FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3608, 1332 aa 1>>>pF1KE3608 1332 - 1332 aa - 1332 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 18.3533+/-0.000567; mu= -33.3016+/- 0.036 mean_var=1084.5168+/-235.601, 0's: 0 Z-trim(124.2): 608 B-trim: 2521 in 1/61 Lambda= 0.038945 statistics sampled from 44447 (45353) to 44447 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.532), width: 16 Scan time: 15.300 The best scores are: opt bits E(85289) NP_722549 (OMIM: 609426) misshapen-like kinase 1 i (1332) 9048 525.3 1.1e-147 XP_011522208 (OMIM: 609426) PREDICTED: misshapen-l (1329) 9012 523.3 4.5e-147 XP_006721599 (OMIM: 609426) PREDICTED: misshapen-l (1324) 7182 420.5 4e-116 XP_016880197 (OMIM: 609426) PREDICTED: misshapen-l (1290) 6149 362.4 1.2e-98 XP_016880196 (OMIM: 609426) PREDICTED: misshapen-l (1306) 6149 362.4 1.2e-98 XP_016880193 (OMIM: 609426) PREDICTED: misshapen-l (1358) 6149 362.5 1.2e-98 XP_006721594 (OMIM: 609426) PREDICTED: misshapen-l (1361) 6149 362.5 1.2e-98 XP_006721595 (OMIM: 609426) PREDICTED: misshapen-l (1360) 6132 361.5 2.3e-98 XP_016880194 (OMIM: 609426) PREDICTED: misshapen-l (1341) 5263 312.7 1.2e-83 NP_001020108 (OMIM: 609426) misshapen-like kinase (1312) 5224 310.5 5.2e-83 NP_001155033 (OMIM: 610005,617028) TRAF2 and NCK-i (1331) 4900 292.3 1.6e-77 XP_016860839 (OMIM: 604666) PREDICTED: mitogen-act (1330) 4753 284.0 4.8e-75 NP_733763 (OMIM: 609426) misshapen-like kinase 1 i (1303) 4749 283.8 5.6e-75 NP_056531 (OMIM: 609426) misshapen-like kinase 1 i (1295) 4745 283.5 6.5e-75 XP_005264107 (OMIM: 604666) PREDICTED: mitogen-act (1338) 4727 282.5 1.3e-74 XP_005264109 (OMIM: 604666) PREDICTED: mitogen-act (1337) 4717 282.0 2e-74 NP_001308165 (OMIM: 609426) misshapen-like kinase (1240) 4386 263.4 7.4e-69 XP_016880195 (OMIM: 609426) PREDICTED: misshapen-l (1323) 4301 258.6 2.1e-67 NP_001155034 (OMIM: 610005,617028) TRAF2 and NCK-i (1323) 3143 193.5 8.2e-48 XP_016860838 (OMIM: 604666) PREDICTED: mitogen-act (1352) 2937 182.0 2.5e-44 NP_001155032 (OMIM: 610005,617028) TRAF2 and NCK-i (1352) 2778 173.0 1.2e-41 XP_005264105 (OMIM: 604666) PREDICTED: mitogen-act (1384) 2695 168.4 3.2e-40 NP_001229488 (OMIM: 604666) mitogen-activated prot (1239) 2684 167.7 4.5e-40 XP_016860842 (OMIM: 604666) PREDICTED: mitogen-act (1306) 2684 167.8 4.7e-40 XP_016860840 (OMIM: 604666) PREDICTED: mitogen-act (1311) 2684 167.8 4.7e-40 XP_016860854 (OMIM: 604666) PREDICTED: mitogen-act (1243) 2678 167.4 5.7e-40 XP_016860841 (OMIM: 604666) PREDICTED: mitogen-act (1307) 2678 167.4 6e-40 XP_005264115 (OMIM: 604666) PREDICTED: mitogen-act (1312) 2678 167.4 6e-40 XP_005264114 (OMIM: 604666) PREDICTED: mitogen-act (1315) 2678 167.4 6e-40 NP_001229489 (OMIM: 604666) mitogen-activated prot (1235) 2651 165.9 1.6e-39 XP_016860855 (OMIM: 604666) PREDICTED: mitogen-act (1243) 2651 165.9 1.6e-39 XP_016860843 (OMIM: 604666) PREDICTED: mitogen-act (1299) 2651 165.9 1.7e-39 XP_006712928 (OMIM: 604666) PREDICTED: mitogen-act (1307) 2651 165.9 1.7e-39 XP_016860844 (OMIM: 604666) PREDICTED: mitogen-act (1296) 2647 165.7 2e-39 XP_016860856 (OMIM: 604666) PREDICTED: mitogen-act (1234) 2644 165.5 2.1e-39 XP_016860850 (OMIM: 604666) PREDICTED: mitogen-act (1266) 2635 165.0 3.1e-39 XP_016860848 (OMIM: 604666) PREDICTED: mitogen-act (1274) 2635 165.0 3.1e-39 NP_663719 (OMIM: 604666) mitogen-activated protein (1273) 2630 164.7 3.8e-39 XP_016860845 (OMIM: 604666) PREDICTED: mitogen-act (1281) 2630 164.7 3.8e-39 XP_016860851 (OMIM: 604666) PREDICTED: mitogen-act (1265) 2627 164.5 4.2e-39 XP_016860849 (OMIM: 604666) PREDICTED: mitogen-act (1273) 2627 164.5 4.3e-39 XP_016860846 (OMIM: 604666) PREDICTED: mitogen-act (1276) 2626 164.5 4.4e-39 XP_005264116 (OMIM: 604666) PREDICTED: mitogen-act (1284) 2626 164.5 4.5e-39 XP_006712932 (OMIM: 604666) PREDICTED: mitogen-act (1189) 2623 164.3 4.7e-39 XP_016860852 (OMIM: 604666) PREDICTED: mitogen-act (1253) 2622 164.3 5.1e-39 XP_005264119 (OMIM: 604666) PREDICTED: mitogen-act (1261) 2622 164.3 5.1e-39 XP_005264117 (OMIM: 604666) PREDICTED: mitogen-act (1280) 2621 164.2 5.4e-39 XP_016860860 (OMIM: 604666) PREDICTED: mitogen-act (1186) 2616 163.9 6.2e-39 XP_016860847 (OMIM: 604666) PREDICTED: mitogen-act (1275) 2617 164.0 6.3e-39 XP_005264121 (OMIM: 604666) PREDICTED: mitogen-act (1258) 2616 163.9 6.5e-39 >>NP_722549 (OMIM: 609426) misshapen-like kinase 1 isofo (1332 aa) initn: 9048 init1: 9048 opt: 9048 Z-score: 2772.4 bits: 525.3 E(85289): 1.1e-147 Smith-Waterman score: 9048; 99.8% identity (99.9% similar) in 1332 aa overlap (1-1332:1-1332) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV ::::::::::::::::::::::::::::::::::::::::::::::::::.::: ::::: NP_722 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1270 1280 1290 1300 1310 1320 1330 pF1KE3 FMTLNRNCIMNW :::::::::::: NP_722 FMTLNRNCIMNW 1330 >>XP_011522208 (OMIM: 609426) PREDICTED: misshapen-like (1329 aa) initn: 6915 init1: 6915 opt: 9012 Z-score: 2761.5 bits: 523.3 E(85289): 4.5e-147 Smith-Waterman score: 9012; 99.6% identity (99.7% similar) in 1332 aa overlap (1-1332:1-1329) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_011 QLKDHIDRSRKKR---EETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV ::::::::::::::::::::::::::::::::::::::::::::::::::.::: ::::: XP_011 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1260 1270 1280 1290 1300 1310 1330 pF1KE3 FMTLNRNCIMNW :::::::::::: XP_011 FMTLNRNCIMNW 1320 >>XP_006721599 (OMIM: 609426) PREDICTED: misshapen-like (1324 aa) initn: 7251 init1: 4064 opt: 7182 Z-score: 2205.8 bits: 420.5 E(85289): 4e-116 Smith-Waterman score: 8617; 95.0% identity (95.1% similar) in 1361 aa overlap (1-1332:1-1324) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- ::::::::::::::::::::::::::::::: XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL :::: ::::::::::::::::::: XP_006 AVRA-------------------------------------SNPDLRRSDPGWERSDSVL 730 740 760 770 780 790 800 810 pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD :::::::::::::::::::.::: :::::::::::::::::::::::::::::::::::: XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD 750 760 770 780 790 800 820 830 840 850 860 870 pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV 810 820 830 840 850 860 880 890 900 910 920 930 pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 870 880 890 900 910 920 940 950 960 970 980 990 pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK 930 940 950 960 970 980 1000 1010 1020 1030 1040 1050 pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 990 1000 1010 1020 1030 1040 1060 1070 1080 1090 1100 1110 pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1050 1060 1070 1080 1090 1100 1120 1130 1140 1150 1160 1170 pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1110 1120 1130 1140 1150 1160 1180 1190 1200 1210 1220 1230 pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1170 1180 1190 1200 1210 1220 1240 1250 1260 1270 1280 1290 pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1230 1240 1250 1260 1270 1280 1300 1310 1320 1330 pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ::::::::::::::::::::::::::::::::::::::::: XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1290 1300 1310 1320 >>XP_016880197 (OMIM: 609426) PREDICTED: misshapen-like (1290 aa) initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.3 bits: 362.4 E(85289): 1.2e-98 Smith-Waterman score: 8522; 97.6% identity (97.7% similar) in 1290 aa overlap (72-1332:1-1290) 50 60 70 80 90 100 pF1KE3 GRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQL :::::::::::::::::::::::::::::: XP_016 MLKKYSHHRNIATYYGAFIKKSPPGNDDQL 10 20 30 110 120 130 140 150 160 pF1KE3 WLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLL 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE3 TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE3 TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE3 QLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSS 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE3 IMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQ 280 290 300 310 320 330 410 420 430 440 450 pF1KE3 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY---------- :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQR 340 350 360 370 380 390 460 470 480 490 pF1KE3 -------------------KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQ ::::::::::::::::::::::::::::::::::::::::: XP_016 QLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQ 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE3 QQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIP 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE3 QASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAA 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE3 FPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRT 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE3 SSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE3 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDH ::::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::: XP_016 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDH 700 710 720 730 740 750 800 810 820 830 840 850 pF1KE3 RSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTP 760 770 780 790 800 810 860 870 880 890 900 910 pF1KE3 GGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDV 820 830 840 850 860 870 920 930 940 950 960 970 pF1KE3 VQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT 880 890 900 910 920 930 980 990 1000 1010 1020 1030 pF1KE3 ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNL 940 950 960 970 980 990 1040 1050 1060 1070 1080 1090 pF1KE3 LVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRN 1000 1010 1020 1030 1040 1050 1100 1110 1120 1130 1140 1150 pF1KE3 KILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1060 1070 1080 1090 1100 1110 1160 1170 1180 1190 1200 1210 pF1KE3 AFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITP 1120 1130 1140 1150 1160 1170 1220 1230 1240 1250 1260 1270 pF1KE3 HAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK 1180 1190 1200 1210 1220 1230 1280 1290 1300 1310 1320 1330 pF1KE3 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1240 1250 1260 1270 1280 1290 >>XP_016880196 (OMIM: 609426) PREDICTED: misshapen-like (1306 aa) initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.2 bits: 362.4 E(85289): 1.2e-98 Smith-Waterman score: 8621; 97.6% identity (97.7% similar) in 1306 aa overlap (56-1332:1-1306) 30 40 50 60 70 80 pF1KE3 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATY :::::::::::::::::::::::::::::: XP_016 MDVTEDEEEEIKQEINMLKKYSHHRNIATY 10 20 30 90 100 110 120 130 140 pF1KE3 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 PDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDF 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 IDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSG 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE3 SEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE3 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQA 340 350 360 370 380 390 450 460 470 pF1KE3 EREQEY-----------------------------KRKQLEEQRQSERLQRQLQQEHAYL :::::: ::::::::::::::::::::::::: XP_016 EREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYL 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE3 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE3 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE3 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPA 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE3 WVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTP 640 650 660 670 680 690 720 730 740 750 760 770 pF1KE3 KPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLD ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: : XP_016 KPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPD 700 710 720 730 740 750 780 790 800 810 820 830 pF1KE3 SSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD 760 770 780 790 800 810 840 850 860 870 880 890 pF1KE3 EEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEER 820 830 840 850 860 870 900 910 920 930 940 950 pF1KE3 NLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVD 880 890 900 910 920 930 960 970 980 990 1000 1010 pF1KE3 LGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKK 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KE3 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITIS 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 1130 pF1KE3 GKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKS 1060 1070 1080 1090 1100 1110 1140 1150 1160 1170 1180 1190 pF1KE3 SVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGN 1120 1130 1140 1150 1160 1170 1200 1210 1220 1230 1240 1250 pF1KE3 SYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT 1180 1190 1200 1210 1220 1230 1260 1270 1280 1290 1300 1310 pF1KE3 SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS 1240 1250 1260 1270 1280 1290 1320 1330 pF1KE3 SQVYFMTLNRNCIMNW :::::::::::::::: XP_016 SQVYFMTLNRNCIMNW 1300 >>XP_016880193 (OMIM: 609426) PREDICTED: misshapen-like (1358 aa) initn: 8158 init1: 6035 opt: 6149 Z-score: 1892.0 bits: 362.5 E(85289): 1.2e-98 Smith-Waterman score: 8944; 97.5% identity (97.6% similar) in 1361 aa overlap (1-1332:1-1358) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_016 QLKDHIDRSRKKR---EETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 360 370 380 390 400 410 430 440 450 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- ::::::::::::::::::::::::::::::: XP_016 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD :::::::::::::::::::.::: :::::::::::::::::::::::::::::::::::: XP_016 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1200 1210 1220 1230 1240 1250 1240 1250 1260 1270 1280 1290 pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1260 1270 1280 1290 1300 1310 1300 1310 1320 1330 pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ::::::::::::::::::::::::::::::::::::::::: XP_016 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1320 1330 1340 1350 >>XP_006721594 (OMIM: 609426) PREDICTED: misshapen-like (1361 aa) initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.0 bits: 362.5 E(85289): 1.2e-98 Smith-Waterman score: 8980; 97.7% identity (97.8% similar) in 1361 aa overlap (1-1332:1-1361) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- ::::::::::::::::::::::::::::::: XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD :::::::::::::::::::.::: :::::::::::::::::::::::::::::::::::: XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ::::::::::::::::::::::::::::::::::::::::: XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1330 1340 1350 1360 >>XP_006721595 (OMIM: 609426) PREDICTED: misshapen-like (1360 aa) initn: 6429 init1: 3242 opt: 6132 Z-score: 1886.8 bits: 361.5 E(85289): 2.3e-98 Smith-Waterman score: 8963; 97.6% identity (97.7% similar) in 1361 aa overlap (1-1332:1-1360) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- ::::::::::::::::::::::::::::::: XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD :::::::::::::::::::.::: :::::::::::::::::::::::::::::::::::: XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGR-DGDTDSVSTMVVHDV 850 860 870 880 890 880 890 900 910 920 930 pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1200 1210 1220 1230 1240 1250 1240 1250 1260 1270 1280 1290 pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1260 1270 1280 1290 1300 1310 1300 1310 1320 1330 pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ::::::::::::::::::::::::::::::::::::::::: XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1320 1330 1340 1350 1360 >>XP_016880194 (OMIM: 609426) PREDICTED: misshapen-like (1341 aa) initn: 8178 init1: 4991 opt: 5263 Z-score: 1623.0 bits: 312.7 E(85289): 1.2e-83 Smith-Waterman score: 8795; 96.3% identity (96.3% similar) in 1361 aa overlap (1-1332:1-1341) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- ::::::::::::::::::::::::::::::: XP_016 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS ::::::::::: ::::::::::::::::::::::::::::: XP_016 VEPQEGPHKSL--------------------QDQPTRNLAAFPASHDPDPAIPAPTATPS 610 620 630 640 640 650 660 670 680 690 pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ 650 660 670 680 690 700 700 710 720 730 740 750 pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL 710 720 730 740 750 760 760 770 780 790 800 810 pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD :::::::::::::::::::.::: :::::::::::::::::::::::::::::::::::: XP_016 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD 770 780 790 800 810 820 820 830 840 850 860 870 pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV 830 840 850 860 870 880 880 890 900 910 920 930 pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 890 900 910 920 930 940 940 950 960 970 980 990 pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK 950 960 970 980 990 1000 1000 1010 1020 1030 1040 1050 pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1010 1020 1030 1040 1050 1060 1060 1070 1080 1090 1100 1110 pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1070 1080 1090 1100 1110 1120 1120 1130 1140 1150 1160 1170 pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1130 1140 1150 1160 1170 1180 1180 1190 1200 1210 1220 1230 pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1190 1200 1210 1220 1230 1240 1240 1250 1260 1270 1280 1290 pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1250 1260 1270 1280 1290 1300 1300 1310 1320 1330 pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ::::::::::::::::::::::::::::::::::::::::: XP_016 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1310 1320 1330 1340 >>NP_001020108 (OMIM: 609426) misshapen-like kinase 1 is (1312 aa) initn: 4991 init1: 4991 opt: 5224 Z-score: 1611.3 bits: 310.5 E(85289): 5.2e-83 Smith-Waterman score: 8863; 98.3% identity (98.4% similar) in 1332 aa overlap (1-1332:1-1312) 10 20 30 40 50 60 pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ :::::::::::::::::::::::::::::::::::::::::: NP_001 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 550 560 570 580 610 620 630 640 650 660 pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV ::::::::::::::::::::::::::::::::::::::::::::::::::.::: ::::: NP_001 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 830 840 850 860 870 880 910 920 930 940 950 960 pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1190 1200 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1250 1260 1270 1280 1290 1300 1330 pF1KE3 FMTLNRNCIMNW :::::::::::: NP_001 FMTLNRNCIMNW 1310 1332 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:25:16 2016 done: Sat Nov 5 22:25:18 2016 Total Scan time: 15.300 Total Display time: 0.810 Function used was FASTA [36.3.4 Apr, 2011]