FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4315, 323 aa 1>>>pF1KE4315 323 - 323 aa - 323 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1755+/-0.000394; mu= 17.0125+/- 0.024 mean_var=73.7454+/-14.960, 0's: 0 Z-trim(113.2): 51 B-trim: 0 in 0/49 Lambda= 0.149351 statistics sampled from 22385 (22435) to 22385 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.263), width: 16 Scan time: 6.060 The best scores are: opt bits E(85289) NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 2170 476.9 2.5e-134 NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 1848 407.5 1.9e-113 NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1847 407.3 2.2e-113 NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1843 406.4 4e-113 NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1818 401.0 1.7e-111 NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1818 401.0 1.7e-111 NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1285 286.2 6.3e-77 NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 1132 253.2 4.8e-67 NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1066 239.0 9.8e-63 XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 1032 231.7 1.5e-60 NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 1032 231.7 1.5e-60 NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1011 227.2 3.6e-59 XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 965 217.2 3.5e-56 NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 936 211.0 2.8e-54 XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 936 211.0 2.8e-54 NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 905 204.3 2.8e-52 NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 905 204.3 2.8e-52 NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 905 204.3 2.8e-52 NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 905 204.3 2.8e-52 NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 699 159.7 3.3e-39 NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 653 149.7 3.2e-36 XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 651 149.5 7.4e-36 NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 621 142.9 4.5e-34 XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 621 142.9 4.5e-34 XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 590 136.3 5.4e-32 XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 590 136.3 5.4e-32 NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 513 119.8 6.7e-27 XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 429 101.6 1.3e-21 NP_036199 (OMIM: 608477) aflatoxin B1 aldehyde red ( 331) 171 46.2 0.00011 XP_011539348 (OMIM: 608477) PREDICTED: aflatoxin B ( 375) 171 46.2 0.00013 NP_003680 (OMIM: 603418) aflatoxin B1 aldehyde red ( 359) 157 43.2 0.00099 >>NP_001809 (OMIM: 600451,614279) aldo-keto reductase fa (323 aa) initn: 2170 init1: 2170 opt: 2170 Z-score: 2532.7 bits: 476.9 E(85289): 2.5e-134 Smith-Waterman score: 2170; 99.7% identity (99.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_001 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY ::::::::::::::::::::::: NP_001 RNYRYVVMDFLMDHPDYPFSDEY 310 320 >>NP_001344 (OMIM: 600449) aldo-keto reductase family 1 (323 aa) initn: 1848 init1: 1848 opt: 1848 Z-score: 2157.7 bits: 407.5 E(85289): 1.9e-113 Smith-Waterman score: 1848; 83.0% identity (95.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: ::: :.::::::::::::::::: :::...:.:.:::::::::::::::.::::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::::. .:..:.:::: :::.::::::::::.:::. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ..:::: .:::::::..:::::: ::::..:::::::::::::::::: :::::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: ::...:.. :.::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_003730 (OMIM: 603966) aldo-keto reductase family 1 (323 aa) initn: 1847 init1: 1847 opt: 1847 Z-score: 2156.6 bits: 407.3 E(85289): 2.2e-113 Smith-Waterman score: 1847; 84.2% identity (93.5% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: :.: :.::::::::::::::::::::::..:.:::::::::::::::::.::::::: NP_003 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::: :: .:..:.::::.:::: :::::::::.: :: NP_003 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP .::::: : ::::::::: ::: .:::.::::::::::::::::::: :::::::::: NP_003 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:.::::::::::::::::.::::.:: : :::::::::::::: NP_003 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::.::::..:::. NP_003 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: .: : . .::.::.:::: NP_003 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_001240837 (OMIM: 603966) aldo-keto reductase family (323 aa) initn: 1843 init1: 1843 opt: 1843 Z-score: 2151.9 bits: 406.4 E(85289): 4e-113 Smith-Waterman score: 1843; 83.9% identity (93.5% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: :.: ..::::::::::::::::::::::..:.:::::::::::::::::.::::::: NP_001 MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::: :: .:..:.::::.:::: :::::::::.: :: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP .::::: : ::::::::: ::: .:::.::::::::::::::::::: :::::::::: NP_001 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:.::::::::::::::::.::::.:: : :::::::::::::: NP_001 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::.::::..:::. NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: .: : . .::.::.:::: NP_001 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_995317 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 1818 init1: 1818 opt: 1818 Z-score: 2122.8 bits: 401.0 E(85289): 1.7e-111 Smith-Waterman score: 1818; 81.7% identity (94.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..:::::: NP_995 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::. NP_995 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ..:::: .:::::::..:::::: ::::.:::::::::::::::::::.: :::::::: NP_995 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: NP_995 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: NP_995 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: ::...:.. :.::::::: NP_995 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_001345 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 1818 init1: 1818 opt: 1818 Z-score: 2122.8 bits: 401.0 E(85289): 1.7e-111 Smith-Waterman score: 1818; 81.7% identity (94.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..:::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ..:::: .:::::::..:::::: ::::.:::::::::::::::::::.: :::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: ::...:.. :.::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa) initn: 1259 init1: 1200 opt: 1285 Z-score: 1502.1 bits: 286.2 E(85289): 6.3e-77 Smith-Waterman score: 1285; 56.7% identity (84.6% similar) in 319 aa overlap (6-323:8-326) 10 20 30 40 50 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNN .:. :.::. .:..:.:::. :. .:.. . .:.::..:.::::.::.:.: NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLH :..:: ::: :::.:.:.:::::: .::: : :.::.:.:: .:. :::::::::... NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMIL :::.:::. :.::::: .. .: ::::.:: ::::::.::.:::::: ::::.:: NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLE ::::::.::: ::::::::..: ::: ::...:::..:.: :::.:. .::. .:: ::. NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLD : .: .:.:....: : :.::...::::::. ::.: .::.::.:.:.:.:: :.:: .. NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 250 260 270 280 290 300 300 310 320 pF1KE4 GLNRNYRYVVMDFLMDHPDYPFSDEY .::.: :.: . . :::.::: ::: NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY 310 320 >>NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-steroi (290 aa) initn: 1106 init1: 1047 opt: 1132 Z-score: 1324.6 bits: 253.2 E(85289): 4.8e-67 Smith-Waterman score: 1132; 57.7% identity (85.3% similar) in 279 aa overlap (6-283:8-286) 10 20 30 40 50 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNN .:. :.::. .:..:.:::. :. .:.. . .:.::..:.::::.::.:.: NP_001 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLH :..:: ::: :::.:.:.:::::: .::: : :.::.:.:: .:. :::::::::... NP_001 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMIL :::.:::. :.::::: .. .: ::::.:: ::::::.::.:::::: ::::.:: NP_001 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLE ::::::.::: ::::::::..: ::: ::...:::..:.: :::.:. .::. .:: ::. NP_001 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLD : .: .:.:....: : :.::...::::::. ::.: .::.::.:: NP_001 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQVARSS 250 260 270 280 290 300 310 320 pF1KE4 GLNRNYRYVVMDFLMDHPDYPFSDEY >>NP_001619 (OMIM: 103880) aldose reductase isoform 1 [H (316 aa) initn: 986 init1: 726 opt: 1066 Z-score: 1247.3 bits: 239.0 E(85289): 9.8e-63 Smith-Waterman score: 1066; 48.3% identity (79.5% similar) in 317 aa overlap (7-323:4-316) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :. ::.: ::.::.::. : : ....:..:.::..:.:::: :..:.::.. NP_001 MASRLLLNNGAKMPILGLGTWKSP--P-GQVTEAVKVAIDVGYRHIDCAHVYQNENE 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM ::.::. :. . ::::..: .::::::. . .:. : ...:. :.:::.::::.:.: NP_001 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ..:::. .: ::.:.:. . ... :: .::. : ::.:.::.::::. :.::::::: NP_001 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::. ::.::::::.: ::...:.:: ::..:.: ::. . :. :..: ::::: NP_001 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN . :.: ::..: : . .:. .::..::. :: . .:: ::..::.:.:.:.:: .: . : NP_001 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 240 250 260 270 280 290 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY ::.: .. .: :::: .:. NP_001 RNWRVCALLSCTSHKDYPFHEEF 300 310 >>XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto reduc (297 aa) initn: 1020 init1: 1020 opt: 1032 Z-score: 1208.0 bits: 231.7 E(85289): 1.5e-60 Smith-Waterman score: 1638; 76.8% identity (87.9% similar) in 323 aa overlap (1-323:1-297) 10 20 30 40 50 60 pF1KE4 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ :: ::: :.::::::::::::::::: :::...:.:.:::::::::::::::.::::::: XP_016 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM :::::::::::::::::::::::::::. .:..:.:::: :::.::::::::::.:::. XP_016 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP ..: ..:::::::::::::::::: :::::::::: XP_016 SVK--------------------------AVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: XP_016 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: XP_016 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 220 230 240 250 260 270 310 320 pF1KE4 RNYRYVVMDFLMDHPDYPFSDEY :: ::...:.. :.::::::: XP_016 RNVRYLTLDIFAGPPNYPFSDEY 280 290 323 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:14:08 2016 done: Sat Nov 5 23:14:09 2016 Total Scan time: 6.060 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]