FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4505, 529 aa 1>>>pF1KE4505 529 - 529 aa - 529 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6749+/-0.000389; mu= 16.3919+/- 0.024 mean_var=73.6485+/-15.169, 0's: 0 Z-trim(112.8): 13 B-trim: 714 in 1/57 Lambda= 0.149449 statistics sampled from 21800 (21804) to 21800 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.256), width: 16 Scan time: 8.420 The best scores are: opt bits E(85289) NP_000511 (OMIM: 272800,606869) beta-hexosaminidas ( 529) 3650 796.7 0 NP_001305754 (OMIM: 272800,606869) beta-hexosamini ( 540) 3075 672.7 7.7e-193 NP_000512 (OMIM: 268800,606873) beta-hexosaminidas ( 556) 2043 450.2 7.6e-126 NP_001278933 (OMIM: 268800,606873) beta-hexosamini ( 331) 1552 344.2 3.6e-94 >>NP_000511 (OMIM: 272800,606869) beta-hexosaminidase su (529 aa) initn: 3650 init1: 3650 opt: 3650 Z-score: 4253.2 bits: 796.7 E(85289): 0 Smith-Waterman score: 3650; 99.8% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 YLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_000 YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV 430 440 450 460 470 480 490 500 510 520 pF1KE4 AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT ::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT 490 500 510 520 >>NP_001305754 (OMIM: 272800,606869) beta-hexosaminidase (540 aa) initn: 3066 init1: 3066 opt: 3075 Z-score: 3583.1 bits: 672.7 E(85289): 7.7e-193 Smith-Waterman score: 3618; 97.8% identity (98.0% similar) in 540 aa overlap (1-529:1-540) 10 20 30 40 50 60 pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV 10 20 30 40 50 60 70 80 90 100 pF1KE4 LDEAFQRYRDLLFGSGSWPRPYLTG-----------KRHTLEKNVLVVSVVTPGCNQLPT ::::::::::::::::::::::::: :::::::::::::::::::::::: NP_001 LDEAFQRYRDLLFGSGSWPRPYLTGWPHQAYPVFLGKRHTLEKNVLVVSVVTPGCNQLPT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 LESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPH 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 RGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNP 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 VTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGP 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 VNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFK 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 QLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTK 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 AGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNL ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_001 AGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 VPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT 490 500 510 520 530 540 >>NP_000512 (OMIM: 268800,606873) beta-hexosaminidase su (556 aa) initn: 2021 init1: 805 opt: 2043 Z-score: 2380.3 bits: 450.2 E(85289): 7.6e-126 Smith-Waterman score: 2043; 56.9% identity (80.4% similar) in 504 aa overlap (22-525:55-554) 10 20 30 40 50 pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVS :::: : . . . . : :.:: .... . NP_000 AMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE4 SAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLE :.: :.:..:.:::.::. .:: .: . . .: ...:: .. :. .:.. NP_000 STAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNIS 90 100 110 120 130 140 120 130 140 150 160 170 pF1KE4 SVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRG : :.::: ... .: .. :::::::::::::::.... ::: ::.. : : ::: ::: NP_000 SDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRG 150 160 170 180 190 200 180 190 200 210 220 230 pF1KE4 LLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVT .:.::::::::.. :: :::.::.::.::.:::.::: ::::.:.::::: ::::. .. NP_000 ILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-LS 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE4 HIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVN :.:: .::. ::::::::::::: :::::::::::: : ::::::: .. .:::.: NP_000 HVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPIN 270 280 290 300 310 320 300 310 320 330 340 350 pF1KE4 PSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQL :.::.:: :..::: :.: :::: ..:::::::.: ::.:::.::::::.:::: :::.: NP_000 PTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKL 330 340 350 360 370 380 360 370 380 390 400 410 pF1KE4 ESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAG :::::: .:::... .:: .:::::::.:.:. : ::..::... : .:: :: .: NP_000 ESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSA---YPEELSRVTASG 390 400 410 420 430 440 420 430 440 450 460 470 pF1KE4 FRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVP : ..:::::::. :::: ::. .: :::: : :: .:: : ::::::.:::::: :::.: NP_000 FPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTP 450 460 470 480 490 500 480 490 500 510 520 pF1KE4 RLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT ::::::.::.:::::.: . :. ::.::.. ::....::. :::: .:.:..: NP_000 RLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM 510 520 530 540 550 >>NP_001278933 (OMIM: 268800,606873) beta-hexosaminidase (331 aa) initn: 1530 init1: 805 opt: 1552 Z-score: 1811.6 bits: 344.2 E(85289): 3.6e-94 Smith-Waterman score: 1552; 63.7% identity (84.4% similar) in 333 aa overlap (193-525:1-329) 170 180 190 200 210 220 pF1KE4 DFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELM ::.::.::.:::.::: ::::.:.::::: NP_001 MAFNKFNVLHWHIVDDQSFPYQSITFPELS 10 20 30 230 240 250 260 270 280 pF1KE4 RKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSE ::::. ..:.:: .::. ::::::::::::: :::::::::::: : ::::::: .. NP_001 NKGSYS-LSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQN 40 50 60 70 80 290 300 310 320 330 340 pF1KE4 PSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKK .:::.::.::.:: :..::: :.: :::: ..:::::::.: ::.:::.::::::.: NP_001 KLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQK 90 100 110 120 130 140 350 360 370 380 390 400 pF1KE4 GFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMK ::: :::.::::::: .:::... .:: .:::::::.:.:. : ::..::... : . NP_001 GFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSA---YPE 150 160 170 180 190 200 410 420 430 440 450 460 pF1KE4 ELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGE :: :: .:: ..:::::::. :::: ::. .: :::: : :: .:: : ::::::.::: NP_001 ELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGE 210 220 230 240 250 260 470 480 490 500 510 520 pF1KE4 YVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFC ::: :::.:::::::.::.:::::.: . :. ::.::.. ::....::. :::: .:.: NP_001 YVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYC 270 280 290 300 310 320 pF1KE4 EQEFEQT ..: NP_001 NHENM 330 529 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:15:29 2016 done: Mon Nov 7 15:15:30 2016 Total Scan time: 8.420 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]