Result of FASTA (omim) for
pFN21AE6354
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6354, 385 aa
1>>>pF1KE6354 385 - 385 aa - 385 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4353+/-0.000357; mu= 17.2683+/- 0.022
mean_var=90.7229+/-17.705, 0's: 0 Z-trim(116.4): 281 B-trim: 37 in 1/51
Lambda= 0.134653
statistics sampled from 27151 (27459) to 27151 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.322), width: 16
Scan time: 5.730
The best scores are: opt bits E(85289)
NP_037402 (OMIM: 607950) probable threonine protea ( 385) 2703 535.1 1.1e-151
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 553 117.4 5.2e-26
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 544 115.6 1.5e-25
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 544 115.6 1.5e-25
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 544 115.6 1.5e-25
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 542 115.2 2.1e-25
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 538 114.4 3.7e-25
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 538 114.4 3.7e-25
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 535 113.9 5.5e-25
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 530 112.9 1e-24
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 511 109.3 1.6e-23
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 511 109.3 1.7e-23
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 511 109.3 1.7e-23
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 511 109.3 1.7e-23
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 511 109.3 1.7e-23
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 511 109.3 1.7e-23
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 504 107.8 3.2e-23
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 493 105.6 1.4e-22
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 444 96.4 1.9e-19
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 444 96.5 1.9e-19
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 444 96.5 1.9e-19
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 444 96.5 2.2e-19
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 444 96.5 2.2e-19
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 444 96.6 2.4e-19
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 444 96.6 2.4e-19
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 431 93.7 7.7e-19
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 431 93.8 8.6e-19
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 431 93.8 9.2e-19
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 431 93.8 9.2e-19
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 431 93.9 9.7e-19
NP_001306120 (OMIM: 104300,191840,601709) urokinas ( 345) 388 85.3 2.3e-16
NP_001138503 (OMIM: 104300,191840,601709) urokinas ( 414) 388 85.4 2.7e-16
XP_011538168 (OMIM: 104300,191840,601709) PREDICTE ( 431) 388 85.4 2.7e-16
NP_002649 (OMIM: 104300,191840,601709) urokinase-t ( 431) 388 85.4 2.7e-16
XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188) 371 81.8 1.5e-15
NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188) 371 81.8 1.5e-15
NP_001088 (OMIM: 102480) acrosin precursor [Homo s ( 421) 373 82.5 2e-15
NP_001306118 (OMIM: 173370,612348) tissue-type pla ( 473) 373 82.5 2.2e-15
NP_127509 (OMIM: 173370,612348) tissue-type plasmi ( 516) 373 82.6 2.3e-15
NP_000921 (OMIM: 173370,612348) tissue-type plasmi ( 562) 373 82.6 2.5e-15
NP_036349 (OMIM: 609272) tryptase delta precursor ( 242) 367 81.1 3e-15
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 368 81.6 4.2e-15
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 368 81.6 4.4e-15
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 368 81.6 4.5e-15
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 368 81.6 4.8e-15
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 356 79.0 1.4e-14
NP_056933 (OMIM: 609444) chymotrypsin-like elastas ( 269) 353 78.4 2.2e-14
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 353 78.6 2.7e-14
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 353 78.6 3.1e-14
XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 353 78.7 3.4e-14
>>NP_037402 (OMIM: 607950) probable threonine protease P (385 aa)
initn: 2703 init1: 2703 opt: 2703 Z-score: 2844.6 bits: 535.1 E(85289): 1.1e-151
Smith-Waterman score: 2703; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385)
10 20 30 40 50 60
pF1KE6 MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 ARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 VPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 TVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 TVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 HREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 HREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQ
310 320 330 340 350 360
370 380
pF1KE6 ALALPAPSRTLLLALPLPLSLLAAL
:::::::::::::::::::::::::
NP_037 ALALPAPSRTLLLALPLPLSLLAAL
370 380
>>NP_002764 (OMIM: 600823) prostasin preproprotein [Homo (343 aa)
initn: 529 init1: 329 opt: 553 Z-score: 588.0 bits: 117.4 E(85289): 5.2e-26
Smith-Waterman score: 553; 33.5% identity (60.8% similar) in 263 aa overlap (94-353:30-281)
70 80 90 100 110 120
pF1KE6 TCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARR
.:: : :: . : ::: .
NP_002 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAP---CGVA-PQARITGGSSAVAGQ
10 20 30 40 50
130 140 150 160 170 180
pF1KE6 WPWMVSVRANGTHICAGTIIASQWVLTVAHCLI--WRDVIYSVRVGSPWIDQMTQTASDV
:::.::. .:.:.:.:.... ::::..:::. . : :..:. .:.... :.
NP_002 WPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVS
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE6 PVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCT
. ..: : : . :. .::.::.:.. . .: :.::::::... . . .::
NP_002 TLKDIIPHPSYLQE------GSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCT
120 130 140 150 160
250 260 270 280 290 300
pF1KE6 VTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTH
::::: . . .:. :: ... . :. .: :. : .... .:.:: ..
NP_002 VTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLY-NIDAKPEEPHFVQEDMVCAGYVE
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE6 REK-FCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQ
: : .: :: : .:: :::.:.:::: .: . : .: .::: ::
NP_002 GGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTEL
230 240 250 260 270 280
370 380
pF1KE6 ALALPAPSRTLLLALPLPLSLLAAL
NP_002 QPRVVPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
290 300 310 320 330 340
>>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 551 init1: 203 opt: 544 Z-score: 579.7 bits: 115.6 E(85289): 1.5e-25
Smith-Waterman score: 544; 34.6% identity (61.5% similar) in 234 aa overlap (124-353:48-274)
100 110 120 130 140 150
pF1KE6 SEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAH
:::..:.. :.:.:.:..:: :::::.::
XP_011 AGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAH
20 30 40 50 60 70
160 170 180 190 200 210
pF1KE6 CLIWRDVI--YSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLK
:. : . : ::.:. . . . . .::: .:.. : . : .:..::.
XP_011 CFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSED------GARGDLALLQ
80 90 100 110 120 130
220 230 240 250 260 270
pF1KE6 LKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNK
:.. . : :.:.::: . : ::::: . :..: .: .: .:...
XP_011 LRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSR
140 150 160 170 180 190
280 290 300 310 320
pF1KE6 ECDNFYHNFTKIPTLVQIIKSQMMCA--EDTHREKFCYELTGEPLVCSMEGTWYLVGLVS
::..:: . .: .:. .:: . :.. : .: ::.: . :.: :::.::
XP_011 TCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDA-CQGDSGGPLTCLQSGSWVLVGVVS
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE6 WGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL
:: :: . : .: .:..:. ::
XP_011 WGKGCALPNRPGVYTSVATYSPWIQARVSF
260 270 280
>>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa)
initn: 551 init1: 203 opt: 544 Z-score: 579.7 bits: 115.6 E(85289): 1.5e-25
Smith-Waterman score: 544; 34.6% identity (61.5% similar) in 234 aa overlap (124-353:48-274)
100 110 120 130 140 150
pF1KE6 SEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAH
:::..:.. :.:.:.:..:: :::::.::
NP_690 AGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAH
20 30 40 50 60 70
160 170 180 190 200 210
pF1KE6 CLIWRDVI--YSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLK
:. : . : ::.:. . . . . .::: .:.. : . : .:..::.
NP_690 CFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSED------GARGDLALLQ
80 90 100 110 120 130
220 230 240 250 260 270
pF1KE6 LKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNK
:.. . : :.:.::: . : ::::: . :..: .: .: .:...
NP_690 LRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSR
140 150 160 170 180 190
280 290 300 310 320
pF1KE6 ECDNFYHNFTKIPTLVQIIKSQMMCA--EDTHREKFCYELTGEPLVCSMEGTWYLVGLVS
::..:: . .: .:. .:: . :.. : .: ::.: . :.: :::.::
NP_690 TCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDA-CQGDSGGPLTCLQSGSWVLVGVVS
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE6 WGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL
:: :: . : .: .:..:. ::
NP_690 WGKGCALPNRPGVYTSVATYSPWIQARVSF
260 270 280
>>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 551 init1: 203 opt: 544 Z-score: 579.7 bits: 115.6 E(85289): 1.5e-25
Smith-Waterman score: 544; 34.6% identity (61.5% similar) in 234 aa overlap (124-353:48-274)
100 110 120 130 140 150
pF1KE6 SEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAH
:::..:.. :.:.:.:..:: :::::.::
XP_011 AGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAH
20 30 40 50 60 70
160 170 180 190 200 210
pF1KE6 CLIWRDVI--YSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLK
:. : . : ::.:. . . . . .::: .:.. : . : .:..::.
XP_011 CFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSED------GARGDLALLQ
80 90 100 110 120 130
220 230 240 250 260 270
pF1KE6 LKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNK
:.. . : :.:.::: . : ::::: . :..: .: .: .:...
XP_011 LRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSR
140 150 160 170 180 190
280 290 300 310 320
pF1KE6 ECDNFYHNFTKIPTLVQIIKSQMMCA--EDTHREKFCYELTGEPLVCSMEGTWYLVGLVS
::..:: . .: .:. .:: . :.. : .: ::.: . :.: :::.::
XP_011 TCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDA-CQGDSGGPLTCLQSGSWVLVGVVS
200 210 220 230 240 250
330 340 350 360 370 380
pF1KE6 WGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL
:: :: . : .: .:..:. ::
XP_011 WGKGCALPNRPGVYTSVATYSPWIQARVSF
260 270 280
>>NP_006790 (OMIM: 608159) testisin isoform 1 preproprot (314 aa)
initn: 544 init1: 209 opt: 542 Z-score: 576.9 bits: 115.2 E(85289): 2.1e-25
Smith-Waterman score: 542; 31.5% identity (63.3% similar) in 286 aa overlap (104-377:33-310)
80 90 100 110 120 130
pF1KE6 WQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRAN
:: . . .: ::::. :.:
NP_006 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW
10 20 30 40 50 60
140 150 160 170 180 190
pF1KE6 GTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIM--HSR
.:.:. .... .:.::.:::. .. .. : :. :. : .: .: . .. ..:
NP_006 DSHVCGVSLLSHRWALTAAHCF---ETYSDLSDPSGWMVQFGQLTS-MPSFWSLQAYYTR
70 80 90 100 110
200 210 220 230 240
pF1KE6 YRAQRFW---SWVGQAN-DIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGL
: .. .. ..:.. ::.:.::. . :.....:::: .. . ..... : :::::
NP_006 YFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGY
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE6 SKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREK-FC
: : :. .:.:: .: :.::. :. : : : .. . : ..:.:: ... : :
NP_006 IKEDEALPSPHTLQEVQVAIINNSMCN---HLFLKY-SFRKDIFGDMVCAGNAQGGKDAC
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE6 YELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPA
. .: ::.:. .: :: .:.::::.:: . . : .: ..: . .:: . .... :
NP_006 FGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPD
240 250 260 270 280 290
370 380
pF1KE6 PSRTLLL-----ALPLPLSLLAAL
:: ::. ::::
NP_006 PSWPLLFFPLLWALPLLGPV
300 310
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 464 init1: 187 opt: 538 Z-score: 572.7 bits: 114.4 E(85289): 3.7e-25
Smith-Waterman score: 538; 31.6% identity (63.1% similar) in 282 aa overlap (103-369:40-309)
80 90 100 110 120 130
pF1KE6 LWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRA
.:: . . .. ... .:::.::..
NP_071 LGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK
10 20 30 40 50 60
140 150 160 170 180
pF1KE6 NGTHICAGTIIASQWVLTVAHCL---IWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMH
:::: :::....:.::.:.:::. . . ..:: .:. . . . .. : : : :
NP_071 NGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPH
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE6 SRYRAQRFWSWV-GQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLS
: :: : ::.:..:.. ...:. : ::::: .. : ...: ..::: :
NP_071 PVY------SWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWG-S
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE6 KADGM-WPQFRTIQEKEVIILNNKECDNFY-HNFTKIPTLVQIIKSQMMCAEDTHREK-F
::. :. .:.:. .: :.... :...: .. . : : .:.:: . :.
NP_071 IQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGP-----ITEDMLCAGYLEGERDA
190 200 210 220 230
310 320 330 340 350 360
pF1KE6 CYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQAL---
: .: ::.:...:.: :.:..::: :: . . : .:...:... :. ..: :
NP_071 CLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGR
240 250 260 270 280 290
370 380
pF1KE6 -----ALPAPSRTLLLALPLPLSLLAAL
:: :::.
NP_071 AQGGGALRAPSQGSGAAARS
300 310
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 464 init1: 187 opt: 538 Z-score: 572.7 bits: 114.4 E(85289): 3.7e-25
Smith-Waterman score: 538; 31.6% identity (63.1% similar) in 282 aa overlap (103-369:40-309)
80 90 100 110 120 130
pF1KE6 LWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRA
.:: . . .. ... .:::.::..
XP_005 LGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK
10 20 30 40 50 60
140 150 160 170 180
pF1KE6 NGTHICAGTIIASQWVLTVAHCL---IWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMH
:::: :::....:.::.:.:::. . . ..:: .:. . . . .. : : : :
XP_005 NGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPH
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE6 SRYRAQRFWSWV-GQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLS
: :: : ::.:..:.. ...:. : ::::: .. : ...: ..::: :
XP_005 PVY------SWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWG-S
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE6 KADGM-WPQFRTIQEKEVIILNNKECDNFY-HNFTKIPTLVQIIKSQMMCAEDTHREK-F
::. :. .:.:. .: :.... :...: .. . : : .:.:: . :.
XP_005 IQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGP-----ITEDMLCAGYLEGERDA
190 200 210 220 230
310 320 330 340 350 360
pF1KE6 CYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQAL---
: .: ::.:...:.: :.:..::: :: . . : .:...:... :. ..: :
XP_005 CLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGR
240 250 260 270 280 290
370 380
pF1KE6 -----ALPAPSRTLLLALPLPLSLLAAL
:: :::.
XP_005 AQGGGALRAPSQGSGAAARS
300 310
>>NP_659205 (OMIM: 608159) testisin isoform 2 preproprot (312 aa)
initn: 468 init1: 256 opt: 535 Z-score: 569.6 bits: 113.9 E(85289): 5.5e-25
Smith-Waterman score: 535; 31.2% identity (62.8% similar) in 288 aa overlap (104-377:33-308)
80 90 100 110 120 130
pF1KE6 WQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRAN
:: . . .: ::::. :.:
NP_659 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW
10 20 30 40 50 60
140 150 160 170 180
pF1KE6 GTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSP--WIDQMTQTASDVPVLQVIM--H
.:.:. .... .:.::.::: . . ...: :. :. : .: .: . .. .
NP_659 DSHVCGVSLLSHRWALTAAHC-------FETDLSDPSGWMVQFGQLTS-MPSFWSLQAYY
70 80 90 100 110
190 200 210 220 230 240
pF1KE6 SRYRAQRFW---SWVGQAN-DIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGW
.:: .. .. ..:.. ::.:.::. . :.....:::: .. . ..... : ::::
NP_659 TRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGW
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE6 GLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREK-
: : : :. .:.:: .: :.::. :. : : : .. . : ..:.:: ... :
NP_659 GYIKEDEALPSPHTLQEVQVAIINNSMCN---HLFLKY-SFRKDIFGDMVCAGNAQGGKD
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE6 FCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALAL
:. .: ::.:. .: :: .:.::::.:: . . : .: ..: . .:: . ....
NP_659 ACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQ
240 250 260 270 280 290
370 380
pF1KE6 PAPSRTLLL-----ALPLPLSLLAAL
: :: ::. ::::
NP_659 PDPSWPLLFFPLLWALPLLGPV
300 310
>>NP_114154 (OMIM: 608018) serine protease 27 isoform 1 (290 aa)
initn: 532 init1: 215 opt: 530 Z-score: 564.8 bits: 112.9 E(85289): 1e-24
Smith-Waterman score: 530; 30.3% identity (63.0% similar) in 254 aa overlap (103-353:25-272)
80 90 100 110 120 130
pF1KE6 LWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRA
.:: . . .. .:::.::..
NP_114 MRRPAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQR
10 20 30 40 50
140 150 160 170 180 190
pF1KE6 NGTHICAGTIIASQWVLTVAHCL--IWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHS
::.:.:.:..:: :::::.:::. . .:.: .:. . : : . : :: .
NP_114 NGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNP
60 70 80 90 100 110
200 210 220 230 240 250
pF1KE6 RYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKA
:.. .... :..:..:. . ..::. :.::: . ... : ::::: .
NP_114 LYQG------TASSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSE
120 130 140 150 160
260 270 280 290 300
pF1KE6 DGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAE-DTHREKFCYEL
. . :. : .:. : :... .:. .: . :.. . ::..:.:: . .. :
NP_114 EDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGD
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE6 TGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSR
.: :::: . .: .:..::: :: ... : .:..:.....::
NP_114 SGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQFQPARLGG
230 240 250 260 270 280
370 380
pF1KE6 TLLLALPLPLSLLAAL
NP_114 QK
290
385 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:24:25 2016 done: Tue Nov 8 12:24:26 2016
Total Scan time: 5.730 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]