Result of FASTA (omim) for
pFN21AE6233
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6233, 291 aa
1>>>pF1KE6233 291 - 291 aa - 291 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9436+/-0.000345; mu= 17.4866+/- 0.021
mean_var=63.0144+/-12.707, 0's: 0 Z-trim(114.5): 10 B-trim: 0 in 0/51
Lambda= 0.161568
statistics sampled from 24325 (24332) to 24325 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.285), width: 16
Scan time: 6.000
The best scores are: opt bits E(85289)
NP_000696 (OMIM: 137217) potassium-transporting AT ( 291) 2032 482.0 5.6e-136
NP_001669 (OMIM: 182331) sodium/potassium-transpor ( 290) 785 191.4 1.8e-48
NP_001290192 (OMIM: 182331) sodium/potassium-trans ( 208) 490 122.5 6.8e-28
NP_001670 (OMIM: 601867) sodium/potassium-transpor ( 279) 457 114.9 1.8e-25
NP_001668 (OMIM: 145500,182330) sodium/potassium-t ( 303) 389 99.1 1.1e-20
>>NP_000696 (OMIM: 137217) potassium-transporting ATPase (291 aa)
initn: 2032 init1: 2032 opt: 2032 Z-score: 2562.2 bits: 482.0 E(85289): 5.6e-136
Smith-Waterman score: 2032; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291)
10 20 30 40 50 60
pF1KE6 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
190 200 210 220 230 240
250 260 270 280 290
pF1KE6 YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
250 260 270 280 290
>>NP_001669 (OMIM: 182331) sodium/potassium-transporting (290 aa)
initn: 704 init1: 314 opt: 785 Z-score: 991.3 bits: 191.4 E(85289): 1.8e-48
Smith-Waterman score: 785; 39.2% identity (73.0% similar) in 296 aa overlap (1-291:1-289)
10 20 30 40 50 60
pF1KE6 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
:. .:::.::: .::.... ::: : :..::: . :..: :.:..:: .:..:.: ..
NP_001 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
:..:::. .:: :::.: .::. .:: . ..:... ::::...: . .: :. :: :
NP_001 VMLQTVSDHTPKYQDRLATPGLMIRPKT---ENLDVIVNVSDTESWDQHVQKLNKFLEPY
70 80 90 100 110
130 140 150 160 170
pF1KE6 SPA--AQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADP-NFGFEEGKP
. . ::.... : .:. : . . :. : .:.:. .: ::::..: ..:. :.:
NP_001 NDSIQAQKNDV-CRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 CFIIKMNRIVKFLPSNGSAPRVDCAFL-DQPRE-LGQPLQVKYYPPNGTFSLHYFPYYGK
: .:::::...: . ... : :: :. : ::. .. .: ::...: :::::::
NP_001 CVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVM---FPANGNIDLMYFPYYGK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 KAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
: . .:..::::.:.::. :.:: . :.. : ... .. .: . :.: :::.:.:
NP_001 KFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
240 250 260 270 280 290
>>NP_001290192 (OMIM: 182331) sodium/potassium-transport (208 aa)
initn: 404 init1: 248 opt: 490 Z-score: 621.8 bits: 122.5 E(85289): 6.8e-28
Smith-Waterman score: 490; 36.6% identity (70.0% similar) in 213 aa overlap (84-291:2-207)
60 70 80 90 100 110
pF1KE6 LFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTL
.:: . ..:... ::::...: . .: :
NP_001 MIRPKT---ENLDVIVNVSDTESWDQHVQKL
10 20
120 130 140 150 160 170
pF1KE6 HAFLAGYSPA--AQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADP-NF
. :: :. . ::.... : .:. : . . :. : .:.:. .: ::::..: ..
NP_001 NKFLEPYNDSIQAQKNDV-CRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHY
30 40 50 60 70 80
180 190 200 210 220
pF1KE6 GFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFL-DQPRE-LGQPLQVKYYPPNGTFSLH
:. :.:: .:::::...: . ... : :: :. : ::. .. .: ::...:
NP_001 GYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVM---FPANGNIDLM
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE6 YFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLK
:::::::: . .:..::::.:.::. :.:: . :.. : ... .. .: . :.: :::.
NP_001 YFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLR
150 160 170 180 190 200
290
pF1KE6 IEK
:.:
NP_001 INKT
>>NP_001670 (OMIM: 601867) sodium/potassium-transporting (279 aa)
initn: 580 init1: 237 opt: 457 Z-score: 578.4 bits: 114.9 E(85289): 1.8e-25
Smith-Waterman score: 632; 35.4% identity (66.0% similar) in 285 aa overlap (6-287:5-275)
10 20 30 40 50 60
pF1KE6 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
:::. .: . :.. . .:: ::..:::: . : : :.:..:: ...::.. ..
NP_001 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMW
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
:..::.. .: :.::. :::. . : .:: ... :: ..: . :. :: :
NP_001 VMLQTLNDEVPKYRDQIPSPGLMVFPKPV--TALEYTFSRSDPTSYAGYIEDLKKFLKPY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
. :.. : . : : ..: .. .:.: ..:: :::. ::.::. .:.::..
NP_001 TLEEQKNLTVCPDGALFEQ---KGPVYV--ACQFPISLLQACSGMNDPDFGYSQGNPCIL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
.:::::. . : . .::.::. .. : .: :: :: ..:.:::::::: .
NP_001 VKMNRIIGLKPEG--VPRIDCV----SKNEDIP-NVAVYPHNGMIDLKYFPYYGKKLHVG
180 190 200 210 220
250 260 270 280 290
pF1KE6 YSNPLVAAKLLNIPRNA--EVAIVCKV-MAEHVTFNNPHDPYEGKVEFKLKIEK
: .::::... : :. ::.. ::. . .. .. .: . :.: ::.
NP_001 YLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
230 240 250 260 270
>>NP_001668 (OMIM: 145500,182330) sodium/potassium-trans (303 aa)
initn: 477 init1: 194 opt: 389 Z-score: 492.2 bits: 99.1 E(85289): 1.1e-20
Smith-Waterman score: 522; 30.1% identity (61.8% similar) in 306 aa overlap (11-290:4-302)
10 20 30 40 50
pF1KE6 MAALQEKKTCGQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALC
:. :: .... :: . ..:::: . : : :.:: :: ..:.:
NP_001 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGT
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 LYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLA
. :.. :.. . : :::.. ::.: :.. . :: . .: ... . .. ::
NP_001 IQVMLLTISEFKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 GYSPAAQEDSI---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFE
:. .::.:.. .: . .: .: . :.: . : ::::: : ..:..
NP_001 KYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYK
120 130 140 150 160 170
180 190 200 210
pF1KE6 EGKPCFIIKMNRIVKFLPS---------------NGSAPRVDCAFL-DQPRE-LGQPLQV
:::::.:::.::.. : :. : .. :.:. :. .. .:. :
NP_001 EGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGN---V
180 190 200 210 220
220 230 240 250 260 270
pF1KE6 KYYPPNGT--FSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNN
.:. ... : :.:.::::: ::.: .::.:... :. ..:. : ::...:.. ...
NP_001 EYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE
230 240 250 260 270 280
280 290
pF1KE6 PHDPYEGKVEFKLKIEK
.: ..:. . :....
NP_001 -KDRFQGRFDVKIEVKS
290 300
291 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:19:09 2016 done: Tue Nov 8 11:19:10 2016
Total Scan time: 6.000 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]