FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6348, 331 aa 1>>>pF1KE6348 331 - 331 aa - 331 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3612+/-0.000776; mu= 15.0534+/- 0.047 mean_var=57.6223+/-11.644, 0's: 0 Z-trim(106.3): 27 B-trim: 0 in 0/51 Lambda= 0.168958 statistics sampled from 8891 (8917) to 8891 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.274), width: 16 Scan time: 1.830 The best scores are: opt bits E(32554) CCDS193.1 AKR7A3 gene_id:22977|Hs108|chr1 ( 331) 2247 555.9 1.6e-158 CCDS194.1 AKR7A2 gene_id:8574|Hs108|chr1 ( 359) 1999 495.5 2.7e-140 CCDS56.1 KCNAB2 gene_id:8514|Hs108|chr1 ( 353) 267 73.3 3.3e-13 CCDS55.1 KCNAB2 gene_id:8514|Hs108|chr1 ( 367) 267 73.3 3.4e-13 CCDS55571.1 KCNAB2 gene_id:8514|Hs108|chr1 ( 300) 263 72.3 5.6e-13 CCDS33882.1 KCNAB1 gene_id:7881|Hs108|chr3 ( 401) 261 71.8 1e-12 CCDS3175.1 KCNAB1 gene_id:7881|Hs108|chr3 ( 408) 261 71.8 1e-12 CCDS3174.1 KCNAB1 gene_id:7881|Hs108|chr3 ( 419) 261 71.8 1.1e-12 >>CCDS193.1 AKR7A3 gene_id:22977|Hs108|chr1 (331 aa) initn: 2247 init1: 2247 opt: 2247 Z-score: 2959.4 bits: 555.9 E(32554): 1.6e-158 Smith-Waterman score: 2247; 99.4% identity (100.0% similar) in 331 aa overlap (1-331:1-331) 10 20 30 40 50 60 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEH ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: CCDS19 TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 250 260 270 280 290 300 310 320 330 pF1KE6 AAEEGPLEPAVVDAFNQAWHLVAHECPNYFR ::::::::::::::::::::::.:::::::: CCDS19 AAEEGPLEPAVVDAFNQAWHLVTHECPNYFR 310 320 330 >>CCDS194.1 AKR7A2 gene_id:8574|Hs108|chr1 (359 aa) initn: 1994 init1: 1994 opt: 1999 Z-score: 2632.1 bits: 495.5 E(32554): 2.7e-140 Smith-Waterman score: 1999; 87.2% identity (95.2% similar) in 335 aa overlap (2-331:25-359) 10 20 30 pF1KE6 MSRQLSRARP-----ATVLGAMEMGRRMDAPTSAAVT .: :. .:: :.:::.::::::::::.:::.. CCDS19 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 RAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLR ::::::::::.::::.::.:::::::::::: :::.:::::: ::: : :.::::::.: CCDS19 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 FQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAE ::::::::::::.::::::: :::.:::::::.::..::::::::::::::::.::::: CCDS19 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 ICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYE :::::::::::::::::::::: :::::::::::::::::::::.::::::::::::::: CCDS19 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 DKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMY ::::::::::::::.::: ::::.:::::::.::::::::::::::::::.:::.::::: CCDS19 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE6 HHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR :::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: CCDS19 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 310 320 330 340 350 >>CCDS56.1 KCNAB2 gene_id:8514|Hs108|chr1 (353 aa) initn: 222 init1: 109 opt: 267 Z-score: 350.6 bits: 73.3 E(32554): 3.3e-13 Smith-Waterman score: 291; 28.8% identity (57.2% similar) in 299 aa overlap (20-306:48-327) 10 20 30 40 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY :. : . .: :. . : . .::: :: CCDS56 TGSPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAY-DNGINLFDTAEVY 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE6 SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQC . :..:..::.. . : . : :: : :.. .: . :..::.::: CCDS56 AAGKAEVVLGNIIKKKGWRRSSLVITTK-IFWGGKAETERGLSRKHIIEGLKASLERLQL 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE6 PRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL ::. . . :: .::.:::.:: .. ..: . : : ... :. : .. .. . CCDS56 EYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTP 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE6 PTVYQGMYNAITRQ-VETELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR : :. :. . :. ::..: : : : .:. ....::: :...::: .: : .: CCDS56 PICEQAEYHMFQREKVEVQL-PELFHKIGVGAMTWSPLACGIVSGKYD----SGIPPYSR 200 210 220 230 240 250 230 240 250 260 270 pF1KE6 --FFGNTWAEMYRNRYWKEHHFEGIALVEKALQAA---YGASAPSMTSATLRWMYHHSQL . : : ... .:. . : . : ::: : . :... : : .. CCDS56 ASLKGYQW---LKDKILSEEGRRQQAKL-KELQAIAERLGCTLPQLAIA---WCLRN--- 260 270 280 290 300 280 290 300 310 320 330 pF1KE6 QGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR .:. ..:.:: :. .:: .:..: . : CCDS56 EGV--SSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 310 320 330 340 350 >>CCDS55.1 KCNAB2 gene_id:8514|Hs108|chr1 (367 aa) initn: 222 init1: 109 opt: 267 Z-score: 350.3 bits: 73.3 E(32554): 3.4e-13 Smith-Waterman score: 291; 28.8% identity (57.2% similar) in 299 aa overlap (20-306:62-341) 10 20 30 40 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY :. : . .: :. . : . .::: :: CCDS55 PKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAY-DNGINLFDTAEVY 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE6 SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQC . :..:..::.. . : . : :: : :.. .: . :..::.::: CCDS55 AAGKAEVVLGNIIKKKGWRRSSLVITTK-IFWGGKAETERGLSRKHIIEGLKASLERLQL 100 110 120 130 140 110 120 130 140 150 160 pF1KE6 PRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL ::. . . :: .::.:::.:: .. ..: . : : ... :. : .. .. . CCDS55 EYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTP 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE6 PTVYQGMYNAITRQ-VETELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR : :. :. . :. ::..: : : : .:. ....::: :...::: .: : .: CCDS55 PICEQAEYHMFQREKVEVQL-PELFHKIGVGAMTWSPLACGIVSGKYD----SGIPPYSR 210 220 230 240 250 260 230 240 250 260 270 pF1KE6 --FFGNTWAEMYRNRYWKEHHFEGIALVEKALQAA---YGASAPSMTSATLRWMYHHSQL . : : ... .:. . : . : ::: : . :... : : .. CCDS55 ASLKGYQW---LKDKILSEEGRRQQAKL-KELQAIAERLGCTLPQLAIA---WCLRN--- 270 280 290 300 310 280 290 300 310 320 330 pF1KE6 QGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR .:. ..:.:: :. .:: .:..: . : CCDS55 EGV--SSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 320 330 340 350 360 >>CCDS55571.1 KCNAB2 gene_id:8514|Hs108|chr1 (300 aa) initn: 222 init1: 109 opt: 263 Z-score: 346.4 bits: 72.3 E(32554): 5.6e-13 Smith-Waterman score: 287; 29.1% identity (57.8% similar) in 282 aa overlap (37-306:11-274) 10 20 30 40 50 60 pF1KE6 RARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLG . : . .::: ::. :..:..::.. . : CCDS55 MAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKG 10 20 30 40 70 80 90 100 110 120 pF1KE6 GSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQCPRVDLFYLHMPDHSTPV . : :: : :.. .: . :..::.::: ::. . . :: .::. CCDS55 WRRSSLVITTK-IFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPM 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ-VE :::.:: .. ..: . : : ... :. : .. .. . : :. :. . :. :: CCDS55 EETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVE 100 110 120 130 140 150 190 200 210 220 230 pF1KE6 TELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR--FFGNTWAEMYRNRYW ..: : : : .:. ....::: :...::: .: : .: . : : ... CCDS55 VQL-PELFHKIGVGAMTWSPLACGIVSGKYD----SGIPPYSRASLKGYQW---LKDKIL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE6 KEHHFEGIALVEKALQAA---YGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQ .:. . : . : ::: : . :... : : .. .:. ..:.:: :. .: CCDS55 SEEGRRQQAKL-KELQAIAERLGCTLPQLAIA---WCLRN---EGV--SSVLLGASNADQ 220 230 240 250 260 300 310 320 330 pF1KE6 LEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR : .:..: . : CCDS55 LMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 270 280 290 300 >>CCDS33882.1 KCNAB1 gene_id:7881|Hs108|chr3 (401 aa) initn: 258 init1: 103 opt: 261 Z-score: 341.8 bits: 71.8 E(32554): 1e-12 Smith-Waterman score: 279; 27.5% identity (58.0% similar) in 295 aa overlap (20-306:96-375) 10 20 30 40 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY :. : . .: :. : : . .::: :: CCDS33 AKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAY-ESGVNLFDTAEVY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KE6 SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQC . :..:.:::.. . : . : :: . :.. .: . :. ::.::: CCDS33 AAGKAEVILGSIIKKKGWRRSSLVITTK-LYWGGKAETERGLSRKHIIEGLKGSLQRLQL 130 140 150 160 170 180 110 120 130 140 150 160 pF1KE6 PRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL ::. . . :: .::.:: .:: .. ..: . : : ..: :. : .. .. . : CCDS33 EYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIP 190 200 210 220 230 240 170 180 190 200 210 220 pF1KE6 PTVYQGMYNAITRQ-VETELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR :. :. :. . :. ::..: : : : .:. ....::: :...::: .... . CCDS33 PVCEQAEYHLFQREKVEVQL-PELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLK 250 260 270 280 290 300 230 240 250 260 270 280 pF1KE6 FFGNTWAEMYRNRYWKEHH-FEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAH . .. .. :... .. .. . . : : . :... : : .. .:. CCDS33 CYQWLKERIVSEEGRKQQNKLKDLSPIAERL----GCTLPQLAVA---WCLRN---EGV- 310 320 330 340 350 290 300 310 320 330 pF1KE6 GDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR ..:.:: :. ::: .::.: . : CCDS33 -SSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 360 370 380 390 400 >>CCDS3175.1 KCNAB1 gene_id:7881|Hs108|chr3 (408 aa) initn: 258 init1: 103 opt: 261 Z-score: 341.6 bits: 71.8 E(32554): 1e-12 Smith-Waterman score: 279; 27.5% identity (58.0% similar) in 295 aa overlap (20-306:103-382) 10 20 30 40 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY :. : . .: :. : : . .::: :: CCDS31 RAETGMAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAY-ESGVNLFDTAEVY 80 90 100 110 120 130 50 60 70 80 90 100 pF1KE6 SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQC . :..:.:::.. . : . : :: . :.. .: . :. ::.::: CCDS31 AAGKAEVILGSIIKKKGWRRSSLVITTK-LYWGGKAETERGLSRKHIIEGLKGSLQRLQL 140 150 160 170 180 190 110 120 130 140 150 160 pF1KE6 PRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL ::. . . :: .::.:: .:: .. ..: . : : ..: :. : .. .. . : CCDS31 EYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIP 200 210 220 230 240 250 170 180 190 200 210 220 pF1KE6 PTVYQGMYNAITRQ-VETELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR :. :. :. . :. ::..: : : : .:. ....::: :...::: .... . CCDS31 PVCEQAEYHLFQREKVEVQL-PELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLK 260 270 280 290 300 230 240 250 260 270 280 pF1KE6 FFGNTWAEMYRNRYWKEHH-FEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAH . .. .. :... .. .. . . : : . :... : : .. .:. CCDS31 CYQWLKERIVSEEGRKQQNKLKDLSPIAERL----GCTLPQLAVA---WCLRN---EGV- 310 320 330 340 350 290 300 310 320 330 pF1KE6 GDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR ..:.:: :. ::: .::.: . : CCDS31 -SSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 360 370 380 390 400 >>CCDS3174.1 KCNAB1 gene_id:7881|Hs108|chr3 (419 aa) initn: 258 init1: 103 opt: 261 Z-score: 341.5 bits: 71.8 E(32554): 1.1e-12 Smith-Waterman score: 279; 27.5% identity (58.0% similar) in 295 aa overlap (20-306:114-393) 10 20 30 40 pF1KE6 MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY :. : . .: :. : : . .::: :: CCDS31 VCTTGMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAY-ESGVNLFDTAEVY 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE6 SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQ-----LETSLKRLQC . :..:.:::.. . : . : :: . :.. .: . :. ::.::: CCDS31 AAGKAEVILGSIIKKKGWRRSSLVITTK-LYWGGKAETERGLSRKHIIEGLKGSLQRLQL 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE6 PRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL ::. . . :: .::.:: .:: .. ..: . : : ..: :. : .. .. . : CCDS31 EYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIP 210 220 230 240 250 260 170 180 190 200 210 220 pF1KE6 PTVYQGMYNAITRQ-VETELFPCLRH-FGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGR :. :. :. . :. ::..: : : : .:. ....::: :...::: .... . CCDS31 PVCEQAEYHLFQREKVEVQL-PELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLK 270 280 290 300 310 320 230 240 250 260 270 280 pF1KE6 FFGNTWAEMYRNRYWKEHH-FEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAH . .. .. :... .. .. . . : : . :... : : .. .:. CCDS31 CYQWLKERIVSEEGRKQQNKLKDLSPIAERL----GCTLPQLAVA---WCLRN---EGV- 330 340 350 360 290 300 310 320 330 pF1KE6 GDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR ..:.:: :. ::: .::.: . : CCDS31 -SSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 370 380 390 400 410 331 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:20:56 2016 done: Tue Nov 8 12:20:57 2016 Total Scan time: 1.830 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]