FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6338, 313 aa 1>>>pF1KE6338 313 - 313 aa - 313 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3640+/-0.000399; mu= 15.1987+/- 0.025 mean_var=68.7673+/-14.250, 0's: 0 Z-trim(113.0): 16 B-trim: 1200 in 2/48 Lambda= 0.154662 statistics sampled from 22089 (22098) to 22089 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.259), width: 16 Scan time: 4.680 The best scores are: opt bits E(85289) NP_001121557 (OMIM: 271900,608034) aspartoacylase ( 313) 2146 487.9 1.1e-137 XP_016880150 (OMIM: 271900,608034) PREDICTED: aspa ( 313) 2146 487.9 1.1e-137 NP_000040 (OMIM: 271900,608034) aspartoacylase [Ho ( 313) 2146 487.9 1.1e-137 NP_542389 (OMIM: 614413) N-acyl-aromatic-L-amino a ( 319) 981 228.0 2e-59 XP_016874039 (OMIM: 614413) PREDICTED: N-acyl-arom ( 326) 961 223.5 4.5e-58 XP_016874038 (OMIM: 614413) PREDICTED: N-acyl-arom ( 326) 961 223.5 4.5e-58 XP_016874040 (OMIM: 614413) PREDICTED: N-acyl-arom ( 302) 877 204.8 1.8e-52 >>NP_001121557 (OMIM: 271900,608034) aspartoacylase [Hom (313 aa) initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137 Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK 250 260 270 280 290 300 310 pF1KE6 LTLNAKSIRCCLH ::::::::::::: NP_001 LTLNAKSIRCCLH 310 >>XP_016880150 (OMIM: 271900,608034) PREDICTED: aspartoa (313 aa) initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137 Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK 250 260 270 280 290 300 310 pF1KE6 LTLNAKSIRCCLH ::::::::::::: XP_016 LTLNAKSIRCCLH 310 >>NP_000040 (OMIM: 271900,608034) aspartoacylase [Homo s (313 aa) initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137 Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK 250 260 270 280 290 300 310 pF1KE6 LTLNAKSIRCCLH ::::::::::::: NP_000 LTLNAKSIRCCLH 310 >>NP_542389 (OMIM: 614413) N-acyl-aromatic-L-amino acid (319 aa) initn: 980 init1: 961 opt: 981 Z-score: 1187.9 bits: 228.0 E(85289): 2e-59 Smith-Waterman score: 981; 44.8% identity (76.0% similar) in 308 aa overlap (1-308:1-308) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK : : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :.. NP_542 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS : ::.: :::: : :... . : :::: ::.:.:.:.::: : ...:...::::::. NP_542 CRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG ::: :: ..:.. : ... .... . : : :.: .. . . . :.:: .:.:.: NP_542 NMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA :::::::::::...:: .. .::::. ::.: :: .:.:. . ::.:: : :..: NP_542 PQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK . .::.:::.:..::.:: :.: ..:. . :. ::::::.:::::::: ::..: : NP_542 GTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK 250 260 270 280 290 300 310 pF1KE6 LTLNAKSIRCCLH .:... .. NP_542 FTFTVPAMPALTPAPSPAS 310 >>XP_016874039 (OMIM: 614413) PREDICTED: N-acyl-aromatic (326 aa) initn: 946 init1: 716 opt: 961 Z-score: 1163.6 bits: 223.5 E(85289): 4.5e-58 Smith-Waterman score: 961; 43.8% identity (74.6% similar) in 315 aa overlap (1-308:1-315) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK : : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :.. XP_016 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF : ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:... XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY ::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.:: XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR .:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.:: XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE : :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.:::::::: XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV 250 260 270 280 290 300 300 310 pF1KE6 AFAKTTKLTLNAKSIRCCLH ::..: :.:... .. XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS 310 320 >>XP_016874038 (OMIM: 614413) PREDICTED: N-acyl-aromatic (326 aa) initn: 946 init1: 716 opt: 961 Z-score: 1163.6 bits: 223.5 E(85289): 4.5e-58 Smith-Waterman score: 961; 43.8% identity (74.6% similar) in 315 aa overlap (1-308:1-315) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK : : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :.. XP_016 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF : ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:... XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY ::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.:: XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR .:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.:: XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE : :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.:::::::: XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV 250 260 270 280 290 300 300 310 pF1KE6 AFAKTTKLTLNAKSIRCCLH ::..: :.:... .. XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS 310 320 >>XP_016874040 (OMIM: 614413) PREDICTED: N-acyl-aromatic (302 aa) initn: 877 init1: 716 opt: 877 Z-score: 1062.8 bits: 204.8 E(85289): 1.8e-52 Smith-Waterman score: 877; 43.3% identity (74.6% similar) in 291 aa overlap (25-308:1-291) 10 20 30 40 50 60 pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK ..::.:..:::. ::.::... . : ..:: :.. XP_016 MSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG 10 20 30 70 80 90 100 110 pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF : ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:... XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY ::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.:: XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR .:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.:: XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE : :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.:::::::: XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV 220 230 240 250 260 270 300 310 pF1KE6 AFAKTTKLTLNAKSIRCCLH ::..: :.:... .. XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS 280 290 300 313 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:14:53 2016 done: Tue Nov 8 12:14:54 2016 Total Scan time: 4.680 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]