FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1549, 509 aa 1>>>pF1KE1549 509 - 509 aa - 509 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9691+/-0.000379; mu= 20.3375+/- 0.024 mean_var=70.6976+/-14.685, 0's: 0 Z-trim(112.7): 175 B-trim: 304 in 1/55 Lambda= 0.152536 statistics sampled from 21502 (21681) to 21502 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.254), width: 16 Scan time: 8.680 The best scores are: opt bits E(85289) NP_000777 (OMIM: 601637) lanosterol 14-alpha demet ( 509) 3392 756.0 6e-218 NP_001139624 (OMIM: 601637) lanosterol 14-alpha de ( 404) 2717 607.3 2.6e-173 NP_057677 (OMIM: 605994) 24-hydroxycholesterol 7-a ( 469) 433 104.8 5.9e-22 NP_063938 (OMIM: 605207,614416) cytochrome P450 26 ( 512) 386 94.4 8.2e-19 XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 385 94.2 9.9e-19 NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 385 94.2 9.9e-19 XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 385 94.2 9.9e-19 XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 420) 382 93.5 1.3e-18 XP_016866410 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 471) 382 93.5 1.4e-18 XP_005264490 (OMIM: 605207,614416) PREDICTED: cyto ( 454) 373 91.5 5.5e-18 XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 352 86.9 1.2e-16 NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 352 87.0 1.5e-16 NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 345 85.4 3.8e-16 NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 345 85.4 4.3e-16 NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 345 85.4 4.3e-16 XP_016876422 (OMIM: 604087) PREDICTED: cholesterol ( 462) 344 85.2 4.6e-16 XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 344 85.2 4.7e-16 NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500) 344 85.2 4.9e-16 NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 343 85.0 5.7e-16 NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 343 85.0 5.7e-16 XP_011534667 (OMIM: 604087) PREDICTED: cholesterol ( 347) 340 84.2 6.8e-16 NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 340 84.2 6.8e-16 NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 340 84.2 6.9e-16 XP_005267331 (OMIM: 604087) PREDICTED: cholesterol ( 355) 340 84.2 7e-16 NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 341 84.6 8e-16 XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 340 84.3 9e-16 NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 340 84.3 9e-16 NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 340 84.3 9.2e-16 NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 340 84.3 9.2e-16 XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 336 83.3 1.2e-15 XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15 XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15 XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 336 83.3 1.3e-15 XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15 XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15 XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 336 83.3 1.3e-15 NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 337 83.7 1.4e-15 XP_016877442 (OMIM: 108330) PREDICTED: cytochrome ( 484) 335 83.2 1.9e-15 XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 335 83.2 2e-15 NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 330 82.0 3.5e-15 NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 331 82.4 3.7e-15 NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 331 82.4 3.7e-15 NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 330 82.1 4.2e-15 NP_476498 (OMIM: 602239) cytochrome P450 26A1 isof ( 428) 329 81.8 4.3e-15 NP_000774 (OMIM: 602239) cytochrome P450 26A1 isof ( 497) 329 81.9 4.8e-15 NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 328 81.7 5.8e-15 NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 324 80.8 1.1e-14 XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 319 79.6 1.8e-14 XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 319 79.6 1.8e-14 XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 318 79.4 2e-14 >>NP_000777 (OMIM: 601637) lanosterol 14-alpha demethyla (509 aa) initn: 3392 init1: 3392 opt: 3392 Z-score: 4033.8 bits: 756.0 E(85289): 6e-218 Smith-Waterman score: 3392; 99.8% identity (100.0% similar) in 509 aa overlap (1-509:1-509) 10 20 30 40 50 60 pF1KE1 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_000 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 430 440 450 460 470 480 490 500 pF1KE1 IDGYFPTVNYTTMIHTPENPVIRYKRRSK ::::::::::::::::::::::::::::: NP_000 IDGYFPTVNYTTMIHTPENPVIRYKRRSK 490 500 >>NP_001139624 (OMIM: 601637) lanosterol 14-alpha demeth (404 aa) initn: 2717 init1: 2717 opt: 2717 Z-score: 3232.4 bits: 607.3 E(85289): 2.6e-173 Smith-Waterman score: 2717; 99.8% identity (100.0% similar) in 404 aa overlap (106-509:1-404) 80 90 100 110 120 130 pF1KE1 FLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAED :::::::::::::::::::::::::::::: NP_001 MVGKTFTYLLGSDAAALLFNSKNEDLNAED 10 20 30 140 150 160 170 180 190 pF1KE1 VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGES 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 GEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPS 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 FRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE1 TLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH 340 350 360 370 380 390 500 pF1KE1 TPENPVIRYKRRSK :::::::::::::: NP_001 TPENPVIRYKRRSK 400 >>NP_057677 (OMIM: 605994) 24-hydroxycholesterol 7-alpha (469 aa) initn: 194 init1: 170 opt: 433 Z-score: 515.1 bits: 104.8 E(85289): 5.9e-22 Smith-Waterman score: 433; 23.6% identity (55.7% similar) in 483 aa overlap (45-507:7-468) 20 30 40 50 60 70 pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI ... .. : :. ... :: : . : NP_057 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI 10 20 30 80 90 100 110 120 130 pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN :..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : : NP_057 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA 40 50 60 70 80 90 140 150 160 170 180 pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY .... : .. .:. ::: .. :::. .. ....: .. . .: .: NP_057 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW .:. : : .. . . .:. .. . : .: . : ..:. : . : : ... NP_057 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQ 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD : : .: ..... . ..: : : . . :. . :::.:: . :. NP_057 L-----PECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK 210 220 230 240 250 260 310 320 330 340 350 pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT : . :.: :: :. .. .. : .. ..: . ..: :.. .. NP_057 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD :.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .: NP_057 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE . : :.:.:. . : ..: .. ::.:. .: .. :: .... .: :. NP_057 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYD 380 390 400 410 420 430 480 490 500 pF1KE1 FDLIDGYFPTVNYTTMIHTPENP---VIRYKRRSK .:.: .: .: .. .:. :.::.: NP_057 CSLLDP-LPKQSYLHLVGVPQPEGQCRIEYKQRI 440 450 460 >>NP_063938 (OMIM: 605207,614416) cytochrome P450 26B1 i (512 aa) initn: 183 init1: 91 opt: 386 Z-score: 458.7 bits: 94.4 E(85289): 8.2e-19 Smith-Waterman score: 388; 22.0% identity (55.2% similar) in 495 aa overlap (29-504:5-490) 10 20 30 40 50 pF1KE1 MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSML--LIACAFTLSLV-------YLIR : .:.: : : :: ...:. . .: NP_063 MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLR 10 20 30 60 70 80 90 100 110 pF1KE1 LAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTF :: . . . . . : : :: . :.. : . :::: ::. ..:. . NP_063 WAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSG---FQSSRREKYGNVFKTHLLGRPL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 TYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNI . :.. . .. .... ...: . : : ..: ... . . . ...:.... .. NP_063 IRVTGAENVRKILMGEHHLVSTE--WPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSH 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 AHFKQHVSIIEKETKEYFESWGESGEK-NVFEALSELIILTASHCLHGKEIRSQLNEKVA ..... :. .. ...:. : ::.. ..: . : . : : : .: .. NP_063 EALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP---EEDLG 160 170 180 190 200 240 250 260 270 280 pF1KE1 QLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID--DIL .:. .. : .. :: ::. ..:: .:.. .. . :::... : . : : : NP_063 HLF-EVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDAL 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE1 QTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQK . :.... . :. .: .:. . :..:. :....:. . . : . :. .: : . NP_063 DLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELR 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 T---VCGENLP---PLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIP . . . . : : : :. : :: :::..:: :. .: . . :. :: NP_063 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIP 330 340 350 360 370 380 410 420 430 440 450 460 pF1KE1 PGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE-KFAYVPFGAGRHRCIGENFA : .: : .. . . :.:::. : . . .: :.:::.: . :.:...: NP_063 KGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLA 390 400 410 420 430 440 470 480 490 500 pF1KE1 YVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK . .:.. . .:.: :: .. . ..: .. ... NP_063 KLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAM 450 460 470 480 490 500 NP_063 LSATV 510 >>XP_011525994 (OMIM: 611495) PREDICTED: cytochrome P450 (531 aa) initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19 Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496) 110 120 130 140 150 160 pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK .:.. . : .: :. . . . .... XP_011 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR 100 110 120 130 140 150 170 180 190 200 210 pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL-- .: .... .: ...:... . . .: : . ..:: .: . . . ..:. XP_011 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY---- .... . .... .. . .:.. . . : .: . .: : : :. :. . XP_011 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT 220 230 240 250 260 270 280 290 300 310 pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG ..::.::.. : : :....:: : .::. :.:... . ... : XP_011 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL . :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.: XP_011 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD : ::: .. :. . : :: : .: :: ... : . .:: :. : XP_011 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI :: . .:::::.:: . :::..::....... . :.::. XP_011 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR 460 470 480 490 500 510 500 pF1KE1 HTPENPVIRYKRRSK XP_011 TENGLWLKVEPLPPRA 520 530 >>NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Homo sa (531 aa) initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19 Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496) 110 120 130 140 150 160 pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK .:.. . : .: :. . . . .... NP_775 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR 100 110 120 130 140 150 170 180 190 200 210 pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL-- .: .... .: ...:... . . .: : . ..:: .: . . . ..:. NP_775 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY---- .... . .... .. . .:.. . . : .: . .: : : :. :. . NP_775 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT 220 230 240 250 260 270 280 290 300 310 pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG ..::.::.. : : :....:: : .::. :.:... . ... : NP_775 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL . :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.: NP_775 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD : ::: .. :. . : :: : .: :: ... : . .:: :. : NP_775 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI :: . .:::::.:: . :::..::....... . :.::. NP_775 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR 460 470 480 490 500 510 500 pF1KE1 HTPENPVIRYKRRSK NP_775 TENGLWLKVEPLPPRA 520 530 >>XP_011525995 (OMIM: 611495) PREDICTED: cytochrome P450 (531 aa) initn: 320 init1: 155 opt: 385 Z-score: 457.3 bits: 94.2 E(85289): 9.9e-19 Smith-Waterman score: 414; 25.1% identity (58.2% similar) in 371 aa overlap (134-475:129-496) 110 120 130 140 150 160 pF1KE1 FTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK .:.. . : .: :. . . . .... XP_011 WMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK-WSRHRR 100 110 120 130 140 150 170 180 190 200 210 pF1KE1 MLKSGLNIAHFKQHVSIIEKETKEYFESW-----GESGEKNVFEALSELIILTASHCL-- .: .... .: ...:... . . .: : . ..:: .: . . . ..:. XP_011 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD-RAHREIKDIFY---- .... . .... .. . .:.. . . : .: . .: : : :. :. . XP_011 YNSNCQEKMSDYISAII-ELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT 220 230 240 250 260 270 280 290 300 310 pF1KE1 KAIQKRRQS-------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAG ..::.::.. : : :....:: : .::. :.:... . ... : XP_011 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEG 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE1 QHTSSTTSAWMGFFLARDKTLQKKCYLE-QKTVCGENLPPLTYDQLKDLNLLDRCIKETL . :.:. .:: : ::. :.:: : :... :..: : .:.: .: . ::::.: XP_011 HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESL 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE1 RLRPPVMIMMRMARTPQTVA-GYTIPPGHQVC-VSPTVNQRLKDSWVERLDFNPDRYLQD : ::: .. :. . : :: : .: :: ... : . .:: :. : XP_011 RQYPPVTLVSRQCTEDIKLPDGRIIPKG-IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE1 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS-TMLRLYEFDLIDGYFPTVNYTTMI :: . .:::::.:: . :::..::....... . :.::. XP_011 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILR 460 470 480 490 500 510 500 pF1KE1 HTPENPVIRYKRRSK XP_011 TENGLWLKVEPLPPRA 520 530 >>XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxychole (420 aa) initn: 194 init1: 170 opt: 382 Z-score: 455.1 bits: 93.5 E(85289): 1.3e-18 Smith-Waterman score: 382; 23.6% identity (55.6% similar) in 428 aa overlap (45-455:7-414) 20 30 40 50 60 70 pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI ... .. : :. ... :: : . : XP_005 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI 10 20 30 80 90 100 110 120 130 pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN :..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : : XP_005 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA 40 50 60 70 80 90 140 150 160 170 180 pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY .... : .. .:. ::: .. :::. .. ....: .. . .: .: XP_005 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW .:. : : .. . . .:. .. . : .: . : ..:. : . : : ... XP_005 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGS- 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD :: .: ..... . ..: : : . . :. . :::.:: . :. XP_005 ----QLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK 210 220 230 240 250 260 310 320 330 340 350 pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT : . :.: :: :. .. .. : .. ..: . ..: :.. .. XP_005 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD :.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .: XP_005 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE . : :.:.:. . : ..: .. ::.:. .: XP_005 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARKGF 380 390 400 410 420 480 490 500 pF1KE1 FDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK >>XP_016866410 (OMIM: 605994) PREDICTED: 24-hydroxychole (471 aa) initn: 194 init1: 170 opt: 382 Z-score: 454.4 bits: 93.5 E(85289): 1.4e-18 Smith-Waterman score: 382; 23.6% identity (55.6% similar) in 428 aa overlap (45-455:7-414) 20 30 40 50 60 70 pF1KE1 AGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPI ... .. : :. ... :: : . : XP_016 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWI 10 20 30 80 90 100 110 120 130 pF1KE1 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--LN :..: .. :::.:.::.:.: ::::.:. .:. .:.. .. ....::. : : XP_016 PWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELA 40 50 60 70 80 90 140 150 160 170 180 pF1KE1 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK----MLKSGLNIAHFKQHVSIIEKETKEY .... : .. .:. ::: .. :::. .. ....: .. . .: .: XP_016 VQNIVYRTAS----------IPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQ 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVA---QLYADLDGGFSHAAW .:. : : .. . . .:. .. . : .: . : ..:. : . : : ... XP_016 LENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGS- 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE1 LLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDD :: .: ..... . ..: : : . . :. . :::.:: . :. XP_016 ----QLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM-TLLQATLDIVETETSK 210 220 230 240 250 260 310 320 330 340 350 pF1KE1 EVA---GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV---CGENLPPLT : . :.: :: :. .. .. : .. ..: . ..: :.. .. XP_016 ENSPNYGLL--LLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 YDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD :.:..: :. :. ::.::. : .: .... : . .: :: : . .:: .: XP_016 EDDLENLLLIKWCVLETIRLKAPGVITRKVVK-PVEILNYIIPSGDLLMLSPFWLHRNPK 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE1 SWVERLDFNPDRYLQDNPASGEKF--AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE . : :.:.:. . : ..: .. ::.:. .: XP_016 YFPEPELFKPERWKKAN-LEKHSFLDCFMAFGSGKFQCPARKTNRKEQHEPPDFFRNCSL 380 390 400 410 420 430 480 490 500 pF1KE1 FDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK XP_016 QSEESHYSRQSHIKLYDLNGGIRRRVFSVEENFFE 440 450 460 470 >>XP_005264490 (OMIM: 605207,614416) PREDICTED: cytochro (454 aa) initn: 183 init1: 91 opt: 373 Z-score: 443.9 bits: 91.5 E(85289): 5.5e-18 Smith-Waterman score: 373; 21.9% identity (56.7% similar) in 425 aa overlap (90-504:14-432) 60 70 80 90 100 110 pF1KE1 LPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA : . :::: ::. ..:. . . :.. XP_005 MKNKTCVLVCGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAEN 10 20 30 40 120 130 140 150 160 170 pF1KE1 AALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVS . .. .... ...: . : : ..: ... . . . ...:.... .. ..... XP_005 VRKILMGEHHLVSTE--WPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLP 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE1 IIEKETKEYFESWGESGEK-NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG :. .. ...:. : ::.. ..: . : . : : : .: ...:. .. XP_005 KIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP---EEDLGHLF-EVYQ 110 120 130 140 150 240 250 260 270 280 290 pF1KE1 GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID--DILQTLLDATY : .. :: ::. ..:: .:.. .. . :::... : . : : :. :.... XP_005 QFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSK 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE1 KDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT---VCGE . :. .: .:. . :..:. :....:. . . : . :. .: : .. . . XP_005 EHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSG 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE1 NLP---PLTYDQLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAGYTIPPGHQVCVS . : : : :. : :: :::..:: :. .: . . :. :: : .: : XP_005 GCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYS 280 290 300 310 320 330 420 430 440 450 460 pF1KE1 PTVNQRLKDSWVERLDFNPDRYLQDNPASGE-KFAYVPFGAGRHRCIGENFAYVQIKTIW .. . . :.:::. : . . .: :.:::.: . :.:...: . .:.. XP_005 IRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLA 340 350 360 370 380 390 470 480 490 500 pF1KE1 STMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK . .:.: :: .. . ..: .. ... XP_005 VELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV 400 410 420 430 440 450 509 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:06:48 2016 done: Mon Nov 7 00:06:49 2016 Total Scan time: 8.680 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]