FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3606, 479 aa 1>>>pF1KE3606 479 - 479 aa - 479 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1895+/-0.000307; mu= 10.2567+/- 0.019 mean_var=129.9400+/-26.168, 0's: 0 Z-trim(120.6): 5 B-trim: 352 in 2/53 Lambda= 0.112513 statistics sampled from 36044 (36049) to 36044 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.756), E-opt: 0.2 (0.423), width: 16 Scan time: 9.750 The best scores are: opt bits E(85289) NP_060895 (OMIM: 609763) phosphatidylinositol 4-ki ( 479) 3296 546.0 8.3e-155 NP_060793 (OMIM: 612101) phosphatidylinositol 4-ki ( 481) 1853 311.8 2.7e-84 XP_005248232 (OMIM: 612101) PREDICTED: phosphatidy ( 385) 1845 310.4 5.6e-84 XP_005248231 (OMIM: 612101) PREDICTED: phosphatidy ( 476) 1801 303.4 9.3e-82 >>NP_060895 (OMIM: 609763) phosphatidylinositol 4-kinase (479 aa) initn: 3296 init1: 3296 opt: 3296 Z-score: 2900.2 bits: 546.0 E(85289): 8.3e-155 Smith-Waterman score: 3296; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KE3 MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 VPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 AVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW 430 440 450 460 470 >>NP_060793 (OMIM: 612101) phosphatidylinositol 4-kinase (481 aa) initn: 1926 init1: 1172 opt: 1853 Z-score: 1634.3 bits: 311.8 E(85289): 2.7e-84 Smith-Waterman score: 1891; 59.8% identity (78.8% similar) in 490 aa overlap (9-479:17-481) 10 20 30 40 pF1KE3 MDETSPLVSPERAQPPDYT--FPSGSGAHFPQ--VPGGAVRVAAAAG----S :::. . . .: . :: :. .::.:::. ::: . NP_060 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAH-PRRGAPGSAVRLLDAAGEEGEA 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 G----PSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRE : : :::. : .: . :::.: :. . :.... : NP_060 GDEELPLPPGDVGVSRSSSAELDRSRPAV----SVTIGTS-------------------E 60 70 80 90 110 120 130 140 150 160 pF1KE3 RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYG : : .:::: .. .:: ::: :::::: ::::::::::::. .::.:::::.::::: NP_060 MNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYG 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE3 HLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASET .:::::::...:.:::::::: ::. :::::::::: :::.::.:.:::.::::.:.::: NP_060 QLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSET 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 FNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAE :::.::::.:::::. :::::::::..:.:::::::.:::::::::::.:.::::.:::. NP_060 FNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEAD 220 230 240 250 260 270 290 300 310 320 330 pF1KE3 PLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYD---CPMDSSSSRDTDWVVVKE ::::: .:. ::::::.::::::::::::::::..:. : . . ... :. .: NP_060 PLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDH-KESKWIDDEE 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE3 PVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDL .::.::::::::::.:::: ::::::.::::::::::::.::..:::: ::: :::.:: NP_060 FLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDL 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE3 EEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSH :::::::: : :::.. :..:..:::::::::::::.:.:::..:::.: :::: ... NP_060 CEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGG 400 410 420 430 440 450 460 470 pF1KE3 QRSS----SESYTQSFQSRKPFFSWW ... :.:.::. . :::::: : NP_060 SQGRIVHLSNSFTQTVNCRKPFFSSW 460 470 480 >>XP_005248232 (OMIM: 612101) PREDICTED: phosphatidylino (385 aa) initn: 1831 init1: 1168 opt: 1845 Z-score: 1628.7 bits: 310.4 E(85289): 5.6e-84 Smith-Waterman score: 1845; 68.6% identity (87.5% similar) in 385 aa overlap (102-479:2-385) 80 90 100 110 120 130 pF1KE3 GQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIY : : .:::: .. .:: ::: :::::: XP_005 MNAFLDDPEFADIMLRAEQAIEVGIFPERIS 10 20 30 140 150 160 170 180 190 pF1KE3 QGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYL ::::::::::::. .::.:::::.:::::.:::::::...:.:::::::: ::. ::::: XP_005 QGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGYL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 SEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRI ::::: :::.::.:.:::.::::.:.::::::.::::.:::::. :::::::::..:.:: XP_005 SEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHRI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 GLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGN :::::.:::::::::::.:.::::.:::.::::: .:. ::::::.:::::::::::: XP_005 GLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRGN 160 170 180 190 200 210 320 330 340 350 360 pF1KE3 DNWLIKYD---CPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAW ::::..:. : . . ... :. .: .::.::::::::::.:::: ::::::.::: XP_005 DNWLVRYEKQKCEKEIDH-KESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAW 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 LPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQIL :::::::::.::..:::: ::: :::.:: :::::::: : :::.. :..:..::::::: XP_005 LPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQIL 280 290 300 310 320 330 430 440 450 460 470 pF1KE3 NLTQALKDNKSPLHLVQMPPVIVETARSHQRSS----SESYTQSFQSRKPFFSWW ::::::.:.:::..:::.: :::: ... ... :.:.::. . :::::: : XP_005 NLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW 340 350 360 370 380 >>XP_005248231 (OMIM: 612101) PREDICTED: phosphatidylino (476 aa) initn: 1573 init1: 795 opt: 1801 Z-score: 1588.8 bits: 303.4 E(85289): 9.3e-82 Smith-Waterman score: 1839; 59.0% identity (77.8% similar) in 490 aa overlap (9-479:17-476) 10 20 30 40 pF1KE3 MDETSPLVSPERAQPPDYT--FPSGSGAHFPQ--VPGGAVRVAAAAG----S :::. . . .: . :: :. .::.:::. ::: . XP_005 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAH-PRRGAPGSAVRLLDAAGEEGEA 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 G----PSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRE : : :::. : .: . :::.: :. . :.... : XP_005 GDEELPLPPGDVGVSRSSSAELDRSRPAV----SVTIGTS-------------------E 60 70 80 90 110 120 130 140 150 160 pF1KE3 RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYG : : .:::: .. .:: ::: :::::: ::::::::::::. .::.:::::.::::: XP_005 MNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYG 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE3 HLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASET .:::::::...:.:::::::: ::. :::::::::: :::.::.:.:::.::::.:.::: XP_005 QLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSET 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 FNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAE :::.::::.:::::. :::::::::..:.::::::: :::::::.:.::::.:::. XP_005 FNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPK-----LFVEGYKEAEYWLRKFEAD 220 230 240 250 260 270 290 300 310 320 330 pF1KE3 PLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYD---CPMDSSSSRDTDWVVVKE ::::: .:. ::::::.::::::::::::::::..:. : . . ... :. .: XP_005 PLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDH-KESKWIDDEE 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE3 PVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDL .::.::::::::::.:::: ::::::.::::::::::::.::..:::: ::: :::.:: XP_005 FLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDL 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE3 EEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSH :::::::: : :::.. :..:..:::::::::::::.:.:::..:::.: :::: ... XP_005 CEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGG 400 410 420 430 440 450 460 470 pF1KE3 QRSS----SESYTQSFQSRKPFFSWW ... :.:.::. . :::::: : XP_005 SQGRIVHLSNSFTQTVNCRKPFFSSW 460 470 479 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:04:26 2016 done: Tue Nov 8 05:04:28 2016 Total Scan time: 9.750 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]