FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1387, 982 aa 1>>>pF1KE1387 982 - 982 aa - 982 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.0724+/-0.00112; mu= -6.8691+/- 0.068 mean_var=457.1890+/-93.916, 0's: 0 Z-trim(115.8): 18 B-trim: 520 in 2/54 Lambda= 0.059983 statistics sampled from 16373 (16388) to 16373 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.503), width: 16 Scan time: 4.120 The best scores are: opt bits E(32554) CCDS2948.1 CBLB gene_id:868|Hs108|chr3 ( 982) 6926 614.5 3.4e-175 CCDS8418.1 CBL gene_id:867|Hs108|chr11 ( 906) 2587 238.9 3.4e-62 CCDS12643.1 CBLC gene_id:23624|Hs108|chr19 ( 474) 1408 136.7 1.1e-31 CCDS46109.1 CBLC gene_id:23624|Hs108|chr19 ( 428) 700 75.3 2.9e-13 >>CCDS2948.1 CBLB gene_id:868|Hs108|chr3 (982 aa) initn: 6926 init1: 6926 opt: 6926 Z-score: 3258.8 bits: 614.5 E(32554): 3.4e-175 Smith-Waterman score: 6926; 99.9% identity (100.0% similar) in 982 aa overlap (1-982:1-982) 10 20 30 40 50 60 pF1KE1 MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 QNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 QNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 AIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 FWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 QPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 TGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 ELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 IIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 IIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 PGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 PGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 DKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSKDPPMPLEAWCPRDVFG :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: CCDS29 DKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 TNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 GSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 GSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 SQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 SQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 ARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 ARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 SSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 SSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 APARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 APARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNV 910 920 930 940 950 960 970 980 pF1KE1 EVARSILREFAFPPPVSPRLNL :::::::::::::::::::::: CCDS29 EVARSILREFAFPPPVSPRLNL 970 980 >>CCDS8418.1 CBL gene_id:867|Hs108|chr11 (906 aa) initn: 2823 init1: 2118 opt: 2587 Z-score: 1230.0 bits: 238.9 E(32554): 3.4e-62 Smith-Waterman score: 2878; 50.6% identity (66.6% similar) in 998 aa overlap (11-970:13-895) 10 20 30 40 50 pF1KE1 MANSMNGRNPGGRG-GNPRKGRILGII-DAIQDA------VGPPKQAAADRRTVEKTW :: : :. .: ..:.. ::.: ..: ...:.. ::: : CCDS84 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 KLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIY ::::::::::::::: ::::::::::.::::::::: :::.:. :. :.:::::... CCDS84 KLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEG--KMETLGENEYFRVF 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 IDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDN ...::::.:..: ::::::::::::.:: :::::::::::::::::.:.:::.: ::::. CCDS84 MENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 FRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISV :::::::::::::: ::.::::::: ::: ::::: :::::::::::::::::::::::: CCDS84 FRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 FEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCT :::::::::::::.:.::::: :::::::::::::::::::::::. :::::::::::: CCDS84 FEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 RLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPH :::::::::::.::::::::::::::::::::: ::::::.::::. ::::::::::::. CCDS84 RLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 DHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPF ::::::::::::::::::::::::::::::::::::::::::::::::.::::.:::::: CCDS84 DHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPF 360 370 380 390 400 410 420 430 440 450 460 pF1KE1 CRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDR--EESL-MMNRLANV :::::::::::.::::::: :: . . : : . :::::. ...: ::..::. CCDS84 CRCEIKGTEPIVVDPFDPRGSGSLLRQGAE--GAPSPNYDDDDDERADDTLFMMKELAG- 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE1 RKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQI-PHLSLPPVPPRLDLIQKGIVRSPCGSP :. ..: :.:... :. :::::::::::. . . .: CCDS84 -------------------AKVERP-PSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASA 480 490 500 510 530 540 550 560 570 580 pF1KE1 TGSPKSSPCMVRKQDKPLPAPPPPLRD-PPPPPPERPPPIPPDNRLSRHIHHVE--SVPS :. ... ..:::::.:: ::: ::::::.:: . ..: .:. . :: CCDS84 LGTASKAASGSLHKDKPLPVPPT-LRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPS 520 530 540 550 560 570 590 600 610 620 630 pF1KE1 KD--PPMPL----EAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPV .: ::.: ..: :: . :: ..: :. ::: CCDS84 RDKLPPVPSSRLGDSWLPRPI----------------PKVPVSAPSS---------SDPW 580 590 600 640 650 660 670 680 690 pF1KE1 LMRK-HRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSE :. ::.:: ...: .. : : : : . : : .:.: CCDS84 TGRELTNRHSLP----------------FSLPSQMEPRPDV----PRLGSTFSLDTSMSM 610 620 630 640 700 710 720 730 740 750 pF1KE1 KTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSN .. : . : :: ..:: : :. : . : CCDS84 NSSPLVGPECD-------HP-----------KIKP--SSSANAIYSLAARPLP------- 650 660 670 680 760 770 780 790 800 810 pF1KE1 IPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAF-- .: : :. .. : . :. : : : :. .:. : : : .:. CCDS84 VPKLP---PGEQCEGEEDTEYMTPSSRPLR--PLDTSQSSRA-CDCDQQIDSCTYEAMYN 690 700 710 720 730 820 830 840 850 860 870 pF1KE1 -DALPPSLPPPPPPARHSLIE-HSKP-PGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPP .. ::. .. .: :.. : : ..: : .:. : :: CCDS84 IQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYD---VPKPP--------VPAVL 740 750 760 770 780 880 890 900 910 920 pF1KE1 ARRLPGENVKTNRT----SQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHH---RKPHG ::: .. ... . : : : . ..:::.: ::::: ::: : . .. : CCDS84 ARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSG 790 800 810 820 830 840 930 940 950 960 970 980 pF1KE1 PEA----ALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRL : : : .....: .::..::.......:: :::::.:.:..::::: CCDS84 PAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVA 850 860 870 880 890 900 pF1KE1 NL CCDS84 T >>CCDS12643.1 CBLC gene_id:23624|Hs108|chr19 (474 aa) initn: 1428 init1: 1310 opt: 1408 Z-score: 682.3 bits: 136.7 E(32554): 1.1e-31 Smith-Waterman score: 1408; 49.4% identity (76.4% similar) in 403 aa overlap (32-426:4-404) 10 20 30 40 50 60 pF1KE1 ANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQ ::.: . . :.. .. ...... . : CCDS12 MALAVAPWGRQWEEARALGRAVRMLQRLEEQCV 10 20 30 70 80 90 100 110 pF1KE1 NPKLQLKNSPPYILDILPDTYQHLRLILSKY---DDNQKLAQLSENEYFKIYIDSLMKKS .:.:.. ::: . :.:: : : :: . . . . . .... ::. .: :: CCDS12 DPRLSV--SPPSLRDLLPRTAQLLREVAHSRRAAGGGGPGGPGGSGDFLLIYLANLEAKS 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 KRAIRLF-----KEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRI ... :. . ....... :. ::.:.::..::::: ::..:.::.:.. : ... CCDS12 RQVAALLPPRGRRSANDELFRAGSRLRRQLAKLAIIFSHMHAELHALFPGGKYCGHMYQL 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 TKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEF ::: : :::. : . ..:: :.. : : . : :.::..::::::. ..:.::: CCDS12 TKAPAHTFWRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTIDLTCSGHVSIFEF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 DIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLG :.:::::::: ..:.::..:::.:::::::::::::. ::: :::::::: :::::: CCDS12 DVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPGSYIFRPSCTRLG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE1 QWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHI :::::::..::.:::::: :::: :.:..:...::::::::...::::: : . :...: CCDS12 QWAIGYVSSDGSILQTIPANKPLSQVLLEGQKDGFYLYPDGKTHNPDLTELGQAEPQQRI 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE1 KVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRC .:..:: .:: : :::.:::::::..:::::::::::.:. ::.:::.::.: :::::: CCDS12 HVSEEQLQLYWAMDSTFELCKICAESNKDVKIEPCGHLLCSCCLAAWQHSDSQTCPFCRC 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 EIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDR :::: : . . : CCDS12 EIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPRKPRNAQ 400 410 420 430 440 450 >>CCDS46109.1 CBLC gene_id:23624|Hs108|chr19 (428 aa) initn: 1184 init1: 602 opt: 700 Z-score: 351.7 bits: 75.3 E(32554): 2.9e-13 Smith-Waterman score: 1062; 40.9% identity (65.8% similar) in 403 aa overlap (32-426:4-358) 10 20 30 40 50 60 pF1KE1 ANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQ ::.: . . :.. .. ...... . : CCDS46 MALAVAPWGRQWEEARALGRAVRMLQRLEEQCV 10 20 30 70 80 90 100 110 pF1KE1 NPKLQLKNSPPYILDILPDTYQHLRLILSKY---DDNQKLAQLSENEYFKIYIDSLMKKS .:.:.. ::: . :.:: : : :: . . . . . .... ::. .: :: CCDS46 DPRLSV--SPPSLRDLLPRTAQLLREVAHSRRAAGGGGPGGPGGSGDFLLIYLANLEAKS 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 KRAIRLF-----KEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRI ... :. . ....... :. ::.:.::..::::: ::..:.::.:.. : ... CCDS46 RQVAALLPPRGRRSANDELFRAGSRLRRQLAKLAIIFSHMHAELHALFPGGKYCGHMYQL 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 TKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEF ::: : :::. : . ..:: :.. : : . : :.::..::::::. ..:.::: CCDS46 TKAPAHTFWRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTIDLTCSGHVSIFEF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 DIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLG :.:::::::: ..:.::..:::.:::::::::::::. ::: ::::: CCDS46 DVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPGSY---------- 220 230 240 250 260 300 310 320 330 340 350 pF1KE1 QWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHI :::::...::::: : . :...: CCDS46 ------------------------------------LYPDGKTHNPDLTELGQAEPQQRI 270 280 360 370 380 390 400 410 pF1KE1 KVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRC .:..:: .:: : :::.:::::::..:::::::::::.:. ::.:::.::.: :::::: CCDS46 HVSEEQLQLYWAMDSTFELCKICAESNKDVKIEPCGHLLCSCCLAAWQHSDSQTCPFCRC 290 300 310 320 330 340 420 430 440 450 460 470 pF1KE1 EIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDR :::: : . . : CCDS46 EIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPRKPRNAQ 350 360 370 380 390 400 982 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:02:01 2016 done: Mon Nov 7 00:02:01 2016 Total Scan time: 4.120 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]