FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6326, 430 aa 1>>>pF1KE6326 430 - 430 aa - 430 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1182+/-0.000395; mu= 18.2035+/- 0.025 mean_var=61.3211+/-12.062, 0's: 0 Z-trim(111.0): 66 B-trim: 26 in 1/54 Lambda= 0.163783 statistics sampled from 19414 (19483) to 19414 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.228), width: 16 Scan time: 6.140 The best scores are: opt bits E(85289) NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 2867 686.3 4.1e-197 XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 2699 646.6 3.5e-185 XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 1911 460.3 2.9e-129 XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 821 202.8 1.3e-51 NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 814 201.2 4.3e-51 NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 756 187.4 5.5e-47 XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 755 187.2 7e-47 XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 755 187.2 7.2e-47 NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 744 184.6 4.2e-46 NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 735 182.5 1.8e-45 XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 733 182.0 2.6e-45 XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 729 181.1 5.4e-45 NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 725 180.1 9.2e-45 NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 725 180.1 9.3e-45 NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 723 179.6 1.2e-44 NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 689 171.6 3.3e-42 XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 674 168.1 4.3e-41 XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 674 168.1 4.3e-41 XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 670 167.2 8.9e-41 XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 666 166.1 1.2e-40 XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 665 166.0 1.7e-40 XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 665 166.0 1.8e-40 NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 645 161.2 3.7e-39 XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 640 160.1 1.1e-38 XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 640 160.1 1.1e-38 XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 640 160.1 1.1e-38 NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 625 156.5 1.3e-37 XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 607 152.2 2.1e-36 NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 588 147.8 5e-35 XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 579 145.6 1.8e-34 NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 575 144.8 6e-34 NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 565 142.4 2.9e-33 NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 565 142.4 3.1e-33 NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 565 142.4 3.2e-33 XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 565 142.4 3.2e-33 NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 565 142.4 3.3e-33 XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 560 141.1 4.7e-33 XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 560 141.1 4.7e-33 XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 557 140.5 1.1e-32 XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 557 140.5 1.1e-32 XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 530 134.0 5.9e-31 XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 493 125.4 3.6e-28 XP_016877647 (OMIM: 243500,607036) PREDICTED: isov ( 308) 468 119.3 1.4e-26 NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 451 115.4 2.9e-25 XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 430 110.4 9.3e-24 NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 424 109.0 2.4e-23 XP_016882069 (OMIM: 231670,608801) PREDICTED: glut ( 442) 424 109.0 2.5e-23 XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 424 109.0 2.5e-23 XP_011526202 (OMIM: 231670,608801) PREDICTED: glut ( 443) 424 109.0 2.5e-23 NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 398 102.7 1e-21 >>NP_001599 (OMIM: 609576) long-chain specific acyl-CoA (430 aa) initn: 2867 init1: 2867 opt: 2867 Z-score: 3659.8 bits: 686.3 E(85289): 4.1e-197 Smith-Waterman score: 2867; 100.0% identity (100.0% similar) in 430 aa overlap (1-430:1-430) 10 20 30 40 50 60 pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE 370 380 390 400 410 420 430 pF1KE6 LIAREIVFDK :::::::::: NP_001 LIAREIVFDK 430 >>XP_005246574 (OMIM: 609576) PREDICTED: long-chain spec (409 aa) initn: 2697 init1: 2697 opt: 2699 Z-score: 3445.6 bits: 646.6 E(85289): 3.5e-185 Smith-Waterman score: 2699; 99.0% identity (99.3% similar) in 409 aa overlap (22-430:1-409) 10 20 30 40 50 60 pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF . : :::::::::::::::::::::::::::::::::: XP_005 MTALVCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF 10 20 30 70 80 90 100 110 120 pF1KE6 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE6 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE6 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE 340 350 360 370 380 390 430 pF1KE6 LIAREIVFDK :::::::::: XP_005 LIAREIVFDK 400 >>XP_016859444 (OMIM: 609576) PREDICTED: long-chain spec (289 aa) initn: 1911 init1: 1911 opt: 1911 Z-score: 2441.6 bits: 460.3 E(85289): 2.9e-129 Smith-Waterman score: 1911; 100.0% identity (100.0% similar) in 289 aa overlap (142-430:1-289) 120 130 140 150 160 170 pF1KE6 GDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIA :::::::::::::::::::::::::::::: XP_016 MSYITNHGSEEQIKHFIPQMTAGKCIGAIA 10 20 30 180 190 200 210 220 230 pF1KE6 MTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGIS 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE6 LFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQE 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE6 RLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNC 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE6 LQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIY 220 230 240 250 260 270 420 430 pF1KE6 GGTNEIMKELIAREIVFDK ::::::::::::::::::: XP_016 GGTNEIMKELIAREIVFDK 280 >>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa) initn: 812 init1: 680 opt: 821 Z-score: 1047.4 bits: 202.8 E(85289): 1.3e-51 Smith-Waterman score: 821; 34.9% identity (69.8% similar) in 384 aa overlap (53-429:26-405) 30 40 50 60 70 80 pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA ..::. .:... ::.::.. :. .: ... XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDRS 10 20 30 40 50 90 100 110 120 130 pF1KE6 GEVS--REVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSG .: . :: :.. :. :.::.. . :: : ..: :: . :. : ... ::. XP_016 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE6 IVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNG . .. .. .:.: : ....:.. .:. :::.::.::.::::. ..: .:.: :. .:::: XP_016 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE6 SKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTA .: .:.:: .::.:: : :. : ..::. :.::.:: :: ..:: :.:.....: XP_016 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE6 ELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKA ::.::: ..::. .::.:::: : .:. : :::..: .. . ....: :.. :.: XP_016 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE6 FGKTVAHLQTVQHKLAELKTHICVTRAFVDN----CLQLHEAKRLDSATACMAKYWASEL ::. ..:.: .: :.:.. :.. . : .: : : . : . . : : . . ...: XP_016 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAK-DCAGVIL---YSAEC 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE6 QNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK ..:: : .: :: ::. ..:... ::.. : .::.:. . .:.: . : XP_016 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH 360 370 380 390 400 >>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa) initn: 787 init1: 680 opt: 814 Z-score: 1038.2 bits: 201.2 E(85289): 4.3e-51 Smith-Waterman score: 814; 34.9% identity (69.5% similar) in 384 aa overlap (53-429:45-424) 30 40 50 60 70 80 pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA .: :. .:... ::.::.. :. .: ... NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS 20 30 40 50 60 70 90 100 110 120 130 pF1KE6 GEVS--REVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSG .: . :: :.. :. :.::.. . :: : ..: :: . :. : ... ::. NP_002 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE6 IVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNG . .. .. .:.: : ....:.. .:. :::.::.::.::::. ..: .:.: :. .:::: NP_002 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE6 SKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTA .: .:.:: .::.:: : :. : ..::. :.::.:: :: ..:: :.:.....: NP_002 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE6 ELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKA ::.::: ..::. .::.:::: : .:. : :::..: .. . ....: :.. :.: NP_002 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA 260 270 280 290 300 310 320 330 340 350 360 370 pF1KE6 FGKTVAHLQTVQHKLAELKTHICVTRAFVDN----CLQLHEAKRLDSATACMAKYWASEL ::. ..:.: .: :.:.. :.. . : .: : : . : . . : : . . ...: NP_002 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAK-DCAGVIL---YSAEC 320 330 340 350 360 370 380 390 400 410 420 430 pF1KE6 QNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK ..:: : .: :: ::. ..:... ::.. : .::.:. . .:.: . : NP_002 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH 380 390 400 410 420 >>NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA dehy (396 aa) initn: 746 init1: 680 opt: 756 Z-score: 964.6 bits: 187.4 E(85289): 5.5e-47 Smith-Waterman score: 756; 35.3% identity (68.9% similar) in 351 aa overlap (84-429:48-394) 60 70 80 90 100 110 pF1KE6 SPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGD : .: :.. :. :.::.. . :: : NP_001 WRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQEFWKQLGNLGVLGITAPVQYGGSGLG 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE6 LYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAM ..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. :::.:: NP_001 YLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAM 80 90 100 110 120 130 180 190 200 210 220 230 pF1KE6 TEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISL .::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : ..::. NP_001 SEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITA 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE6 FLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQER :.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:. : :: NP_001 FIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLER 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE6 LLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDN-- :..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : .: : NP_001 LVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVA 260 270 280 290 300 310 360 370 380 390 400 pF1KE6 --CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQ : . : . . : : . . ...: ..:: : .: :: ::. ..:... ::.. NP_001 KACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLY 320 330 340 350 360 370 410 420 430 pF1KE6 PIYGGTNEIMKELIAREIVFDK : .::.:. . .:.: . : NP_001 EIGAGTSEVRRLVIGRAFNADFH 380 390 >>XP_016877643 (OMIM: 243500,607036) PREDICTED: isovaler (436 aa) initn: 802 init1: 680 opt: 755 Z-score: 962.7 bits: 187.2 E(85289): 7e-47 Smith-Waterman score: 760; 32.9% identity (65.1% similar) in 413 aa overlap (53-429:26-434) 30 40 50 60 70 80 pF1KE6 PAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA ..::. .:... ::.::.. :. .: ... XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDRS 10 20 30 40 50 90 100 110 pF1KE6 GE-----VSREV--------------------------WEKAGKQGLLGVNIAEHLGGIG .: :: :: :.. :. :.::.. . :: : XP_016 NEFKNLRVSWEVRAVGGSQGVGLSCTAAWKSSHSFLEFWKQLGNLGVLGITAPVQYGGSG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 GDLYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAI ..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. :::. XP_016 LGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGAL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 AMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGI ::.::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : ..:: XP_016 AMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 SLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQ . :.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:. : XP_016 TAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 ERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDN :::..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : .: : XP_016 ERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYN 300 310 320 330 340 350 360 370 380 390 400 pF1KE6 ----CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDAR : . : . . : : . . ...: ..:: : .: :: ::. ..:... ::. XP_016 VAKACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAK 360 370 380 390 400 410 410 420 430 pF1KE6 VQPIYGGTNEIMKELIAREIVFDK . : .::.:. . .:.: . : XP_016 LYEIGAGTSEVRRLVIGRAFNADFH 420 430 >>XP_016877641 (OMIM: 243500,607036) PREDICTED: isovaler (455 aa) initn: 743 init1: 680 opt: 755 Z-score: 962.4 bits: 187.2 E(85289): 7.2e-47 Smith-Waterman score: 755; 35.1% identity (68.8% similar) in 356 aa overlap (79-429:103-453) 50 60 70 80 90 100 pF1KE6 IRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLG : :... : :.. :. :.::.. . : XP_016 RSNEFKNLRVSWEVRAVGGSQGVGLSCTAAW-KSSHSFLEFWKQLGNLGVLGITAPVQYG 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE6 GIGGDLYSAAIVWEEQAY-SNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCI : : ..: :: . :. : ... ::.. .. .. .:.: : ....:.. .:. : XP_016 GSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYI 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE6 GAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPA ::.::.::.::::. ..: .:.: :. .::::.: .:.:: .::.:: : :. : . XP_016 GALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPAS 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE6 HGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKE .::. :.::.:: :: ..:: :.:.....: ::.::: ..::. .::.:::: : .:. XP_016 RGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSG 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE6 LPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAF : :::..: .. . ....: :.. :.:::. ..:.: .: :.:.. :.. . : . XP_016 LDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQY 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE6 VDN----CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYV : : : . : . . : : . . ...: ..:: : .: :: ::. ..:... XP_016 VYNVAKACDEGHCTAK-DCAGVIL---YSAECATQVALDGIQCFGGNGYINDFPMGRFLR 380 390 400 410 420 410 420 430 pF1KE6 DARVQPIYGGTNEIMKELIAREIVFDK ::.. : .::.:. . .:.: . : XP_016 DAKLYEIGAGTSEVRRLVIGRAFNADFH 430 440 450 >>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa) initn: 733 init1: 407 opt: 744 Z-score: 948.7 bits: 184.6 E(85289): 4.2e-46 Smith-Waterman score: 744; 32.3% identity (64.9% similar) in 436 aa overlap (1-426:4-428) 10 20 30 40 50 pF1KE6 MAARLLRGSLRVLGGHR----APRQLPAARCSHSGGEERLETPSAKKLTDIGIR--- .:.:::::: :.: . . ..: . : .: :. .:. ::. NP_001 MEGLAVRLLRGS-RLLRRNFLTCLSSWKIPPHVSKSSQSEALLN------ITNNGIHFAP 10 20 30 40 50 60 70 80 90 100 pF1KE6 -RIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGG . :. :. ....::.:: ::.. : : .. ... . : . .:::.:... . :: NP_001 LQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 IGGDLYSAAIVWEEQAYSNCSGPGFS-IHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIG :... :...: :: : . : : :.. .. . : .::.::: ..::.:. : .: NP_001 TGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEK-VG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 AIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAH .. ..: ::::: ..:: : :.:. ..:::::..::.. . . .:.: .. :. .. NP_001 SFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVD---PTIGY 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 -GISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKE ::. :::. :. :. .:.::.:..: : ::....: . .::. ..:. : . NP_001 KGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGS 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE6 LPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAF : . :. :: .. .. :. : :.:.: ::: . .: .::..:.. :.. ..: . NP_001 LNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE6 VDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARV . : .: :: . : ::::.:::. .... :.. :: :: .::. : . ::.. NP_001 TYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKI 350 360 370 380 390 400 410 420 430 pF1KE6 QPIYGGTNEIMKELIAREIVFDK :: :...:. . ::..: NP_001 GTIYEGASNIQLNTIAKHIDAEY 410 420 430 >>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa) initn: 659 init1: 415 opt: 735 Z-score: 937.5 bits: 182.5 E(85289): 1.8e-45 Smith-Waterman score: 735; 33.0% identity (65.2% similar) in 397 aa overlap (30-423:10-403) 10 20 30 40 50 pF1KE6 MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPE-HDI :: .: : : . . . :: :.. NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQM 10 20 30 40 60 70 80 90 100 110 pF1KE6 FRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAI . .. : : ..:..: .. .: .: : :::.... :.::: : : . :: NP_000 LLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 VWEEQAYSNCSGPG--FSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGA . :: . . :.. : .:..... .. : . ::.:: . .. .:.: :: .:..::: NP_000 AMEEISRG-CASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGN 110 120 130 140 150 180 190 200 210 220 230 pF1KE6 GSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVEN ::: . .:.:. .:..:.:::.:..:.:. .....: : :.. . .::: ::: NP_000 GSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQN--KGISAFLVPM 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE6 GMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIAD :. :.: :.:.....::.:.::: :.: ...::: . :: :. : . :. ::. NP_000 PTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIAS 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE6 VAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEA :.. .. .. . ::...: ::: ...::..: :::.. . .: .. .:.. NP_000 QALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDN 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE6 KRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEI :. : ::: ::: ...... .:. :: ::. :.: . : :::. :: ::.:: NP_000 KKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEI 340 350 360 370 380 390 420 430 pF1KE6 MKELIAREIVFDK .. .:: NP_000 QRLVIAGHLLRSYRS 400 410 430 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:07:58 2016 done: Tue Nov 8 12:07:59 2016 Total Scan time: 6.140 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]