FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6224, 270 aa 1>>>pF1KE6224 270 - 270 aa - 270 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3698+/-0.0003; mu= 15.7825+/- 0.019 mean_var=83.8179+/-16.604, 0's: 0 Z-trim(118.2): 177 B-trim: 29 in 1/56 Lambda= 0.140090 statistics sampled from 30747 (30950) to 30747 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.363), width: 16 Scan time: 6.020 The best scores are: opt bits E(85289) NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 1929 399.0 4.7e-111 XP_011507760 (OMIM: 600889) PREDICTED: complement ( 266) 1876 388.3 7.7e-108 XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 1808 374.6 1e-103 XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 1325 276.9 2.1e-74 XP_011507762 (OMIM: 600889) PREDICTED: complement ( 201) 1272 266.2 3.5e-71 NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 1201 252.0 1.1e-66 NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 1028 216.9 3.1e-56 XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 980 207.2 2.1e-53 XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 943 199.8 4.5e-51 NP_110414 (OMIM: 608593,614809) complement factor ( 569) 929 197.2 5.7e-50 NP_001299601 (OMIM: 600889) complement factor H-re ( 146) 907 192.3 4.4e-49 XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 895 190.3 6.2e-48 XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 851 181.4 3.2e-45 NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 826 176.7 1.9e-43 NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 784 167.7 2.5e-41 NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 756 162.0 1.3e-39 XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 756 162.1 1.4e-39 XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 756 162.2 1.9e-39 NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 756 162.2 1.9e-39 NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 756 162.2 1.9e-39 XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 538 118.2 3.2e-26 XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 534 117.3 5.2e-26 XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 534 117.3 5.3e-26 XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 448 100.0 1.1e-20 NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 448 100.0 1.2e-20 XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 448 100.1 1.2e-20 XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 448 100.1 1.2e-20 XP_016856597 (OMIM: 126700,134370,235400,609814,61 ( 446) 435 97.3 5.3e-20 NP_001014975 (OMIM: 126700,134370,235400,609814,61 ( 449) 435 97.3 5.4e-20 NP_000565 (OMIM: 125240,613793) complement decay-a ( 381) 256 61.0 3.7e-09 NP_001287833 (OMIM: 125240,613793) complement deca ( 384) 256 61.0 3.7e-09 XP_016855956 (OMIM: 125240,613793) PREDICTED: comp ( 412) 256 61.1 3.9e-09 NP_001287832 (OMIM: 125240,613793) complement deca ( 439) 256 61.1 4.1e-09 NP_001108224 (OMIM: 125240,613793) complement deca ( 440) 256 61.1 4.1e-09 NP_001287831 (OMIM: 125240,613793) complement deca ( 444) 256 61.1 4.1e-09 XP_005273309 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 254 60.8 6.8e-09 NP_000706 (OMIM: 120830) C4b-binding protein alpha ( 597) 254 60.8 6.8e-09 XP_005273308 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 254 60.8 6.8e-09 NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 249 59.6 9.1e-09 XP_016856799 (OMIM: 120920,612922) PREDICTED: memb ( 348) 229 55.6 1.5e-07 NP_758860 (OMIM: 120920,612922) membrane cofactor ( 349) 229 55.6 1.5e-07 NP_758871 (OMIM: 120920,612922) membrane cofactor ( 355) 229 55.6 1.5e-07 NP_758862 (OMIM: 120920,612922) membrane cofactor ( 362) 229 55.6 1.6e-07 XP_016856798 (OMIM: 120920,612922) PREDICTED: memb ( 363) 229 55.6 1.6e-07 NP_758863 (OMIM: 120920,612922) membrane cofactor ( 369) 229 55.6 1.6e-07 XP_011507866 (OMIM: 120920,612922) PREDICTED: memb ( 370) 229 55.6 1.6e-07 NP_758861 (OMIM: 120920,612922) membrane cofactor ( 377) 229 55.6 1.6e-07 XP_016856797 (OMIM: 120920,612922) PREDICTED: memb ( 378) 229 55.6 1.6e-07 NP_722548 (OMIM: 120920,612922) membrane cofactor ( 384) 229 55.6 1.6e-07 XP_011507865 (OMIM: 120920,612922) PREDICTED: memb ( 385) 229 55.6 1.6e-07 >>NP_005657 (OMIM: 600889) complement factor H-related p (270 aa) initn: 1929 init1: 1929 opt: 1929 Z-score: 2114.8 bits: 399.0 E(85289): 4.7e-111 Smith-Waterman score: 1929; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 190 200 210 220 230 240 250 260 270 pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK :::::::::::::::::::::::::::::: NP_005 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 250 260 270 >>XP_011507760 (OMIM: 600889) PREDICTED: complement fact (266 aa) initn: 1880 init1: 991 opt: 1876 Z-score: 2057.0 bits: 388.3 E(85289): 7.7e-108 Smith-Waterman score: 1876; 98.1% identity (98.5% similar) in 270 aa overlap (1-270:1-266) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN ::::::::::::::::::: .:::::::::::::::::::::::::::::::::::: XP_011 QNNENNISCVERGWSTPPK----FSAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 180 190 200 210 220 230 250 260 270 pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK :::::::::::::::::::::::::::::: XP_011 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 240 250 260 >>XP_011507761 (OMIM: 600889) PREDICTED: complement fact (250 aa) initn: 1808 init1: 1808 opt: 1808 Z-score: 1983.1 bits: 374.6 E(85289): 1e-103 Smith-Waterman score: 1808; 100.0% identity (100.0% similar) in 250 aa overlap (21-270:1-250) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::: XP_011 MFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 170 180 190 200 210 220 250 260 270 pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK :::::::::::::::::::::::::::::: XP_011 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 230 240 250 >>XP_005245170 (OMIM: 600889) PREDICTED: complement fact (205 aa) initn: 1325 init1: 1325 opt: 1325 Z-score: 1456.7 bits: 276.9 E(85289): 2.1e-74 Smith-Waterman score: 1325; 100.0% identity (100.0% similar) in 185 aa overlap (86-270:21-205) 60 70 80 90 100 110 pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN :::::::::::::::::::::::::::::: XP_005 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN 10 20 30 40 50 120 130 140 150 160 170 pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE6 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD 120 130 140 150 160 170 240 250 260 270 pF1KE6 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK ::::::::::::::::::::::::::::::::::: XP_005 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 180 190 200 >>XP_011507762 (OMIM: 600889) PREDICTED: complement fact (201 aa) initn: 1381 init1: 903 opt: 1272 Z-score: 1398.9 bits: 266.2 E(85289): 3.5e-71 Smith-Waterman score: 1272; 97.3% identity (97.8% similar) in 185 aa overlap (86-270:21-201) 60 70 80 90 100 110 pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN :::::::::::::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN 10 20 30 40 50 120 130 140 150 160 170 pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE :::::::::::::::::::::::: .::::::::::::::::::::::::::::::: XP_011 TGYRLQNNENNISCVERGWSTPPK----FSAEKCGPPPPIDNGDITSFLLSVYAPGSSVE 60 70 80 90 100 180 190 200 210 220 230 pF1KE6 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD 110 120 130 140 150 160 240 250 260 270 pF1KE6 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK ::::::::::::::::::::::::::::::::::: XP_011 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 170 180 190 200 >>NP_002104 (OMIM: 134371,235400,603075) complement fact (330 aa) initn: 1669 init1: 1008 opt: 1201 Z-score: 1318.5 bits: 252.0 E(85289): 1.1e-66 Smith-Waterman score: 1460; 74.1% identity (77.7% similar) in 301 aa overlap (1-242:1-301) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_002 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 pF1KE6 QNNENNISCVERGWSTPPKCRST-----------------------ISAE---------- ::::::::::::::::::::::: :.: NP_002 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 130 140 150 160 170 180 150 160 170 180 pF1KE6 --------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL :::::::::::::::: ::::::.:::::::::: NP_002 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 190 200 210 220 230 240 190 200 210 220 230 240 pF1KE6 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC ::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .:::: NP_002 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 250 260 270 280 290 300 250 260 270 pF1KE6 KSGYHPTKSHSFRAMCQNGKLVYPSCEEK : NP_002 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 310 320 330 >>NP_001160096 (OMIM: 235400,603075,605336) complement f (269 aa) initn: 1211 init1: 965 opt: 1028 Z-score: 1130.7 bits: 216.9 E(85289): 3.1e-56 Smith-Waterman score: 1028; 48.0% identity (77.0% similar) in 269 aa overlap (1-268:1-269) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV : ::..::: .: ..:.. :::: :.:: :. :. .:. : .:. . : :. .: NP_001 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL .:: :.: : :...::::. ::: :.::..:::.... :. ..:..... :. :: : NP_001 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN . .....:.:.::: :.: . :.:::::::::.::: :::::.::.: : :::::: NP_001 PKAQTTVTCTEKGWSPTPRCIRVNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV :.:.:.: .:: ::.:::::.:. ::.:..: :.: ::::: ...: :..::: .::. NP_001 YYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFM 190 200 210 220 230 240 250 260 270 pF1KE6 CKSGYHPTKS-HSFRAMCQNGKLVYPSCEEK :: ::. . : ::.:.:..: . :: :: NP_001 CKLGYNANTSILSFQAVCREGIVEYPRCE 250 260 >>XP_016856598 (OMIM: 600889) PREDICTED: complement fact (211 aa) initn: 909 init1: 909 opt: 980 Z-score: 1079.7 bits: 207.2 E(85289): 2.1e-53 Smith-Waterman score: 1377; 78.1% identity (78.1% similar) in 270 aa overlap (1-270:1-211) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL :::::::::::::::::::::::: XP_016 SPSKSFWTRITCAEEGWSPTPKCL------------------------------------ 70 80 130 140 150 160 170 180 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN ::::::::::::::::::::::::::::::::::::: XP_016 -----------------------ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 90 100 110 120 190 200 210 220 230 240 pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 130 140 150 160 170 180 250 260 270 pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK :::::::::::::::::::::::::::::: XP_016 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 190 200 210 >>XP_011507759 (OMIM: 134371,235400,603075) PREDICTED: c (265 aa) initn: 1078 init1: 599 opt: 943 Z-score: 1038.0 bits: 199.8 E(85289): 4.5e-51 Smith-Waterman score: 966; 62.0% identity (70.2% similar) in 245 aa overlap (86-270:21-265) 60 70 80 90 100 110 pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN :::::::::::::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN 10 20 30 40 50 120 130 140 pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRST-----------------------ISAE----- :::::::::::::::::::::::::::: :.: XP_011 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE 60 70 80 90 100 110 150 160 170 pF1KE6 -------------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEY :::::::::::::::: ::::::.::::: XP_011 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 QCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDI :::::::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. XP_011 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES 180 190 200 210 220 230 240 250 260 270 pF1KE6 VEFVCKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK .::::: ::. ..::..:. : .::: ::.: .. XP_011 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 240 250 260 >>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa) initn: 1476 init1: 857 opt: 929 Z-score: 1018.2 bits: 197.2 E(85289): 5.7e-50 Smith-Waterman score: 929; 53.5% identity (72.2% similar) in 273 aa overlap (1-270:1-265) 10 20 30 40 50 60 pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV : :: :::::: .:.::::. .::::::.::.::::: :.:::::::::::::::::::: NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL ::::::::::::.::::::::::::.: ::::.:::::::: ::::::::::::::: : NP_110 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC-Q ::::.::::::::::::: : ... .: : : : : : :. ....: . NP_110 QNNEKNISCVERGWSTPPIC--SFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 NLYQLEGNNQITCRNGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVE :: .. :.... : . :: : : . : ..: ... :... ..:: NP_110 NLIRV-GSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE-YGHN-EVVE 180 190 200 210 220 230 240 250 260 270 pF1KE6 FVCKSGYHPTKSHSFRAMCQNGK-LVYPSCEEK . :. .. . . .: .:. . :.: :. NP_110 YDCNPNF--IINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVS 240 250 260 270 280 290 NP_110 VEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHN 300 310 320 330 340 350 >-- initn: 566 init1: 490 opt: 657 Z-score: 721.1 bits: 142.2 E(85289): 2e-33 Smith-Waterman score: 657; 42.1% identity (67.5% similar) in 228 aa overlap (47-268:345-569) 20 30 40 50 60 70 pF1KE6 GGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG .:. : .. . . . . . .: . NP_110 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGK 320 330 340 350 360 370 80 90 100 110 120 130 pF1KE6 WSPTPKCL--RLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVE :.: : : : : . :... .. .. .:. : ..:. .: : . .. : : . NP_110 WNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE-IVCKD 380 390 400 410 420 430 140 150 160 170 180 190 pF1KE6 RGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT :.. :.: . :. ::::: :.::: ::: :::: :::.: :.::..:.:.:. .: NP_110 GRWQSLPRC--VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVT 440 450 460 470 480 490 200 210 220 230 240 250 pF1KE6 CRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPT-KS ::: ::::::.::::::.:.: :.: ::.::: :. :::..::: ::: :: .. .: NP_110 CRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISS 500 510 520 530 540 550 260 270 pF1KE6 HSFRAMCQNGKLVYPSCEEK :::.::.::. :: :: NP_110 PPFRAICQEGKFEYPICE 560 270 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:14:17 2016 done: Tue Nov 8 11:14:18 2016 Total Scan time: 6.020 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]