42.0 0.0028
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 185 40.0 0.006
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 189 40.9 0.0063
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 187 40.5 0.0071
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 185 40.2 0.0085
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 186 40.5 0.0088
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 187 40.7 0.0089
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 187 40.7 0.0089
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 187 40.7 0.0089
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 185 40.3 0.0099
>>NP_002182 (OMIM: 147380) inhibin alpha chain prepropro (366 aa)
initn: 2566 init1: 2566 opt: 2566 Z-score: 2228.9 bits: 421.0 E(85289): 2.1e-117
Smith-Waterman score: 2566; 100.0% identity (100.0% similar) in 366 aa overlap (1-366:1-366)
10 20 30 40 50 60
pF1KE3 MVLHLLLFLLLTPQGGHSCQGLELARELVLAKVRALFLDALGPPAVTREGGDPGVRRLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVLHLLLFLLLTPQGGHSCQGLELARELVLAKVRALFLDALGPPAVTREGGDPGVRRLPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RHALGGFTHRGSEPEEEEDVSQAILFPATDASCEDKSAARGLAQEAEEGLFRYMFRPSQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RHALGGFTHRGSEPEEEEDVSQAILFPATDASCEDKSAARGLAQEAEEGLFRYMFRPSQH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TRSRQVTSAQLWFHTGLDRQGTAASNSSEPLLGLLALSPGGPVAVPMSLGHAPPHWAVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TRSRQVTSAQLWFHTGLDRQGTAASNSSEPLLGLLALSPGGPVAVPMSLGHAPPHWAVLH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 LATSALSLLTHPVLVLLLRCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPLMSWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LATSALSLLTHPVLVLLLRCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPLMSWP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 WSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 PNLSLPVPGAPPTPAQPYSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNLSLPVPGAPPTPAQPYSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLT
310 320 330 340 350 360
pF1KE3 QHCACI
::::::
NP_002 QHCACI
>>NP_113667 (OMIM: 612031) inhibin beta E chain prepropr (350 aa)
initn: 193 init1: 128 opt: 246 Z-score: 223.9 bits: 50.0 E(85289): 9.9e-06
Smith-Waterman score: 277; 28.3% identity (47.5% similar) in 396 aa overlap (5-365:11-349)
10 20 30 40
pF1KE3 MVLHLLLFLLLTPQG-GH---SCQGLELA----RELVLAKVRALFLDAL---GP
.::. :. :: : :: : .:: : ::: .. .::.: .
NP_113 MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVLELAKQQILDGLHLTSR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 PAVTREGGDPGVRRLPRRHALGGFTHRGSEPEEEEDVSQAILFPATDASCEDKSAARGLA
: .:. . .. : :: :. . : . :.: : : :. :...: .
NP_113 PRITHPPPQAALTRALRRLQPGSVA-----PGNGEEV---ISF----ATVTDSTSAYS--
70 80 90 100
110 120 130 140 150 160
pF1KE3 QEAEEGLFRYMFRPSQHTRSRQVTSAQLWFHTGLDRQGTAASNSSEPLLGLLALSPGGPV
.:. . . ::... :.::.:. :: : .. .:
NP_113 -----SLLTFHLSTP---RSHHLYHARLWLHVLPTLPGTLC-------LRIFRWGPRRRR
110 120 130 140 150
170 180 190 200 210
pF1KE3 AVPMSLGHAPPH-----WAVLHLATSALSLLTHPVLVLLLRC-PL---CTCSARPE----
.: : : : .: : .:.: :: : : : :: : ...:.
NP_113 QGSRTL-LAEHHITNLGWHTLTLPSSGLRGEKSGVLKLQLDCRPLEGNSTVTGQPRRLLD
160 170 180 190 200 210
220 230 240 250 260
pF1KE3 ----ATPFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRPPEEPAAHANCHRVA
::: . :. :..: :::: :: :::. :.:
NP_113 TAGHQQPFLELKIRANEPGAG-RARRRTPTC-----------------EPATPLCCRR-D
220 230 240 250
270 280 290 300 310 320
pF1KE3 LNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPG-APPTPAQPYSLL----
..::::::. ::. : .. ..:: : : ::.:. :: : . .:::
NP_113 HYVDFQELGWRDWILQPEGYQLNYCSGQC----PPHLA-GSPGIAASFHSAVFSLLKANN
260 270 280 290 300
330 340 350 360
pF1KE3 --PGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
:.. :: .: . ::: . . .: : . ::..... :.:
NP_113 PWPASTSCC--VPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS
310 320 330 340 350
>>NP_001483 (OMIM: 187500,208530,217095,602880,613854) e (372 aa)
initn: 157 init1: 135 opt: 225 Z-score: 205.4 bits: 46.6 E(85289): 0.00011
Smith-Waterman score: 225; 28.0% identity (53.9% similar) in 193 aa overlap (189-365:190-371)
160 170 180 190 200 210
pF1KE3 PGGPVAVPMSLGHAPPHWAVLHLATSALSLLTHPVLVLLLRCPLCTCSARPEATPFLVAH
: :: . :: .. :.. . .:
NP_001 EGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALA-
160 170 180 190 200 210
220 230 240 250 260 270
pF1KE3 TRTRPPSGGERARRSTPLMSWPWSPSALRLLQRP--PEEPAAHAN----CHRVALNISFQ
: : :.. : ... :. .: . : :: ::. .. :. : .::.
NP_001 LRPRAPAACARLAEAS-LLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFR
220 230 240 250 260 270
280 290 300 310 320
pF1KE3 ELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPT------PAQPYSLLPGAQ-
:.::.::.. : .:. .::.: :.: . .: :.::. : .. :::
NP_001 EVGWHRWVIAPRGFLANYCQGQCALPV----ALSGSGGPPALNHAVLRALMHAAAPGAAD
280 290 300 310 320 330
330 340 350 360
pF1KE3 -PCCAALPGTMRPLHVR--TTSDGGYSFKYETVPNLLTQHCACI
::: .:. . :. : .::. .:: ......:.:
NP_001 LPCC--VPARLSPISVLFFDNSDNVVLRQYE---DMVVDECGCR
340 350 360 370
>>NP_001192 (OMIM: 112263) bone morphogenetic protein 3 (472 aa)
initn: 254 init1: 160 opt: 226 Z-score: 204.9 bits: 46.9 E(85289): 0.00011
Smith-Waterman score: 226; 25.5% identity (56.5% similar) in 161 aa overlap (210-365:317-471)
180 190 200 210 220 230
pF1KE3 HLATSALSLLTHPVLVLLLRCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPL---
: :. . .... : ... .:. :
NP_001 KKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKS
290 300 310 320 330 340
240 250 260 270 280 290
pF1KE3 MSWPWSPSALRLLQRPPE-EPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGC
.. .. ..:. .: :: :: : :...: ..:: .::. : :: .:: :.:
NP_001 QTLQFDEQTLKKARRKQWIEPR---NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGAC
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE3 GLHIPPNLSLPVPGAPPTPAQPYSLLPGA-QPCCAALPGTMRPLHVRTTSDGGYSFKYET
. .: .:. .. . .. ...:: .::: .: : : . : . . ..
NP_001 QFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCC--VPEKMSSLSI-LFFDENKNVVLKV
410 420 430 440 450 460
360
pF1KE3 VPNLLTQHCACI
::. .. :::
NP_001 YPNMTVESCACR
470
>>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa)
initn: 138 init1: 138 opt: 211 Z-score: 192.1 bits: 44.5 E(85289): 0.00058
Smith-Waterman score: 211; 27.5% identity (51.6% similar) in 153 aa overlap (223-365:315-454)
200 210 220 230 240 250
pF1KE3 VLVLLLRCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRP
::::. :: :: :: : .:
NP_001 QRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDAR--------PWLPSPGRRRRRT
290 300 310 320 330
260 270 280 290 300
pF1KE3 P---EEPAAHAN-----CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLS
.. :.. : . :...:.::::. ::. : . ..:.: : . . .:
NP_001 AFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLE
340 350 360 370 380 390
310 320 330 340 350 360
pF1KE3 LPVPGAPPTPAQPYSLLPGAQP--CCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQH
:. : . :. ::. : :: .: . :. . :.: . :. .....
NP_001 -PTNHAI-IQTLMNSMDPGSTPPSCC--VPTKLTPISI-LYIDAGNNVVYKQYEDMVVES
400 410 420 430 440 450
pF1KE3 CACI
:.:
NP_001 CGCR
>>NP_004953 (OMIM: 601361) growth/differentiation factor (478 aa)
initn: 218 init1: 132 opt: 207 Z-score: 188.4 bits: 43.9 E(85289): 0.00093
Smith-Waterman score: 207; 29.5% identity (58.1% similar) in 105 aa overlap (262-365:376-477)
240 250 260 270 280 290
pF1KE3 RSTPLMSWPWSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYC
: : :...: ..::..::. : :: .::
NP_004 EVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYC
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE3 HGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGA-QPCCAALPGTMRPLHVRTTSDGGYSF
:.: . .: . .. . .. ...:: .::: .: : : : : . .
NP_004 AGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCC--VPDKMNSLGV-LFLDENRNV
410 420 430 440 450 460
360
pF1KE3 KYETVPNLLTQHCACI
.. ::. .. :::
NP_004 VLKVYPNMSVDTCACR
470
>>NP_001711 (OMIM: 602284) bone morphogenetic protein 8B (402 aa)
initn: 226 init1: 122 opt: 196 Z-score: 179.9 bits: 42.0 E(85289): 0.0028
Smith-Waterman score: 206; 23.7% identity (46.8% similar) in 393 aa overlap (11-365:25-401)
10 20 30 40
pF1KE3 MVLHLLLFLLLTPQGGHSCQGLEL-ARELVLAKVRALFLDALGPPA
: : : : .: ::: :. .: .:: :.
NP_001 MTALPGPLWLLGLALCALGGGGPGLRPPPG--CPQRRLGARE--RRDVQREILAVLGLPG
10 20 30 40 50
50 60 70 80 90
pF1KE3 VTREGGDPGVRRLPRR---------HALGGFTHRGSEPEEEEDVSQAILFPATDASCEDK
: . :.. ::: ::..: . . : :.. ... .. .:.
NP_001 RPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDR
60 70 80 90 100 110
100 110 120 130 140
pF1KE3 SAARGLAQEAEEGLFRYMFR--PSQHT------RSRQVTSAQLW---FHTGLDRQGTAAS
. .. :: . ::. . :. .. : .: : .: .:... . :
NP_001 ALGH---QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQS
120 130 140 150 160 170
150 160 170 180 190
pF1KE3 NSSEPL--LGLLALSPGGPVAVPMSLGHAPPHWAVLHLATSALSLLTH--------PVLV
: : : : .: : . ... : : . . .: : .. : :.
NP_001 NRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLA
180 190 200 210 220 230
200 210 220 230 240 250
pF1KE3 LLL--RCPLCTCSARPEATPFLVAH-TRTRPPSGGERARRSTPLMSWPWSPSALRLLQRP
:: : : : .: .. :. : . : : . . :: : : :.: ::
NP_001 GLLGQRAPR---SQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNEL-PQANRLPGIF
240 250 260 270 280
260 270 280 290 300 310
pF1KE3 PEEPAAHAN--CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGA
. ..:. :.: : .:::.::: :.. : .. .::.: :.. : . . . .
NP_001 DDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSF--PLDSCMNATNH
290 300 310 320 330 340
320 330 340 350 360
pF1KE3 PPTPAQPYSLLPGAQP--CCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
. . ..: : : ::: . . .:.. :.. :.... :.:
NP_001 AILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHR---NMVVKACGCH
350 360 370 380 390 400
>>NP_001316835 (OMIM: 270100,601265) nodal homolog isofo (214 aa)
initn: 149 init1: 122 opt: 185 Z-score: 173.9 bits: 40.0 E(85289): 0.006
Smith-Waterman score: 185; 26.8% identity (51.4% similar) in 138 aa overlap (237-366:94-214)
210 220 230 240 250 260
pF1KE3 ARPEATPFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRPPEEPAAHANCHRVA
.:: :. .: . : :..:
NP_001 YSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKR-----HRRHHLPDRSQLCRKVK
70 80 90 100 110
270 280 290 300 310 320
pF1KE3 LNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGA--PPTPAQPYSLLPGA
....:. .:: ::.:: .. . :.: : :: :: : . : :::
NP_001 FQVDFNLIGWGSWIIYPKQYNAYRCEGEC-----PN---PVGEEFHPTNHAYIQSLLKRY
120 130 140 150 160 170
330 340 350 360
pF1KE3 QP------CCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
:: ::: : .:: . ...: . .. ......:.:.
NP_001 QPHRVPSTCCA--PVKTKPLSMLYVDNGRVLLDHH--KDMIVEECGCL
180 190 200 210
>>XP_011540326 (OMIM: 602284) PREDICTED: bone morphogene (427 aa)
initn: 226 init1: 122 opt: 189 Z-score: 173.5 bits: 40.9 E(85289): 0.0063
Smith-Waterman score: 213; 26.3% identity (50.2% similar) in 205 aa overlap (167-365:244-426)
140 150 160 170 180 190
pF1KE3 LDRQGTAASNSSEPLLGLLALSPGGPVAVPMSLGHAPPHWAV-LHLATSALSLLTHPVLV
. :...: :.. :: : . .:.:
XP_011 LGLRLYVETEDGETWTGWGWTKDSRLQMWKLRLSRTP--WVLSLHAPGPAQAPAERPLLC
220 230 240 250 260 270
200 210 220 230 240 250
pF1KE3 LLL-RCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRPPE
:: .:: : : :: : : : : ..:. : :.: :: .
XP_011 LLQGHCP---ASPSPIRTPRAVRPLRRRQP------KKSNEL------PQANRLPGIFDD
280 290 300 310
260 270 280 290 300 310
pF1KE3 EPAAHAN--CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPP
..:. :.: : .:::.::: :.. : .. .::.: :.. : . . . .
XP_011 VHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSF--PLDSCMNATNHAI
320 330 340 350 360 370
320 330 340 350 360
pF1KE3 TPAQPYSLLPGAQP--CCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
. . ..: : : ::: . . .:.. :.. :.... :.:
XP_011 LQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHR---NMVVKACGCH
380 390 400 410 420
>>NP_065685 (OMIM: 606522,613702,613703,613704) growth/d (364 aa)
initn: 170 init1: 170 opt: 187 Z-score: 172.6 bits: 40.5 E(85289): 0.0071
Smith-Waterman score: 187; 26.0% identity (56.1% similar) in 123 aa overlap (243-365:245-363)
220 230 240 250 260 270
pF1KE3 PFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRPPEEPAAHANCHRVALNISFQ
:: : : . . . ::: : :.:.
NP_065 NFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFR
220 230 240 250 260 270
280 290 300 310 320 330
pF1KE3 ELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAALP
.:::..::. : .:. .:::: : . . ..:: . : ... : : . .:
NP_065 DLGWHKWIIAPKGFMANYCHGECPFSL--TISLNSSNYAFMQALMHAVDPEI-PQAVCIP
280 290 300 310 320 330
340 350 360
pF1KE3 GTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
. :. . .:.. . . ......:.:
NP_065 TKLSPISM-LYQDNNDNVILRHYEDMVVDECGCG
340 350 360
366 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:15:52 2016 done: Sun Nov 6 23:15:54 2016
Total Scan time: 9.680 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]