FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4486, 502 aa 1>>>pF1KE4486 502 - 502 aa - 502 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8967+/-0.000388; mu= 20.1204+/- 0.024 mean_var=64.3087+/-13.295, 0's: 0 Z-trim(112.0): 190 B-trim: 1850 in 2/49 Lambda= 0.159933 statistics sampled from 20522 (20743) to 20522 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.611), E-opt: 0.2 (0.243), width: 16 Scan time: 9.520 The best scores are: opt bits E(85289) NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 3312 773.3 0 NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 3185 744.0 2.2e-214 NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 2878 673.2 4.8e-193 NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 2871 671.6 1.5e-192 NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 2800 655.2 1.2e-187 NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 2595 607.9 2.2e-173 NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 2583 605.1 1.5e-172 XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2542 595.6 8.5e-170 XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2542 595.6 8.5e-170 NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 2542 595.6 8.5e-170 XP_016867269 (OMIM: 124010) PREDICTED: cytochrome ( 449) 2392 561.0 2.5e-159 XP_006715922 (OMIM: 145500,605325) PREDICTED: cyto ( 381) 2226 522.7 7.4e-148 NP_476437 (OMIM: 606534) cytochrome P450 3A43 isof ( 420) 2160 507.5 3.1e-143 XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 2115 497.0 3.3e-140 XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2007 472.2 1.2e-132 XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2007 472.2 1.2e-132 XP_016868033 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1832 431.7 1.7e-120 XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1832 431.7 1.7e-120 NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 1481 350.8 4.2e-96 NP_001177413 (OMIM: 145500,605325) cytochrome P450 ( 140) 721 175.1 1.2e-43 NP_001159725 (OMIM: 231095,274180,614158) thrombox ( 580) 633 155.2 4.6e-37 NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 588 144.8 5.6e-34 NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 582 143.4 1.4e-33 NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 576 142.1 3.8e-33 NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 573 141.3 5.5e-33 NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 573 141.4 6.1e-33 NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 567 140.0 1.6e-32 XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 567 140.0 1.6e-32 NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 567 140.0 1.6e-32 NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 561 138.6 4.2e-32 NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 555 137.2 1.1e-31 XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 550 136.1 2.5e-31 NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 547 135.4 4e-31 XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 547 135.4 4e-31 XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 547 135.4 4e-31 XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 545 134.9 5e-31 XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 543 134.4 6e-31 NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 543 134.4 7.5e-31 NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 543 134.4 7.5e-31 NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 539 133.5 1.4e-30 NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 536 132.8 2.3e-30 NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 534 132.4 3.1e-30 NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 534 132.4 3.2e-30 NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 531 131.7 5.1e-30 XP_016868061 (OMIM: 231095,274180,614158) PREDICTE ( 411) 529 131.1 5.9e-30 XP_016868060 (OMIM: 231095,274180,614158) PREDICTE ( 418) 529 131.1 5.9e-30 XP_016868059 (OMIM: 231095,274180,614158) PREDICTE ( 451) 529 131.2 6.3e-30 NP_112246 (OMIM: 231095,274180,614158) thromboxane ( 460) 529 131.2 6.4e-30 XP_011514846 (OMIM: 231095,274180,614158) PREDICTE ( 463) 529 131.2 6.4e-30 NP_001124438 (OMIM: 231095,274180,614158) thrombox ( 534) 529 131.2 7.2e-30 >>NP_000768 (OMIM: 145500,605325) cytochrome P450 3A5 is (502 aa) initn: 3312 init1: 3312 opt: 3312 Z-score: 4128.0 bits: 773.3 E(85289): 0 Smith-Waterman score: 3312; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG 430 440 450 460 470 480 490 500 pF1KE4 LLQPEKPIVLKVDSRDGTLSGE :::::::::::::::::::::: NP_000 LLQPEKPIVLKVDSRDGTLSGE 490 500 >>NP_001278759 (OMIM: 145500,605325) cytochrome P450 3A5 (492 aa) initn: 3183 init1: 3183 opt: 3185 Z-score: 3969.8 bits: 744.0 E(85289): 2.2e-214 Smith-Waterman score: 3185; 98.6% identity (99.4% similar) in 490 aa overlap (14-502:3-492) 10 20 30 40 50 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYL-YGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK :: . :.::.. ::::::::::::::::::::::::::::::::::: NP_001 MQLLMLELLLLFIVYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK 10 20 30 40 60 70 80 90 100 110 pF1KE4 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 410 420 430 440 450 460 480 490 500 pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE ::::::::::::::::::::::: NP_001 GLLQPEKPIVLKVDSRDGTLSGE 470 480 490 >>NP_059488 (OMIM: 124010) cytochrome P450 3A4 isoform 1 (503 aa) initn: 2397 init1: 2397 opt: 2878 Z-score: 3586.8 bits: 673.2 E(85289): 4.8e-193 Smith-Waterman score: 2878; 84.3% identity (95.6% similar) in 502 aa overlap (1-501:1-502) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF : :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. : NP_059 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL : ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::. NP_059 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS ::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.::::: NP_059 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL :::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::. . NP_059 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI ::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.:::: NP_059 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :::::::::::::::: .::::::::::::::.:::::::::::::::.:.::::::::: NP_059 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS ::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: ::::: NP_059 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ :: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::. NP_059 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 430 440 450 460 470 480 480 490 500 pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE ::::::::.::::.:::::.:: NP_059 GLLQPEKPVVLKVESRDGTVSGA 490 500 >>NP_001189784 (OMIM: 124010) cytochrome P450 3A4 isofor (502 aa) initn: 1588 init1: 1588 opt: 2871 Z-score: 3578.1 bits: 671.6 E(85289): 1.5e-192 Smith-Waterman score: 2871; 84.5% identity (95.6% similar) in 502 aa overlap (1-501:1-501) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF : :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. : NP_001 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL : ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::. NP_001 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS ::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.::::: NP_001 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL :::::.:::::::::::::::::::.:::.:.: ::::.::::: :::: :..:.::. . NP_001 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSII-FPFLIPILEVLNICV 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI ::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.:::: NP_001 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :::::::::::::::: .::::::::::::::.:::::::::::::::.:.::::::::: NP_001 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS ::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: ::::: NP_001 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ :: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::. NP_001 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 420 430 440 450 460 470 480 490 500 pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE ::::::::.::::.:::::.:: NP_001 GLLQPEKPVVLKVESRDGTVSGA 480 490 500 >>NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo sap (503 aa) initn: 2364 init1: 2364 opt: 2800 Z-score: 3489.5 bits: 655.2 E(85289): 1.2e-187 Smith-Waterman score: 2800; 81.9% identity (94.6% similar) in 502 aa overlap (1-501:1-502) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF :::::::::::::::::::.::::::::::::::.::::::::::.:::.::.:.: : : NP_000 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL : :::::: :.:: :. : :.:::::::.:.::::::::::::::: .:::::::.:::. NP_000 DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS ::::::::::::::::::::::::: ::::::::::::::::::: ::::::: .::::: NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL :::::.:::::.:::::::::::::.:::.:.:. :::. ::: .::::::..::::... NP_000 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI ::. .:.::.:::...:..::.. ::::.:::::::::::::..:.::::::::: :::: NP_000 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :::::::::::::::: .::::::::::::.:::::.:::::::::::.:.:.::::::: NP_000 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS ::::::::::.::::.:::::::::.::::: .:.::.:.::::::::::::.: ::::: NP_000 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ :: ::.::::::::::.::::::::::::.::::::.:::::::::::::::::::: NP_000 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 430 440 450 460 470 480 480 490 500 pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE ::: :::::::..::: :.:: NP_000 GLLLTEKPIVLKAESRDETVSGA 490 500 >>NP_476436 (OMIM: 606534) cytochrome P450 3A43 isoform (503 aa) initn: 2185 init1: 2185 opt: 2595 Z-score: 3233.9 bits: 607.9 E(85289): 2.2e-173 Smith-Waterman score: 2595; 75.7% identity (91.8% similar) in 502 aa overlap (1-501:1-502) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF ::::::.:.:::.:.:.::::::.:::..: :::.::::::::::.::..: : .:::.: NP_476 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL : :: .:::.::: :::: :.:.: :::.:.:::::::::::::. :::.::.:::.:. NP_476 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS ::::::::::.::::.::: :.::: :::.: ::.:::.::.:::..: ..:::.::::. NP_476 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL ::::::: ::::.::::::::::... ::.::. ::::..: : :::::::::::::..: NP_476 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI ::::. .::..:..:::.:::.::::::.::.: ::::::::::.::::::::::.:::: NP_476 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :.:::.:.:::..: : .::::::::::::::.::::::::::: ::::.:::::::::: NP_476 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS :::::::::. :. :.::::.:::::::::: :..: ::::::::::::::.: ::::: NP_476 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ :: ::::: : : :::.:::::::::::: :.:::.::.:::::::::::::::::::. NP_476 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 430 440 450 460 470 480 480 490 500 pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE .::::::::::: ::: :: NP_476 PILQPEKPIVLKVHLRDGITSGP 490 500 >>NP_073731 (OMIM: 606534) cytochrome P450 3A43 isoform (504 aa) initn: 2160 init1: 2160 opt: 2583 Z-score: 3218.9 bits: 605.1 E(85289): 1.5e-172 Smith-Waterman score: 2583; 75.5% identity (91.7% similar) in 503 aa overlap (1-501:1-503) 10 20 30 40 50 60 pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF ::::::.:.:::.:.:.::::::.:::..: :::.::::::::::.::..: : .:::.: NP_073 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL : :: .:::.::: :::: :.:.: :::.:.:::::::::::::. :::.::.:::.:. NP_073 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS ::::::::::.::::.::: :.::: :::.: ::.:::.::.:::..: ..:::.::::. NP_073 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL ::::::: ::::.::::::::::... ::.::. ::::..: : :::::::::::::..: NP_073 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI ::::. .::..:..:::.:::.::::::.::.: ::::::::::.::::::::::.:::: NP_073 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV :.:::.:.:::..: : .::::::::::::::.::::::::::: ::::.:::::::::: NP_073 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE-RF :::::::::. :. :.::::.:::::::::: :..: ::::::::::::::.: :: :: NP_073 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 SKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT ::: ::::: : : :::.:::::::::::: :.:::.::.:::::::::::::::::::. NP_073 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 430 440 450 460 470 480 480 490 500 pF1KE4 QGLLQPEKPIVLKVDSRDGTLSGE .::::::::::: ::: :: NP_073 LPILQPEKPIVLKVHLRDGITSGP 490 500 >>XP_011514145 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa) initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170 Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389) 90 100 110 120 130 140 pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK :::::::::::::::::::::::::::::: XP_011 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK 10 20 30 150 160 170 180 190 200 pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE 340 350 360 370 380 >>XP_016867270 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa) initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170 Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389) 90 100 110 120 130 140 pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK :::::::::::::::::::::::::::::: XP_016 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK 10 20 30 150 160 170 180 190 200 pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE 340 350 360 370 380 >>NP_001278758 (OMIM: 145500,605325) cytochrome P450 3A5 (389 aa) initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170 Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389) 90 100 110 120 130 140 pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK :::::::::::::::::::::::::::::: NP_001 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK 10 20 30 150 160 170 180 190 200 pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE 340 350 360 370 380 502 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:49:39 2016 done: Sun Nov 6 00:49:41 2016 Total Scan time: 9.520 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]