FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7764, 501 aa 1>>>pF1KB7764 501 - 501 aa - 501 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.8347+/-0.000412; mu= -13.4729+/- 0.026 mean_var=531.5318+/-106.250, 0's: 0 Z-trim(125.7): 24 B-trim: 0 in 0/60 Lambda= 0.055630 statistics sampled from 49863 (49887) to 49863 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.835), E-opt: 0.2 (0.585), width: 16 Scan time: 9.290 The best scores are: opt bits E(85289) NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 3370 284.7 4.3e-76 XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 3279 277.4 7e-74 XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 941 89.7 1.9e-17 NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 941 89.7 2e-17 NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 797 78.2 6.1e-14 NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 795 78.0 6.8e-14 XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 757 74.9 5e-13 NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 727 72.5 2.9e-12 NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 727 72.5 2.9e-12 XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 727 72.5 2.9e-12 NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 703 70.7 1.2e-11 NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 703 70.7 1.2e-11 NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 703 70.7 1.2e-11 XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 626 64.4 7.7e-10 NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 626 64.4 7.8e-10 NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 603 62.7 3.2e-09 NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 603 62.7 3.2e-09 >>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa) initn: 3370 init1: 3370 opt: 3370 Z-score: 1487.1 bits: 284.7 E(85289): 4.3e-76 Smith-Waterman score: 3370; 99.8% identity (99.8% similar) in 501 aa overlap (1-501:1-501) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 RPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP : :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 RLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP 430 440 450 460 470 480 490 500 pF1KB7 VPRRPQNHLDAALVLSALSSS ::::::::::::::::::::: NP_077 VPRRPQNHLDAALVLSALSSS 490 500 >>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa) initn: 3490 init1: 3279 opt: 3279 Z-score: 1447.4 bits: 277.4 E(85289): 7e-74 Smith-Waterman score: 3279; 99.6% identity (99.8% similar) in 486 aa overlap (1-486:1-486) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 RPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP : :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQP 430 440 450 460 470 480 490 500 pF1KB7 VPRRPQNHLDAALVLSALSSS :::::. XP_005 VPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPNPSRISPP 490 500 510 520 >>XP_016865334 (OMIM: 606197) PREDICTED: iroquois-class (449 aa) initn: 759 init1: 592 opt: 941 Z-score: 434.2 bits: 89.7 E(85289): 1.9e-17 Smith-Waterman score: 1098; 47.3% identity (64.4% similar) in 463 aa overlap (1-457:1-415) 10 20 30 40 50 pF1KB7 MSFPQLGY-QYIRPLYPS----ERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS :::::::: ::. :. ::::. ......:.: .. ::.::.. :. . ...: XP_016 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP : : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : : XP_016 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS :.:::::.:.:::.:::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG :::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: .. XP_016 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED .: : .. .::::. . : . : .. :: .:. :.. . .: XP_016 IDEHDGDQS-NEDDEDK----AEAPHAPAAP----SALARDQGS----PLAAADVLKPQD 240 250 260 270 300 310 320 330 340 350 pF1KB7 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET : :: . . :: : .: : :: .. :: :::::::::: XP_016 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFP :::::. :. ::: .: : :: .::: : .: : . .::: ::: : XP_016 ATSPDGAPKASPPPPAGHP-GAH-GPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 GPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLL . : . :.:: . :: :: : : : : XP_016 A--QGSLLNMRSFLGVGAPH------AAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRS 390 400 410 420 430 480 490 500 pF1KB7 KTAFQPVPRRPQNHLDAALVLSALSSS XP_016 SPTLPALWPRRRERRGS 440 >>NP_077313 (OMIM: 606197) iroquois-class homeodomain pr (480 aa) initn: 759 init1: 592 opt: 941 Z-score: 433.8 bits: 89.7 E(85289): 2e-17 Smith-Waterman score: 1118; 44.8% identity (61.7% similar) in 525 aa overlap (1-501:1-480) 10 20 30 40 50 pF1KB7 MSFPQLGY-QYIRPLYPS----ERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSS :::::::: ::. :. ::::. ......:.: .. ::.::.. :. . ...: NP_077 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGG-GAGAAAVTS 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 VYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHP : : ::::. :.: .:.:::::::.: .: :.:.::::::.::: :::. :: : : NP_077 VLGM-YAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGV-HPATFAA--HTAP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 AFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS :.:::::.:.:::.:::::::::::::::::::::::::::::::::::::::::::::: NP_077 AYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 TWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGG :::::::::::::::.::. ::. .:.: .::. : : :. :.: .:..:: .. NP_077 TWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG-DPEKAEDD--EEIDLESIDIDK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 EEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED .: : .. .::::. : :. : .: : : .:.. . .: NP_077 IDEHDGDQS-NEDDEDK----------AEAPHAPAAPSALAR-DQG-SPLAAADVLKPQD 240 250 260 270 300 310 320 330 340 350 pF1KB7 SSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAET : :: . . :: : .: : :: .. :: :::::::::: NP_077 S-------PLGLAKEAPEP-----GSTRLLSPGAAAGGLQGAPHG-----KPKIWSLAET 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 ATSPDN-PRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTN---- :::::. :. ::: .: : .: .::: : .: : . .::: ::: NP_077 ATSPDGAPKASPPPPAGHP--GAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFL 330 340 350 360 370 380 420 430 440 450 pF1KB7 --------RPFPG-PPPGPRPHPLSLLGSAPPH--LLGLPGAAGHPAAAAAFARPAEPEG : : : : :: : . ::. . ::: . :.. . :. :: NP_077 AQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVR-SSPTLPE- 390 400 410 420 430 460 470 480 490 500 pF1KB7 GTDRCSALEVEKKLLKTAFQPVPRR---PQNHLDAALVLSALSSS : . . ::. :::: ::. . .:.:: :. NP_077 -RDLVPRPDSPAQQLKSPFQPVRDNSLAPQE--GTPRILAALPSA 440 450 460 470 480 >>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa) initn: 758 init1: 522 opt: 797 Z-score: 371.3 bits: 78.2 E(85289): 6.1e-14 Smith-Waterman score: 806; 38.3% identity (57.0% similar) in 491 aa overlap (1-479:1-465) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP ::.:: :: : :: . . . :... . : ..::. :.: : .: NP_005 MSYPQ-GYLY----QPSASLALYSCPAYSTSVIS--GPRTDELGRSSSGSAF------SP 10 20 30 40 70 80 90 100 110 pF1KB7 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP ::...: .: . ::.. : :.:. : .: :: . :. :... . :: : NP_005 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA :.: .:::. :::::..:.::::::::::::::::::::::::::::::::::::::: NP_005 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEE ::::::::::::::.::.:.. :: . :...::: . :: . . : : :: : NP_005 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 ED--TGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSED . .: : : . : :. .. ... . : : :: . : . NP_005 QKAASGCERLQGPPTPAGKETE---GSLSDSDFKEPPSEGRLDALQ-GPPRTGGPSPAGP 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 SSEGLEDRP---LPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSL .. : . : :. . ::.: :.: : :. : :. : : : ..: :::.::: NP_005 AAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSL 280 290 300 310 320 330 360 370 380 390 400 pF1KB7 AETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAW :: ::: :. . . : ::: :: .: .:: : :. : : : :: ::. NP_005 AEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGG 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB7 TNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALE : : .: . :: :: : :: . :... . . . .: .:: NP_005 TVLSRPLYYTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALA 400 410 420 430 440 450 470 480 490 500 pF1KB7 VEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS . :.:.. : NP_005 KDPKMLRSQSQLDLCKDSPYELKKGMSDI 460 470 480 >>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa) initn: 751 init1: 515 opt: 795 Z-score: 370.5 bits: 78.0 E(85289): 6.8e-14 Smith-Waterman score: 804; 38.1% identity (56.6% similar) in 491 aa overlap (1-479:1-464) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP ::.:: :: : :: . . . :... . : ..::. :.: : .: NP_001 MSYPQ-GYLY----QPSASLALYSCPAYSTSVIS--GPRTDELGRSSSGSAF------SP 10 20 30 40 70 80 90 100 110 pF1KB7 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP ::...: .: . ::.. : :.:. : .: :: . :. :... . :: : NP_001 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA :.: .:::. :::::..:.::::::::::::::::::::::::::::::::::::::: NP_001 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKR----ELELEEEEL ::::::::::::::.::.:.. :: . :...::: . :: : :.. NP_001 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGAEQKAA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 GGEEEDTGGEGLADDDEDEEIDLENLDGAATEPEL-SLAGAARRDGDLGLGPISDSKNSD .: :. : : . . .. .. .: .: .: : : : :: . NP_001 SGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGP---AAARL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 SEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSL .:: . :. . ::.: :.: : :. : :. : : : ..: :::.::: NP_001 AEDPAPHY-----PAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSL 290 300 310 320 330 360 370 380 390 400 pF1KB7 AETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAW :: ::: :. . . : ::: :: .: .:: : :. : : : :: ::. NP_001 AEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGG 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB7 TNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALE : : .: . :: :: : :: . :... . . . .: .:: NP_001 TVLSRPLYYTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALA 400 410 420 430 440 450 470 480 490 500 pF1KB7 VEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS . :.:.. : NP_001 KDPKMLRSQSQLDLCKDSPYELKKGMSDI 460 470 480 >>XP_011521111 (OMIM: 606195,611174) PREDICTED: iroquois (413 aa) initn: 717 init1: 522 opt: 757 Z-score: 354.8 bits: 74.9 E(85289): 5e-13 Smith-Waterman score: 757; 40.7% identity (58.3% similar) in 393 aa overlap (98-479:15-395) 70 80 90 100 110 120 pF1KB7 AAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGD :: . :. :... . :: : :.: .:: XP_011 MEGRAAVARSAHGGSPYDHTPGMAGSLGY-HPYAAPLGSYPYGD 10 20 30 40 130 140 150 160 170 180 pF1KB7 PSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK :. :::::..:.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB7 ENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEED--TGGE ::::::.::.:.. :: . :...::: . :: . . : : :: :. .: : XP_011 ENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAEQKAASGCE 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB7 GLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDR : . : :. .. ... . : : :: . : . .. : . XP_011 RLQGPPTPAGKETE---GSLSDSDFKEPPSEGRL-DALQGPPRTGGPSPAGPAAARLAED 170 180 190 200 210 310 320 330 340 350 360 pF1KB7 P---LPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPD : :. . ::.: :.: : :. : :. : : : ..: :::.::::: ::: : XP_011 PAPHYPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPKLWSLAEIATSSD 220 230 240 250 260 270 370 380 390 400 410 pF1KB7 NPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGP . . . : ::: :: .: .:: : :. : : : :: ::. : : XP_011 KVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-PFPGGTVLSRPLY 280 290 300 310 320 330 420 430 440 450 460 470 pF1KB7 PPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKT .: . :: :: : :: . :... . . . .: .:: . :.:.. XP_011 YTAPFYPGYTNYGSFG-HLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRS 340 350 360 370 380 390 480 490 500 pF1KB7 AFQPVPRRPQNHLDAALVLSALSSS : XP_011 QSQLDLCKDSPYELKKGMSDI 400 410 >>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa) initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12 Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP ::.:: :: : . ::. . . : . ..:.: :: : .. ....: : NP_150 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P 10 20 30 40 70 80 90 100 110 pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH- .:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::. NP_150 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV : ::: :..::. :::::..:.:::::::::::::::::::::::::::::::::: NP_150 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG ::::::::::::::::::::::.....: . :. . .:: :. . : :.: .. NP_150 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE ..:.: . . : : :.: : .: : .:. .: . :....: : NP_150 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E 230 240 250 260 270 300 310 320 330 340 pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ .. .:: : :: : :: .::: :. . .: : .: :: :: . NP_150 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG :::.::::: ::: . :: : ::: ::.::.. :... : : :: NP_150 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG 330 340 350 360 370 410 420 430 440 450 460 pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR . : . . :: : . .: :.. :: .::. :. : : : ..: NP_150 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG 380 390 400 410 420 430 470 480 490 500 pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS :: . . ...: NP_150 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 440 450 460 470 >>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa) initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12 Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP ::.:: :: : . ::. . . : . ..:.: :: : .. ....: : NP_001 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P 10 20 30 40 70 80 90 100 110 pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH- .:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::. NP_001 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV : ::: :..::. :::::..:.:::::::::::::::::::::::::::::::::: NP_001 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG ::::::::::::::::::::::.....: . :. . .:: :. . : :.: .. NP_001 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE ..:.: . . : : :.: : .: : .:. .: . :....: : NP_001 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E 230 240 250 260 270 300 310 320 330 340 pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ .. .:: : :: : :: .::: :. . .: : .: :: :: . NP_001 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG :::.::::: ::: . :: : ::: ::.::.. :... : : :: NP_001 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG 330 340 350 360 370 410 420 430 440 450 460 pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR . : . . :: : . .: :.. :: .::. :. : : : ..: NP_001 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG 380 390 400 410 420 430 470 480 490 500 pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS :: . . ...: NP_001 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 440 450 460 470 >>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa) initn: 650 init1: 513 opt: 727 Z-score: 341.1 bits: 72.5 E(85289): 2.9e-12 Smith-Waterman score: 782; 38.2% identity (58.4% similar) in 497 aa overlap (1-480:1-452) 10 20 30 40 50 60 pF1KB7 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP ::.:: :: : . ::. . . : . ..:.: :: : .. ....: : XP_011 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P 10 20 30 40 70 80 90 100 110 pF1KB7 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH- .:: .: :: :.:. : :.:. ::. .:: :. . :. ..: .. ::. XP_011 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD-AHTTGM---TGAISY-HPYG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV : ::: :..::. :::::..:.:::::::::::::::::::::::::::::::::: XP_011 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG ::::::::::::::::::::::.....: . :. . .:: :. . : :.: .. XP_011 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE ..:.: . . : : :.: : .: : .:. .: . :....: : XP_011 -----LHVDSLTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E 230 240 250 260 270 300 310 320 330 340 pF1KB7 DSSEGLEDRPLPVLSL------AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQ .. .:: : :: : :: .::: :. . .: : .: :: :: . XP_011 EGERGLAP-PKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----S 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 KPKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLG :::.::::: ::: . :: : ::: ::.::.. :... : : :: XP_011 KPKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPL----LG 330 340 350 360 370 410 420 430 440 450 460 pF1KB7 KFPAWTNRPFPGPPPGPRPHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDR . : . . :: : . .: :.. :: .::. :. : : : ..: XP_011 R-PLYYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAG 380 390 400 410 420 430 470 480 490 500 pF1KB7 CSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS :: . . ...: XP_011 AHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 440 450 460 470 501 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:13:50 2016 done: Tue Nov 8 05:13:51 2016 Total Scan time: 9.290 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]