FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6227, 219 aa 1>>>pF1KE6227 219 - 219 aa - 219 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7590+/-0.000419; mu= 16.8943+/- 0.026 mean_var=64.7865+/-13.393, 0's: 0 Z-trim(110.0): 40 B-trim: 89 in 1/51 Lambda= 0.159343 statistics sampled from 18260 (18289) to 18260 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.214), width: 16 Scan time: 4.000 The best scores are: opt bits E(85289) NP_872354 (OMIM: 609427,610265) tetraspan membrane ( 219) 1489 351.1 8.2e-97 XP_005250384 (OMIM: 609719) PREDICTED: lipoma HMGI ( 232) 1069 254.6 1e-67 NP_945351 (OMIM: 609719) lipoma HMGIC fusion partn ( 236) 1066 253.9 1.6e-67 NP_940962 (OMIM: 610240) lipoma HMGIC fusion partn ( 247) 994 237.4 1.6e-62 XP_016861848 (OMIM: 610240) PREDICTED: lipoma HMGI ( 247) 994 237.4 1.6e-62 XP_016861849 (OMIM: 610240) PREDICTED: lipoma HMGI ( 138) 653 158.8 4.1e-39 NP_005771 (OMIM: 606710) lipoma HMGIC fusion partn ( 200) 278 72.7 4.9e-13 XP_011533163 (OMIM: 606710) PREDICTED: lipoma HMGI ( 200) 278 72.7 4.9e-13 XP_006714578 (OMIM: 609718) PREDICTED: lipoma HMGI ( 228) 242 64.5 1.7e-10 NP_005770 (OMIM: 609718) lipoma HMGIC fusion partn ( 228) 242 64.5 1.7e-10 XP_011529246 (OMIM: 300566) PREDICTED: lipoma HMGI ( 220) 231 61.9 9.4e-10 NP_835469 (OMIM: 300566) lipoma HMGIC fusion partn ( 220) 231 61.9 9.4e-10 XP_011529245 (OMIM: 300566) PREDICTED: lipoma HMGI ( 243) 231 62.0 1e-09 XP_016884974 (OMIM: 300566) PREDICTED: lipoma HMGI ( 243) 231 62.0 1e-09 >>NP_872354 (OMIM: 609427,610265) tetraspan membrane pro (219 aa) initn: 1489 init1: 1489 opt: 1489 Z-score: 1859.1 bits: 351.1 E(85289): 8.2e-97 Smith-Waterman score: 1489; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219) 10 20 30 40 50 60 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 YFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 CNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 CNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFM 130 140 150 160 170 180 190 200 210 pF1KE6 LAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV ::::::::::::::::::::::::::::::::::::::: NP_872 LAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV 190 200 210 >>XP_005250384 (OMIM: 609719) PREDICTED: lipoma HMGIC fu (232 aa) initn: 1082 init1: 1066 opt: 1069 Z-score: 1336.9 bits: 254.6 E(85289): 1e-67 Smith-Waterman score: 1069; 66.5% identity (90.7% similar) in 215 aa overlap (4-218:15-229) 10 20 30 40 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYW .::::::::.:::::::::::.::.:. .::::... .. :::::: XP_005 MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIVNVVCFIQPYW 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 IGDSVNTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLII :::.:.:::::::::: ::.:: .: :: :.:. :::..:: :::.: ::..:.:.::: XP_005 IGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLII 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE6 GSIICFSLFFICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYT . ::::.:::.:::::::::::::::..:. :..::...::::::.::.:::::.: ::: XP_005 ACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWDSDEVKRMCGEKTDKYT 130 140 150 160 170 180 170 180 190 200 210 pF1KE6 LGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV :: :..:::..:::..: ::::::::::::: :::.:. .. ::.. .. XP_005 LGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEELKAENKDDGNA 190 200 210 220 230 >>NP_945351 (OMIM: 609719) lipoma HMGIC fusion partner-l (236 aa) initn: 1081 init1: 1063 opt: 1066 Z-score: 1333.1 bits: 253.9 E(85289): 1.6e-67 Smith-Waterman score: 1066; 67.8% identity (91.0% similar) in 211 aa overlap (4-214:15-225) 10 20 30 40 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYW .::::::::.:::::::::::.::.:. .::::... .. :::::: NP_945 MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIVNVVCFIQPYW 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 IGDSVNTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLII :::.:.:::::::::: ::.:: .: :: :.:. :::..:: :::.: ::..:.:.::: NP_945 IGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLII 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE6 GSIICFSLFFICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYT . ::::.:::.:::::::::::::::..:. :..::...::::::.::.:::::.: ::: NP_945 ACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWDSDEVKRMCGEKTDKYT 130 140 150 160 170 180 170 180 190 200 210 pF1KE6 LGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV :: :..:::..:::..: ::::::::::::: :::.:. .. ::. NP_945 LGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEELKAENKVLLSQYSLE 190 200 210 220 230 >>NP_940962 (OMIM: 610240) lipoma HMGIC fusion partner-l (247 aa) initn: 989 init1: 649 opt: 994 Z-score: 1243.4 bits: 237.4 E(85289): 1.6e-62 Smith-Waterman score: 994; 61.8% identity (84.8% similar) in 217 aa overlap (4-219:1-217) 10 20 30 40 50 60 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG .::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. : NP_940 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG 10 20 30 40 50 70 80 90 100 110 pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF ::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : :::::: NP_940 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF .::::::::::::::: :: :..::...:::::. .: ::: .::::.:: :..:::. NP_940 FCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAY 120 130 140 150 160 170 180 190 200 210 pF1KE6 MLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV .:::..: .:::::::::::: :: :: .. : .. . : NP_940 ILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVL 180 190 200 210 220 230 NP_940 PCPVAHSQGP 240 >>XP_016861848 (OMIM: 610240) PREDICTED: lipoma HMGIC fu (247 aa) initn: 989 init1: 649 opt: 994 Z-score: 1243.4 bits: 237.4 E(85289): 1.6e-62 Smith-Waterman score: 994; 61.8% identity (84.8% similar) in 217 aa overlap (4-219:1-217) 10 20 30 40 50 60 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG .::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. : XP_016 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG 10 20 30 40 50 70 80 90 100 110 pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF ::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : :::::: XP_016 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF .::::::::::::::: :: :..::...:::::. .: ::: .::::.:: :..:::. XP_016 FCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAY 120 130 140 150 160 170 180 190 200 210 pF1KE6 MLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV .:::..: .:::::::::::: :: :: .. : .. . : XP_016 ILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVL 180 190 200 210 220 230 XP_016 PCPVAHSQGP 240 >>XP_016861849 (OMIM: 610240) PREDICTED: lipoma HMGIC fu (138 aa) initn: 648 init1: 354 opt: 653 Z-score: 823.2 bits: 158.8 E(85289): 4.1e-39 Smith-Waterman score: 653; 65.9% identity (87.4% similar) in 135 aa overlap (4-137:1-135) 10 20 30 40 50 60 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG .::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. : XP_016 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG 10 20 30 40 50 70 80 90 100 110 pF1KE6 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF ::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : :::::: XP_016 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF .::::::::::::::: : XP_016 FCNTATVYKICAWMQLLAGGM 120 130 >>NP_005771 (OMIM: 606710) lipoma HMGIC fusion partner p (200 aa) initn: 275 init1: 182 opt: 278 Z-score: 355.1 bits: 72.7 E(85289): 4.9e-13 Smith-Waterman score: 282; 30.3% identity (60.5% similar) in 195 aa overlap (26-203:9-195) 10 20 30 40 50 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLT-ICFSVLVMALFIQPYWI-GDSVNTPQ ::.:. :. .: .. ...:. :::. :.... : NP_005 MASSLTCTGVIWALLSFLCAATSCVGFFM-PYWLWGSQLGKPV 10 20 30 40 60 70 80 90 100 110 pF1KE6 AGYFGLFSYCVGNVL--SSELI-----CKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGS . :: : : : : ... : : .:..::: .. . ..:: :.. NP_005 S--FGTFRRCSYPVHDESRQMMVMVEEC-GRYASFQGIPSAEWRICTIVTGLGCGLLL-- 50 60 70 80 90 120 130 140 150 160 pF1KE6 IICFSLFFICNTA-----TVYKICAWMQLAAATGLMIG--CLVYPDGWDSSEVRRMCGEQ .. .. .. : .. :: .. . .:. . ::.:: : .:: :::: :::. :: NP_005 LVALTALMGCCVSDLISRTVGRVAGGIQFLG--GLLIGAGCALYPLGWDSEEVRQTCGYT 100 110 120 130 140 150 170 180 190 200 210 pF1KE6 TGKYTLGHCTIRWAFMLAILSIGDALIL-SFLAFVLGYRQDKLLPDDYKADGTEEV .:.. ::.: : ::.. . . :..: ..:: : .: NP_005 SGQFDLGKCEIGWAYYCTGAGATAAMLLCTWLACFSGKKQKHYPY 160 170 180 190 200 >>XP_011533163 (OMIM: 606710) PREDICTED: lipoma HMGIC fu (200 aa) initn: 275 init1: 182 opt: 278 Z-score: 355.1 bits: 72.7 E(85289): 4.9e-13 Smith-Waterman score: 282; 30.3% identity (60.5% similar) in 195 aa overlap (26-203:9-195) 10 20 30 40 50 pF1KE6 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLT-ICFSVLVMALFIQPYWI-GDSVNTPQ ::.:. :. .: .. ...:. :::. :.... : XP_011 MASSLTCTGVIWALLSFLCAATSCVGFFM-PYWLWGSQLGKPV 10 20 30 40 60 70 80 90 100 110 pF1KE6 AGYFGLFSYCVGNVL--SSELI-----CKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGS . :: : : : : ... : : .:..::: .. . ..:: :.. XP_011 S--FGTFRRCSYPVHDESRQMMVMVEEC-GRYASFQGIPSAEWRICTIVTGLGCGLLL-- 50 60 70 80 90 120 130 140 150 160 pF1KE6 IICFSLFFICNTA-----TVYKICAWMQLAAATGLMIG--CLVYPDGWDSSEVRRMCGEQ .. .. .. : .. :: .. . .:. . ::.:: : .:: :::: :::. :: XP_011 LVALTALMGCCVSDLISRTVGRVAGGIQFLG--GLLIGAGCALYPLGWDSEEVRQTCGYT 100 110 120 130 140 150 170 180 190 200 210 pF1KE6 TGKYTLGHCTIRWAFMLAILSIGDALIL-SFLAFVLGYRQDKLLPDDYKADGTEEV .:.. ::.: : ::.. . . :..: ..:: : .: XP_011 SGQFDLGKCEIGWAYYCTGAGATAAMLLCTWLACFSGKKQKHYPY 160 170 180 190 200 >>XP_006714578 (OMIM: 609718) PREDICTED: lipoma HMGIC fu (228 aa) initn: 147 init1: 130 opt: 242 Z-score: 309.6 bits: 64.5 E(85289): 1.7e-10 Smith-Waterman score: 242; 24.5% identity (56.5% similar) in 184 aa overlap (45-218:44-220) 20 30 40 50 60 70 pF1KE6 HTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAGYFGLFSYCVGNV-- ..: : . : .:... :. : XP_006 TLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYARCIRNPGV 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 --LSSELICKGGPL--DFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFICNTA---- .. . .: :: .:. : : .... .:.:.:.: :. . :.: .: . XP_006 QHFQRDTLC--GPYAESFGEIASGFWQATAIFLAVGIF-ILCMVALVSVFTMCVQSIMKK 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE6 TVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAIL .....:. .: :. :..: ..:: :: ... .::. .. : : :.. :::. :: XP_006 SIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI- 140 150 160 170 180 190 200 210 pF1KE6 SIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV . .:.:. :.. . . .: . :: XP_006 ---GGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICLL 190 200 210 220 >>NP_005770 (OMIM: 609718) lipoma HMGIC fusion partner-l (228 aa) initn: 147 init1: 130 opt: 242 Z-score: 309.6 bits: 64.5 E(85289): 1.7e-10 Smith-Waterman score: 242; 24.5% identity (56.5% similar) in 184 aa overlap (45-218:44-220) 20 30 40 50 60 70 pF1KE6 HTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAGYFGLFSYCVGNV-- ..: : . : .:... :. : NP_005 TLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYARCIRNPGV 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 --LSSELICKGGPL--DFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFICNTA---- .. . .: :: .:. : : .... .:.:.:.: :. . :.: .: . NP_005 QHFQRDTLC--GPYAESFGEIASGFWQATAIFLAVGIF-ILCMVALVSVFTMCVQSIMKK 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE6 TVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAIL .....:. .: :. :..: ..:: :: ... .::. .. : : :.. :::. :: NP_005 SIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI- 140 150 160 170 180 190 200 210 pF1KE6 SIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV . .:.:. :.. . . .: . :: NP_005 ---GGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICLL 190 200 210 220 219 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:15:57 2016 done: Tue Nov 8 11:15:58 2016 Total Scan time: 4.000 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]