FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1560, 246 aa 1>>>pF1KE1560 246 - 246 aa - 246 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0020+/-0.000324; mu= 15.8371+/- 0.020 mean_var=58.4872+/-12.035, 0's: 0 Z-trim(116.4): 299 B-trim: 2220 in 2/52 Lambda= 0.167704 statistics sampled from 27231 (27549) to 27231 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.323), width: 16 Scan time: 6.950 The best scores are: opt bits E(85289) NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 1676 413.4 1.9e-115 XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 1445 357.4 1.1e-98 NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 1178 292.9 3.6e-79 NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 1104 275.0 8.4e-74 NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 982 245.5 6.9e-65 NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 916 229.4 3.3e-60 XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 910 228.0 1.3e-59 NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 775 195.4 8e-50 NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 765 192.8 3e-49 NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 567 145.1 1.2e-34 NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 555 142.2 9e-34 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 552 141.4 1.5e-33 NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 548 140.5 2.9e-33 NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 548 140.5 2.9e-33 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 548 140.5 3.3e-33 NP_001919 (OMIM: 134350,613912) complement factor ( 253) 537 137.8 1.8e-32 NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 535 137.3 2.5e-32 NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 531 136.3 4.9e-32 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 518 133.2 4.2e-31 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 518 133.2 4.2e-31 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 518 133.2 4.7e-31 NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 505 130.0 3.8e-30 NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 488 125.9 6.4e-29 XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 488 126.1 1.1e-28 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 482 124.5 1.9e-28 NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 481 124.2 2.1e-28 NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 481 124.2 2.1e-28 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 480 124.0 2.5e-28 NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 472 122.1 9.6e-28 NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 472 122.1 9.6e-28 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 465 120.4 3.1e-27 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 453 117.5 2.3e-26 XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 441 114.5 1.5e-25 NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 440 114.3 2e-25 NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 439 114.1 2.4e-25 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 439 114.1 2.5e-25 NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 435 113.1 5.5e-25 NP_001691 (OMIM: 162815) azurocidin preproprotein ( 251) 434 112.9 5.6e-25 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 433 112.6 6.4e-25 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 433 112.7 8.4e-25 NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 432 112.4 8.9e-25 XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 432 112.4 8.9e-25 XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 432 112.4 8.9e-25 NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 432 112.4 8.9e-25 NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 432 112.4 8.9e-25 NP_001245280 (OMIM: 600311) granzyme M isoform 2 [ ( 218) 423 110.2 3.1e-24 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 426 111.3 6.9e-24 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 426 111.3 7e-24 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 426 111.3 7e-24 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 426 111.3 7.1e-24 >>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa) initn: 1676 init1: 1676 opt: 1676 Z-score: 2193.6 bits: 413.4 E(85289): 1.9e-115 Smith-Waterman score: 1676; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_219 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_219 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_219 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK 190 200 210 220 230 240 pF1KE1 RTMKRL :::::: NP_219 RTMKRL >>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa) initn: 1445 init1: 1445 opt: 1445 Z-score: 1892.5 bits: 357.4 E(85289): 1.1e-98 Smith-Waterman score: 1445; 100.0% identity (100.0% similar) in 212 aa overlap (35-246:1-212) 10 20 30 40 50 60 pF1KE1 LLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAH :::::::::::::::::::::::::::::: XP_011 MAFVQFLQEKSRKRCGGILVRKDFVLTAAH 10 20 30 70 80 90 100 110 120 pF1KE1 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK 160 170 180 190 200 210 pF1KE1 RL :: XP_011 RL >>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa) initn: 1178 init1: 837 opt: 1178 Z-score: 1542.4 bits: 292.9 E(85289): 3.6e-79 Smith-Waterman score: 1178; 71.5% identity (85.8% similar) in 246 aa overlap (1-245:1-246) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::.:::::::: : : . :::::::::::::::::.... ..:: :::::.:.: :::: NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW ::::: ::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_004 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN : ::.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: .. NP_004 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI :. . :.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. :: NP_004 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 190 200 210 220 230 240 240 pF1KE1 KRTMKRL :.:::: NP_004 KKTMKRY >>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa) initn: 1104 init1: 763 opt: 1104 Z-score: 1446.0 bits: 275.0 E(85289): 8.4e-74 Smith-Waterman score: 1104; 71.8% identity (86.3% similar) in 227 aa overlap (20-245:8-234) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::::::::::::::::.... ..:: :::::.:.: :::: NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 10 20 30 40 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW ::::: ::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 50 60 70 80 90 100 130 140 150 160 170 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGN : ::.::::::.:::::::: ::::::: .. .. . ::::: .:::.: .:: .. NP_001 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWI :. . :.:::::. .:.:::::::::::. :::::.::: ..: :: . ::: :. :: NP_001 YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 170 180 190 200 210 220 240 pF1KE1 KRTMKRL :.:::: NP_001 KKTMKRY 230 >>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa) initn: 967 init1: 707 opt: 982 Z-score: 1285.9 bits: 245.5 E(85289): 6.9e-65 Smith-Waterman score: 982; 57.8% identity (82.0% similar) in 244 aa overlap (1-244:1-243) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.:::: NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW ::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :... NP_001 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY . : :. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.: NP_001 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSY 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK . .::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::. NP_001 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIR 180 190 200 210 220 230 pF1KE1 RTMKRL ::. NP_001 TTMRSFKLLDQMETPL 240 250 >>NP_001257709 (OMIM: 116831) granzyme H isoform 2 precu (182 aa) initn: 907 init1: 907 opt: 916 Z-score: 1201.8 bits: 229.4 E(85289): 3.3e-60 Smith-Waterman score: 1099; 74.0% identity (74.0% similar) in 246 aa overlap (1-246:1-182) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY ::::::::::::::: NP_001 TTAVRPLRLPSSKAQ--------------------------------------------- 130 190 200 210 220 230 240 pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK ::::::::::::::::::::::::::::::::::::::::: NP_001 -------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK 140 150 160 170 pF1KE1 RTMKRL :::::: NP_001 RTMKRL 180 >>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa) initn: 959 init1: 634 opt: 910 Z-score: 1191.4 bits: 228.0 E(85289): 1.3e-59 Smith-Waterman score: 949; 55.0% identity (77.9% similar) in 258 aa overlap (1-244:1-257) 10 20 30 40 pF1KE1 MQPFLLLLAFLLTPGA--GTE------------EIIGGHEAKPHSRPYMAFVQFLQEKSR :::.:::::::: :: :. :::::.:..::::::::..:. . .. XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPAGQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFS .::::.:::.::::::::: ::.::::::::::...: ::: : ..: : :: :: .... XP_011 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 NDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTV :::::::: :... . : :. :: .. ..:: ::.::::: ::: . ::.:: : : XP_011 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 QKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPP :.: :: :.: :.:. .::::: .. ...:::::::::.:..::.::.:::...:.:: XP_011 QRDRQCLRIF-GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPP 190 200 210 220 230 230 240 pF1KE1 GVYIKVSHFLPWIKRTMKRL :. .:: :::::. ::. XP_011 EVFTRVSSFLPWIRTTMRSFKLLDQMETPL 240 250 260 >>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa) initn: 637 init1: 374 opt: 775 Z-score: 1015.4 bits: 195.4 E(85289): 8e-50 Smith-Waterman score: 775; 48.4% identity (74.4% similar) in 246 aa overlap (1-244:3-245) 10 20 30 40 50 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKS-RKRCGGILVRKD . :. ::: ::: : . ::::: : :::::::::..... .. : :::.:.:.. NP_001 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 FVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK :::::::: : ::.:::::::: :.: : : . : . . :: :: ... .:::::.:..: NP_001 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 AKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLF :. : :: : .::. : ::..: ::::: .. .. . ::::: : .. : .. NP_001 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF- 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 HGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFL .... ..:::.:.::...:::::::::.: :::::.::: . . ::.:. ..::. NP_001 -RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYR 180 190 200 210 220 230 240 pF1KE1 PWIKRTMKRL :::.. .. NP_001 PWINQILQAN 240 >>NP_001257710 (OMIM: 116831) granzyme H isoform 3 precu (160 aa) initn: 765 init1: 765 opt: 765 Z-score: 1005.2 bits: 192.8 E(85289): 3e-49 Smith-Waterman score: 913; 65.0% identity (65.0% similar) in 246 aa overlap (1-246:1-160) 10 20 30 40 50 60 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQ------- 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE1 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK ::::::::::::::::::::::::::::::::::::::::: NP_001 -------------------GDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK 120 130 140 150 pF1KE1 RTMKRL :::::: NP_001 RTMKRL 160 >>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa) initn: 529 init1: 242 opt: 567 Z-score: 743.1 bits: 145.1 E(85289): 1.2e-34 Smith-Waterman score: 585; 41.8% identity (69.9% similar) in 249 aa overlap (6-244:14-259) 10 20 30 40 50 pF1KE1 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGI .....:: : :.::::.:. :::::::.... :..:. :.: NP_006 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLS-LDRKT--ICAGA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 LVRKDFVLTAAHCQ-GSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIML :. ::.:::::::. .. .: ::::.: ..: :.:.. ::. .:.: :.: . .:. : NP_006 LIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMS-TLATTLQEVLLTVQKDC ::: .::: . : :.::.. .:::: .:.::::: . : . . ::.:: .:. NP_006 LQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRK 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 QCERLFHGNYSRA---TEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYG--NKKGTP :. : :.. . . .:.:. . . . .::::.::.:. : .:. :.: :: : : NP_006 VCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDP 180 190 200 210 220 230 230 240 pF1KE1 --PGVYIKVSH-FLPWIKRTMKRL ::::: .:. : :: :.: NP_006 RGPGVYILLSKKHLNWIIMTIKGAV 240 250 260 246 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:23:35 2016 done: Mon Nov 7 00:23:37 2016 Total Scan time: 6.950 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]