FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4528, 577 aa 1>>>pF1KE4528 577 - 577 aa - 577 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5817+/-0.000411; mu= 22.6399+/- 0.025 mean_var=60.7011+/-13.036, 0's: 0 Z-trim(111.0): 26 B-trim: 1115 in 1/49 Lambda= 0.164617 statistics sampled from 19417 (19429) to 19417 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.228), width: 16 Scan time: 8.700 The best scores are: opt bits E(85289) NP_001284365 (OMIM: 601463) hyaluronan synthase 1 ( 577) 3932 942.8 0 NP_001514 (OMIM: 601463) hyaluronan synthase 1 iso ( 578) 3920 940.0 0 XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan ( 328) 2050 495.7 9.9e-140 NP_001186209 (OMIM: 602428) hyaluronan synthase 3 ( 553) 1677 407.3 6.8e-113 XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1677 407.3 6.8e-113 XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan ( 553) 1677 407.3 6.8e-113 NP_005320 (OMIM: 602428) hyaluronan synthase 3 iso ( 553) 1677 407.3 6.8e-113 NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Ho ( 552) 1671 405.9 1.8e-112 NP_619515 (OMIM: 602428) hyaluronan synthase 3 iso ( 281) 357 93.5 9.6e-19 >>NP_001284365 (OMIM: 601463) hyaluronan synthase 1 isof (577 aa) initn: 3932 init1: 3932 opt: 3932 Z-score: 5041.9 bits: 942.8 E(85289): 0 Smith-Waterman score: 3932; 99.7% identity (99.8% similar) in 577 aa overlap (1-577:1-577) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDTR ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_001 AYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 YSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 TMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHL 490 500 510 520 530 540 550 560 570 pF1KE4 AAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV ::::::::::::::::::::::::::::::::::::: NP_001 AAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV 550 560 570 >>NP_001514 (OMIM: 601463) hyaluronan synthase 1 isoform (578 aa) initn: 3919 init1: 3919 opt: 3920 Z-score: 5026.5 bits: 940.0 E(85289): 0 Smith-Waterman score: 3920; 99.5% identity (99.7% similar) in 578 aa overlap (1-577:1-578) 10 20 30 40 50 pF1KE4 MRQ-DAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG ::: ::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH 490 500 510 520 530 540 540 550 560 570 pF1KE4 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV :::::::::::::::::::::::::::::::::::::: NP_001 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV 550 560 570 >>XP_011525186 (OMIM: 601463) PREDICTED: hyaluronan synt (328 aa) initn: 2049 init1: 2049 opt: 2050 Z-score: 2629.6 bits: 495.7 E(85289): 9.9e-140 Smith-Waterman score: 2050; 99.0% identity (99.4% similar) in 310 aa overlap (1-309:1-310) 10 20 30 40 50 pF1KE4 MRQ-DAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG ::: ::::::::: :::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: XP_011 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR :::::::::: XP_011 CVSCISGPLGTPPGPAATQRRPRPSCGG 310 320 >>NP_001186209 (OMIM: 602428) hyaluronan synthase 3 isof (553 aa) initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113 Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA : : : ::: .:: . ::..: . . :.:::::: NP_001 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA 10 20 30 40 50 70 80 90 100 110 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. NP_001 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... NP_001 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD : : :. .::. :. :.::::::::::::::::::.::.:::::: NP_001 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF : ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.:::::::::::: NP_001 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS ::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.:: NP_001 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV .: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. ::: NP_001 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA ..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..: NP_001 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY ..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. : NP_001 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA--- 460 470 480 490 500 510 540 550 560 570 pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV :..:: : ::::.: :: . . : : .. : NP_001 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV 520 530 540 550 >>XP_011521363 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa) initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113 Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA : : : ::: .:: . ::..: . . :.:::::: XP_011 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA 10 20 30 40 50 70 80 90 100 110 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. XP_011 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... XP_011 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD : : :. .::. :. :.::::::::::::::::::.::.:::::: XP_011 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF : ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.:::::::::::: XP_011 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS ::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.:: XP_011 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV .: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. ::: XP_011 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA ..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..: XP_011 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY ..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. : XP_011 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA--- 460 470 480 490 500 510 540 550 560 570 pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV :..:: : ::::.: :: . . : : .. : XP_011 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV 520 530 540 550 >>XP_005255978 (OMIM: 602428) PREDICTED: hyaluronan synt (553 aa) initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113 Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA : : : ::: .:: . ::..: . . :.:::::: XP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA 10 20 30 40 50 70 80 90 100 110 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. XP_005 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... XP_005 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD : : :. .::. :. :.::::::::::::::::::.::.:::::: XP_005 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF : ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.:::::::::::: XP_005 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS ::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.:: XP_005 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV .: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. ::: XP_005 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA ..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..: XP_005 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY ..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. : XP_005 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA--- 460 470 480 490 500 510 540 550 560 570 pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV :..:: : ::::.: :: . . : : .. : XP_005 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV 520 530 540 550 >>NP_005320 (OMIM: 602428) hyaluronan synthase 3 isoform (553 aa) initn: 2044 init1: 1619 opt: 1677 Z-score: 2147.8 bits: 407.3 E(85289): 6.8e-113 Smith-Waterman score: 2081; 55.6% identity (77.7% similar) in 556 aa overlap (20-573:10-546) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA : : : ::: .:: . ::..: . . :.:::::: NP_005 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA 10 20 30 40 50 70 80 90 100 110 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. NP_005 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... NP_005 ISFPD--LKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD : : :. .::. :. :.::::::::::::::::::.::.:::::: NP_005 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF : ::: .:..:::.:::.::.:::::.::: :::.:::::.:::.:::::::::::: NP_005 TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYF 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 HCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRS ::.:::::::.:::.::::::: ::.:::::..:.::::::::::.::.:: ::::.:: NP_005 GCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 RCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATV .: .:::...::::.::::::::::::::::.::.:.:: :::::.::.:.::::. ::: NP_005 KCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATV 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 LRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLA ..::: :: : .: :: :: :.. ::..: .::: .:...:::. ::: .:::::..: NP_005 IQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFA 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE4 LVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAY ..:.:.::::::::. ...:.. :.:...:. .:::::. .. . : . .. : NP_005 IATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQ---DLFSETELA--- 460 470 480 490 500 510 540 550 560 570 pF1KE4 HLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV :..:: : ::::.: :: . . : : .. : NP_005 FLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV 520 530 540 550 >>NP_005319 (OMIM: 601636) hyaluronan synthase 2 [Homo s (552 aa) initn: 2058 init1: 1603 opt: 1671 Z-score: 2140.1 bits: 405.9 E(85289): 1.8e-112 Smith-Waterman score: 2081; 53.9% identity (78.5% similar) in 553 aa overlap (20-571:11-543) 10 20 30 40 50 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVP-LASDRYGLLAFGLYG : . : :.. .: .: :: .: . .: : ..::::: NP_005 MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNY-YFSFGLYG 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 AFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARA :::..::. :::::.::::.. . . :. ..::: :.:::::: :::.:: :.. NP_005 AFLASHLIIQSLFAFLEHRKMKKSLETPI--KLNKTVALCIAAYQEDPDYLRKCLQSVKR 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGA : :: ..:.::.::: .::::.:.: ::.. . :::.: .:.:. : NP_005 LTYPG--IKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEK---------GP 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 GAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSDT : : . :. . : :: . . .:. :.::::::::::::.::: :.:::::::::: NP_005 GETDESHKESSQH--VTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDT 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 RLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH ::: . .:.:.::.::: ::.:::::.::: :::.:::::.:::.:::.:::::::: NP_005 MLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSR ::.:::::::.:::.::..:.: ::::.:.:..:.::::::::::.::.:::::::.::. NP_005 CVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSK 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 CYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVL : .::: .::::.:::::::::::::::::.:.:.:: ::::::...:.::::. :::. NP_005 CLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVI 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 RLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLAL .::: :. : .: :: :: :.: :..::. ::: . ::..:::. ::: .:::::..:. NP_005 QLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAI 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE4 VTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYH .:.:..:::::::. ...:.. :.:...: .::::.. .. .:.. .: .... NP_005 ATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTV---- 460 470 480 490 500 510 540 550 560 570 pF1KE4 LAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV : .:. :. ::: .:::: : . . ::. : NP_005 LIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV 520 530 540 550 >>NP_619515 (OMIM: 602428) hyaluronan synthase 3 isoform (281 aa) initn: 727 init1: 355 opt: 357 Z-score: 457.5 bits: 93.5 E(85289): 9.6e-19 Smith-Waterman score: 761; 50.4% identity (70.8% similar) in 250 aa overlap (20-267:10-246) 10 20 30 40 50 60 pF1KE4 MRQDAPKPTPAARRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGA : : : ::: .:: . ::..: . . :.:::::: NP_619 MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGA 10 20 30 40 50 70 80 90 100 110 pF1KE4 FLSAHLVAQSLFAYLEHRRVAAAARG-PLDAATARSVALTISAYQEDPAYLRQCLASARA .:. ::. :::::.:::::. :... : . :::: :.:::::: :::.:: ::. NP_619 ILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATY-VWDGNYHQPWEPAAAGAVG . .: :.:.::::::: :: ::.:.:.::.. . : . :: .:.:. : . ... NP_619 ISFP--DLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQ 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 AGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSMDYVQVCDSD : : :. .::. :. :.::::::::::::::::::.::.:::::: NP_619 EGMDR-----------VRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSD 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 TRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYF : ::: .:..:::.:::.::.:::::. NP_619 TVLDPACTIEMLRVLEEDPQVGGVGGDVQPPGKGMAVEDDQVQAAQVRATEAWSVHQRHV 220 230 240 250 260 270 577 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:14:18 2016 done: Sun Nov 6 00:14:19 2016 Total Scan time: 8.700 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]