Result of FASTA (omim) for
pFN21AE1524
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1524, 661 aa
1>>>pF1KE1524 661 - 661 aa - 661 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.4164+/-0.000485; mu= -16.0070+/- 0.030
mean_var=683.9913+/-152.836, 0's: 0 Z-trim(123.3): 795 B-trim: 2408 in 1/56
Lambda= 0.049040
statistics sampled from 41681 (42768) to 41681 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.501), width: 16
Scan time: 14.500
The best scores are: opt bits E(85289)
NP_003976 (OMIM: 608076) non-receptor tyrosine-pro ( 661) 4609 341.6 5.4e-93
XP_011522347 (OMIM: 608076) PREDICTED: non-recepto ( 661) 4609 341.6 5.4e-93
NP_001238831 (OMIM: 608076) non-receptor tyrosine- ( 666) 4589 340.2 1.5e-92
XP_011522348 (OMIM: 608076) PREDICTED: non-recepto ( 659) 4580 339.6 2.2e-92
XP_011522350 (OMIM: 608076) PREDICTED: non-recepto ( 504) 3506 263.4 1.4e-69
XP_011522349 (OMIM: 608076) PREDICTED: non-recepto ( 532) 3453 259.7 2e-68
XP_016860999 (OMIM: 606994) PREDICTED: activated C (1055) 1347 111.1 2.2e-23
XP_011510622 (OMIM: 606994) PREDICTED: activated C (1055) 1347 111.1 2.2e-23
XP_005269327 (OMIM: 606994) PREDICTED: activated C (1055) 1347 111.1 2.2e-23
XP_011510620 (OMIM: 606994) PREDICTED: activated C (1085) 1347 111.1 2.2e-23
NP_001010938 (OMIM: 606994) activated CDC42 kinase (1086) 1347 111.1 2.2e-23
XP_005269325 (OMIM: 606994) PREDICTED: activated C (1118) 1347 111.1 2.3e-23
XP_011510619 (OMIM: 606994) PREDICTED: activated C (1219) 1347 111.1 2.4e-23
NP_005772 (OMIM: 606994) activated CDC42 kinase 1 (1038) 1326 109.6 6.1e-23
NP_001294975 (OMIM: 606994) activated CDC42 kinase (1040) 1326 109.6 6.1e-23
XP_016860998 (OMIM: 606994) PREDICTED: activated C (1069) 1326 109.6 6.2e-23
XP_016860997 (OMIM: 606994) PREDICTED: activated C (1072) 1326 109.6 6.2e-23
XP_011510623 (OMIM: 606994) PREDICTED: activated C ( 979) 1072 91.6 1.5e-17
XP_005269331 (OMIM: 606994) PREDICTED: activated C ( 816) 740 68.0 1.6e-10
NP_001005862 (OMIM: 137800,164870,211980,613659) r (1225) 639 61.0 2.9e-08
NP_001276865 (OMIM: 137800,164870,211980,613659) r (1240) 639 61.1 2.9e-08
NP_004439 (OMIM: 137800,164870,211980,613659) rece (1255) 639 61.1 2.9e-08
XP_016869176 (OMIM: 600758) PREDICTED: focal adhes ( 934) 635 60.6 2.9e-08
XP_016869168 (OMIM: 600758) PREDICTED: focal adhes (1011) 635 60.7 3.1e-08
XP_016869148 (OMIM: 600758) PREDICTED: focal adhes (1031) 635 60.7 3.1e-08
XP_016869165 (OMIM: 600758) PREDICTED: focal adhes (1034) 635 60.7 3.2e-08
XP_016869163 (OMIM: 600758) PREDICTED: focal adhes (1047) 635 60.7 3.2e-08
XP_016869164 (OMIM: 600758) PREDICTED: focal adhes (1047) 635 60.7 3.2e-08
XP_016869141 (OMIM: 600758) PREDICTED: focal adhes (1075) 635 60.7 3.2e-08
XP_016869179 (OMIM: 600758) PREDICTED: focal adhes ( 913) 627 60.1 4.3e-08
XP_016869178 (OMIM: 600758) PREDICTED: focal adhes ( 919) 627 60.1 4.3e-08
XP_016869177 (OMIM: 600758) PREDICTED: focal adhes ( 919) 627 60.1 4.3e-08
XP_016869175 (OMIM: 600758) PREDICTED: focal adhes ( 942) 627 60.1 4.4e-08
XP_016869174 (OMIM: 600758) PREDICTED: focal adhes ( 948) 627 60.1 4.4e-08
XP_016869173 (OMIM: 600758) PREDICTED: focal adhes ( 949) 627 60.1 4.4e-08
XP_016869172 (OMIM: 600758) PREDICTED: focal adhes ( 955) 627 60.1 4.4e-08
NP_001303271 (OMIM: 600758) focal adhesion kinase ( 955) 627 60.1 4.4e-08
XP_016869171 (OMIM: 600758) PREDICTED: focal adhes ( 976) 627 60.1 4.5e-08
XP_016869170 (OMIM: 600758) PREDICTED: focal adhes ( 980) 627 60.1 4.5e-08
XP_006716672 (OMIM: 600758) PREDICTED: focal adhes ( 983) 627 60.1 4.5e-08
XP_005251070 (OMIM: 600758) PREDICTED: focal adhes ( 983) 627 60.1 4.5e-08
XP_006716673 (OMIM: 600758) PREDICTED: focal adhes ( 983) 627 60.1 4.5e-08
XP_016869169 (OMIM: 600758) PREDICTED: focal adhes ( 995) 627 60.1 4.6e-08
XP_016869167 (OMIM: 600758) PREDICTED: focal adhes (1016) 627 60.1 4.6e-08
XP_016869166 (OMIM: 600758) PREDICTED: focal adhes (1032) 627 60.1 4.7e-08
XP_016869162 (OMIM: 600758) PREDICTED: focal adhes (1052) 627 60.1 4.7e-08
NP_722560 (OMIM: 600758) focal adhesion kinase 1 i (1052) 627 60.1 4.7e-08
XP_016869160 (OMIM: 600758) PREDICTED: focal adhes (1055) 627 60.1 4.7e-08
XP_016869161 (OMIM: 600758) PREDICTED: focal adhes (1055) 627 60.1 4.7e-08
XP_016869159 (OMIM: 600758) PREDICTED: focal adhes (1058) 627 60.1 4.7e-08
>>NP_003976 (OMIM: 608076) non-receptor tyrosine-protein (661 aa)
initn: 4609 init1: 4609 opt: 4609 Z-score: 1790.5 bits: 341.6 E(85289): 5.4e-93
Smith-Waterman score: 4609; 100.0% identity (100.0% similar) in 661 aa overlap (1-661:1-661)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
610 620 630 640 650 660
pF1KE1 P
:
NP_003 P
>>XP_011522347 (OMIM: 608076) PREDICTED: non-receptor ty (661 aa)
initn: 4609 init1: 4609 opt: 4609 Z-score: 1790.5 bits: 341.6 E(85289): 5.4e-93
Smith-Waterman score: 4609; 100.0% identity (100.0% similar) in 661 aa overlap (1-661:1-661)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
610 620 630 640 650 660
pF1KE1 P
:
XP_011 P
>>NP_001238831 (OMIM: 608076) non-receptor tyrosine-prot (666 aa)
initn: 2907 init1: 2862 opt: 4589 Z-score: 1782.8 bits: 340.2 E(85289): 1.5e-92
Smith-Waterman score: 4589; 99.2% identity (99.2% similar) in 666 aa overlap (1-661:1-666)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGS-----PDST
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDST
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE1 APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE1 PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE1 SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR
610 620 630 640 650 660
660
pF1KE1 YVLARP
::::::
NP_001 YVLARP
>>XP_011522348 (OMIM: 608076) PREDICTED: non-receptor ty (659 aa)
initn: 3295 init1: 3250 opt: 4580 Z-score: 1779.4 bits: 339.6 E(85289): 2.2e-92
Smith-Waterman score: 4580; 99.7% identity (99.7% similar) in 661 aa overlap (1-661:1-659)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDG--KKANLWDAPPAR
430 440 450 460 470
490 500 510 520 530 540
pF1KE1 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE1 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE1 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
600 610 620 630 640 650
pF1KE1 P
:
XP_011 P
>>XP_011522350 (OMIM: 608076) PREDICTED: non-receptor ty (504 aa)
initn: 3506 init1: 3506 opt: 3506 Z-score: 1370.1 bits: 263.4 E(85289): 1.4e-69
Smith-Waterman score: 3506; 100.0% identity (100.0% similar) in 504 aa overlap (158-661:1-504)
130 140 150 160 170 180
pF1KE1 GVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLV
::::::::::::::::::::::::::::::
XP_011 MGTELGDFLREVSVMMNLEHPHVLRLHGLV
10 20 30
190 200 210 220 230 240
pF1KE1 LGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLA
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE1 TRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVW
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE1 MFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADR
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE1 PSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKV
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE1 GSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMP
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE1 LERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQP
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE1 SRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQT
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE1 ALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
460 470 480 490 500
>>XP_011522349 (OMIM: 608076) PREDICTED: non-receptor ty (532 aa)
initn: 3476 init1: 3444 opt: 3453 Z-score: 1349.6 bits: 259.7 E(85289): 2e-68
Smith-Waterman score: 3453; 94.2% identity (95.5% similar) in 534 aa overlap (1-533:1-531)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
430 440 450 460 470 480
490 500 510 520 530
pF1KE1 GQRRNMPLERMKGISRSLESVLSLGPR-PTGGGSSPPEIRQARAVPQGPPGLPPRPPLSS
::::::::::::: . : . . : : . : . . ::: .:::
XP_011 GQRRNMPLERMKG---GAECAWGHPPGVPDSTRSHWGRCGFCHPEPQGRSALPPE
490 500 510 520 530
540 550 560 570 580 590
pF1KE1 SSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHG
>>XP_016860999 (OMIM: 606994) PREDICTED: activated CDC42 (1055 aa)
initn: 1505 init1: 421 opt: 1347 Z-score: 540.8 bits: 111.1 E(85289): 2.2e-23
Smith-Waterman score: 1358; 40.6% identity (63.2% similar) in 601 aa overlap (1-578:33-604)
10 20 30
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEEL
: :: :. :::.:: ..:: :.. . ..:
XP_016 AARRFPGLELSFPLLARLRRRLYTRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDL
10 20 30 40 50 60
40 50 60 70 80
pF1KE1 NVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGG------FA
:::: ::..:: :::. ::::::.:::: ::.:: .. : :.:. :...: :
XP_016 NVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE1 PEHKEPTLPSDSPRHL-PEPEGGLK---CLIPEGAVCRGELLGSGCFGVVHRGLWTLPSG
:.:.. :. . :: : :: :. ::: : . : ::.: ::::.:: : :::
XP_016 PHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSG
130 140 150 160 170 180
150 160 170 180 190
pF1KE1 KSVPVAVKSLRVGPEGPMGTE-LGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELA
:.: :::: :. :. : . ::.:::..: .:.: ...::.:.:: :..:: :::
XP_016 KTVSVAVKCLK--PDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELA
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE1 PLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTI
::::: :: .:.. : . :.: .:.:: .. ..:::::.::::::. .
XP_016 PLGSLLDRLRKHQGH--FLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV
250 260 270 280 290
260 270 280 290 300 310
pF1KE1 KVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSG
:..::::.: : .::: : .:.::::::::. .:: :::.:::::::::::.
XP_016 KIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTY
300 310 320 330 340 350
320 330 340 350 360 370
pF1KE1 GEEPWAGVPPYLILQRLEDRA-RLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQ
:.::: :. ::.... .. ::::: : . .:.. ..::: .: :::.: :. .:
XP_016 GQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLL
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE1 EAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKVGSFPASAVTLA
:: :.. ..: :: :... .: :::::: .. :.::: ::. :: :: ..::
XP_016 EAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVT--
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE1 DAGGLPA---TRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRR-NMPLERMKGI
...:: : ..:.. . : : :.: .. : : . . :.. .
XP_016 SVAGLSAQDISQPLQNSFI-----HTGHGDSDPRHC--WGFPDRIDELYLGNPMDPPDLL
480 490 500 510 520
500 510 520 530 540 550
pF1KE1 SRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPW
: : . : :. :: : . :: ::.: . ...: . :... :
XP_016 SVELST--SRPPQHLGG------------VKREPPPRPPQPAFFTQKPTYDPVSEDQDPL
530 540 550 560 570
560 570 580 590 600
pF1KE1 PK-------RKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQT
. ::: . : :. :. .: . :
XP_016 SSDFKRLGLRKP--GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCA
580 590 600 610 620 630
610 620 630 640 650 660
pF1KE1 ALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
XP_016 PSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFE
640 650 660 670 680 690
>>XP_011510622 (OMIM: 606994) PREDICTED: activated CDC42 (1055 aa)
initn: 1685 init1: 421 opt: 1347 Z-score: 540.8 bits: 111.1 E(85289): 2.2e-23
Smith-Waterman score: 1358; 40.6% identity (63.2% similar) in 601 aa overlap (1-578:1-572)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
: :: :. :::.:: ..:: :.. . ..::::: ::..:: :::. ::::::.::::
XP_011 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 EALKRLRSGPKSKNWVYKILGG------FAPEHKEPTLPSDSPRHL-PEPEGGLK---CL
::.:: .. : :.:. :...: : :.:.. :. . :: : :: :. ::
XP_011 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE-LGDFLREV
: : . : ::.: ::::.:: : ::::.: :::: :. :. : . ::.:::
XP_011 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK--PDVLSQPEAMDDFIREV
130 140 150 160 170
170 180 190 200 210 220
pF1KE1 SVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQL
..: .:.: ...::.:.:: :..:: :::::::: :: .:.. : . :.
XP_011 NAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH--FLLGTLSRYAVQV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE1 AGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAW
: .:.:: .. ..:::::.::::::. .:..::::.: : .::: : .:.::
XP_011 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE1 CAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRA-RLPRPPLC
::::::. .:: :::.:::::::::::. :.::: :. ::.... .. ::::: :
XP_011 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE1 SRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVI
. .:.. ..::: .: :::.: :. .: :: :.. ..: :: :... .: ::::
XP_011 PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVI
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE1 EGSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPA---TRPVHRGTPARGDQHPGSID
:: .. :.::: ::. :: :: ..:: ...:: : ..:.. . : : :
XP_011 EGRAENYWWRGQNTRTLCVGPFPRNVVT--SVAGLSAQDISQPLQNSFI-----HTGHGD
420 430 440 450 460
470 480 490 500 510 520
pF1KE1 GDRKKANLWDAPPARGQRR-NMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAV
.: .. : : . . :.. .: : . : :. :: :
XP_011 SDPRHC--WGFPDRIDELYLGNPMDPPDLLSVELST--SRPPQHLGG------------V
470 480 490 500 510
530 540 550 560 570
pF1KE1 PQGPPGLPPRPPLSSSSPQPSQPSRERLPWPK-------RKPPHNHPMGMPGARKAAALS
. :: ::.: . ...: . :... : . ::: . : :. :. .: .
XP_011 KREPPPRPPQPAFFTQKPTYDPVSEDQDPLSSDFKRLGLRKP--GLPRGLWLAKPSARVP
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE1 GGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRA
:
XP_011 GTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPL
580 590 600 610 620 630
>>XP_005269327 (OMIM: 606994) PREDICTED: activated CDC42 (1055 aa)
initn: 1685 init1: 421 opt: 1347 Z-score: 540.8 bits: 111.1 E(85289): 2.2e-23
Smith-Waterman score: 1358; 40.6% identity (63.2% similar) in 601 aa overlap (1-578:1-572)
10 20 30 40 50 60
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
: :: :. :::.:: ..:: :.. . ..::::: ::..:: :::. ::::::.::::
XP_005 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 EALKRLRSGPKSKNWVYKILGG------FAPEHKEPTLPSDSPRHL-PEPEGGLK---CL
::.:: .. : :.:. :...: : :.:.. :. . :: : :: :. ::
XP_005 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE-LGDFLREV
: : . : ::.: ::::.:: : ::::.: :::: :. :. : . ::.:::
XP_005 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK--PDVLSQPEAMDDFIREV
130 140 150 160 170
170 180 190 200 210 220
pF1KE1 SVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQL
..: .:.: ...::.:.:: :..:: :::::::: :: .:.. : . :.
XP_005 NAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH--FLLGTLSRYAVQV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE1 AGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAW
: .:.:: .. ..:::::.::::::. .:..::::.: : .::: : .:.::
XP_005 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE1 CAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRA-RLPRPPLC
::::::. .:: :::.:::::::::::. :.::: :. ::.... .. ::::: :
XP_005 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE1 SRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVI
. .:.. ..::: .: :::.: :. .: :: :.. ..: :: :... .: ::::
XP_005 PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVI
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE1 EGSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPA---TRPVHRGTPARGDQHPGSID
:: .. :.::: ::. :: :: ..:: ...:: : ..:.. . : : :
XP_005 EGRAENYWWRGQNTRTLCVGPFPRNVVT--SVAGLSAQDISQPLQNSFI-----HTGHGD
420 430 440 450 460
470 480 490 500 510 520
pF1KE1 GDRKKANLWDAPPARGQRR-NMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAV
.: .. : : . . :.. .: : . : :. :: :
XP_005 SDPRHC--WGFPDRIDELYLGNPMDPPDLLSVELST--SRPPQHLGG------------V
470 480 490 500 510
530 540 550 560 570
pF1KE1 PQGPPGLPPRPPLSSSSPQPSQPSRERLPWPK-------RKPPHNHPMGMPGARKAAALS
. :: ::.: . ...: . :... : . ::: . : :. :. .: .
XP_005 KREPPPRPPQPAFFTQKPTYDPVSEDQDPLSSDFKRLGLRKP--GLPRGLWLAKPSARVP
520 530 540 550 560 570
580 590 600 610 620 630
pF1KE1 GGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRA
:
XP_005 GTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPL
580 590 600 610 620 630
>>XP_011510620 (OMIM: 606994) PREDICTED: activated CDC42 (1085 aa)
initn: 1677 init1: 421 opt: 1347 Z-score: 540.7 bits: 111.1 E(85289): 2.2e-23
Smith-Waterman score: 1358; 40.6% identity (63.2% similar) in 601 aa overlap (1-578:33-604)
10 20 30
pF1KE1 MLPEAGSLWLLKLLRDIQLAQFYWPILEEL
: :: :. :::.:: ..:: :.. . ..:
XP_011 AARRFPGLELSFPLLARLRRRLYTRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDL
10 20 30 40 50 60
40 50 60 70 80
pF1KE1 NVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGG------FA
:::: ::..:: :::. ::::::.:::: ::.:: .. : :.:. :...: :
XP_011 NVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE1 PEHKEPTLPSDSPRHL-PEPEGGLK---CLIPEGAVCRGELLGSGCFGVVHRGLWTLPSG
:.:.. :. . :: : :: :. ::: : . : ::.: ::::.:: : :::
XP_011 PHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSG
130 140 150 160 170 180
150 160 170 180 190
pF1KE1 KSVPVAVKSLRVGPEGPMGTE-LGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELA
:.: :::: :. :. : . ::.:::..: .:.: ...::.:.:: :..:: :::
XP_011 KTVSVAVKCLK--PDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELA
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE1 PLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTI
::::: :: .:.. : . :.: .:.:: .. ..:::::.::::::. .
XP_011 PLGSLLDRLRKHQGH--FLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV
250 260 270 280 290
260 270 280 290 300 310
pF1KE1 KVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSG
:..::::.: : .::: : .:.::::::::. .:: :::.:::::::::::.
XP_011 KIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTY
300 310 320 330 340 350
320 330 340 350 360 370
pF1KE1 GEEPWAGVPPYLILQRLEDRA-RLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQ
:.::: :. ::.... .. ::::: : . .:.. ..::: .: :::.: :. .:
XP_011 GQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLL
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE1 EAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKVGSFPASAVTLA
:: :.. ..: :: :... .: :::::: .. :.::: ::. :: :: ..::
XP_011 EAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVT--
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE1 DAGGLPA---TRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRR-NMPLERMKGI
...:: : ..:.. . : : :.: .. : : . . :.. .
XP_011 SVAGLSAQDISQPLQNSFI-----HTGHGDSDPRHC--WGFPDRIDELYLGNPMDPPDLL
480 490 500 510 520
500 510 520 530 540 550
pF1KE1 SRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPW
: : . : :. :: : . :: ::.: . ...: . :... :
XP_011 SVELST--SRPPQHLGG------------VKREPPPRPPQPAFFTQKPTYDPVSEDQDPL
530 540 550 560 570
560 570 580 590 600
pF1KE1 PK-------RKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQT
. ::: . : :. :. .: . :
XP_011 SSDFKRLGLRKP--GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCA
580 590 600 610 620 630
610 620 630 640 650 660
pF1KE1 ALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
XP_011 PSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFE
640 650 660 670 680 690
661 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:47:44 2016 done: Sun Nov 6 23:47:46 2016
Total Scan time: 14.500 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]