FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9665, 672 aa 1>>>pF1KE9665 672 - 672 aa - 672 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7196+/-0.000413; mu= 17.0602+/- 0.026 mean_var=71.1551+/-14.259, 0's: 0 Z-trim(110.4): 33 B-trim: 36 in 1/53 Lambda= 0.152045 statistics sampled from 18765 (18782) to 18765 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.22), width: 16 Scan time: 9.420 The best scores are: opt bits E(85289) NP_079021 (OMIM: 611027) SHC SH2 domain-binding pr ( 672) 4475 991.5 0 NP_001311247 (OMIM: 611027) SHC SH2 domain-binding ( 634) 3865 857.7 0 XP_011521637 (OMIM: 611027) PREDICTED: SHC SH2 dom ( 468) 3004 668.8 1.3e-191 NP_001311248 (OMIM: 611027) SHC SH2 domain-binding ( 594) 2411 538.7 2.3e-152 >>NP_079021 (OMIM: 611027) SHC SH2 domain-binding protei (672 aa) initn: 4475 init1: 4475 opt: 4475 Z-score: 5302.5 bits: 991.5 E(85289): 0 Smith-Waterman score: 4475; 99.9% identity (100.0% similar) in 672 aa overlap (1-672:1-672) 10 20 30 40 50 60 pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: NP_079 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK 610 620 630 640 650 660 670 pF1KE9 WNGKGSFGTFLF :::::::::::: NP_079 WNGKGSFGTFLF 670 >>NP_001311247 (OMIM: 611027) SHC SH2 domain-binding pro (634 aa) initn: 3864 init1: 3864 opt: 3865 Z-score: 4579.7 bits: 857.7 E(85289): 0 Smith-Waterman score: 4127; 94.0% identity (94.2% similar) in 672 aa overlap (1-672:1-634) 10 20 30 40 50 60 pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM :::::::::::::::::::: ::::::::::::::::::::::::::::::: NP_001 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKP-------- 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH :::::::::::::::::::::::::::::: NP_001 ------------------------------ADCKASEVQEFTAEFLEKVLEPSGWRAVWH 60 70 80 130 140 150 160 170 180 pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: NP_001 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK 570 580 590 600 610 620 670 pF1KE9 WNGKGSFGTFLF :::::::::::: NP_001 WNGKGSFGTFLF 630 >>XP_011521637 (OMIM: 611027) PREDICTED: SHC SH2 domain- (468 aa) initn: 2997 init1: 2997 opt: 3004 Z-score: 3561.1 bits: 668.8 E(85289): 1.3e-191 Smith-Waterman score: 3004; 96.8% identity (98.5% similar) in 465 aa overlap (1-465:1-464) 10 20 30 40 50 60 pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK :::::::::::::::::::::::::::: .: ...... .: : XP_011 DTFVDCTGADIKISGIKFVQHDAVEGIL-THGSRSNFDFQILLFEKYTS 430 440 450 460 490 500 510 520 530 540 pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE >>NP_001311248 (OMIM: 611027) SHC SH2 domain-binding pro (594 aa) initn: 2403 init1: 2403 opt: 2411 Z-score: 2856.5 bits: 538.7 E(85289): 2.3e-152 Smith-Waterman score: 3798; 88.1% identity (88.2% similar) in 672 aa overlap (1-672:1-594) 10 20 30 40 50 60 pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRL---------- 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------YVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE 240 250 260 270 280 370 380 390 400 410 420 pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK 350 360 370 380 390 400 490 500 510 520 530 540 pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE 410 420 430 440 450 460 550 560 570 580 590 600 pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: NP_001 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA 470 480 490 500 510 520 610 620 630 640 650 660 pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK 530 540 550 560 570 580 670 pF1KE9 WNGKGSFGTFLF :::::::::::: NP_001 WNGKGSFGTFLF 590 672 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:12:50 2016 done: Mon Nov 7 00:12:51 2016 Total Scan time: 9.420 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]