FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4466, 488 aa 1>>>pF1KE4466 488 - 488 aa - 488 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3337+/-0.000375; mu= 13.6616+/- 0.023 mean_var=98.1568+/-19.751, 0's: 0 Z-trim(115.2): 20 B-trim: 0 in 0/52 Lambda= 0.129454 statistics sampled from 25453 (25467) to 25453 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.299), width: 16 Scan time: 8.040 The best scores are: opt bits E(85289) NP_036211 (OMIM: 604900,615863) diacylglycerol O-a ( 488) 3345 635.3 1.2e-181 XP_011515658 (OMIM: 604900,615863) PREDICTED: diac ( 431) 2876 547.7 2.5e-155 XP_011537152 (OMIM: 601311) PREDICTED: sterol O-ac ( 466) 432 91.2 6.7e-18 XP_011537151 (OMIM: 601311) PREDICTED: sterol O-ac ( 502) 432 91.3 7.1e-18 NP_003569 (OMIM: 601311) sterol O-acyltransferase ( 522) 432 91.3 7.3e-18 NP_001239441 (OMIM: 102642) sterol O-acyltransfera ( 485) 405 86.2 2.3e-16 NP_001239440 (OMIM: 102642) sterol O-acyltransfera ( 492) 405 86.2 2.3e-16 NP_003092 (OMIM: 102642) sterol O-acyltransferase ( 550) 405 86.2 2.5e-16 XP_011508213 (OMIM: 102642) PREDICTED: sterol O-ac ( 550) 405 86.2 2.5e-16 >>NP_036211 (OMIM: 604900,615863) diacylglycerol O-acylt (488 aa) initn: 3345 init1: 3345 opt: 3345 Z-score: 3382.3 bits: 635.3 E(85289): 1.2e-181 Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488) 10 20 30 40 50 60 pF1KE4 MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN 430 440 450 460 470 480 pF1KE4 YEAPAAEA :::::::: NP_036 YEAPAAEA >>XP_011515658 (OMIM: 604900,615863) PREDICTED: diacylgl (431 aa) initn: 2875 init1: 2875 opt: 2876 Z-score: 2909.7 bits: 547.7 E(85289): 2.5e-155 Smith-Waterman score: 2876; 99.5% identity (99.5% similar) in 424 aa overlap (65-488:8-431) 40 50 60 70 80 90 pF1KE4 AAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVV : ::::::::::::::::::::::::::: XP_011 MGAELVGEAWCHRLQDSLFSSDSGFSNYRGILNWCVV 10 20 30 100 110 120 130 140 150 pF1KE4 MLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE4 AVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE4 NSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE4 KRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIW 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE4 LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPML 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE4 RRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGN 340 350 360 370 380 390 460 470 480 pF1KE4 AAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA :::::::::::::::::::::::::::::::::: XP_011 AAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA 400 410 420 430 >>XP_011537152 (OMIM: 601311) PREDICTED: sterol O-acyltr (466 aa) initn: 306 init1: 213 opt: 432 Z-score: 442.4 bits: 91.2 E(85289): 6.7e-18 Smith-Waterman score: 473; 31.2% identity (56.9% similar) in 343 aa overlap (145-477:123-441) 120 130 140 150 160 170 pF1KE4 VDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLA .: .:. . : :. :. .:: .: : XP_011 LLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHA 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 TILC-FPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKA ..:: .:. :. :: : .: .:. . . :: . :: :. :.: . : ... XP_011 VVLCALPVHVA--VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRG 160 170 180 190 200 240 250 260 270 280 290 pF1KE4 SSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQ . :: :: :::: ::: :. ..::.: .: .. . . . : . XP_011 EGIQAPSFSSY---------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYA 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 VGLIQQWMVPTIQN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAE .. . ::.. : : .::. .. .:. ..:. .. :..:. ..: ::: :: XP_011 CFILGRLCVPVFANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAE 260 270 280 290 300 310 360 370 380 390 400 pF1KE4 LMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFL ...:::: :::::::: : . ....::. :: : . :. :: :. .. .: :::: XP_011 MLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFL 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE4 ASAFFHEYLVSVPLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIG .:: :::. : .: :. : : : ... : :. .: :..: XP_011 VSAVAHEYIFCFVLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLG 380 390 400 410 420 470 480 pF1KE4 QPIAVLMYVHDYYVLNYEAPAAEA : : : .: ...: XP_011 QGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT 430 440 450 460 >>XP_011537151 (OMIM: 601311) PREDICTED: sterol O-acyltr (502 aa) initn: 306 init1: 213 opt: 432 Z-score: 441.9 bits: 91.3 E(85289): 7.1e-18 Smith-Waterman score: 473; 31.2% identity (56.9% similar) in 343 aa overlap (145-477:159-477) 120 130 140 150 160 170 pF1KE4 VDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLA .: .:. . : :. :. .:: .: : XP_011 LLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 TILC-FPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKA ..:: .:. :. :: : .: .:. . . :: . :: :. :.: . : ... XP_011 VVLCALPVHVA--VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 SSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQ . :: :: :::: ::: :. ..::.: .: .. . . . : . XP_011 EGIQAPSFSSY---------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYA 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 VGLIQQWMVPTIQN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAE .. . ::.. : : .::. .. .:. ..:. .. :..:. ..: ::: :: XP_011 CFILGRLCVPVFANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAE 300 310 320 330 340 360 370 380 390 400 pF1KE4 LMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFL ...:::: :::::::: : . ....::. :: : . :. :: :. .. .: :::: XP_011 MLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFL 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 ASAFFHEYLVSVPLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIG .:: :::. : .: :. : : : ... : :. .: :..: XP_011 VSAVAHEYIFCFVLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLG 410 420 430 440 450 460 470 480 pF1KE4 QPIAVLMYVHDYYVLNYEAPAAEA : : : .: ...: XP_011 QGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT 470 480 490 500 >>NP_003569 (OMIM: 601311) sterol O-acyltransferase 2 [H (522 aa) initn: 306 init1: 213 opt: 432 Z-score: 441.7 bits: 91.3 E(85289): 7.3e-18 Smith-Waterman score: 479; 27.9% identity (54.8% similar) in 451 aa overlap (45-477:79-497) 20 30 40 50 60 pF1KE4 RPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAP-----NKDGDAGVGSGHWELRCH : : : : .. . ..:. . . . NP_003 KAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRK 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE4 RLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLEN---LIKYGILVDPIQVVSLFLK : : :. . . :. .. :..: . : :... :... .:. . . : : NP_003 SLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLAL- 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE4 DPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGL-LLHVANLATILC-FPAAVVL .: .: .. . .: .:. . : :. :. .:: .: :..:: .:. :. NP_003 --VTW-VPMFLSTL----LAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVA- 170 180 190 200 210 190 200 210 220 230 240 pF1KE4 LVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYP :: : .: .:. . . :: . :: :. :.: . : ... . :: :: NP_003 -VEHQLPPASRCVLVFEQVRFL-MKSY----SFLREAVPGTLRA-RRGEGIQAPSFSSY- 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE4 DNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTI :::: ::: :. ..::.: .: .. . . . : . .. . ::.. NP_003 --------LYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVF 280 290 300 310 320 310 320 330 340 350 360 pF1KE4 QN-SMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRD : : .::. .. .:. ..:. .. :..:. ..: ::: ::...:::: :::: NP_003 ANMSREPFST---RALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRD 330 340 350 360 370 380 370 380 390 400 410 420 pF1KE4 WWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRR-GS-SKWMARTGVFLASAFFHEYLVSV :::: : . ....::. :: : . :. :: :. .. .: ::::.:: :::. NP_003 WWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCF 390 400 410 420 430 440 430 440 450 460 470 pF1KE4 PLRMFR-----LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDY : .: :. : : : ... : :. .: :..:: : : .: ... NP_003 VLGFFYPVMLILFLVIGGM----LNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEW 450 460 470 480 490 480 pF1KE4 YVLNYEAPAAEA : NP_003 YARRHCPLPQATFWGLVTPRSWSCHT 500 510 520 >>NP_001239441 (OMIM: 102642) sterol O-acyltransferase 1 (485 aa) initn: 358 init1: 231 opt: 405 Z-score: 414.9 bits: 86.2 E(85289): 2.3e-16 Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:45-458) 30 40 50 60 70 80 pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF :: : .:. . . : : :. : NP_001 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD--- 20 30 40 50 60 70 90 100 110 120 130 pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI . : : . ...::: .. . : : :: ....: : : : ..: .. NP_001 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM 80 90 100 110 120 140 150 160 170 180 190 pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT ..:.: : . .. :.: . :.:. . ... .: : . :.:. .. NP_001 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR :.. .. :.: .. ..:. :. .. ...:. :: :: : : NP_001 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN 190 200 210 220 230 260 270 280 290 300 pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S . :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: . NP_001 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN ..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.:::: NP_001 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR : : . ....::. :: : . :: .: :... : .:: .:: ::: ..: : NP_001 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS 350 360 370 380 390 400 430 440 450 460 470 pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL .: :. : :: . ..:. . :. .: ::..:. . . .: ...: NP_001 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR 410 420 430 440 450 460 480 pF1KE4 NYEAPAAEA NP_001 QHCPLKNPTFLDYVRPRSWTCRYVF 470 480 >>NP_001239440 (OMIM: 102642) sterol O-acyltransferase 1 (492 aa) initn: 358 init1: 231 opt: 405 Z-score: 414.8 bits: 86.2 E(85289): 2.3e-16 Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:52-465) 30 40 50 60 70 80 pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF :: : .:. . . : : :. : NP_001 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD--- 30 40 50 60 70 90 100 110 120 130 pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI . : : . ...::: .. . : : :: ....: : : : ..: .. NP_001 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT ..:.: : . .. :.: . :.:. . ... .: : . :.:. .. NP_001 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR :.. .. :.: .. ..:. :. .. ...:. :: :: : : NP_001 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN 200 210 220 230 260 270 280 290 300 pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S . :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: . NP_001 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN ..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.:::: NP_001 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR : : . ....::. :: : . :: .: :... : .:: .:: ::: ..: : NP_001 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL .: :. : :: . ..:. . :. .: ::..:. . . .: ...: NP_001 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR 420 430 440 450 460 480 pF1KE4 NYEAPAAEA NP_001 QHCPLKNPTFLDYVRPRSWTCRYVF 470 480 490 >>NP_003092 (OMIM: 102642) sterol O-acyltransferase 1 is (550 aa) initn: 358 init1: 231 opt: 405 Z-score: 414.1 bits: 86.2 E(85289): 2.5e-16 Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:110-523) 30 40 50 60 70 80 pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF :: : .:. . . : : :. : NP_003 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD--- 80 90 100 110 120 130 90 100 110 120 130 pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI . : : . ...::: .. . : : :: ....: : : : ..: .. NP_003 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM 140 150 160 170 180 190 140 150 160 170 180 190 pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT ..:.: : . .. :.: . :.:. . ... .: : . :.:. .. NP_003 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR :.. .. :.: .. ..:. :. .. ...:. :: :: : : NP_003 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN 250 260 270 280 290 260 270 280 290 300 pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S . :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: . NP_003 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN ..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.:::: NP_003 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN 360 370 380 390 400 370 380 390 400 410 420 pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR : : . ....::. :: : . :: .: :... : .:: .:: ::: ..: : NP_003 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS 410 420 430 440 450 460 430 440 450 460 470 pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL .: :. : :: . ..:. . :. .: ::..:. . . .: ...: NP_003 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR 470 480 490 500 510 520 480 pF1KE4 NYEAPAAEA NP_003 QHCPLKNPTFLDYVRPRSWTCRYVF 530 540 550 >>XP_011508213 (OMIM: 102642) PREDICTED: sterol O-acyltr (550 aa) initn: 358 init1: 231 opt: 405 Z-score: 414.1 bits: 86.2 E(85289): 2.5e-16 Smith-Waterman score: 446; 26.6% identity (56.0% similar) in 448 aa overlap (53-477:110-523) 30 40 50 60 70 80 pF1KE4 GPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGF :: : .:. . . : : :. : XP_011 LIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVD--- 80 90 100 110 120 130 90 100 110 120 130 pF1KE4 SNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSL-FLKDP---YSWPAPCLVI . : : . ...::: .. . : : :: ....: : : : ..: .. XP_011 -HIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTW----WIM 140 150 160 170 180 190 140 150 160 170 180 190 pF1KE4 AANVFAVAAFQVEKRLAVGALTEQA--------GLLLHVANLATILCFPAAVVLLVESIT ..:.: : . .. :.: . :.:. . ... .: : . :.:. .. XP_011 FLSTFSVPYF-LFQHWATGYSKSSHPLIRSLFHGFLFMIFQIG-VLGFGPTYVVLAYTLP 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 PVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYR :.. .. :.: .. ..:. :. .. ...:. :: :: : : XP_011 PASRFI------IIFEQIRFVMKAHSFVRENVPRVLNSAKEKSS-----TVPIP---TVN 250 260 270 280 290 260 270 280 290 300 pF1KE4 DLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEML--FFTQLQVGLIQQWMVPTIQN-S . :::::::: :. ..::.: .: .. .. ... :: . ... .: ..: . XP_011 QYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYI--FERLCAPLFRNIK 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE4 MKPFKDMDYSRI-IERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWN ..::. .:. . ... .:. :: .. :. ..: ::: ::...:::: ::.:::: XP_011 QEPFS----ARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWN 360 370 380 390 400 370 380 390 400 410 420 pF1KE4 SESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKW--MARTGVFLASAFFHEYLVSVPLR : : . ....::. :: : . :: .: :... : .:: .:: ::: ..: : XP_011 STSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLS 410 420 430 440 450 460 430 440 450 460 470 pF1KE4 -----MFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVL .: :. : :: . ..:. . :. .: ::..:. . . .: ...: XP_011 FFYPVLFVLFMFFGMA----FNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYAR 470 480 490 500 510 520 480 pF1KE4 NYEAPAAEA XP_011 QHCPLKNPTFLDYVRPRSWTCRYVF 530 540 550 488 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:31:37 2016 done: Sun Nov 6 00:31:38 2016 Total Scan time: 8.040 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]