FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5619, 481 aa 1>>>pF1KE5619 481 - 481 aa - 481 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4489+/-0.000402; mu= 17.9573+/- 0.025 mean_var=76.1033+/-15.264, 0's: 0 Z-trim(112.7): 26 B-trim: 1084 in 1/49 Lambda= 0.147019 statistics sampled from 21661 (21676) to 21661 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.254), width: 16 Scan time: 7.000 The best scores are: opt bits E(85289) NP_112597 (OMIM: 616283,617051) tRNA pseudouridine ( 481) 3241 697.1 2.8e-200 XP_005271744 (OMIM: 616283,617051) PREDICTED: tRNA ( 382) 2435 526.1 6.7e-149 NP_001258914 (OMIM: 616283,617051) tRNA pseudourid ( 273) 1879 408.1 1.6e-113 XP_005271745 (OMIM: 616283,617051) PREDICTED: tRNA ( 176) 1059 234.0 2.6e-61 NP_001002020 (OMIM: 600462,608109) tRNA pseudourid ( 399) 165 44.6 0.0006 NP_001002019 (OMIM: 600462,608109) tRNA pseudourid ( 399) 165 44.6 0.0006 NP_079491 (OMIM: 600462,608109) tRNA pseudouridine ( 427) 165 44.6 0.00064 >>NP_112597 (OMIM: 616283,617051) tRNA pseudouridine(38/ (481 aa) initn: 3241 init1: 3241 opt: 3241 Z-score: 3716.7 bits: 697.1 E(85289): 2.8e-200 Smith-Waterman score: 3241; 99.6% identity (100.0% similar) in 481 aa overlap (1-481:1-481) 10 20 30 40 50 60 pF1KE5 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSSGAGKTKRAFDFSAH :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: NP_112 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 ILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 ILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 ELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 ELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 MLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 QGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEDNTNLETPTKRVCVDTEIKSI :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_112 QGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIKSI 430 440 450 460 470 480 pF1KE5 I : NP_112 I >>XP_005271744 (OMIM: 616283,617051) PREDICTED: tRNA pse (382 aa) initn: 2428 init1: 2428 opt: 2435 Z-score: 2794.2 bits: 526.1 E(85289): 6.7e-149 Smith-Waterman score: 2435; 97.8% identity (99.4% similar) in 363 aa overlap (119-481:20-382) 90 100 110 120 130 140 pF1KE5 IEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSEDFNVK .:... .:::::::::::::::::::::: XP_005 MRARAPAQKTHSDSFLSRKRGAAGCRKVISLDLRSQFPRGRDSEDFNVK 10 20 30 40 150 160 170 180 190 200 pF1KE5 EEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVT 50 60 70 80 90 100 210 220 230 240 250 260 pF1KE5 MDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFE 110 120 130 140 150 160 270 280 290 300 310 320 pF1KE5 VTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCK 170 180 190 200 210 220 330 340 350 360 370 380 pF1KE5 FENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEW 230 240 250 260 270 280 390 400 410 420 430 440 pF1KE5 GNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETK 290 300 310 320 330 340 450 460 470 480 pF1KE5 AKRDCNDTLEEDNTNLETPTKRVCVDTEIKSII :::::::::::.::::::::::::::::::::: XP_005 AKRDCNDTLEEENTNLETPTKRVCVDTEIKSII 350 360 370 380 >>NP_001258914 (OMIM: 616283,617051) tRNA pseudouridine( (273 aa) initn: 1879 init1: 1879 opt: 1879 Z-score: 2159.0 bits: 408.1 E(85289): 1.6e-113 Smith-Waterman score: 1879; 99.6% identity (100.0% similar) in 273 aa overlap (209-481:1-273) 180 190 200 210 220 230 pF1KE5 PVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQ :::::::::::::::::::::::::::::: NP_001 MDYAAQKYVGTHDFRNLCKMDVANGVINFQ 10 20 30 240 250 260 270 280 290 pF1KE5 RTILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEI 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE5 IDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVK 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE5 THMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRP 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE5 KCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEDNTNLETPTKRVCVDTEIK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_001 KCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIK 220 230 240 250 260 270 480 pF1KE5 SII ::: NP_001 SII >>XP_005271745 (OMIM: 616283,617051) PREDICTED: tRNA pse (176 aa) initn: 1059 init1: 1059 opt: 1059 Z-score: 1221.7 bits: 234.0 E(85289): 2.6e-61 Smith-Waterman score: 1059; 98.8% identity (99.4% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KE5 MADNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSSGAGKTKRAFDFSAH :: ::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: XP_005 MAYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV :::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRYGCRISSSLI 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT >>NP_001002020 (OMIM: 600462,608109) tRNA pseudouridine (399 aa) initn: 280 init1: 108 opt: 165 Z-score: 191.8 bits: 44.6 E(85289): 0.0006 Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:55-368) 40 50 60 70 80 pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI .:...: .:: : ::.:. . .... :: NP_001 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED :. : ::... . :. . ...::.:::::::: :::.:: . .: NP_001 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD 90 100 110 120 130 150 160 170 180 190 200 pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL . :. : .: :: ::::. : .:... : ::: :..: . NP_001 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF 140 150 160 170 180 210 220 230 240 250 pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW---- : . : .... .... .. . .:. ::. . : :.:. :. NP_001 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM 190 200 210 220 230 260 270 280 290 300 pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P .::: .. ..: ::.:..::.: :.... : .:. .... . :: : NP_001 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML . : ....: . :. .: : . : :: . . .... . . NP_001 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG :: : :.:.:. NP_001 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD 360 370 380 390 >>NP_001002019 (OMIM: 600462,608109) tRNA pseudouridine (399 aa) initn: 280 init1: 108 opt: 165 Z-score: 191.8 bits: 44.6 E(85289): 0.0006 Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:55-368) 40 50 60 70 80 pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI .:...: .:: : ::.:. . .... :: NP_001 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED :. : ::... . :. . ...::.:::::::: :::.:: . .: NP_001 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD 90 100 110 120 130 150 160 170 180 190 200 pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL . :. : .: :: ::::. : .:... : ::: :..: . NP_001 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF 140 150 160 170 180 210 220 230 240 250 pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW---- : . : .... .... .. . .:. ::. . : :.:. :. NP_001 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM 190 200 210 220 230 260 270 280 290 300 pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P .::: .. ..: ::.:..::.: :.... : .:. .... . :: : NP_001 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML . : ....: . :. .: : . : :: . . .... . . NP_001 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG :: : :.:.:. NP_001 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD 360 370 380 390 >>NP_079491 (OMIM: 600462,608109) tRNA pseudouridine syn (427 aa) initn: 253 init1: 108 opt: 165 Z-score: 191.4 bits: 44.6 E(85289): 0.00064 Smith-Waterman score: 270; 25.4% identity (53.5% similar) in 342 aa overlap (62-374:83-396) 40 50 60 70 80 pF1KE5 QAKNKEDSNIRENSSGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNN--TI .:...: .:: : ::.:. . .... :: NP_079 AGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTI 60 70 80 90 100 110 90 100 110 120 130 140 pF1KE5 EEKLFEALTKTRLV-----ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSED :. : ::... . :. . ...::.:::::::: :::.:: . .: NP_079 EDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLI-------DD 120 130 140 150 160 150 160 170 180 190 200 pF1KE5 FNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADL . :. : .: :: ::::. : .:... : ::: :..: . NP_079 --ILEKIN--------SH-----LPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAF 170 180 190 200 210 210 220 230 240 250 pF1KE5 DIVTMDYAAQKY-VGTHDFRNLCKMDVA-NGVINFQRTILSAQVQLVGQSPGEGRW---- : . : .... .... .. . .:. ::. . : :.:. :. NP_079 AHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFH----NFTSQKGPQDPSACRYILEM 220 230 240 250 260 260 270 280 290 300 pF1KE5 --QEPF-----QLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKN--P .::: .. ..: ::.:..::.: :.... : .:. .... . :: : NP_079 YCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVP 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE5 QKPQYSMAVE-FPLVLYDCKFEN------VKWIYDQEAQEFNITHLQQLWANHAVKTHML . : ....: . :. .: : . : :: . . .... . . NP_079 KAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWA--QEEGKVAAFKEEHIYPTIIGTERDE 330 340 350 360 370 380 370 380 390 400 410 420 pF1KE5 YSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQG :: : :.:.:. NP_079 RSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD 390 400 410 420 481 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:13:16 2016 done: Tue Nov 8 05:13:17 2016 Total Scan time: 7.000 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]