FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4390, 412 aa 1>>>pF1KE4390 412 - 412 aa - 412 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9594+/-0.000393; mu= 19.0171+/- 0.024 mean_var=67.4625+/-13.680, 0's: 0 Z-trim(110.5): 65 B-trim: 0 in 0/54 Lambda= 0.156150 statistics sampled from 18754 (18819) to 18754 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.221), width: 16 Scan time: 8.640 The best scores are: opt bits E(85289) NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 2669 610.6 2.2e-174 NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 2303 528.2 1.4e-149 NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 947 222.7 1.4e-57 NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 901 212.4 1.8e-54 NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 901 212.4 1.8e-54 NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 897 211.4 3.1e-54 NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 894 210.7 4.3e-54 NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 858 202.7 1.5e-51 XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 857 202.4 1.6e-51 NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 854 201.8 2.7e-51 NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 814 192.7 1.3e-48 XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 814 192.8 1.4e-48 XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 814 192.8 1.5e-48 XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 810 191.9 2.7e-48 XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 810 191.9 2.7e-48 XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 810 191.9 2.7e-48 NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 778 184.7 4.1e-46 NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 755 179.6 1.9e-44 XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 740 176.1 1.6e-43 XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 738 175.7 2.1e-43 XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 734 174.7 3.6e-43 NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 727 173.2 1.1e-42 NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 715 170.6 9.2e-42 XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 715 170.6 9.7e-42 XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 715 170.6 9.8e-42 NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 715 170.6 9.9e-42 NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 715 170.6 1e-41 XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 715 170.6 1e-41 NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 715 170.6 1e-41 XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 712 169.8 1.1e-41 XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 712 169.8 1.1e-41 XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 697 166.4 1.3e-40 XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 696 166.2 1.6e-40 XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 694 165.8 2.1e-40 XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 688 164.4 4.9e-40 XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 687 164.2 6e-40 XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 682 162.9 1e-39 XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 657 157.3 5.3e-38 XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 651 156.1 1.9e-37 XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 638 153.1 1e-36 XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 613 147.4 5.5e-35 NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 597 143.9 7.5e-34 NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 588 141.7 1.9e-33 XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 587 141.5 2.6e-33 XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 576 139.2 2e-32 NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 568 137.3 6.8e-32 XP_016882069 (OMIM: 231670,608801) PREDICTED: glut ( 442) 568 137.4 7e-32 XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 568 137.4 7e-32 XP_011526202 (OMIM: 231670,608801) PREDICTED: glut ( 443) 568 137.4 7e-32 NP_079523 (OMIM: 611181) acyl-CoA dehydrogenase fa (1059) 507 123.9 1.9e-27 >>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa) initn: 2669 init1: 2669 opt: 2669 Z-score: 3251.8 bits: 610.6 E(85289): 2.2e-174 Smith-Waterman score: 2669; 99.8% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_000 GTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAIS 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 HQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 370 380 390 400 410 >>NP_001289483 (OMIM: 201470,606885) short-chain specifi (408 aa) initn: 2336 init1: 1296 opt: 2303 Z-score: 2806.2 bits: 528.2 E(85289): 1.4e-149 Smith-Waterman score: 2303; 89.2% identity (91.8% similar) in 417 aa overlap (1-412:1-408) 10 20 30 40 50 60 pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN :::::::::::::::::::::::::::::::::::::: : : . : ..: NP_001 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGP-SLLGPT-------GPIFAL- 130 140 150 160 170 190 200 210 220 230 pF1KE4 GTKAWITNAWEASAAVVFA-STDRA----LQNKSISAFLVPMPTPGLTLGKKEDKLGIRG : . . :. : .: : .:. : ..:::::::::::::::::::::::::: NP_001 GQVGCPCPSSAATEACTFPRSRQRVSRPELLREGISAFLVPMPTPGLTLGKKEDKLGIRG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 SSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 NRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 ATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 360 370 380 390 400 >>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa) initn: 878 init1: 756 opt: 947 Z-score: 1155.0 bits: 222.7 E(85289): 1.4e-57 Smith-Waterman score: 947; 40.8% identity (72.0% similar) in 375 aa overlap (36-410:59-432) 10 20 30 40 50 60 pF1KE4 LARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHL . ..:. .. . ::.... :... .:.. NP_001 PPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSK 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE4 FPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLG . . .. . ::....: : ::.: ..:. ....::... ::..:. ..:.: NP_001 MEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINT 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE4 PILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAW : : :..::: ... .:. .:.: : ::: : :::. : .: : ::: .::::.: : NP_001 LIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMW 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE4 ITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFED :..: .:. .:.:..: .. :.:..::: :::: .:: :.:::.:.::: : ::. NP_001 ISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFEN 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE4 CRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLT ..:. .:::. : :.: :. .:. ::::::.: ::.:: .: .. : ..:. :: : NP_001 VKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLF 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE4 KLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQ .: .: ..: .: ::.:::::. :: : . :::::::.::: ::: : . . :. NP_001 DFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIE 330 340 350 360 370 380 370 380 390 400 410 pF1KE4 ILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS .::.::. ..:.:...:::.: ::::.:.:: .:: :. : NP_001 WMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY 390 400 410 420 430 >>NP_000007 (OMIM: 201450,607008) medium-chain specific (421 aa) initn: 726 init1: 549 opt: 901 Z-score: 1099.1 bits: 212.4 E(85289): 1.8e-54 Smith-Waterman score: 904; 37.5% identity (66.7% similar) in 411 aa overlap (15-412:13-421) 10 20 30 40 50 pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFAEK :.. ::. :: . : :. : .. . : : ::.. NP_000 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFARE 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 ELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCAS :..:.::. :: .:. ... :::. .::. :: :: . . ::.. :: NP_000 EIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC-- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 TGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTA ::: ... ::: ::. :. .::. .. .: . . ..::: :::... .: : NP_000 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 RAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLGKK . .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .:.: NP_000 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 EDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTAL : ..: : :.: ...::: ..::...: : :::.:: ..: : .:. :.:.:: :: NP_000 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRAL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 DCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAM : :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . :.. NP_000 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 AKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLL :: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . . NP_000 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI 360 370 380 390 400 410 410 pF1KE4 RSYRS .:.. NP_000 DKYKN 420 >>NP_001120800 (OMIM: 201450,607008) medium-chain specif (425 aa) initn: 726 init1: 549 opt: 901 Z-score: 1099.1 bits: 212.4 E(85289): 1.8e-54 Smith-Waterman score: 908; 37.2% identity (66.0% similar) in 427 aa overlap (1-412:1-425) 10 20 30 40 pF1KE4 MAAAL--LARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFA :::.. : : . :.. ::. :: . : :. : .. . : : :: NP_001 MAAGFGRCCRCSLQVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 EKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGC ..:..:.::. :: .:. ... :::. .::. :: :: . . ::.. :: NP_001 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 ASTGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAAST ::: ... ::: ::. :. .::. .. .: . . ..::: :::... .: NP_001 --TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKT 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 TARAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLG :. .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .: NP_001 KAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIG 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 KKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQT .:: ..: : :.: ...::: ..::...: : :::.:: ..: : .:. :.:.:: NP_001 RKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQR 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 ALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEA ::: :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . : NP_001 ALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 AMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGH ..:: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . NP_001 SIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVARE 360 370 380 390 400 410 410 pF1KE4 LLRSYRS . .:.. NP_001 HIDKYKN 420 >>NP_001272971 (OMIM: 201450,607008) medium-chain specif (385 aa) initn: 722 init1: 549 opt: 897 Z-score: 1094.8 bits: 211.4 E(85289): 3.1e-54 Smith-Waterman score: 897; 38.5% identity (68.8% similar) in 384 aa overlap (33-412:4-385) 10 20 30 40 50 60 pF1KE4 AALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDK :. : .. . : : ::..:..:.::. :: NP_001 MLQEFTEQQKEFQATARKFAREEIIPVAAEYDK 10 20 30 70 80 90 100 110 120 pF1KE4 EHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVN-NS .:. ... :::. .::. :: :: . . ::.. :: ::: ... :: NP_001 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC--TGVQTAIEGNS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 LYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNG : ::. :. .::. .. .: . . ..::: :::... .: :. .:: ...:: NP_001 LGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIING 100 110 120 130 140 150 190 200 210 220 230 pF1KE4 TKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSST : ::::. .:. ..: .: .: ::....:.: :::. .:.:: ..: : :.: NP_001 QKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 ANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRM ...::: ..::...: : :::.:: ..: : .:. :.:.:: ::: :..:: .: NP_001 RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERK 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 AFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATA .:: :.. :.:.: ::.::. .: ::. ::: :. . :..:: :.. :. NP_001 TFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQ 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 ISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . . .:.. NP_001 LATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN 340 350 360 370 380 >>NP_001317103 (OMIM: 600301,610006) short/branched chai (330 aa) initn: 850 init1: 756 opt: 894 Z-score: 1092.1 bits: 210.7 E(85289): 4.3e-54 Smith-Waterman score: 894; 44.1% identity (72.8% similar) in 331 aa overlap (80-410:1-330) 50 60 70 80 90 100 pF1KE4 EKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGC ....: : ::.: ..:. ....::... NP_001 MGIEVDPEYGGTGASFLSTVLVIEELAKVD 10 20 30 110 120 130 140 150 160 pF1KE4 ASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTT ::..:. ..:.: : : :..::: ... .:. .:.: : ::: : :::. : .: NP_001 ASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTR 40 50 60 70 80 170 180 190 200 210 220 pF1KE4 ARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKED : ::: .::::.: ::..: .:. .:.:..: .. :.:..::: :::: .:: :. NP_001 ADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPEN 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE4 KLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDC :::.:.::: : ::. ..:. .:::. : :.: :. .:. ::::::.: ::.:: .: NP_001 KLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDY 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 AVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAK .. : ..:. :: : .: .: ..: .: ::.:::::. :: : . :::::::.::: NP_001 TIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAK 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 LAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRS ::: : . . :. .::.::. ..:.:...:::.: ::::.:.:: .:: :. NP_001 YYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAE 270 280 290 300 310 320 410 pF1KE4 YRS : NP_001 Y 330 >>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa) initn: 798 init1: 487 opt: 858 Z-score: 1046.7 bits: 202.7 E(85289): 1.5e-51 Smith-Waterman score: 858; 37.8% identity (70.5% similar) in 373 aa overlap (34-402:45-417) 10 20 30 40 50 60 pF1KE4 ALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKE : : ...: :: : ...: : : ..:. NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE4 HLFPAAQV--KKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNS . : . :..:.::.:.. .: . ::.:: :: ....::::::. ...:. ...... NP_002 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE4 LYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNG : .. ... :.. ::. .. . ::. :: .:.:::. :::. . . :. .:. ..::: NP_002 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG 140 150 160 170 180 190 190 200 210 220 230 pF1KE4 TKAWITNAWEASAAVVFASTDRAL--QNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTA .: ::::. .:.. .:.:.:: : ...:.::.: ::.. .:: ::::.:::.: NP_002 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE4 NLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMA .::::::.:: .:::. . : . :. ::. :. .:. ::. :..:: .. : . : : NP_002 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA 260 270 280 290 300 310 300 310 320 330 340 350 pF1KE4 FGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAI :: . ..:..: :.::: : . : .. .: :. . :. : . : ..: :: . NP_002 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQV 320 330 340 350 360 370 360 370 380 390 400 410 pF1KE4 SHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS . ..:: .:: ::....: : :::.. :: ::::..:::: NP_002 ALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH 380 390 400 410 420 >>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa) initn: 833 init1: 487 opt: 857 Z-score: 1045.7 bits: 202.4 E(85289): 1.6e-51 Smith-Waterman score: 857; 37.2% identity (68.7% similar) in 387 aa overlap (20-402:13-398) 10 20 30 40 50 60 pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV : :.. : :: . : :: : ...: : : .. XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAE-LRQTMAKFLQEHLAPKAQEI 10 20 30 40 50 70 80 90 100 110 pF1KE4 DKEHLFPAAQV--KKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSV :. . : . :..:.::.:.. .: . ::.:: :: ....::::::. ...:. ... XP_016 DRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 NNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWV ...: .. ... :.. ::. .. . ::. :: .:.:::. :::. . . :. .:. .. XP_016 HSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LNGTKAWITNAWEASAAVVFASTDRAL--QNKSISAFLVPMPTPGLTLGKKEDKLGIRGS :::.: ::::. .:.. .:.:.:: : ...:.::.: ::.. .:: ::::.::: XP_016 LNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 STANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAEN .: .::::::.:: .:::. . : . :. ::. :. .:. ::. :..:: .. : . XP_016 NTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 RMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAA : ::: . ..:..: :.::: : . : .. .: :. . :. : . : ..: : XP_016 REAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 TAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS : .. ..:: .:: ::....: : :::.. :: ::::..:::: XP_016 TQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH 360 370 380 390 400 >>NP_055199 (OMIM: 604773,611283) isobutyryl-CoA dehydro (415 aa) initn: 737 init1: 318 opt: 854 Z-score: 1042.0 bits: 201.8 E(85289): 2.7e-51 Smith-Waterman score: 854; 36.9% identity (69.7% similar) in 396 aa overlap (15-408:21-414) 10 20 30 40 50 pF1KE4 MAAALLARASGPARRALCPRAWRQLHT-IYQSVELPETHQMLLQTCRDFAEKEL :.: . :.: . : :. : : .. . .. ::: .:. NP_055 MLWSGCRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLNEEQKEFQKVAFDFAAREM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 FPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTG : :. :...:::. ..: . ::. .. . ..::.::. : .. .: .. ::.:: NP_055 APNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 VIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAE . .:..: . : .::..::.. . :. . .:.. . :.:::.::::.. :.:. . NP_055 AYISIHN-MCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 GDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGI :: ..:::.::.:..: :.. ::. : :.:: ..: ::::..:::: :.: NP_055 GDHYILNGSKAFISGAGESDIYVVMCRTGGP-GPKGISCIVVEKGTPGLSFGKKEKKVGW 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 RGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNY .. : .::::: .: . .: :.:: ::.. :. :::.::: .:: :.... . .. NP_055 NSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRDH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 AENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAM-LKDNKKPFIKEAAMAKLAA . : :: ::.. : .:: ::::: : .:::.. ::. :....: . .:::: : NP_055 LNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 SEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS .. :: .::.:. ::.::. .. .... ::.:. .: ::..:..:..:. ::. NP_055 TDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE 360 370 380 390 400 410 412 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:56:24 2016 done: Sat Nov 5 22:56:26 2016 Total Scan time: 8.640 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]