FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4491, 512 aa 1>>>pF1KE4491 512 - 512 aa - 512 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8718+/-0.000416; mu= 15.5621+/- 0.026 mean_var=78.3348+/-16.029, 0's: 0 Z-trim(112.6): 177 B-trim: 775 in 2/50 Lambda= 0.144909 statistics sampled from 21342 (21523) to 21342 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.252), width: 16 Scan time: 8.360 The best scores are: opt bits E(85289) NP_001306146 (OMIM: 108330) cytochrome P450 1A1 is ( 512) 3459 733.0 4.8e-211 NP_000490 (OMIM: 108330) cytochrome P450 1A1 isofo ( 512) 3459 733.0 4.8e-211 NP_001306145 (OMIM: 108330) cytochrome P450 1A1 is ( 483) 2604 554.3 2.9e-157 NP_000752 (OMIM: 124060) cytochrome P450 1A2 [Homo ( 516) 2549 542.8 9e-154 XP_016877442 (OMIM: 108330) PREDICTED: cytochrome ( 484) 1787 383.5 7.7e-106 NP_000095 (OMIM: 231300,600975,601771,604229) cyto ( 543) 1277 276.9 1.1e-73 NP_000093 (OMIM: 202110,609300) steroid 17-alpha-h ( 508) 910 200.2 1.2e-50 XP_011528270 (OMIM: 124030,608902) PREDICTED: cyto ( 491) 852 188.0 5.4e-47 NP_000097 (OMIM: 124030,608902) cytochrome P450 2D ( 497) 850 187.6 7.3e-47 XP_011528268 (OMIM: 124030,608902) PREDICTED: cyto ( 502) 850 187.6 7.3e-47 NP_898898 (OMIM: 610670,615030) cytochrome P450 2U ( 544) 820 181.4 6.1e-45 XP_005262774 (OMIM: 610670,615030) PREDICTED: cyto ( 562) 820 181.4 6.3e-45 NP_000757 (OMIM: 608055) cytochrome P450 2A13 [Hom ( 494) 690 154.2 8.5e-37 NP_000766 (OMIM: 601258) cytochrome P450 2J2 [Homo ( 502) 677 151.4 5.7e-36 NP_000753 (OMIM: 122700,122720,188890,211980) cyto ( 494) 664 148.7 3.7e-35 NP_000765 (OMIM: 124070) cytochrome P450 2F1 precu ( 491) 660 147.9 6.5e-35 XP_016881874 (OMIM: 124070) PREDICTED: cytochrome ( 566) 660 147.9 7.4e-35 NP_085079 (OMIM: 608054) cytochrome P450 2A7 isofo ( 443) 656 147.0 1.1e-34 NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494) 656 147.0 1.2e-34 NP_000760 (OMIM: 124020,609535) cytochrome P450 2C ( 490) 655 146.8 1.3e-34 XP_016871247 (OMIM: 122700,601130) PREDICTED: cyto ( 490) 654 146.6 1.6e-34 NP_000762 (OMIM: 122700,601130) cytochrome P450 2C ( 490) 654 146.6 1.6e-34 NP_000491 (OMIM: 201910,613815) steroid 21-hydroxy ( 495) 654 146.6 1.6e-34 NP_000763 (OMIM: 601131) cytochrome P450 2C18 isof ( 490) 652 146.2 2.1e-34 NP_001185784 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 647 145.1 3.8e-34 NP_001185782 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 647 145.1 3.8e-34 NP_000761 (OMIM: 601129) cytochrome P450 2C8 isofo ( 490) 647 145.2 4.3e-34 NP_001020332 (OMIM: 124030,608902) cytochrome P450 ( 446) 646 144.9 4.6e-34 XP_011528272 (OMIM: 124030,608902) PREDICTED: cyto ( 451) 646 144.9 4.6e-34 NP_001185783 (OMIM: 601129) cytochrome P450 2C8 is ( 388) 644 144.5 5.4e-34 NP_000758 (OMIM: 123930,614546) cytochrome P450 2B ( 491) 641 143.9 1e-33 NP_085125 (OMIM: 611529) cytochrome P450 2S1 precu ( 504) 612 137.8 7e-32 NP_000764 (OMIM: 124040) cytochrome P450 2E1 precu ( 493) 609 137.2 1.1e-31 NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501) 604 136.2 2.2e-31 XP_016872681 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_016872680 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_011518197 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_016872682 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_011518200 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_016872683 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_016872684 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29 XP_016872679 (OMIM: 600081,608713) PREDICTED: vita ( 446) 572 129.5 2.1e-29 XP_005252846 (OMIM: 600081,608713) PREDICTED: vita ( 447) 572 129.5 2.1e-29 XP_005252845 (OMIM: 600081,608713) PREDICTED: vita ( 453) 572 129.5 2.1e-29 XP_011524856 (OMIM: 124070) PREDICTED: cytochrome ( 434) 541 123.0 1.8e-27 XP_011524854 (OMIM: 124070) PREDICTED: cytochrome ( 498) 541 123.0 2e-27 XP_011524853 (OMIM: 124070) PREDICTED: cytochrome ( 498) 541 123.0 2e-27 NP_001122062 (OMIM: 201910,613815) steroid 21-hydr ( 465) 540 122.8 2.2e-27 XP_016881873 (OMIM: 124070) PREDICTED: cytochrome ( 573) 541 123.0 2.3e-27 XP_011524851 (OMIM: 123930,614546) PREDICTED: cyto ( 294) 532 121.0 4.8e-27 >>NP_001306146 (OMIM: 108330) cytochrome P450 1A1 isofor (512 aa) initn: 3459 init1: 3459 opt: 3459 Z-score: 3909.9 bits: 733.0 E(85289): 4.8e-211 Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512) 10 20 30 40 50 60 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 430 440 450 460 470 480 490 500 510 pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :::::::::::::::::::::::::::::::: NP_001 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 490 500 510 >>NP_000490 (OMIM: 108330) cytochrome P450 1A1 isoform 1 (512 aa) initn: 3459 init1: 3459 opt: 3459 Z-score: 3909.9 bits: 733.0 E(85289): 4.8e-211 Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512) 10 20 30 40 50 60 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 430 440 450 460 470 480 490 500 510 pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :::::::::::::::::::::::::::::::: NP_000 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 490 500 510 >>NP_001306145 (OMIM: 108330) cytochrome P450 1A1 isofor (483 aa) initn: 3231 init1: 2604 opt: 2604 Z-score: 2944.3 bits: 554.3 E(85289): 2.9e-157 Smith-Waterman score: 3177; 94.1% identity (94.3% similar) in 512 aa overlap (1-512:1-483) 10 20 30 40 50 60 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL :::::::::::::::::::::::::::: .:: NP_001 DRSHLPYMEAFILETFRHSSFVPFTIPH-----------------------------RKL 370 380 390 430 440 450 460 470 480 pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 400 410 420 430 440 450 490 500 510 pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :::::::::::::::::::::::::::::::: NP_001 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 460 470 480 >>NP_000752 (OMIM: 124060) cytochrome P450 1A2 [Homo sap (516 aa) initn: 2549 init1: 1426 opt: 2549 Z-score: 2881.7 bits: 542.8 E(85289): 9e-154 Smith-Waterman score: 2549; 73.0% identity (90.6% similar) in 508 aa overlap (5-511:7-512) 10 20 30 40 50 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN . .::::.::::.::::::::... ::.::::::.:: ::::::.::.:::::: NP_000 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG ::::::::::.::::::::::::::.::: ::::::::::::::::::::::: :::..: NP_000 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM ::..:: :::::::::::::::.:..::::::::::.::::::::::::..::: ::::: NP_000 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 AGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIP ::::::.:: :::::.::: :.:::... .. .:.::::. ...: :...:::: ::.: NP_000 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 ILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENA ::::::::.:. :: .:..: :.:: :.:::. :.:. .:::: .:..: :. . . NP_000 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH--SKKGPRAS 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR . . .:::.:.: :.:::::::::::::::::::: .:..:::::.:::::::: :::: NP_000 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ :::: .:::.:::::::::::::.::::::::::::.:.:::::: ::::::::.::: NP_000 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 KLWVNPSEFLPERFLTPDG-AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR .:: .:::: :::::: :: ::.: ::::...::::::.::::..:.::.:::::::::. NP_000 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 420 430 440 450 460 470 480 490 500 510 pF1KE4 VEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS .::::: :::::.::::::::::: ::: : .:: NP_000 LEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN 480 490 500 510 >>XP_016877442 (OMIM: 108330) PREDICTED: cytochrome P450 (484 aa) initn: 1787 init1: 1787 opt: 1787 Z-score: 2021.2 bits: 383.5 E(85289): 7.7e-106 Smith-Waterman score: 3199; 94.5% identity (94.5% similar) in 512 aa overlap (1-512:1-484) 10 20 30 40 50 60 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL ::::::::::::::::::::::::::::::::::::::::: XP_016 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLN------------------- 190 200 210 220 250 260 270 280 290 300 pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------AFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 400 410 420 430 440 450 490 500 510 pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :::::::::::::::::::::::::::::::: XP_016 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 460 470 480 >>NP_000095 (OMIM: 231300,600975,601771,604229) cytochro (543 aa) initn: 1175 init1: 626 opt: 1277 Z-score: 1444.2 bits: 276.9 E(85289): 1.1e-73 Smith-Waterman score: 1277; 40.1% identity (70.8% similar) in 504 aa overlap (2-499:13-512) 10 20 30 40 pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLI : :.:.. : .:: .. : : : . . . ::::..:::: NP_000 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 GHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL :. ..:. ::...:....::::.:::.:: :.:::.: .:.::::.::. : :: . NP_000 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV .: ..:.:.::.:. : : ..:: :.. ...: .. .: : :: :: .::. NP_000 ASFRVVSGGRSMAFGHYS-EHWKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARE 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG :.. : . : . ..: .::.:.::. :.::: ::.:. :. :.. :..::..:: NP_000 LVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 SGNPADFIPILRYLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSL .:. .: .: :.:.::: ..:.. ::..: .:. .: .... : ::. :.. NP_000 AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAF 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 IEHCQEKQLDEN--ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI : ..: .. ....:. :.. . :.:::. ::..::..: :. .. : :: .. NP_000 ILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 QEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPK : ::: :.::.: : ..:. .:::. ::. :..: ::::: ::::.:: .::. :..::: NP_000 QAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPK 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA ::::::..::: : :: .: : ::: :: :.: :. .:.::..:::.:::: .. NP_000 DTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELS 420 430 440 450 460 470 470 480 490 500 510 pF1KE4 RWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS . ..:::..:: .. .: . . . :. ::::.: NP_000 KMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNL 480 490 500 510 520 530 NP_000 QAKETCQ 540 >>NP_000093 (OMIM: 202110,609300) steroid 17-alpha-hydro (508 aa) initn: 825 init1: 555 opt: 910 Z-score: 1030.0 bits: 200.2 E(85289): 1.2e-50 Smith-Waterman score: 910; 33.1% identity (66.9% similar) in 487 aa overlap (13-483:4-468) 10 20 30 40 50 pF1KE4 MLFPISMSATEFLLASVIFCL--VFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN :.: ... : .:: : . : : : : . . ::.: . : .. NP_000 MWELVALLLLTLAYLFWPKR----RCP-GAKYPKSLLSLPLVGSLPFLPRH 10 20 30 40 60 70 80 90 100 110 pF1KE4 PHL--ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS :. . .....:: . ..:.:. .:... . ...:...: ::.:::.. :. . : NP_000 GHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 NG-QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQ :. ....:. ::: : .:::: . .:.. .: .. ::. . .: :::: NP_000 NNRKGIAFA-DSGAHWQLHRRLA---MATFALFKDGDQK----LEKIICQE----ISTLC 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 ELMAGP-GHFNPYRY-VVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNP ...: :. . : :.::::: :::. : .. :: . : :... . ... . NP_000 DMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ .:..: :. .:: .:. .:. . ....:..... . :.. : .. :.:. : :. NP_000 VDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLM---QAKM 220 230 240 250 260 270 300 310 320 330 340 pF1KE4 LDENANVQ-------LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE ..:.:. :::..:.. . :.:::: .:.:....:.: .:. ::.:..:. :: NP_000 NSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE4 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC .: .: :: : .:::..: .:: : :..: .:. :::... :.:. : . :: NP_000 IDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTE 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE4 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV--IIFGMGKRKCIGETIAR :..: : ..:..: : .:..:.:::::.: :. ...: .: . :: : :.:::: .:: NP_000 VIINLWALHHNEKEWHQPDQFMPERFLNPAGT--QLISPSVSYLPFGAGPRSCIGEILAR 400 410 420 430 440 470 480 490 500 510 pF1KE4 WEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :.::..: :::: .. :: NP_000 QELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST 450 460 470 480 490 500 >>XP_011528270 (OMIM: 124030,608902) PREDICTED: cytochro (491 aa) initn: 699 init1: 410 opt: 852 Z-score: 964.7 bits: 188.0 E(85289): 5.4e-47 Smith-Waterman score: 865; 31.4% identity (66.0% similar) in 474 aa overlap (38-503:32-487) 10 20 30 40 50 60 pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM . :::: : .:..: . .: .... XP_011 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS ...:::...... ::::::.:: ..:.::: .:.: :: . ... : . : XP_011 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF ::.: .::.. . :....... ::. :..:: : ... . . : : XP_011 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG---NPADFIPILR : . .:.::: .. :::.... ..: :..: .. : :: . . .:.: XP_011 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVLL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANV ..: . .... ... : . ..... :: :.. .. ::.:.... . .. . : . XP_011 HIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPES 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS ...::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::... XP_011 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL :..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. . XP_011 DQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF : .: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. : XP_011 WEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 410 420 430 440 450 460 490 500 510 pF1KE4 SVPLGVKVDMTPIY-GLTMKHACCEHFQMQLRS ::: : . : . :. .:: XP_011 SVPTG---QPRPSHHGVFAFLGCCCTDP 470 480 490 >>NP_000097 (OMIM: 124030,608902) cytochrome P450 2D6 is (497 aa) initn: 699 init1: 410 opt: 850 Z-score: 962.3 bits: 187.6 E(85289): 7.3e-47 Smith-Waterman score: 863; 31.7% identity (67.4% similar) in 454 aa overlap (38-485:32-471) 10 20 30 40 50 60 pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM . :::: : .:..: . .: .... NP_000 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS ...:::...... ::::::.:: ..:.::: .:.: :: . ... : . : NP_000 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF ::.: .::.. . :....... ::. :..:: : ... . . : : NP_000 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA-DFIPILRY : . .:.::: .. :::.... ..: :..: .... : : . . .:.: . NP_000 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANVQ .: . .... ... : . ..... :: :.. .. ::.:.... . .. . : . . NP_000 IPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESS 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD ..::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::...: NP_000 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW ..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. .: NP_000 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS .: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. :: NP_000 EKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS 410 420 430 440 450 460 490 500 510 pF1KE4 VPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :: : NP_000 VPTGQPRPSHHGVFAFLVSPSPYELCAVPR 470 480 490 >>XP_011528268 (OMIM: 124030,608902) PREDICTED: cytochro (502 aa) initn: 699 init1: 410 opt: 850 Z-score: 962.3 bits: 187.6 E(85289): 7.3e-47 Smith-Waterman score: 863; 31.7% identity (67.4% similar) in 454 aa overlap (38-485:32-471) 10 20 30 40 50 60 pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM . :::: : .:..: . .: .... XP_011 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS ...:::...... ::::::.:: ..:.::: .:.: :: . ... : . : XP_011 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF ::.: .::.. . :....... ::. :..:: : ... . . : : XP_011 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA-DFIPILRY : . .:.::: .. :::.... ..: :..: .... : : . . .:.: . XP_011 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANVQ .: . .... ... : . ..... :: :.. .. ::.:.... . .. . : . . XP_011 IPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESS 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD ..::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::...: XP_011 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW ..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. .: XP_011 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS .: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. :: XP_011 EKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS 410 420 430 440 450 460 490 500 510 pF1KE4 VPLGVKVDMTPIYGLTMKHACCEHFQMQLRS :: : XP_011 VPTGQPRPSHHGVFAFLDWLPLWALRDAAVQTPDQ 470 480 490 500 512 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:47:13 2016 done: Sun Nov 6 00:47:14 2016 Total Scan time: 8.360 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]