FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1457, 1269 aa 1>>>pF1KE1457 1269 - 1269 aa - 1269 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1789+/-0.000479; mu= 20.1086+/- 0.030 mean_var=158.5606+/-31.714, 0's: 0 Z-trim(113.7): 416 B-trim: 942 in 1/57 Lambda= 0.101854 statistics sampled from 22624 (23138) to 22624 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.271), width: 16 Scan time: 14.430 The best scores are: opt bits E(85289) NP_002009 (OMIM: 600362) protein flightless-1 homo (1269) 8502 1263.2 0 XP_005256615 (OMIM: 600362) PREDICTED: protein fli (1268) 8485 1260.7 0 NP_001243193 (OMIM: 600362) protein flightless-1 h (1258) 8368 1243.5 0 XP_005256612 (OMIM: 600362) PREDICTED: protein fli (1296) 8193 1217.8 0 XP_005256613 (OMIM: 600362) PREDICTED: protein fli (1295) 8176 1215.3 0 NP_001243194 (OMIM: 600362) protein flightless-1 h (1214) 7335 1091.7 0 XP_016874199 (OMIM: 613397) PREDICTED: advillin is ( 819) 536 92.4 1.3e-17 NP_006567 (OMIM: 613397) advillin [Homo sapiens] ( 819) 536 92.4 1.3e-17 NP_149119 (OMIM: 613416) adseverin isoform 2 [Homo ( 468) 516 89.2 7.2e-17 NP_001106177 (OMIM: 613416) adseverin isoform 1 [H ( 715) 516 89.4 9.4e-17 NP_001255968 (OMIM: 602775,607721) leucine-rich re ( 536) 491 85.6 1e-15 XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15 NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 489 85.3 1.3e-15 NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 489 85.3 1.3e-15 XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15 XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 489 85.3 1.3e-15 NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 489 85.3 1.3e-15 NP_009058 (OMIM: 193040) villin-1 [Homo sapiens] ( 827) 489 85.5 1.6e-15 NP_000168 (OMIM: 105120,137350) gelsolin isoform a ( 782) 472 83.0 8.8e-15 NP_001244958 (OMIM: 105120,137350) gelsolin isofor ( 748) 469 82.5 1.2e-14 XP_011516894 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14 NP_001121137 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14 NP_937895 (OMIM: 105120,137350) gelsolin isoform b ( 731) 464 81.8 1.9e-14 NP_001121134 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14 XP_005252002 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14 XP_011516893 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14 XP_011516895 (OMIM: 105120,137350) PREDICTED: gels ( 731) 464 81.8 1.9e-14 NP_001121136 (OMIM: 105120,137350) gelsolin isofor ( 731) 464 81.8 1.9e-14 NP_001244959 (OMIM: 105120,137350) gelsolin isofor ( 739) 464 81.8 1.9e-14 XP_016870136 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_011516889 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 NP_001121139 (OMIM: 105120,137350) gelsolin isofor ( 742) 464 81.8 1.9e-14 XP_005252001 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_016870135 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_005252000 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_011516892 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_011516888 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_011516890 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 NP_001121138 (OMIM: 105120,137350) gelsolin isofor ( 742) 464 81.8 1.9e-14 XP_011516891 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_006717142 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_016870137 (OMIM: 105120,137350) PREDICTED: gels ( 742) 464 81.8 1.9e-14 XP_016870134 (OMIM: 105120,137350) PREDICTED: gels ( 752) 464 81.8 1.9e-14 XP_011516887 (OMIM: 105120,137350) PREDICTED: gels ( 761) 464 81.8 2e-14 NP_001121135 (OMIM: 105120,137350) gelsolin isofor ( 767) 464 81.8 2e-14 XP_016870132 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14 XP_016870133 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14 XP_011516886 (OMIM: 105120,137350) PREDICTED: gels ( 780) 464 81.8 2e-14 XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 439 77.7 1.5e-13 XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 445 79.3 1.9e-13 >>NP_002009 (OMIM: 600362) protein flightless-1 homolog (1269 aa) initn: 8502 init1: 8502 opt: 8502 Z-score: 6761.0 bits: 1263.2 E(85289): 0 Smith-Waterman score: 8502; 100.0% identity (100.0% similar) in 1269 aa overlap (1-1269:1-1269) 10 20 30 40 50 60 pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA 1210 1220 1230 1240 1250 1260 pF1KE1 WSAFCKALA ::::::::: NP_002 WSAFCKALA >>XP_005256615 (OMIM: 600362) PREDICTED: protein flightl (1268 aa) initn: 5835 init1: 5835 opt: 8485 Z-score: 6747.5 bits: 1260.7 E(85289): 0 Smith-Waterman score: 8485; 99.9% identity (99.9% similar) in 1269 aa overlap (1-1269:1-1268) 10 20 30 40 50 60 pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP 370 380 390 400 410 430 440 450 460 470 480 pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA 1200 1210 1220 1230 1240 1250 pF1KE1 WSAFCKALA ::::::::: XP_005 WSAFCKALA 1260 >>NP_001243193 (OMIM: 600362) protein flightless-1 homol (1258 aa) initn: 8363 init1: 8363 opt: 8368 Z-score: 6654.6 bits: 1243.5 E(85289): 0 Smith-Waterman score: 8368; 99.4% identity (99.5% similar) in 1258 aa overlap (13-1269:1-1258) 10 20 30 40 50 pF1KE1 MEATGVLPFVRGVDLSG-NDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLE .:: : :::::::::::::::::::::::::::::::::::::: NP_001 MDLRGLRPVPGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLE 10 20 30 40 60 70 80 90 100 110 pF1KE1 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTEC 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 PRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 VLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 HFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 PKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQG 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE1 LEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSG 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE1 SLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDIS 530 540 550 560 570 580 600 610 620 630 640 650 pF1KE1 YIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVW 590 600 610 620 630 640 660 670 680 690 700 710 pF1KE1 RGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPE 650 660 670 680 690 700 720 730 740 750 760 770 pF1KE1 DFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 710 720 730 740 750 760 780 790 800 810 820 830 pF1KE1 CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD 770 780 790 800 810 820 840 850 860 870 880 890 pF1KE1 DVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEE 830 840 850 860 870 880 900 910 920 930 940 950 pF1KE1 WNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKA 890 900 910 920 930 940 960 970 980 990 1000 1010 pF1KE1 EGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVV 950 960 970 980 990 1000 1020 1030 1040 1050 1060 1070 pF1KE1 RMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSL 1010 1020 1030 1040 1050 1060 1080 1090 1100 1110 1120 1130 pF1KE1 LNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEE 1070 1080 1090 1100 1110 1120 1140 1150 1160 1170 1180 1190 pF1KE1 PENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD 1130 1140 1150 1160 1170 1180 1200 1210 1220 1230 1240 1250 pF1KE1 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFH 1190 1200 1210 1220 1230 1240 1260 pF1KE1 AWSAFCKALA :::::::::: NP_001 AWSAFCKALA 1250 >>XP_005256612 (OMIM: 600362) PREDICTED: protein flightl (1296 aa) initn: 8193 init1: 8193 opt: 8193 Z-score: 6515.5 bits: 1217.8 E(85289): 0 Smith-Waterman score: 8438; 97.9% identity (97.9% similar) in 1296 aa overlap (1-1269:1-1296) 10 20 30 40 50 60 pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1150 1160 1170 1180 1190 1200 1210 1220 1230 pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQV---------------------------YIQHMRS :::::::::::::::::::::::::: ::::::: XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRS 1210 1220 1230 1240 1250 1260 1240 1250 1260 pF1KE1 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA :::::::::::::::::::::::::::::::::::: XP_005 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA 1270 1280 1290 >>XP_005256613 (OMIM: 600362) PREDICTED: protein flightl (1295 aa) initn: 5526 init1: 5526 opt: 8176 Z-score: 6502.0 bits: 1215.3 E(85289): 0 Smith-Waterman score: 8421; 97.8% identity (97.8% similar) in 1296 aa overlap (1-1269:1-1295) 10 20 30 40 50 60 pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_005 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP 370 380 390 400 410 430 440 450 460 470 480 pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1140 1150 1160 1170 1180 1190 1210 1220 1230 pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQV---------------------------YIQHMRS :::::::::::::::::::::::::: ::::::: XP_005 GQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRS 1200 1210 1220 1230 1240 1250 1240 1250 1260 pF1KE1 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA :::::::::::::::::::::::::::::::::::: XP_005 KEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA 1260 1270 1280 1290 >>NP_001243194 (OMIM: 600362) protein flightless-1 homol (1214 aa) initn: 6833 init1: 5835 opt: 7335 Z-score: 5834.4 bits: 1091.7 E(85289): 0 Smith-Waterman score: 8021; 95.7% identity (95.7% similar) in 1269 aa overlap (1-1269:1-1214) 10 20 30 40 50 60 pF1KE1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV ::::::::::::::::: NP_001 RELENAKNMLVLNLSHN------------------------------------------- 130 190 200 210 220 230 240 pF1KE1 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----------RQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE1 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE1 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAA-GSGP 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE1 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE1 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE1 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE1 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 550 560 570 580 590 600 670 680 690 700 710 720 pF1KE1 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 610 620 630 640 650 660 730 740 750 760 770 780 pF1KE1 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 670 680 690 700 710 720 790 800 810 820 830 840 pF1KE1 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 730 740 750 760 770 780 850 860 870 880 890 900 pF1KE1 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 790 800 810 820 830 840 910 920 930 940 950 960 pF1KE1 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 850 860 870 880 890 900 970 980 990 1000 1010 1020 pF1KE1 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 910 920 930 940 950 960 1030 1040 1050 1060 1070 1080 pF1KE1 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 970 980 990 1000 1010 1020 1090 1100 1110 1120 1130 1140 pF1KE1 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1030 1040 1050 1060 1070 1080 1150 1160 1170 1180 1190 1200 pF1KE1 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1090 1100 1110 1120 1130 1140 1210 1220 1230 1240 1250 1260 pF1KE1 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA 1150 1160 1170 1180 1190 1200 pF1KE1 WSAFCKALA ::::::::: NP_001 WSAFCKALA 1210 >>XP_016874199 (OMIM: 613397) PREDICTED: advillin isofor (819 aa) initn: 460 init1: 201 opt: 536 Z-score: 437.0 bits: 92.4 E(85289): 1.3e-17 Smith-Waterman score: 979; 29.9% identity (56.8% similar) in 783 aa overlap (499-1261:14-711) 470 480 490 500 510 520 pF1KE1 PSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCY ::. .:.::.. .:: . ::.:::.::: XP_016 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCY 10 20 30 40 530 540 550 560 570 580 pF1KE1 IVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESE ..:.: : :. .:..::: ... :...:.::....: .:::. :: . ::. XP_016 VILSTRRVAS-LLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD 50 60 70 80 90 100 590 600 610 620 630 640 pF1KE1 EFLQVFDNDISYIEGGTASGFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFV : : . : : .::.:::. :: .:. : :. .: ::.::. : .. :.. : XP_016 TFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDV 110 120 130 140 150 160 650 660 670 680 690 700 pF1KE1 FLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQEL--PEFWEA :::: : : : : ... . :: :.:. : :: :.:.: .. .: ::. .. XP_016 FLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV 170 180 190 200 210 220 710 720 730 740 750 pF1KE1 LG---GEPSEIKKHVPEDFWPPQPK----LYKVGLGLGYLELPQINYKLSVEHKQRPKVE : :. : :: ::... . : ::... . : : . .. :: XP_016 LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVA--------TRP--- 230 240 250 260 270 760 770 780 790 800 810 pF1KE1 LMPRMRLLQSLLDTRCVYILD-CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHA :.:.::. :::: . ...: :. . . . ::.. . . : : . XP_016 ------LVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSST 280 290 300 310 320 820 830 840 850 860 870 pF1KE1 TVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADL .: .:.:. .:: :..:. . : : . .. : : .:: .: : :. XP_016 NVETVNDGAESAMFKQLFQKWS---VKDQTMGLGKTF-SIGKIAKVFQD-------KFDV 330 340 350 360 370 880 890 900 910 920 930 pF1KE1 TALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFL : .: .: . : :..... : .: . .:. ... . . .: :: :::. : XP_016 T--LLHTKPEV--AAQERMVDDGN---GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVL 380 390 400 410 420 940 950 960 970 980 990 pF1KE1 CRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGW : : .:: :.. :.:.::::.::. XP_016 YTYEV-----------------NGK-------------PHH----ILYIWQGRHASQ-DE 430 440 450 1000 1010 1020 1030 1040 1050 pF1KE1 LTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRG--KRKAVQGAQQP- :. . . . : : ::. . : .:.. :: :..: .: .::. . : XP_016 LAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPV 460 470 480 490 500 510 1060 1070 1080 1090 1100 1110 pF1KE1 SLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEA :.::. : .. :. ... . .: :::. :.:.. : : : :..:. :: XP_016 RLFQIHGNDKS-NTKAVEVPAFASSLNSNDVFLLRTQAEH-------YLWYGKGSSGDER 520 530 540 550 560 1120 1130 1140 1150 1160 pF1KE1 KLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-----HTRLFRC .:... . . : :.... ::.:: .: : .:.. :: .: . .. ..:::.: XP_016 AMAKELASLLCDG--SENTVAEGQEPAEF-WDLLGGKTPYANDKRLQQEILDVQSRLFEC 570 580 590 600 610 620 1170 1180 1190 1200 1210 1220 pF1KE1 SNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ ::. : :.::: .:: :::: :.::::. ..:..:.:.... .: . .: . : :.. XP_016 SNKTGQFVVTE-ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLH 630 640 650 660 670 680 1230 1240 1250 1260 pF1KE1 -HMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA : ... . : . ....: : :: : :: XP_016 THPSGRDPDTP--ILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRI 690 700 710 720 730 XP_016 TADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITR 740 750 760 770 780 790 >>NP_006567 (OMIM: 613397) advillin [Homo sapiens] (819 aa) initn: 460 init1: 201 opt: 536 Z-score: 437.0 bits: 92.4 E(85289): 1.3e-17 Smith-Waterman score: 979; 29.9% identity (56.8% similar) in 783 aa overlap (499-1261:14-711) 470 480 490 500 510 520 pF1KE1 PSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCY ::. .:.::.. .:: . ::.:::.::: NP_006 MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCY 10 20 30 40 530 540 550 560 570 580 pF1KE1 IVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESE ..:.: : :. .:..::: ... :...:.::....: .:::. :: . ::. NP_006 VILSTRRVAS-LLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD 50 60 70 80 90 100 590 600 610 620 630 640 pF1KE1 EFLQVFDNDISYIEGGTASGFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFV : : . : : .::.:::. :: .:. : :. .: ::.::. : .. :.. : NP_006 TFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDV 110 120 130 140 150 160 650 660 670 680 690 700 pF1KE1 FLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQEL--PEFWEA :::: : : : : ... . :: :.:. : :: :.:.: .. .: ::. .. NP_006 FLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKV 170 180 190 200 210 220 710 720 730 740 750 pF1KE1 LG---GEPSEIKKHVPEDFWPPQPK----LYKVGLGLGYLELPQINYKLSVEHKQRPKVE : :. : :: ::... . : ::... . : : . .. :: NP_006 LQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVA--------TRP--- 230 240 250 260 270 760 770 780 790 800 810 pF1KE1 LMPRMRLLQSLLDTRCVYILD-CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHA :.:.::. :::: . ...: :. . . . ::.. . . : : . NP_006 ------LVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSST 280 290 300 310 320 820 830 840 850 860 870 pF1KE1 TVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADL .: .:.:. .:: :..:. . : : . .. : : .:: .: : :. NP_006 NVETVNDGAESAMFKQLFQKWS---VKDQTMGLGKTF-SIGKIAKVFQD-------KFDV 330 340 350 360 370 880 890 900 910 920 930 pF1KE1 TALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFL : .: .: . : :..... : .: . .:. ... . . .: :: :::. : NP_006 T--LLHTKPEV--AAQERMVDDGN---GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVL 380 390 400 410 420 940 950 960 970 980 990 pF1KE1 CRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGW : : .:: :.. :.:.::::.::. NP_006 YTYEV-----------------NGK-------------PHH----ILYIWQGRHASQ-DE 430 440 450 1000 1010 1020 1030 1040 1050 pF1KE1 LTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRG--KRKAVQGAQQP- :. . . . : : ::. . : .:.. :: :..: .: .::. . : NP_006 LAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPV 460 470 480 490 500 510 1060 1070 1080 1090 1100 1110 pF1KE1 SLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEA :.::. : .. :. ... . .: :::. :.:.. : : : :..:. :: NP_006 RLFQIHGNDKS-NTKAVEVPAFASSLNSNDVFLLRTQAEH-------YLWYGKGSSGDER 520 530 540 550 560 1120 1130 1140 1150 1160 pF1KE1 KLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-----HTRLFRC .:... . . : :.... ::.:: .: : .:.. :: .: . .. ..:::.: NP_006 AMAKELASLLCDG--SENTVAEGQEPAEF-WDLLGGKTPYANDKRLQQEILDVQSRLFEC 570 580 590 600 610 620 1170 1180 1190 1200 1210 1220 pF1KE1 SNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ ::. : :.::: .:: :::: :.::::. ..:..:.:.... .: . .: . : :.. NP_006 SNKTGQFVVTE-ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLH 630 640 650 660 670 680 1230 1240 1250 1260 pF1KE1 -HMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA : ... . : . ....: : :: : :: NP_006 THPSGRDPDTP--ILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRI 690 700 710 720 730 NP_006 TADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITR 740 750 760 770 780 790 >>NP_149119 (OMIM: 613416) adseverin isoform 2 [Homo sap (468 aa) initn: 430 init1: 225 opt: 516 Z-score: 423.8 bits: 89.2 E(85289): 7.2e-17 Smith-Waterman score: 612; 30.1% identity (58.1% similar) in 511 aa overlap (769-1263:30-465) 740 750 760 770 780 790 pF1KE1 ELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD--CWSDVFIWLGRKSPRLV ::. .: .::: ...:.: :. . NP_149 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEEC-FILDHGAAKQIFVWKGKDANPQE 10 20 30 40 50 800 810 820 830 840 850 pF1KE1 RAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQS : ::.: ..:. ... ... .. :: :. .:: ::.: : : :: NP_149 RKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDK---D---------QS 60 70 80 90 100 860 870 880 890 900 910 pF1KE1 PGLSGKVKRDAEKKDQMKA-DLTALFLPRQPPMSLAEAEQLMEEWNEDLDG-MEGFVLEG :. ::: .:: :.: . : : .: :. :.. : . : .: .: . .:. NP_149 DGF-GKV-YVTEKVAQIKQIPFDASKLHSSPQMA---AQHNMVD---DGSGKVEIWRVEN 110 120 130 140 150 920 930 940 950 960 970 pF1KE1 KKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEK . .. .. .:.:: :::..: : : .:. NP_149 NGRIQVDQNSYGEFYGGDCYIILYTY--P----------------RGQ------------ 160 170 180 980 990 1000 1010 1020 1030 pF1KE1 QPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHF :.: ::: .:. :: . : ... . :. .:..: .: ..:: : NP_149 --------IIYTWQGANATR-DELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLF 190 200 210 220 230 1040 1050 1060 1070 1080 pF1KE1 KRK-FIIHR-GKRKAVQGAQQPS----LYQIRTNGSALCTRCIQINTDSSLLNSEFCFIL : : .::.. : : .:.: :. :.:.: : ... :: .....:.. :::. :.: NP_149 KDKPLIIYKNGTSK--KGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVL 240 250 260 270 280 290 1090 1100 1110 1120 1130 1140 pF1KE1 KVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGI :.: .:.: : :::.... .: : :: . ... . . :.::::::.: : .. NP_149 KLP----QNSG--YIWVGKGASQEEEKGAEYVASVL---KCKTLRIQEGEEPEEF-WNSL 300 310 320 330 340 1150 1160 1170 1180 1190 1200 pF1KE1 GAQKPYDD----DAEYMKHT-RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQE :..: :. ... : ::. :::. : :.. : ..: :::::.::.:::: .. NP_149 GGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQ 350 360 370 380 390 400 1210 1220 1230 1240 1250 1260 pF1KE1 VYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHER-PRRLRLVRKGNEQHAFTRCFHAWS ...:.: ....:: : :::. ..:.. : . .: : . ....:.: .:: : .:. NP_149 IFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTP--IVIIKQGHEPPTFTGWFLGWD 410 420 430 440 450 460 pF1KE1 AFCKALA . NP_149 SSKW >>NP_001106177 (OMIM: 613416) adseverin isoform 1 [Homo (715 aa) initn: 597 init1: 225 opt: 516 Z-score: 421.7 bits: 89.4 E(85289): 9.4e-17 Smith-Waterman score: 996; 29.2% identity (58.1% similar) in 797 aa overlap (487-1263:6-712) 460 470 480 490 500 510 pF1KE1 NKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEE : : :.. .:. :: .:.::.. : : . NP_001 MARELYHEEFAR-AGKQAGLQVWRIEKLELVPVPQ 10 20 30 520 530 540 550 560 570 pF1KE1 AFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAEC . :: :: .: :.::.: . : .......:.: : . :... .:: .:.. .:::.. NP_001 SAHGDFYVGDAYLVLHTAKTSRG-FTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKP 40 50 60 70 80 90 580 590 600 610 620 630 pF1KE1 RTVREEMGDESEEFLQVFDNDISYIEGGTASGF-YTVEDTHYVTRMYRVYGKKNIKLEPV :: .: ::..:.. : . ..: ::.:::. ... . . :. .: :.. .. : NP_001 VQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEV 100 110 120 130 140 150 640 650 660 670 680 690 pF1KE1 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ ::. :.. :..: : .:: : :.. . :: : : :::::..:. .. . NP_001 PLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEE 160 170 180 190 200 210 700 710 720 730 740 750 pF1KE1 GQELPEFWEALGGEPSEIKKHVPEDFWPP-----QPKLYKVGLGLGYLELPQINYKLSVE :.: :. ..:: .: .:. . ::: :. . : . ...: NP_001 GSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSM-------RVTVV 220 230 240 250 260 760 770 780 790 800 pF1KE1 HKQRPKVELMPRMRLLQSLLDTRCVYILD--CWSDVFIWLGRKSPRLVRAAALKLGQELC .. : : ::. .: .::: ...:.: :. . : ::.: ..:. NP_001 AEENPFSMAM--------LLSEEC-FILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFL 270 280 290 300 310 810 820 830 840 850 860 pF1KE1 GMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAE ... ... .. :: :. .:: ::.: : .. :: :. ::: .: NP_001 QQMNYSKNTQIQVLPEGGETPIFKQFFKDWRD-------KD-----QSDGF-GKV-YVTE 320 330 340 350 360 870 880 890 900 910 920 pF1KE1 KKDQMKA-DLTALFLPRQPPMSLAEAEQLMEEWNEDLDG-MEGFVLEGKKFARLPEEEFG : :.: . : : .: :. :.. : .: .: .: . .:.. .. .. .: NP_001 KVAQIKQIPFDASKLHSSPQMA---AQHNMV---DDGSGKVEIWRVENNGRIQVDQNSYG 370 380 390 400 410 930 940 950 960 970 980 pF1KE1 HFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYF .:: :::..: : : .:. :.: NP_001 EFYGGDCYIIL--YTYP-------------------RGQ-----------------IIYT 420 430 990 1000 1010 1020 1030 1040 pF1KE1 WQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRK ::: .:. :: . : ... . :. .:..: .: ..:: :: : .: . NP_001 WQGANATR-DELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGT 440 450 460 470 480 490 1050 1060 1070 1080 1090 1100 pF1KE1 AVQGAQQPS----LYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVY . .:.: :. :.:.: : ... :: .....:.. :::. :.::.: .:.: : NP_001 SKKGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVLKLP----QNSG--Y 500 510 520 530 540 550 1110 1120 1130 1140 1150 pF1KE1 AWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDD----DA :::.... .: : :: . ... . . :.::::::.: : ..:..: :. .. NP_001 IWVGKGASQEEEKGAEYVASVL---KCKTLRIQEGEEPEEF-WNSLGGKKDYQTSPLLET 560 570 580 590 600 1160 1170 1180 1190 1200 1210 pF1KE1 EYMKHT-RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEI . : ::. :::. : :.. : ..: :::::.::.:::: .....:.: ....:: NP_001 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK 610 620 630 640 650 660 1220 1230 1240 1250 1260 pF1KE1 KLSLKACQVYIQHMRSKEHER-PRRLRLVRKGNEQHAFTRCFHAWSAFCKALA : :::. ..:.. : . .: : . ....:.: .:: : .:.. NP_001 KESLKSAKMYLETDPSGRDKRTP--IVIIKQGHEPPTFTGWFLGWDSSKW 670 680 690 700 710 1269 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:45:26 2016 done: Tue Nov 8 06:45:28 2016 Total Scan time: 14.430 Total Display time: 0.560 Function used was FASTA [36.3.4 Apr, 2011]