FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6415, 480 aa 1>>>pF1KE6415 480 - 480 aa - 480 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7903+/-0.000396; mu= 20.8884+/- 0.025 mean_var=65.1541+/-13.605, 0's: 0 Z-trim(110.0): 81 B-trim: 0 in 0/56 Lambda= 0.158893 statistics sampled from 18201 (18282) to 18201 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.578), E-opt: 0.2 (0.214), width: 16 Scan time: 7.270 The best scores are: opt bits E(85289) NP_733797 (OMIM: 603687) retinal dehydrogenase 2 i ( 480) 3185 739.4 5.1e-213 NP_733798 (OMIM: 603687) retinal dehydrogenase 2 i ( 422) 1652 387.9 2.8e-107 NP_001193826 (OMIM: 603687) retinal dehydrogenase ( 497) 1652 388.0 3.2e-107 NP_003879 (OMIM: 603687) retinal dehydrogenase 2 i ( 518) 1652 388.0 3.3e-107 NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [ ( 501) 1294 305.9 1.6e-82 NP_001280744 (OMIM: 600463,615113) aldehyde dehydr ( 405) 1271 300.6 5.4e-81 NP_000684 (OMIM: 600463,615113) aldehyde dehydroge ( 512) 1271 300.7 6.4e-81 NP_001191818 (OMIM: 100650,610251) aldehyde dehydr ( 470) 1201 284.6 4.1e-76 NP_000681 (OMIM: 100650,610251) aldehyde dehydroge ( 517) 1201 284.6 4.4e-76 NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, ( 517) 1180 279.8 1.2e-74 XP_011516104 (OMIM: 100670) PREDICTED: aldehyde de ( 517) 1180 279.8 1.2e-74 NP_001257294 (OMIM: 600249) cytosolic 10-formyltet ( 801) 870 208.9 4.2e-53 XP_016861103 (OMIM: 600249) PREDICTED: cytosolic 1 ( 828) 870 208.9 4.3e-53 XP_016861102 (OMIM: 600249) PREDICTED: cytosolic 1 ( 838) 870 208.9 4.4e-53 XP_011510657 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 870 209.0 4.6e-53 NP_036322 (OMIM: 600249) cytosolic 10-formyltetrah ( 902) 870 209.0 4.6e-53 XP_006713544 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 870 209.0 4.6e-53 NP_001257293 (OMIM: 600249) cytosolic 10-formyltet ( 912) 870 209.0 4.7e-53 XP_011536288 (OMIM: 613584) PREDICTED: mitochondri ( 777) 829 199.5 2.8e-50 XP_016874378 (OMIM: 613584) PREDICTED: mitochondri ( 777) 829 199.5 2.8e-50 NP_001029345 (OMIM: 613584) mitochondrial 10-formy ( 923) 829 199.6 3.2e-50 NP_001180409 (OMIM: 606467) aldehyde dehydrogenase ( 437) 821 197.5 6.4e-50 XP_011507596 (OMIM: 602733) PREDICTED: 4-trimethyl ( 424) 683 165.8 2.1e-40 NP_000687 (OMIM: 602733) 4-trimethylaminobutyralde ( 518) 683 165.9 2.4e-40 NP_072090 (OMIM: 606467) aldehyde dehydrogenase fa ( 487) 628 153.3 1.5e-36 XP_011536290 (OMIM: 613584) PREDICTED: mitochondri ( 622) 578 141.9 4.9e-33 NP_001071 (OMIM: 271980,610045) succinate-semialde ( 535) 542 133.6 1.3e-30 NP_733936 (OMIM: 271980,610045) succinate-semialde ( 548) 542 133.6 1.4e-30 NP_001188306 (OMIM: 107323,266100) alpha-aminoadip ( 511) 472 117.5 8.8e-26 NP_001173 (OMIM: 107323,266100) alpha-aminoadipic ( 539) 472 117.5 9.1e-26 XP_011541719 (OMIM: 107323,266100) PREDICTED: alph ( 404) 466 116.1 1.9e-25 XP_016864982 (OMIM: 107323,266100) PREDICTED: alph ( 404) 466 116.1 1.9e-25 XP_011522033 (OMIM: 100660) PREDICTED: aldehyde de ( 380) 376 95.4 3e-19 NP_001317079 (OMIM: 100660) aldehyde dehydrogenase ( 380) 376 95.4 3e-19 NP_001128640 (OMIM: 100660) aldehyde dehydrogenase ( 453) 376 95.5 3.4e-19 NP_000682 (OMIM: 100660) aldehyde dehydrogenase, d ( 453) 376 95.5 3.4e-19 NP_001128639 (OMIM: 100660) aldehyde dehydrogenase ( 453) 376 95.5 3.4e-19 XP_005256579 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19 XP_005256580 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19 XP_005256581 (OMIM: 100660) PREDICTED: aldehyde de ( 570) 376 95.6 4e-19 NP_739577 (OMIM: 606467) aldehyde dehydrogenase fa ( 433) 369 93.9 9.9e-19 XP_016879846 (OMIM: 270200,609523) PREDICTED: fatt ( 485) 361 92.1 3.9e-18 XP_016879845 (OMIM: 270200,609523) PREDICTED: fatt ( 485) 361 92.1 3.9e-18 NP_000373 (OMIM: 270200,609523) fatty aldehyde deh ( 485) 361 92.1 3.9e-18 XP_011522034 (OMIM: 270200,609523) PREDICTED: fatt ( 508) 361 92.1 4e-18 XP_011522035 (OMIM: 270200,609523) PREDICTED: fatt ( 508) 361 92.1 4e-18 NP_001026976 (OMIM: 270200,609523) fatty aldehyde ( 508) 361 92.1 4e-18 XP_016879844 (OMIM: 270200,609523) PREDICTED: fatt ( 424) 333 85.6 3e-16 XP_016879847 (OMIM: 270200,609523) PREDICTED: fatt ( 424) 333 85.6 3e-16 NP_005580 (OMIM: 603178,614105) methylmalonate-sem ( 535) 323 83.4 1.7e-15 >>NP_733797 (OMIM: 603687) retinal dehydrogenase 2 isofo (480 aa) initn: 3185 init1: 3185 opt: 3185 Z-score: 3945.3 bits: 739.4 E(85289): 5.1e-213 Smith-Waterman score: 3185; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 430 440 450 460 470 480 >>NP_733798 (OMIM: 603687) retinal dehydrogenase 2 isofo (422 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2046.9 bits: 387.9 E(85289): 2.8e-107 Smith-Waterman score: 2466; 91.0% identity (91.0% similar) in 422 aa overlap (97-480:1-422) 70 80 90 100 110 120 pF1KE6 CEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESL :::::::::::::::::::::::::::::: NP_733 MDASERGRLLDKLADLVERDRAVLATMESL 10 20 30 130 140 150 160 170 180 pF1KE6 NGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 NGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPW 40 50 60 70 80 90 190 200 210 220 pF1KE6 NFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------ :::::::::::::::::::::::::::::::::::::::::: NP_733 NFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTA 100 110 120 130 140 150 230 240 250 260 pF1KE6 --------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVE :::::::::::::::::::::::::::::::::::::::: NP_733 GAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE6 QAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 QAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKK 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE6 QYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 QYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE6 RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGF 340 350 360 370 380 390 450 460 470 480 pF1KE6 KMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::::::::::::::::::::::::::::: NP_733 KMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 400 410 420 >>NP_001193826 (OMIM: 603687) retinal dehydrogenase 2 is (497 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2045.9 bits: 388.0 E(85289): 3.2e-107 Smith-Waterman score: 2856; 91.5% identity (91.5% similar) in 484 aa overlap (35-480:14-497) 10 20 30 40 50 60 pF1KE6 KIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGE :: ::::::::::::::::::::::::: NP_001 MKNQCETVWLKSPIKLKLIFINNEWQNSESGRVFPVYNPATGE 10 20 30 40 70 80 90 100 110 120 pF1KE6 QVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATME 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 SLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQII 110 120 130 140 150 160 190 200 210 220 pF1KE6 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE---------------- :::::::::::::::::::::::::::::::::::::::::::: NP_001 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGP 170 180 190 200 210 220 230 240 250 260 pF1KE6 ----------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA :::::::::::::::::::::::::::::::::::::: NP_001 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE6 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE6 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQE 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE6 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFG 410 420 430 440 450 460 450 460 470 480 pF1KE6 GFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::::::::::::::::::::::::::::::: NP_001 GFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 470 480 490 >>NP_003879 (OMIM: 603687) retinal dehydrogenase 2 isofo (518 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2045.7 bits: 388.0 E(85289): 3.3e-107 Smith-Waterman score: 3066; 92.6% identity (92.6% similar) in 512 aa overlap (7-480:7-518) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 130 140 150 160 170 180 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ :::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP 190 200 210 220 230 240 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD :::::::::::::::::::::::::::::::::: NP_003 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 430 440 450 460 470 480 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::::::::::::::::::::::::::::::::::: NP_003 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 490 500 510 >>NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [Homo (501 aa) initn: 1294 init1: 1294 opt: 1294 Z-score: 1602.3 bits: 305.9 E(85289): 1.6e-82 Smith-Waterman score: 2212; 66.7% identity (84.0% similar) in 493 aa overlap (26-480:9-501) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :: .:.:.::::::::::..: ::. :::.:: NP_000 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNP 10 20 30 40 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL :: :..:.:.:.:: :.::::.::: ::..:: :: :::::::::: :::::.:::: .: NP_000 ATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :::::.:::: . .:. :: : :::.:: :::::::.: :::.::..::.::::::::: NP_000 ATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVC 110 120 130 140 150 160 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ ::::::::::.:. :::.::: ::::::.::::::::.::....:::: NP_000 GQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVP 170 180 190 200 210 220 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD :::::.::::.::::::::::::::: :..:::: NP_000 GYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADAD 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG :: ::: ::.:::..::::: :.::::::::::.:::::::::::. ..:.:. : . :: NP_000 LDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQG 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG :::::.::.:::.::.:: ::::::::: : ::.:..:::::::::.:::::::::: NP_000 PQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ :::.:..::..:.::.::::. .:: :.:::.::.::.:.:::.::::::.:::....:: NP_000 PVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQ 410 420 430 440 450 460 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::::::::::.::.:..::.::::::::: :::: NP_000 CPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 470 480 490 500 >>NP_001280744 (OMIM: 600463,615113) aldehyde dehydrogen (405 aa) initn: 1694 init1: 1271 opt: 1271 Z-score: 1575.1 bits: 300.6 E(85289): 5.4e-81 Smith-Waterman score: 1584; 57.7% identity (74.7% similar) in 454 aa overlap (26-479:20-404) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :: : :::.:.:::::::::..:.::. : . :: NP_001 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL .: ::.:::.:.:: :.::::.::..::. :: :::.:: ::::: .::::::::::.: NP_001 STREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC : ::. : :: NP_001 A-----------------------------AGF----------------------PPGVV 120 190 200 210 220 230 240 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS . :.: : . : . : . : .. . :. :::::..:::.:: NP_001 N-IVPGFGPTVGAAISSHPQI---NKIA------------FTGS--TEVGKLVKEAASRS 130 140 150 160 250 260 270 280 290 300 pF1KE6 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR ::::::::::::.: :. :::::: ::: :::::::::::::::.::.::::..: :::: NP_001 NLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVR 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE6 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF :::: ::.: ::.::: ::::::::.::..::::::.:: :::::::::... ::.: NP_001 RSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLF 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE6 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL :.:::::.:::.::::::::::::: ::.::...:::.:::..:.::.:::::....::: NP_001 IKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKAL 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE6 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS ..::...::::::::::: ::.:::::::::::::.::..: ::.::::::.:. .:: NP_001 KLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP 350 360 370 380 390 400 >>NP_000684 (OMIM: 600463,615113) aldehyde dehydrogenase (512 aa) initn: 1271 init1: 1271 opt: 1271 Z-score: 1573.7 bits: 300.7 E(85289): 6.4e-81 Smith-Waterman score: 2195; 65.9% identity (84.1% similar) in 492 aa overlap (26-479:20-511) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :: : :::.:.:::::::::..:.::. : . :: NP_000 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL .: ::.:::.:.:: :.::::.::..::. :: :::.:: ::::: .::::::::::.: NP_000 STREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :..:... :::::.::..::.: :.:.::.:::::::.: :::.: . :::::::::: NP_000 AALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVC 120 130 140 150 160 170 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ : : ::::::::..::.:::::::::.:.::::::::.:::.:.:::: NP_000 GAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVP 180 190 200 210 220 230 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD ::::..:::.::::::::::::::.: :. :::: NP_000 GFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADAD 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG :: ::: :::::::::::::::.::.::::..: :::::::: ::.: ::.::: :::: NP_000 LDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG ::::.::..::::::.:: :::::::::... ::.::.:::::.:::.:::::::::: NP_000 PQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFG 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ ::: ::.::...:::.:::..:.::.:::::....::: ..::...::::::::::: :: NP_000 PVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQ 420 430 440 450 460 470 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS .:::::::::::::.::..: ::.::::::.:. .:: NP_000 APFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP 480 490 500 510 >>NP_001191818 (OMIM: 100650,610251) aldehyde dehydrogen (470 aa) initn: 1347 init1: 1201 opt: 1201 Z-score: 1487.5 bits: 284.6 E(85289): 4.1e-76 Smith-Waterman score: 1728; 54.2% identity (73.1% similar) in 498 aa overlap (21-480:20-470) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :. . .:.:. . :. ..:::::::... : ..::. :: NP_001 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL .::: .:.: :.::: NP_001 STGEVICQVAEGDKA--------------------------------------------- 60 70 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC .:.:..:::.. .. :::. :.: .::::::::: :: :::.:::.:..:::::.::: NP_001 --LETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVC 80 90 100 110 120 130 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ :::::::::::: :::..::: ::.::.: ::::::.:::.. :::: NP_001 GQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVP 140 150 160 170 180 190 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD .:..:: ::: ::::::::::::::::::..::: NP_001 GFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDAD 200 210 220 230 240 250 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG .:.:::::: ..:::::::: :::: ::.:.::.:::.::: ::: ::::.::: :::: NP_001 MDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQG 260 270 280 290 300 310 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG ::.:. :..::: :..: ::::: ::: . .:.::.::::..: : : :::::::: NP_001 PQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFG 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ ::..::.:::..::. ::::: .::.:::::.:..:: .:.:.::::::.:::....:: NP_001 PVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQ 380 390 400 410 420 430 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::.::::.:::.::.::. :.::::::::.::::: NP_001 SPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 440 450 460 470 >>NP_000681 (OMIM: 100650,610251) aldehyde dehydrogenase (517 aa) initn: 1201 init1: 1201 opt: 1201 Z-score: 1486.9 bits: 284.6 E(85289): 4.4e-76 Smith-Waterman score: 2062; 61.0% identity (81.7% similar) in 498 aa overlap (21-480:20-517) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP :. . .:.:. . :. ..:::::::... : ..::. :: NP_000 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL .::: .:.: :.:: :.::::.::: ::.::: :::::::.:::::..::::.::::. : NP_000 STGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :..:.:..:::.. .. :::. :.: .::::::::: :: :::.:::.:..:::::.::: NP_000 AALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVC 120 130 140 150 160 170 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ :::::::::::: :::..::: ::.::.: ::::::.:::.. :::: NP_000 GQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVP 180 190 200 210 220 230 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD .:..:: ::: ::::::::::::::::::..::: NP_000 GFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDAD 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG .:.:::::: ..:::::::: :::: ::.:.::.:::.::: ::: ::::.::: :::: NP_000 MDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG ::.:. :..::: :..: ::::: ::: . .:.::.::::..: : : :::::::: NP_000 PQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFG 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ ::..::.:::..::. ::::: .::.:::::.:..:: .:.:.::::::.:::....:: NP_000 PVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQ 420 430 440 450 460 470 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS :::::.::::.:::.::.::. :.::::::::.::::: NP_000 SPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 480 490 500 510 >>NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, mit (517 aa) initn: 1180 init1: 1180 opt: 1180 Z-score: 1460.9 bits: 279.8 E(85289): 1.2e-74 Smith-Waterman score: 2051; 60.5% identity (81.4% similar) in 501 aa overlap (18-480:17-517) 10 20 30 40 50 60 pF1KE6 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP : ..: :::: : .: :...:::::::.. : ..::. :: NP_000 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL .::: . .: :.:.::.:.::.::: :: ::: :::::::::::::..:::::::::. : NP_000 TTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC :..:.:..:::: ... .::. :::..::.:::::: :: :::.::..: ::::::.::: NP_000 ASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVC 120 130 140 150 160 170 190 200 210 220 pF1KE6 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ ::::::::::.: .::.:::: :::::.: ::::::::::...:::: NP_000 GQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIIT 180 190 200 210 220 230 230 240 250 260 pF1KE6 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD ::.:::.::: :::::::::::::::.:..:::: NP_000 GYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADAD 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE6 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG ...:::: :...:::.:::: :::: :::::::.::..:.::.::.: ::.::. :.:: NP_000 MEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE6 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG ::.::.:....: :: : ::::: :::. .:..::::.::::..: :::::::::::: NP_000 PQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFG 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE6 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ ::: ...:: ..::.:::::. .::.::::: :..::. ..:.::::::.: :: .. . NP_000 PVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCH 420 430 440 450 460 470 450 460 470 480 pF1KE6 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS .:::::: ::::::.:: ::. :.::::::.:.::::: NP_000 TPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS 480 490 500 510 480 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:03:37 2016 done: Tue Nov 8 13:03:39 2016 Total Scan time: 7.270 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]