FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6708, 739 aa 1>>>pF1KE6708 739 - 739 aa - 739 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7075+/-0.000436; mu= 5.3678+/- 0.027 mean_var=245.5380+/-49.259, 0's: 0 Z-trim(119.6): 24 B-trim: 64 in 1/54 Lambda= 0.081849 statistics sampled from 33808 (33832) to 33808 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.397), width: 16 Scan time: 11.770 The best scores are: opt bits E(85289) NP_036450 (OMIM: 194190,604407) LETM1 and EF-hand ( 739) 4771 577.2 8.3e-164 XP_006713947 (OMIM: 194190,604407) PREDICTED: LETM ( 738) 4753 575.1 3.6e-163 XP_016863676 (OMIM: 194190,604407) PREDICTED: LETM ( 559) 3493 426.2 1.8e-118 >>NP_036450 (OMIM: 194190,604407) LETM1 and EF-hand doma (739 aa) initn: 4771 init1: 4771 opt: 4771 Z-score: 3061.8 bits: 577.2 E(85289): 8.3e-164 Smith-Waterman score: 4771; 100.0% identity (100.0% similar) in 739 aa overlap (1-739:1-739) 10 20 30 40 50 60 pF1KE6 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV 670 680 690 700 710 720 730 pF1KE6 EEKEKAKEKAEKEVAEVKS ::::::::::::::::::: NP_036 EEKEKAKEKAEKEVAEVKS 730 >>XP_006713947 (OMIM: 194190,604407) PREDICTED: LETM1 an (738 aa) initn: 4751 init1: 3251 opt: 4753 Z-score: 3050.3 bits: 575.1 E(85289): 3.6e-163 Smith-Waterman score: 4753; 99.9% identity (99.9% similar) in 739 aa overlap (1-739:1-738) 10 20 30 40 50 60 pF1KE6 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REKELQKRSEVA-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI 490 500 510 520 530 550 560 570 580 590 600 pF1KE6 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE6 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE6 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV 660 670 680 690 700 710 730 pF1KE6 EEKEKAKEKAEKEVAEVKS ::::::::::::::::::: XP_006 EEKEKAKEKAEKEVAEVKS 720 730 >>XP_016863676 (OMIM: 194190,604407) PREDICTED: LETM1 an (559 aa) initn: 3493 init1: 3493 opt: 3493 Z-score: 2247.8 bits: 426.2 E(85289): 1.8e-118 Smith-Waterman score: 3493; 100.0% identity (100.0% similar) in 559 aa overlap (181-739:1-559) 160 170 180 190 200 210 pF1KE6 KSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLV :::::::::::::::::::::::::::::: XP_016 MLWRILNGHSLTRRERRQFLRICADLFRLV 10 20 30 220 230 240 250 260 270 pF1KE6 PFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE6 MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALC 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE6 KLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVT 160 170 180 190 200 210 400 410 420 430 440 450 pF1KE6 EDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV 220 230 240 250 260 270 460 470 480 490 500 510 pF1KE6 KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTE 280 290 300 310 320 330 520 530 540 550 560 570 pF1KE6 PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELE 340 350 360 370 380 390 580 590 600 610 620 630 pF1KE6 LLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQ 400 410 420 430 440 450 640 650 660 670 680 690 pF1KE6 QAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK 460 470 480 490 500 510 700 710 720 730 pF1KE6 VIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 520 530 540 550 739 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:34:35 2016 done: Tue Nov 8 15:34:36 2016 Total Scan time: 11.770 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]