Result of FASTA (omim) for
pFN21AB6681
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6681, 427 aa
1>>>pF1KB6681 427 - 427 aa - 427 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0335+/-0.000683; mu= -11.1031+/- 0.042
mean_var=291.5401+/-59.799, 0's: 0 Z-trim(111.9): 55 B-trim: 466 in 1/52
Lambda= 0.075115
statistics sampled from 20589 (20622) to 20589 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.578), E-opt: 0.2 (0.242), width: 16
Scan time: 7.450
The best scores are: opt bits E(85289)
NP_005794 (OMIM: 606998) flotillin-1 isoform 1 [Ho ( 427) 2658 302.4 1.5e-81
XP_005248837 (OMIM: 606998) PREDICTED: flotillin-1 ( 427) 2658 302.4 1.5e-81
XP_016865646 (OMIM: 606998) PREDICTED: flotillin-1 ( 423) 2389 273.2 8.8e-73
XP_006715010 (OMIM: 606998) PREDICTED: flotillin-1 ( 374) 2191 251.7 2.3e-66
XP_016865647 (OMIM: 606998) PREDICTED: flotillin-1 ( 390) 2189 251.5 2.8e-66
NP_001305804 (OMIM: 606998) flotillin-1 isoform 2 ( 379) 1888 218.9 1.8e-56
NP_001317099 (OMIM: 131560) flotillin-2 isoform 2 ( 428) 1240 148.7 2.7e-35
NP_004466 (OMIM: 131560) flotillin-2 isoform 1 [Ho ( 428) 1240 148.7 2.7e-35
XP_016879885 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 1133 137.1 7.6e-32
XP_016879884 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 1131 136.9 8.8e-32
XP_016879883 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 1131 136.9 8.8e-32
XP_005258010 (OMIM: 131560) PREDICTED: flotillin-2 ( 351) 1054 128.5 2.7e-29
>>NP_005794 (OMIM: 606998) flotillin-1 isoform 1 [Homo s (427 aa)
initn: 2658 init1: 2658 opt: 2658 Z-score: 1585.1 bits: 302.4 E(85289): 1.5e-81
Smith-Waterman score: 2658; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427)
10 20 30 40 50 60
pF1KB6 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
370 380 390 400 410 420
pF1KB6 HKPLRTA
:::::::
NP_005 HKPLRTA
>>XP_005248837 (OMIM: 606998) PREDICTED: flotillin-1 iso (427 aa)
initn: 2658 init1: 2658 opt: 2658 Z-score: 1585.1 bits: 302.4 E(85289): 1.5e-81
Smith-Waterman score: 2658; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427)
10 20 30 40 50 60
pF1KB6 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
370 380 390 400 410 420
pF1KB6 HKPLRTA
:::::::
XP_005 HKPLRTA
>>XP_016865646 (OMIM: 606998) PREDICTED: flotillin-1 iso (423 aa)
initn: 2388 init1: 2388 opt: 2389 Z-score: 1427.7 bits: 273.2 E(85289): 8.8e-73
Smith-Waterman score: 2389; 99.0% identity (99.2% similar) in 395 aa overlap (33-427:29-423)
10 20 30 40 50 60
pF1KB6 FTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVP
: . :::::::::::::::::::::::::
XP_016 MEPGAAEKQGERGKLQPEPCFSLVAQMRPWWSPIQRISLNTLTLNVKSEKVYTRHGVP
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 ISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 DRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 AKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQV
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB6 AKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB6 SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB6 QVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHK
360 370 380 390 400 410
pF1KB6 PLRTA
:::::
XP_016 PLRTA
420
>>XP_006715010 (OMIM: 606998) PREDICTED: flotillin-1 iso (374 aa)
initn: 2276 init1: 2191 opt: 2191 Z-score: 1312.5 bits: 251.7 E(85289): 2.3e-66
Smith-Waterman score: 2191; 99.7% identity (100.0% similar) in 358 aa overlap (70-427:17-374)
40 50 60 70 80 90
pF1KB6 RISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHI
.:::::::::::::::::::::::::::::
XP_006 MFFTCGPNEAMVVSDPEVKIQGQNKEMLAAACQMFLGKTEAEIAHI
10 20 30 40
100 110 120 130 140 150
pF1KB6 ALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQD
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB6 YLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELK
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB6 KAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKEL
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB6 EARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMA
230 240 250 260 270 280
340 350 360 370 380 390
pF1KB6 KKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLD
290 300 310 320 330 340
400 410 420
pF1KB6 ILTRLPESVERLTGVSISQVNHKPLRTA
::::::::::::::::::::::::::::
XP_006 ILTRLPESVERLTGVSISQVNHKPLRTA
350 360 370
>>XP_016865647 (OMIM: 606998) PREDICTED: flotillin-1 iso (390 aa)
initn: 2189 init1: 2189 opt: 2189 Z-score: 1311.0 bits: 251.5 E(85289): 2.8e-66
Smith-Waterman score: 2189; 100.0% identity (100.0% similar) in 357 aa overlap (71-427:34-390)
50 60 70 80 90 100
pF1KB6 ISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIA
::::::::::::::::::::::::::::::
XP_016 GAAEKQGERGKLQPEPCFSLVAQMRPWWSPVKIQGQNKEMLAAACQMFLGKTEAEIAHIA
10 20 30 40 50 60
110 120 130 140 150 160
pF1KB6 LETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDY
70 80 90 100 110 120
170 180 190 200 210 220
pF1KB6 LHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKK
130 140 150 160 170 180
230 240 250 260 270 280
pF1KB6 AAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELE
190 200 210 220 230 240
290 300 310 320 330 340
pF1KB6 ARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAK
250 260 270 280 290 300
350 360 370 380 390 400
pF1KB6 KAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDI
310 320 330 340 350 360
410 420
pF1KB6 LTRLPESVERLTGVSISQVNHKPLRTA
:::::::::::::::::::::::::::
XP_016 LTRLPESVERLTGVSISQVNHKPLRTA
370 380 390
>>NP_001305804 (OMIM: 606998) flotillin-1 isoform 2 [Hom (379 aa)
initn: 1887 init1: 1887 opt: 1888 Z-score: 1134.9 bits: 218.9 E(85289): 1.8e-56
Smith-Waterman score: 2248; 88.8% identity (88.8% similar) in 427 aa overlap (1-427:1-379)
10 20 30 40 50 60
pF1KB6 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
:::::::::: ::
NP_001 VPISVTGIAQ------------------------------------------------EI
70
130 140 150 160 170 180
pF1KB6 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
80 90 100 110 120 130
190 200 210 220 230 240
pF1KB6 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
140 150 160 170 180 190
250 260 270 280 290 300
pF1KB6 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB6 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB6 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
320 330 340 350 360 370
pF1KB6 HKPLRTA
:::::::
NP_001 HKPLRTA
>>NP_001317099 (OMIM: 131560) flotillin-2 isoform 2 [Hom (428 aa)
initn: 1406 init1: 987 opt: 1240 Z-score: 754.6 bits: 148.7 E(85289): 2.7e-35
Smith-Waterman score: 1240; 47.6% identity (80.6% similar) in 418 aa overlap (4-419:6-417)
10 20 30 40 50
pF1KB6 MFFTCGPNEAMVVSGFCRSPPV--MVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVY
: :::::.:::: : . .: :: ... ::.. ::.::...:. . :..
NP_001 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRLSLEVMTILCRCENIE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 TRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT
: .:::. :::.:::::. . ::.::.::..::::. .: ...:.::::: :.:.. .:
NP_001 TSEGVPLFVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLT
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 VEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDA
::.::.::..:.. : .::. :. ::: ..:.:.::..: ::: ::::..:: ::.::
NP_001 VEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 RIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADL
:: :::.::::::::. :.: ........ ..: ..: .::.:.:.. ::: . :.:.:
NP_001 DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB6 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER
::.:: :. .:.:........::.: .:.::. ::: : .::: : ::.::::: .....
NP_001 AYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB6 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDM
.::.:: . .. :.::: ..: ::::: .: : ..::::.: ::::.: : .::.. .
NP_001 IAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMAL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB6 LLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSI
.:: :::.: .:..:::....: .: ::... :::.:: .:..:: ::. ::::..
NP_001 VLEALPQIAAKIAAPLTKVDEI-VVLSGDNS----KVTSEVNRLLAELPASVHALTGVDL
360 370 380 390 400 410
420
pF1KB6 SQVNHKPLRTA
:..
NP_001 SKIPLIKKATGVQV
420
>>NP_004466 (OMIM: 131560) flotillin-2 isoform 1 [Homo s (428 aa)
initn: 1406 init1: 987 opt: 1240 Z-score: 754.6 bits: 148.7 E(85289): 2.7e-35
Smith-Waterman score: 1240; 48.1% identity (80.4% similar) in 418 aa overlap (4-419:6-417)
10 20 30 40 50
pF1KB6 MFFTCGPNEAMVVSGFCRSPPV--MVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVY
: :::::.:::: : . .: :: ... ::.. :::::. .::. . : :
NP_004 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 TRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT
: .:: ..:::.:::::. . ::.::.::..::::. .: ...:.::::: :.:.. .:
NP_004 TAEGVALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLT
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 VEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDA
::.::.::..:.. : .::. :. ::: ..:.:.::..: ::: ::::..:: ::.::
NP_004 VEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 RIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADL
:: :::.::::::::. :.: ........ ..: ..: .::.:.:.. ::: . :.:.:
NP_004 DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB6 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER
::.:: :. .:.:........::.: .:.::. ::: : .::: : ::.::::: .....
NP_004 AYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB6 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDM
.::.:: . .. :.::: ..: ::::: .: : ..::::.: ::::.: : .::.. .
NP_004 IAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMAL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB6 LLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSI
.:: :::.: .:..:::....: .: ::... :::.:: .:..:: ::. ::::..
NP_004 VLEALPQIAAKIAAPLTKVDEI-VVLSGDNS----KVTSEVNRLLAELPASVHALTGVDL
360 370 380 390 400 410
420
pF1KB6 SQVNHKPLRTA
:..
NP_004 SKIPLIKKATGVQV
420
>>XP_016879885 (OMIM: 131560) PREDICTED: flotillin-2 iso (379 aa)
initn: 1279 init1: 987 opt: 1133 Z-score: 692.8 bits: 137.1 E(85289): 7.6e-32
Smith-Waterman score: 1133; 47.9% identity (81.8% similar) in 374 aa overlap (46-419:1-368)
20 30 40 50 60 70
pF1KB6 FCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQG
.:. . :.. : .:::. :::.:::::.
XP_016 MTILCRCENIETSEGVPLFVTGVAQVKIMT
10 20 30
80 90 100 110 120 130
pF1KB6 QNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVA
. ::.::.::..::::. .: ...:.::::: :.:.. .:::.::.::..:.. : .::
XP_016 E-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVA
40 50 60 70 80
140 150 160 170 180 190
pF1KB6 SSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAK
. :. ::: ..:.:.::..: ::: ::::..:: ::.:: :: :::.::::::::. :
XP_016 APDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECK
90 100 110 120 130 140
200 210 220 230 240 250
pF1KB6 QEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQ
.: ........ ..: ..: .::.:.:.. ::: . :.:.:::.:: :. .:.:......
XP_016 KEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIE
150 160 170 180 190 200
260 270 280 290 300 310
pF1KB6 VQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAAS
..::.: .:.::. ::: : .::: : ::.::::: ......::.:: . .. :.::: .
XP_016 IEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEK
210 220 230 240 250 260
320 330 340 350 360 370
pF1KB6 VRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSA
.: ::::: .: : ..::::.: ::::.: : .::.. ..:: :::.: .:..:::..
XP_016 IRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKV
270 280 290 300 310 320
380 390 400 410 420
pF1KB6 NKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
..: .: ::... :::.:: .:..:: ::. ::::..:..
XP_016 DEI-VVLSGDNS----KVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
330 340 350 360 370
>>XP_016879884 (OMIM: 131560) PREDICTED: flotillin-2 iso (379 aa)
initn: 1293 init1: 987 opt: 1131 Z-score: 691.6 bits: 136.9 E(85289): 8.8e-32
Smith-Waterman score: 1131; 48.1% identity (81.8% similar) in 374 aa overlap (46-419:1-368)
20 30 40 50 60 70
pF1KB6 FCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQG
.::. . : : : .:: ..:::.:::::.
XP_016 MTLQPRCEDVETAEGVALTVTGVAQVKIMT
10 20 30
80 90 100 110 120 130
pF1KB6 QNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVA
. ::.::.::..::::. .: ...:.::::: :.:.. .:::.::.::..:.. : .::
XP_016 E-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVA
40 50 60 70 80
140 150 160 170 180 190
pF1KB6 SSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAK
. :. ::: ..:.:.::..: ::: ::::..:: ::.:: :: :::.::::::::. :
XP_016 APDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECK
90 100 110 120 130 140
200 210 220 230 240 250
pF1KB6 QEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQ
.: ........ ..: ..: .::.:.:.. ::: . :.:.:::.:: :. .:.:......
XP_016 KEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIE
150 160 170 180 190 200
260 270 280 290 300 310
pF1KB6 VQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAAS
..::.: .:.::. ::: : .::: : ::.::::: ......::.:: . .. :.::: .
XP_016 IEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEK
210 220 230 240 250 260
320 330 340 350 360 370
pF1KB6 VRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSA
.: ::::: .: : ..::::.: ::::.: : .::.. ..:: :::.: .:..:::..
XP_016 IRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKV
270 280 290 300 310 320
380 390 400 410 420
pF1KB6 NKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
..: .: ::... :::.:: .:..:: ::. ::::..:..
XP_016 DEI-VVLSGDNS----KVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
330 340 350 360 370
427 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:45:19 2016 done: Sat Nov 5 11:45:20 2016
Total Scan time: 7.450 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]