FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0957, 493 aa 1>>>pF1KE0957 493 - 493 aa - 493 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.5540+/-0.000779; mu= -7.0181+/- 0.045 mean_var=708.6042+/-165.429, 0's: 0 Z-trim(112.0): 166 B-trim: 949 in 1/50 Lambda= 0.048181 statistics sampled from 20723 (20830) to 20723 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.244), width: 16 Scan time: 8.370 The best scores are: opt bits E(85289) NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 3323 247.7 5.7e-65 NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2983 224.0 7.1e-58 NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 2185 168.6 3.8e-41 NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 2165 167.2 9.9e-41 NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 2148 166.0 2.2e-40 NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 2100 162.5 2e-39 XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2060 159.8 1.4e-38 XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2055 159.5 1.8e-38 XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2055 159.5 1.8e-38 NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 2051 159.2 2.3e-38 XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1762 138.9 2.2e-32 NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1762 139.1 2.4e-32 NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1584 126.5 1.2e-28 NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1577 126.4 2e-28 XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1577 126.4 2e-28 XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1577 126.4 2e-28 XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28 NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1576 126.3 2.1e-28 XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28 NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1576 126.3 2.1e-28 XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28 NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1576 126.3 2.1e-28 XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28 XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28 NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1576 126.3 2.1e-28 XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1539 123.7 1.2e-27 NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1539 123.7 1.2e-27 XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27 XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1442 116.7 1.1e-25 NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1411 114.8 5.9e-25 NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1411 114.8 5.9e-25 XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1411 114.8 5.9e-25 XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1281 105.7 3.1e-22 XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1281 105.7 3.1e-22 NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1281 105.8 3.2e-22 XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1186 99.0 2.7e-20 XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312) 869 76.8 1e-13 NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 788 71.3 5.7e-12 NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 788 71.5 6.5e-12 NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 788 71.5 6.5e-12 XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 758 69.4 2.8e-11 XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 758 69.4 2.8e-11 NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 758 69.5 2.9e-11 XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 758 69.5 2.9e-11 NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 758 69.5 3e-11 >>NP_660302 (OMIM: 608981) activin receptor type-1C isof (493 aa) initn: 3323 init1: 3323 opt: 3323 Z-score: 1287.4 bits: 247.7 E(85289): 5.7e-65 Smith-Waterman score: 3323; 99.6% identity (99.8% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KE0 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQ :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_660 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_660 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 430 440 450 460 470 480 490 pF1KE0 TISQLCVKEDCKA ::::::::::::: NP_660 TISQLCVKEDCKA 490 >>NP_001104501 (OMIM: 608981) activin receptor type-1C i (443 aa) initn: 2983 init1: 2983 opt: 2983 Z-score: 1160.1 bits: 224.0 E(85289): 7.1e-58 Smith-Waterman score: 2983; 99.5% identity (99.8% similar) in 443 aa overlap (51-493:1-443) 30 40 50 60 70 80 pF1KE0 ELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNN :::::::::::::::::::::::::::::: NP_001 MLTNGKEQVIKSCVSLPELNAQVFCHSSNN 10 20 30 90 100 110 120 130 140 pF1KE0 VTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQ 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 CSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE0 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDN :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDN 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE0 GTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIA ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE0 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE0 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 340 350 360 370 380 390 450 460 470 480 490 pF1KE0 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA 400 410 420 430 440 >>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type (503 aa) initn: 2130 init1: 1881 opt: 2185 Z-score: 859.8 bits: 168.6 E(85289): 3.8e-41 Smith-Waterman score: 2191; 67.3% identity (81.5% similar) in 504 aa overlap (4-492:3-502) 10 20 30 40 50 pF1KE0 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM : .: : :::: :::: : :: :.: : :: ..:::: :.: :..:: NP_004 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT 10 20 30 40 50 60 70 80 90 100 pF1KE0 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASPN :. : . :.. .: . : :. .:: : :: : ::.: .:::. . NP_004 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKS 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 APKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGK .: :::.::: .:. :::.. :. :: :. :..: ... :: :.: . ... : NP_004 SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHR--VPNEEDPSLDRPFISEGT 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 TLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFS ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.::::::: NP_004 TLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 SRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN ::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::: NP_004 SREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 IVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLA ::. :::::::: ::::::::::::::::::::::::.::::::::: :: ::::::: NP_004 TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 VKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC :.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::::::: NP_004 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECW :.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..:::::: NP_004 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW 420 430 440 450 460 470 470 480 490 pF1KE0 YANGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::::.::: .: : NP_004 YANGAARLTALRIKKTLSQLSQQEGIKM 480 490 500 >>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t (507 aa) initn: 2136 init1: 1909 opt: 2165 Z-score: 852.2 bits: 167.2 E(85289): 9.9e-41 Smith-Waterman score: 2186; 66.9% identity (81.3% similar) in 508 aa overlap (4-492:3-506) 10 20 30 40 50 pF1KE0 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM : .: : :::: :::: : :: :.: : :: ..:::: :.: :..:: NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT 10 20 30 40 50 60 70 80 90 100 pF1KE0 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASP- :. : . :.. .: . : :. .:: : :: : ::.: .:::..: NP_001 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 ---NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLV ..: :::.::: .:. :::.. :. :: :. :..: ... :: :.: . .. NP_001 SVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHR--VPNEEDPSLDRPFI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAV . : ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.::: NP_001 SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 KIFSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDY ::::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.:: NP_001 KIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDY 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 LNRNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIAD ::: ::. :::::::: ::::::::::::::::::::::::.::::::::: :: ::: NP_001 LNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIAD 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 LGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEI :::::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::: NP_001 LGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEI 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 ARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIM :::::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..:: NP_001 ARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIM 420 430 440 450 460 470 470 480 490 pF1KE0 RECWYANGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::::::::.::: .: : NP_001 RECWYANGAARLTALRIKKTLSQLSQQEGIKM 480 490 500 >>NP_004293 (OMIM: 601300) activin receptor type-1B isof (505 aa) initn: 2099 init1: 1838 opt: 2148 Z-score: 845.9 bits: 166.0 E(85289): 2.2e-40 Smith-Waterman score: 2156; 65.6% identity (84.5% similar) in 491 aa overlap (13-492:15-504) 10 20 30 40 50 pF1KE0 MTRALCSALRQALLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTN .::::... .: .: :.: : ..:.::.:.::: .:.. . NP_004 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 10 20 30 40 50 60 60 70 80 90 100 pF1KE0 GKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPK : :. ...:. :: . .: ::... .:.::.::.:: : :..:.. :. :. NP_004 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 L-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL . ::.::. ::. :: :: . ... . . .: :....: ..:.: : : . ::: NP_004 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTL 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR .::.::...:::::::::.::::.:::::::::.:::::::::.::: : :::::::::: NP_004 QDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 DERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV .:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::: : NP_004 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 TMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK :. :::::::: ::::::::::::::::::.:::::.::::::::: ::::::::::. NP_004 TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV ::.. .:::: : .::::::::::.::.:.:.. :.::: ::::..:::::::::::. NP_004 HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE0 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA ::. :::::::::.::::::::::::::::::.::.::: ::: :::::::..::::::: NP_004 GGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYA 420 430 440 450 460 470 470 480 490 pF1KE0 NGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::.::: :.:: : NP_004 NGAARLTALRIKKTLSQLSVQEDVKI 480 490 500 >>NP_001104502 (OMIM: 608981) activin receptor type-1C i (413 aa) initn: 2100 init1: 2100 opt: 2100 Z-score: 828.6 bits: 162.5 E(85289): 2e-39 Smith-Waterman score: 2622; 83.4% identity (83.6% similar) in 493 aa overlap (1-493:1-413) 10 20 30 40 50 60 pF1KE0 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV ::::::::::::::::::::::::::::::::::::::::: NP_001 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE0 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQ ::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_001 -GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_001 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE0 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE0 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 350 360 370 380 390 400 490 pF1KE0 TISQLCVKEDCKA ::::::::::::: NP_001 TISQLCVKEDCKA 410 >>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta (434 aa) initn: 2011 init1: 1881 opt: 2060 Z-score: 813.4 bits: 159.8 E(85289): 1.4e-38 Smith-Waterman score: 2060; 73.5% identity (88.2% similar) in 415 aa overlap (78-492:23-433) 50 60 70 80 90 100 pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAP ...:: : :: : ::.: .:::. ..: XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKSSP 10 20 30 40 50 110 120 130 140 150 160 pF1KE0 KLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL :::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ... : :: XP_011 GLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISEGTTL 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR ::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.::::::::: XP_011 KDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSR 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE0 DERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV .:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::: : XP_011 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE0 TMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK :. :::::::: ::::::::::::::::::::::::.::::::::: :: ::::::::. XP_011 TVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR 230 240 250 260 270 280 350 360 370 380 390 400 pF1KE0 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV ::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::::::::. XP_011 HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI 290 300 310 320 330 340 410 420 430 440 450 460 pF1KE0 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA ::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..:::::::: XP_011 GGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYA 350 360 370 380 390 400 470 480 490 pF1KE0 NGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::.::: .: : XP_011 NGAARLTALRIKKTLSQLSQQEGIKM 410 420 430 >>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa) initn: 2026 init1: 1909 opt: 2055 Z-score: 811.5 bits: 159.5 E(85289): 1.8e-38 Smith-Waterman score: 2055; 73.0% identity (87.8% similar) in 419 aa overlap (78-492:23-437) 50 60 70 80 90 100 pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP--- ...:: : :: : ::.: .:::..: XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPFSV 10 20 30 40 50 110 120 130 140 150 160 pF1KE0 -NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNA ..: :::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ... XP_011 KSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISE 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 GKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKI : ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.::::: XP_011 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE0 FSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN ::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.:::: XP_011 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE0 RNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLG : ::. :::::::: ::::::::::::::::::::::::.::::::::: :: ::::: XP_011 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 230 240 250 260 270 280 350 360 370 380 390 400 pF1KE0 LAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIAR :::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::::: XP_011 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 290 300 310 320 330 340 410 420 430 440 450 460 pF1KE0 RCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRE :::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..:::: XP_011 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE 350 360 370 380 390 400 470 480 490 pF1KE0 CWYANGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::::::.::: .: : XP_011 CWYANGAARLTALRIKKTLSQLSQQEGIKM 410 420 430 >>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa) initn: 2026 init1: 1909 opt: 2055 Z-score: 811.5 bits: 159.5 E(85289): 1.8e-38 Smith-Waterman score: 2055; 73.0% identity (87.8% similar) in 419 aa overlap (78-492:23-437) 50 60 70 80 90 100 pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP--- ...:: : :: : ::.: .:::..: XP_016 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPFSV 10 20 30 40 50 110 120 130 140 150 160 pF1KE0 -NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNA ..: :::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ... XP_016 KSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISE 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 GKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKI : ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.::::: XP_016 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE0 FSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN ::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.:::: XP_016 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE0 RNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLG : ::. :::::::: ::::::::::::::::::::::::.::::::::: :: ::::: XP_016 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 230 240 250 260 270 280 350 360 370 380 390 400 pF1KE0 LAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIAR :::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::::: XP_016 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 290 300 310 320 330 340 410 420 430 440 450 460 pF1KE0 RCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRE :::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..:::: XP_016 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE 350 360 370 380 390 400 470 480 490 pF1KE0 CWYANGAARLTALRIKKTISQLCVKEDCKA ::::::::::::::::::.::: .: : XP_016 CWYANGAARLTALRIKKTLSQLSQQEGIKM 410 420 430 >>NP_064732 (OMIM: 601300) activin receptor type-1B isof (453 aa) initn: 1971 init1: 1838 opt: 2051 Z-score: 809.9 bits: 159.2 E(85289): 2.3e-38 Smith-Waterman score: 2051; 67.8% identity (85.6% similar) in 451 aa overlap (49-492:3-452) 20 30 40 50 60 70 pF1KE0 AAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPEL---NAQVFC :.. .: :. ...:. :: . .: NP_064 MVSIFNLDGMEHHVRTCIPKVELVPAGKPFYC 10 20 30 80 90 100 110 120 130 pF1KE0 HSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPKL-GPMELAIIITVPVCLLSIAAML ::... .:.::.::.:: : :..:.. :. :.. ::.::. ::. :: :: . .. NP_064 LSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIII 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 TVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTI . . . .: :....: ..:.: : : . :::.::.::...:::::::::.::::. NP_064 VFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGSGLPLFVQRTV 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 ARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENILG :::::::::.:::::::::.::: : ::::::::::.:: :::::::::::::::::::: NP_064 ARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILG 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE0 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIASGLAHLHMEIV :::::::::::::::::::.:::.:::.::::: ::. :::::::: :::::::::::: NP_064 FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE0 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP ::::::.:::::.::::::::: ::::::::::.::.. .:::: : .::::::::: NP_064 GTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAP 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE0 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM :.::.:.:.. :.::: ::::..:::::::::::. ::. :::::::::.:::::::::: NP_064 EVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEM 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE0 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDC ::::::::.::.::: ::: :::::::..:::::::::::::::::::::.::: :.:: NP_064 RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDV 400 410 420 430 440 450 pF1KE0 KA : NP_064 KI 493 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:38:05 2016 done: Mon Nov 7 00:38:06 2016 Total Scan time: 8.370 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]