FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4530, 592 aa 1>>>pF1KE4530 592 - 592 aa - 592 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.1216+/-0.000595; mu= -9.0783+/- 0.036 mean_var=337.6986+/-70.139, 0's: 0 Z-trim(114.2): 36 B-trim: 178 in 1/52 Lambda= 0.069793 statistics sampled from 23971 (23994) to 23971 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.281), width: 16 Scan time: 11.430 The best scores are: opt bits E(85289) NP_002044 (OMIM: 600411) guanylate-binding protein ( 592) 3832 400.7 7.2e-111 NP_060754 (OMIM: 600413) guanylate-binding protein ( 595) 3359 353.1 1.6e-96 NP_004111 (OMIM: 600412) guanylate-binding protein ( 591) 3018 318.7 3.4e-86 XP_011539535 (OMIM: 600413) PREDICTED: guanylate-b ( 516) 2886 305.4 3e-82 XP_005270800 (OMIM: 600413) PREDICTED: guanylate-b ( 516) 2886 305.4 3e-82 NP_001306108 (OMIM: 600413) guanylate-binding prot ( 516) 2886 305.4 3e-82 NP_001127958 (OMIM: 611467) guanylate-binding prot ( 586) 2567 273.3 1.6e-72 NP_443174 (OMIM: 611467) guanylate-binding protein ( 586) 2567 273.3 1.6e-72 XP_016856502 (OMIM: 600413) PREDICTED: guanylate-b ( 461) 2483 264.8 4.6e-70 NP_001306109 (OMIM: 600413) guanylate-binding prot ( 461) 2483 264.8 4.6e-70 XP_006710637 (OMIM: 600413) PREDICTED: guanylate-b ( 568) 2269 243.3 1.7e-63 NP_001306110 (OMIM: 600413) guanylate-binding prot ( 544) 2244 240.8 9.1e-63 NP_443173 (OMIM: 612466) guanylate-binding protein ( 640) 2151 231.5 6.8e-60 NP_997281 (OMIM: 612468) guanylate-binding protein ( 638) 2149 231.3 7.8e-60 XP_011539137 (OMIM: 612467) PREDICTED: guanylate-b ( 633) 2097 226.0 2.9e-58 NP_940862 (OMIM: 612467) guanylate-binding protein ( 633) 2097 226.0 2.9e-58 XP_016856503 (OMIM: 600413) PREDICTED: guanylate-b ( 380) 1553 171.1 6.1e-42 XP_011539536 (OMIM: 600413) PREDICTED: guanylate-b ( 514) 1553 171.2 7.7e-42 NP_001307186 (OMIM: 612467) guanylate-binding prot ( 503) 1438 159.6 2.3e-38 >>NP_002044 (OMIM: 600411) guanylate-binding protein 1 [ (592 aa) initn: 3832 init1: 3832 opt: 3832 Z-score: 2111.5 bits: 400.7 E(85289): 7.2e-111 Smith-Waterman score: 3832; 99.7% identity (100.0% similar) in 592 aa overlap (1-592:1-592) 10 20 30 40 50 60 pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_002 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_002 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS 550 560 570 580 590 >>NP_060754 (OMIM: 600413) guanylate-binding protein 3 i (595 aa) initn: 3508 init1: 2385 opt: 3359 Z-score: 1854.0 bits: 353.1 E(85289): 1.6e-96 Smith-Waterman score: 3359; 87.4% identity (95.4% similar) in 586 aa overlap (1-586:1-584) 10 20 30 40 50 60 pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG :: ::::::::::::::::.:.:::::::::::::::.:::::::::::::::::::::: NP_060 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV :.:::::::::.::::::::::::::::: : ::::::::::::.:::::::::::.::: NP_060 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW :::::.::::.::::::::::::::::::::::::::::::::: :::::::::::::: NP_060 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENE--DSADFVSFFPDFVW 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR :::::::::::::::::::::: ::::: .::::::..::::::::::::::::::::: NP_060 TLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY :.::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_060 PIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS .:::: :::::::::::::::::::::::::::::.::::::::::.:.::::::::: : NP_060 INAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE :::: ::....:::::::::::.:::::.:::::::::::::::::::.::::::::::: NP_060 EREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ ::::::::::::: ::.::::::.::::::::::::::::::::::::::.::::::::: NP_060 EVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV ::::::::::: ::::::::::::..::: : .::::.::.:::::.:::::::: .:. NP_060 ILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERA 480 490 500 510 520 530 550 560 570 580 590 pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS :::.:::.::. ::::: ..::: : :: ..:::: :: .... NP_060 QLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 540 550 560 570 580 590 >>NP_004111 (OMIM: 600412) guanylate-binding protein 2 [ (591 aa) initn: 3071 init1: 2115 opt: 3018 Z-score: 1668.5 bits: 318.7 E(85289): 3.4e-86 Smith-Waterman score: 3018; 75.7% identity (93.6% similar) in 592 aa overlap (1-591:1-590) 10 20 30 40 50 60 pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG :: ::.. ::: ::.::.:.:..::::::::::::::.:::::::::::::::::::::: NP_004 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV ::.::::::::.::::::::::::::::: : :::::::::::.:::::.:::::::::. NP_004 KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW ::::::::::.:::::::::::.:::::: ::...::: ..: :.:::::::::: ::: NP_004 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSP--GNNSVDDSADFVSFFPAFVW 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR :::::.:.::.::.:.: :.:: ::::.:::..:...:: :::::::::::.:::::: NP_004 TLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDW 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY :. .. ::.::.:..:::.:.:..:::.:::::.:.:..::::::: ::::::::::::: NP_004 PAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS ::::::::::::::::::::::::::::.:::::::::::::::::::.::::::::::: NP_004 VNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE ::::::::...::::::..::..:.:::: .::::::::..:::: : .::: ::.:::: NP_004 EREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ .:: : .:::::::::.::::.::.:::. :::::::.:.:. ::.:::...::.::::: NP_004 DVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV .:.:::: :::::.:::::.:. :::.:.:.:::.::::::.:::::.:::::::: ::. NP_004 SLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRA 480 490 500 510 520 530 550 560 570 580 590 pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRR-RKACTIS ::. :::.::::::::::.::::::..::. ....: :.: . . . :.: NP_004 QLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL 540 550 560 570 580 590 >>XP_011539535 (OMIM: 600413) PREDICTED: guanylate-bindi (516 aa) initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82 Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505) 50 60 70 80 90 100 pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN :::::::::: : ::::::::::::.:::: XP_011 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN 10 20 30 110 120 130 140 150 160 pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA :::::::.::::::::.::::.:::::::::::::::::::::::::::::::: :::: XP_011 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA 40 50 60 70 80 170 180 190 200 210 220 pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF ::::::::::::::::::::::::::::::::: ::::: .::::::..::::::::::: XP_011 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN :::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.:: XP_011 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES :::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:. XP_011 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG ::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::. XP_011 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE :::::::::::::::::::::::: ::.::::::.::::::::::::::::::::::::: XP_011 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE 330 340 350 360 370 380 470 480 490 500 510 520 pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK :.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.: XP_011 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK 390 400 410 420 430 440 530 540 550 560 570 580 pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC ::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: .... XP_011 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR 450 460 470 480 490 500 590 pF1KE4 TIS XP_011 YMSHKLKI 510 >>XP_005270800 (OMIM: 600413) PREDICTED: guanylate-bindi (516 aa) initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82 Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505) 50 60 70 80 90 100 pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN :::::::::: : ::::::::::::.:::: XP_005 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN 10 20 30 110 120 130 140 150 160 pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA :::::::.::::::::.::::.:::::::::::::::::::::::::::::::: :::: XP_005 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA 40 50 60 70 80 170 180 190 200 210 220 pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF ::::::::::::::::::::::::::::::::: ::::: .::::::..::::::::::: XP_005 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN :::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.:: XP_005 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES :::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:. XP_005 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG ::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::. XP_005 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE :::::::::::::::::::::::: ::.::::::.::::::::::::::::::::::::: XP_005 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE 330 340 350 360 370 380 470 480 490 500 510 520 pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK :.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.: XP_005 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK 390 400 410 420 430 440 530 540 550 560 570 580 pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC ::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: .... XP_005 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR 450 460 470 480 490 500 590 pF1KE4 TIS XP_005 YMSHKLKI 510 >>NP_001306108 (OMIM: 600413) guanylate-binding protein (516 aa) initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82 Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505) 50 60 70 80 90 100 pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN :::::::::: : ::::::::::::.:::: NP_001 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN 10 20 30 110 120 130 140 150 160 pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA :::::::.::::::::.::::.:::::::::::::::::::::::::::::::: :::: NP_001 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA 40 50 60 70 80 170 180 190 200 210 220 pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF ::::::::::::::::::::::::::::::::: ::::: .::::::..::::::::::: NP_001 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN :::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.:: NP_001 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES :::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:. NP_001 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG ::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::. NP_001 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE :::::::::::::::::::::::: ::.::::::.::::::::::::::::::::::::: NP_001 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE 330 340 350 360 370 380 470 480 490 500 510 520 pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK :.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.: NP_001 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK 390 400 410 420 430 440 530 540 550 560 570 580 pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC ::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: .... NP_001 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR 450 460 470 480 490 500 590 pF1KE4 TIS NP_001 YMSHKLKI 510 >>NP_001127958 (OMIM: 611467) guanylate-binding protein (586 aa) initn: 2588 init1: 1743 opt: 2567 Z-score: 1423.1 bits: 273.3 E(85289): 1.6e-72 Smith-Waterman score: 2567; 66.7% identity (84.4% similar) in 591 aa overlap (1-591:1-585) 10 20 30 40 50 60 pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG :: ::::. ::::::: : .: .: :::.::::::::.:::::::::::::::::::::: NP_001 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV :.::::..:::::::::::.::::::. :.: ::::::::::::::.::.:: :::::. NP_001 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW :::::::::... :.: :.: :. ::::: .....::: .. ::: :: .:::::.:: NP_001 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDR--VEDPADSASFFPDLVW 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR ::::: : :: ::: .:::::: ::. :.:..:. ..::::::::.:::::::::.:: NP_001 TLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY :.:..:::::: : :.::.:::::::..:::::::.: :::: :::.::: ::..::::: NP_001 PAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS :::::::::::.::::::::: :::::::::::::.:::::::::: :.::::::::: : NP_001 VNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE ::::::::...::::::. ::::: . :. :..:.::.: ::::: ::.::. ::.:::: NP_001 EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ :: ::::::::. ::.:: ..:: :::.::::::::::.:: :::::::.. ::::::: NP_001 AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV .::: ::. . .::::. .: :. : .::.:::::...:: .::...: :: . NP_001 ALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQ 480 490 500 510 520 530 550 560 570 580 590 pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS . : ::.. ..::: :. :: ..: . .:.: : . :.. NP_001 NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 540 550 560 570 580 >>NP_443174 (OMIM: 611467) guanylate-binding protein 5 [ (586 aa) initn: 2588 init1: 1743 opt: 2567 Z-score: 1423.1 bits: 273.3 E(85289): 1.6e-72 Smith-Waterman score: 2567; 66.7% identity (84.4% similar) in 591 aa overlap (1-591:1-585) 10 20 30 40 50 60 pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG :: ::::. ::::::: : .: .: :::.::::::::.:::::::::::::::::::::: NP_443 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV :.::::..:::::::::::.::::::. :.: ::::::::::::::.::.:: :::::. NP_443 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW :::::::::... :.: :.: :. ::::: .....::: .. ::: :: .:::::.:: NP_443 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDR--VEDPADSASFFPDLVW 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR ::::: : :: ::: .:::::: ::. :.:..:. ..::::::::.:::::::::.:: NP_443 TLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY :.:..:::::: : :.::.:::::::..:::::::.: :::: :::.::: ::..::::: NP_443 PAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS :::::::::::.::::::::: :::::::::::::.:::::::::: :.::::::::: : NP_443 VNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE ::::::::...::::::. ::::: . :. :..:.::.: ::::: ::.::. ::.:::: NP_443 EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ :: ::::::::. ::.:: ..:: :::.::::::::::.:: :::::::.. ::::::: NP_443 AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV .::: ::. . .::::. .: :. : .::.:::::...:: .::...: :: . NP_443 ALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQ 480 490 500 510 520 530 550 560 570 580 590 pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS . : ::.. ..::: :. :: ..: . .:.: : . :.. NP_443 NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 540 550 560 570 580 >>XP_016856502 (OMIM: 600413) PREDICTED: guanylate-bindi (461 aa) initn: 2632 init1: 2385 opt: 2483 Z-score: 1378.9 bits: 264.8 E(85289): 4.6e-70 Smith-Waterman score: 2483; 86.0% identity (94.6% similar) in 443 aa overlap (144-586:10-450) 120 130 140 150 160 170 pF1KE4 WIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVS ::::::::::::::::::::: ::::::: XP_016 MQVQRRDPIYVTELTHRIRSKSSPDENENE--DSADFVS 10 20 30 180 190 200 210 220 230 pF1KE4 FFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKK ::::::::::::::::::::::::::::: ::::: .::::::..::::::::::::::: XP_016 FFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKK 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 KCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRL :::::: :.::::::::::::::::::::::::::::::::::::::::::::.:::::: XP_016 KCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 ESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQEL :::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.:::: XP_016 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 LDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQV ::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.:::: XP_016 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE4 IFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTD :::::::::::::::::::: ::.::::::.::::::::::::::::::::::::::.:: XP_016 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTD 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE4 AILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTE ::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.::::: XP_016 AILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE4 KMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS ::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: .... XP_016 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSH 400 410 420 430 440 450 XP_016 KLKI 460 >>NP_001306109 (OMIM: 600413) guanylate-binding protein (461 aa) initn: 2632 init1: 2385 opt: 2483 Z-score: 1378.9 bits: 264.8 E(85289): 4.6e-70 Smith-Waterman score: 2483; 86.0% identity (94.6% similar) in 443 aa overlap (144-586:10-450) 120 130 140 150 160 170 pF1KE4 WIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVS ::::::::::::::::::::: ::::::: NP_001 MQVQRRDPIYVTELTHRIRSKSSPDENENE--DSADFVS 10 20 30 180 190 200 210 220 230 pF1KE4 FFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKK ::::::::::::::::::::::::::::: ::::: .::::::..::::::::::::::: NP_001 FFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKK 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 KCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRL :::::: :.::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_001 KCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 ESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQEL :::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.:::: NP_001 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 LDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQV ::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.:::: NP_001 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE4 IFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTD :::::::::::::::::::: ::.::::::.::::::::::::::::::::::::::.:: NP_001 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTD 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE4 AILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTE ::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.::::: NP_001 AILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE4 KMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS ::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: .... NP_001 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSH 400 410 420 430 440 450 NP_001 KLKI 460 592 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:13:03 2016 done: Sun Nov 6 00:13:04 2016 Total Scan time: 11.430 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]