FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4509, 532 aa 1>>>pF1KE4509 532 - 532 aa - 532 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1149+/-0.000336; mu= 20.4990+/- 0.021 mean_var=76.1961+/-15.823, 0's: 0 Z-trim(115.5): 40 B-trim: 0 in 0/56 Lambda= 0.146929 statistics sampled from 26037 (26077) to 26037 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.306), width: 16 Scan time: 10.750 The best scores are: opt bits E(85289) NP_003029 (OMIM: 600229,616657) neutral amino acid ( 532) 3366 723.0 5.4e-208 XP_006712142 (OMIM: 600229,616657) PREDICTED: neut ( 312) 1976 428.2 1.8e-119 NP_005619 (OMIM: 109190) neutral amino acid transp ( 541) 1893 410.8 5.4e-114 XP_005259224 (OMIM: 109190) PREDICTED: neutral ami ( 469) 1724 374.9 3e-103 NP_001138617 (OMIM: 109190) neutral amino acid tra ( 339) 1381 302.1 1.8e-81 NP_001138616 (OMIM: 109190) neutral amino acid tra ( 313) 1323 289.8 8.5e-78 NP_001180422 (OMIM: 600229,616657) neutral amino a ( 234) 1178 258.9 1.2e-68 XP_011512386 (OMIM: 600111,612656) PREDICTED: exci ( 435) 1041 230.1 1.1e-59 NP_001276868 (OMIM: 600111,612656) excitatory amin ( 496) 1041 230.1 1.2e-59 NP_004163 (OMIM: 600111,612656) excitatory amino a ( 542) 1041 230.2 1.3e-59 XP_005248399 (OMIM: 600111,612656) PREDICTED: exci ( 542) 1041 230.2 1.3e-59 NP_005062 (OMIM: 600637) excitatory amino acid tra ( 564) 1006 222.8 2.2e-57 XP_006722905 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57 XP_006722907 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57 XP_016882641 (OMIM: 600637) PREDICTED: excitatory ( 564) 1006 222.8 2.2e-57 XP_011516312 (OMIM: 133550,615232) PREDICTED: exci ( 477) 984 218.0 5e-56 XP_011516311 (OMIM: 133550,615232) PREDICTED: exci ( 504) 984 218.1 5.2e-56 NP_004161 (OMIM: 133550,615232) excitatory amino a ( 524) 984 218.1 5.3e-56 XP_011516310 (OMIM: 133550,615232) PREDICTED: exci ( 527) 984 218.1 5.4e-56 XP_011516309 (OMIM: 133550,615232) PREDICTED: exci ( 547) 984 218.1 5.5e-56 XP_016873626 (OMIM: 600300,617105) PREDICTED: exci ( 565) 983 217.9 6.5e-56 NP_001239581 (OMIM: 600300,617105) excitatory amin ( 565) 983 217.9 6.5e-56 XP_016873627 (OMIM: 600300,617105) PREDICTED: exci ( 565) 983 217.9 6.5e-56 NP_001182657 (OMIM: 600300,617105) excitatory amin ( 565) 983 217.9 6.5e-56 XP_011518587 (OMIM: 600300,617105) PREDICTED: exci ( 570) 983 217.9 6.6e-56 XP_005253124 (OMIM: 600300,617105) PREDICTED: exci ( 571) 983 217.9 6.6e-56 NP_004162 (OMIM: 600300,617105) excitatory amino a ( 574) 983 217.9 6.6e-56 XP_016873625 (OMIM: 600300,617105) PREDICTED: exci ( 579) 983 217.9 6.7e-56 NP_006662 (OMIM: 604471) excitatory amino acid tra ( 560) 942 209.2 2.7e-53 NP_001274526 (OMIM: 604471) excitatory amino acid ( 472) 938 208.3 4.3e-53 NP_001276869 (OMIM: 600111,612656) excitatory amin ( 430) 863 192.4 2.4e-48 NP_001160167 (OMIM: 600111,612656) excitatory amin ( 497) 747 167.8 6.8e-41 XP_016870532 (OMIM: 133550,615232) PREDICTED: exci ( 488) 728 163.8 1.1e-39 XP_016870531 (OMIM: 133550,615232) PREDICTED: exci ( 511) 728 163.8 1.1e-39 XP_011540304 (OMIM: 604471) PREDICTED: excitatory ( 337) 578 131.9 3.1e-30 NP_001274524 (OMIM: 604471) excitatory amino acid ( 619) 578 132.1 4.9e-30 XP_016873628 (OMIM: 600300,617105) PREDICTED: exci ( 496) 549 125.9 2.9e-28 NP_001259017 (OMIM: 600637) excitatory amino acid ( 312) 456 106.0 1.8e-22 NP_001259016 (OMIM: 600637) excitatory amino acid ( 312) 456 106.0 1.8e-22 NP_001274525 (OMIM: 604471) excitatory amino acid ( 158) 346 82.4 1.1e-15 >>NP_003029 (OMIM: 600229,616657) neutral amino acid tra (532 aa) initn: 3366 init1: 3366 opt: 3366 Z-score: 3855.1 bits: 723.0 E(85289): 5.4e-208 Smith-Waterman score: 3366; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532) 10 20 30 40 50 60 pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL 490 500 510 520 530 >>XP_006712142 (OMIM: 600229,616657) PREDICTED: neutral (312 aa) initn: 1976 init1: 1976 opt: 1976 Z-score: 2265.8 bits: 428.2 E(85289): 1.8e-119 Smith-Waterman score: 1976; 100.0% identity (100.0% similar) in 312 aa overlap (221-532:1-312) 200 210 220 230 240 250 pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF :::::::::::::::::::::::::::::: XP_006 MNILGLVLFALVLGVALKKLGSEGEDLIRF 10 20 30 260 270 280 290 300 310 pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA 220 230 240 250 260 270 500 510 520 530 pF1KE4 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL :::::::::::::::::::::::::::::::::::::::::: XP_006 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL 280 290 300 310 >>NP_005619 (OMIM: 109190) neutral amino acid transporte (541 aa) initn: 1800 init1: 1271 opt: 1893 Z-score: 2167.5 bits: 410.8 E(85289): 5.4e-114 Smith-Waterman score: 1893; 60.9% identity (81.9% similar) in 524 aa overlap (17-532:32-541) 10 20 30 40 pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVL : ::: : :. ..::: :: . ::: NP_005 VADPPRDSKGLAAAEPTANGGLALASIEDQGAAAG-GYCGSR-DQVRRC---LRANLLVL 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 LTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGA ::: .:.::..:: .. : :.:. ... ..::::.:::.:::::::::::::..:: NP_005 LTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 ASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPP :::: . :::::. :. .: .::: ::::.:.::. ..::... ....: .: :. NP_005 ASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 VPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMN ::..:::::::::.:::::: ::::.:.: :. . . .: :. :.:.: :.:::: NP_005 PSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE---ERNITG--TRVKVPVGQEVEGMN 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 ILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV :::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..::: NP_005 ILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFAT ::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.::::.: NP_005 EMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 CSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELN ::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::.. :. NP_005 SSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLD 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 AGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV .:.:::::::::::::::.:::::::.::::::..::. . :::::::.:::. ::. NP_005 FVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVL 420 430 440 450 460 470 470 480 490 500 510 pF1KE4 NVEGDALGAGILH-HLNQKATKKGEQELAEVKVEAI--PNCKSEEETSPLVTH-QNPAGP ::::::::::.:. .... ... : :: .:: : : :: .::. : ..::: NP_005 NVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGD 480 490 500 510 520 530 520 530 pF1KE4 VASAPELESKESVL .. : : ::::. NP_005 ATVASE---KESVM 540 >>XP_005259224 (OMIM: 109190) PREDICTED: neutral amino a (469 aa) initn: 1638 init1: 1168 opt: 1724 Z-score: 1974.7 bits: 374.9 E(85289): 3e-103 Smith-Waterman score: 1724; 63.9% identity (84.4% similar) in 443 aa overlap (17-455:32-463) 10 20 30 40 pF1KE4 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVL : ::: : :. ..::: :: . ::: XP_005 VADPPRDSKGLAAAEPTANGGLALASIEDQGAAAG-GYCGSR-DQVRRC---LRANLLVL 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 LTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGA ::: .:.::..:: .. : :.:. ... ..::::.:::.:::::::::::::..:: XP_005 LTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 ASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPP :::: . :::::. :. .: .::: ::::.:.::. ..::... ....: .: :. XP_005 ASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 VPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMN ::..:::::::::.:::::: ::::.:.: :. . . .: :. :.:.: :.:::: XP_005 PSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE---ERNITG--TRVKVPVGQEVEGMN 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 ILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV :::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..::: XP_005 ILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFAT ::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.::::.: XP_005 EMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 CSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELN ::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::.. :. XP_005 SSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLD 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 AGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV .:.:::::::::::::::.:::::::.::::::..::. . :::::::.: XP_005 FVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVTSGKTF 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 NVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASA >>NP_001138617 (OMIM: 109190) neutral amino acid transpo (339 aa) initn: 1353 init1: 1271 opt: 1381 Z-score: 1583.7 bits: 302.1 E(85289): 1.8e-81 Smith-Waterman score: 1381; 65.0% identity (84.1% similar) in 346 aa overlap (191-532:2-339) 170 180 190 200 210 220 pF1KE4 PPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEG :.: :. . . .: :. :.:.: :.:: NP_001 MYSTTYE---ERNITG--TRVKVPVGQEVEG 10 20 230 240 250 260 270 280 pF1KE4 MNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSK :::::::.::.:.::::.::: ::: :::::::.::::::::::::::.::::::::..: NP_001 MNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGK 30 40 50 60 70 80 290 300 310 320 330 340 pF1KE4 IVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAF ::::.:. .: . :::::. .:::.::: .:::::::.::::::.::: :...:.:::: NP_001 IVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAF 90 100 110 120 130 140 350 360 370 380 390 400 pF1KE4 ATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVE .: ::::::: ::::.:::::: :.::::::::::::::::::.::::::::::::.. NP_001 GTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQS 150 160 170 180 190 200 410 420 430 440 450 460 pF1KE4 LNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTT :. .:.:::::::::::::::.:::::::.::::::..::. . :::::::.:::. : NP_001 LDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCT 210 220 230 240 250 260 470 480 490 500 510 pF1KE4 VVNVEGDALGAGILH-HLNQKATKKGEQELAEVKVEAI--PNCKSEEETSPLVTH-QNPA :.::::::::::.:. .... ... : :: .:: : : :: .::. : ..:: NP_001 VLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPA 270 280 290 300 310 320 520 530 pF1KE4 GPVASAPELESKESVL : .. : : ::::. NP_001 GDATVASE---KESVM 330 >>NP_001138616 (OMIM: 109190) neutral amino acid transpo (313 aa) initn: 1339 init1: 1257 opt: 1323 Z-score: 1517.7 bits: 289.8 E(85289): 8.5e-78 Smith-Waterman score: 1323; 67.7% identity (85.8% similar) in 316 aa overlap (221-532:1-313) 200 210 220 230 240 250 pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF :::::::.::.:.::::.::: ::: :::: NP_001 MNILGLVVFAIVFGVALRKLGPEGELLIRF 10 20 30 260 270 280 290 300 310 pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG :::.::::::::::::::.::::::::..:::::.:. .: . :::::. .:::.::: NP_001 FNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGL 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI .:::::::.::::::.::: :...:.::::.: ::::::: ::::.:::::: :.::::: NP_001 LVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFI 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT :::::::::::::.::::::::::::.. :. .:.:::::::::::::::.::::::: NP_001 LPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLT 160 170 180 190 200 210 440 450 460 470 480 pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILH-HLNQKATKKGEQEL .::::::..::. . :::::::.:::. ::.::::::::::.:. .... ... : :: NP_001 LAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL 220 230 240 250 260 270 490 500 510 520 530 pF1KE4 AEVKVEAI--PNCKSEEETSPLVTH-QNPAGPVASAPELESKESVL .:: : : :: .::. : ..::: .. : : ::::. NP_001 IQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASE---KESVM 280 290 300 310 >>NP_001180422 (OMIM: 600229,616657) neutral amino acid (234 aa) initn: 1447 init1: 1178 opt: 1178 Z-score: 1353.3 bits: 258.9 E(85289): 1.2e-68 Smith-Waterman score: 1298; 75.0% identity (75.0% similar) in 312 aa overlap (221-532:1-234) 200 210 220 230 240 250 pF1KE4 YATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRF :::::::::::::::::::::::::::::: NP_001 MNILGLVLFALVLGVALKKLGSEGEDLIRF 10 20 30 260 270 280 290 300 310 pF1KE4 FNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGG :::::::::::::::: NP_001 FNSLNEATMVLVSWIM-------------------------------------------- 40 320 330 340 350 360 370 pF1KE4 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFI :: :::::::::::::::::::::::: NP_001 --------------------------------CS--ATLPSMMKCIEENNGVDKRISRFI 50 60 70 380 390 400 410 420 430 pF1KE4 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLT 80 90 100 110 120 130 440 450 460 470 480 490 pF1KE4 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA 140 150 160 170 180 190 500 510 520 530 pF1KE4 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL :::::::::::::::::::::::::::::::::::::::::: NP_001 EVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL 200 210 220 230 >>XP_011512386 (OMIM: 600111,612656) PREDICTED: excitato (435 aa) initn: 1170 init1: 992 opt: 1041 Z-score: 1192.7 bits: 230.1 E(85289): 1.1e-59 Smith-Waterman score: 1179; 46.4% identity (74.4% similar) in 414 aa overlap (103-495:2-408) 80 90 100 110 120 130 pF1KE4 TYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALA :.::.. :..: ::.:. ::. : ... XP_011 MAALDSKASGKMGMRAVVYYMTTTIIAVVIG 10 20 30 140 150 160 170 180 190 pF1KE4 VALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYA . ...::.::.:.. ... : : ..:.:::: ::.:: ::: : :. . XP_011 IIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDLIRNMFPPNLVEACFKQFK 40 50 60 70 80 200 210 220 230 pF1KE4 TDY-----KVVTQNSSS--GNV--------------THEKIPIGTEIEGMNILGLVLFAL :.: :: : . . : : :.: .:. ..:.: ::::.:.. XP_011 TNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSM 90 100 110 120 130 140 240 250 260 270 280 290 pF1KE4 VLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLV .: .. .. .:. : .::.::::: : ::. ::::.::::.::...:::::.:. :. XP_011 CFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIG 150 160 170 180 190 200 300 310 320 330 340 350 pF1KE4 TSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPS .:. : . :.: .::. :::::.::. :::::. :. ::: . ::..: ::::::: XP_011 GQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPI 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 MMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILV .::.:::::::::..::.::.:::.::::.:... .::.::::.:: ::: :::.:: . XP_011 TFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISI 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE4 TATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGA ::::.:.::::.: .:..:..:.: ..:::: :. ::.::::..:: :..:: ::.::: XP_011 TATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGA 330 340 350 360 370 380 480 490 500 510 520 530 pF1KE4 GILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESV ::..::... :. . :... .: XP_011 GIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM 390 400 410 420 430 >>NP_001276868 (OMIM: 600111,612656) excitatory amino ac (496 aa) initn: 1170 init1: 992 opt: 1041 Z-score: 1192.0 bits: 230.1 E(85289): 1.2e-59 Smith-Waterman score: 1204; 45.4% identity (74.1% similar) in 432 aa overlap (85-495:45-469) 60 70 80 90 100 110 pF1KE4 GAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLG ..: .. :.: ... : :.::.. :..: NP_001 MERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGMAALDSKASGKMG 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE4 GIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDL ::.:. ::. : .... ...::.::.:.. ... : : ..:.:::: NP_001 MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDL 80 90 100 110 120 180 190 200 210 pF1KE4 ARNLFPSNLVVAAFRTYATDY-----KVVTQNSSS--GNV--------------THEKIP ::.:: ::: : :. . :.: :: : . . : : :.: .: NP_001 IRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVP 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE4 IGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGI . ..:.: ::::.:.. .: .. .. .:. : .::.::::: : ::. ::::.:::: NP_001 VPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGI 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE4 MFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLL .::...:::::.:. :. .:. : . :.: .::. :::::.::. :::::. :. ::: NP_001 LFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLL 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE4 APFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFI . ::..: ::::::: .::.:::::::::..::.::.:::.::::.:... .::.:: NP_001 QALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFI 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE4 AQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDW ::.:: ::: :::.:: .::::.:.::::.: .:..:..:.: ..:::: :. ::.:::: NP_001 AQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDW 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE4 IVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQ ..:: :..:: ::.:::::..::... :. . :... .: NP_001 FLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETE 430 440 450 460 470 480 520 530 pF1KE4 NPAGPVASAPELESKESVL NP_001 KPIDSETKM 490 >>NP_004163 (OMIM: 600111,612656) excitatory amino acid (542 aa) initn: 1400 init1: 992 opt: 1041 Z-score: 1191.4 bits: 230.2 E(85289): 1.3e-59 Smith-Waterman score: 1403; 47.0% identity (75.6% similar) in 479 aa overlap (38-495:44-515) 10 20 30 40 50 60 pF1KE4 NGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSL .: :.:.:::::..:..:. :: .:: . NP_004 RMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRM 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE4 SRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLS : .: :..::::.:.:::.:..:::.. :::.: :.::.. :..: ::.:. ::. NP_004 SYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTII 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE4 ASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAA : .... ...::.::.:.. ... : : ..:.:::: ::.:: ::: : NP_004 AVVIGIIIVIIIHPGKGTKE------NMHREGKI-VRVTAADAFLDLIRNMFPPNLVEAC 140 150 160 170 180 190 200 210 220 pF1KE4 FRTYATDY-----KVVTQNSSS--GNV--------------THEKIPIGTEIEGMNILGL :. . :.: :: : . . : : :.: .:. ..:.: ::: NP_004 FKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 VLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKD :.:.. .: .. .. .:. : .::.::::: : ::. ::::.::::.::...:::::.: NP_004 VVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMED 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 IIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSS . :. .:. : . :.: .::. :::::.::. :::::. :. ::: . ::..: ::: NP_004 MGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSS 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 ATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQI :::: .::.:::::::::..::.::.:::.::::.:... .::.::::.:: ::: ::: NP_004 ATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQI 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 FTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEG .:: .::::.:.::::.: .:..:..:.: ..:::: :. ::.::::..:: :..:: : NP_004 ITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLG 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 DALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELE :.:::::..::... :. . :... .: NP_004 DSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM 490 500 510 520 530 540 532 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:22:00 2016 done: Sun Nov 6 00:22:02 2016 Total Scan time: 10.750 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]