FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3923, 447 aa 1>>>pF1KE3923 447 - 447 aa - 447 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8866+/-0.000369; mu= 15.9962+/- 0.023 mean_var=97.3011+/-19.590, 0's: 0 Z-trim(115.1): 32 B-trim: 1168 in 1/56 Lambda= 0.130022 statistics sampled from 25325 (25356) to 25325 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.297), width: 16 Scan time: 8.060 The best scores are: opt bits E(85289) NP_036309 (OMIM: 606013) F-box only protein 5 isof ( 447) 2990 571.3 1.8e-162 NP_001135994 (OMIM: 606013) F-box only protein 5 i ( 401) 2666 510.5 3.2e-144 NP_001025031 (OMIM: 609110) F-box only protein 43 ( 708) 356 77.4 1.4e-13 XP_011515292 (OMIM: 609110) PREDICTED: F-box only ( 717) 356 77.4 1.4e-13 XP_011515291 (OMIM: 609110) PREDICTED: F-box only ( 717) 356 77.4 1.4e-13 XP_011515289 (OMIM: 609110) PREDICTED: F-box only ( 751) 356 77.4 1.4e-13 >>NP_036309 (OMIM: 606013) F-box only protein 5 isoform (447 aa) initn: 2990 init1: 2990 opt: 2990 Z-score: 3038.0 bits: 571.3 E(85289): 1.8e-162 Smith-Waterman score: 2990; 99.8% identity (100.0% similar) in 447 aa overlap (1-447:1-447) 10 20 30 40 50 60 pF1KE3 MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELETESKRLHNKEN ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_036 KLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 QSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCS 370 380 390 400 410 420 430 440 pF1KE3 DGKLLKASCKIGPLPGTKKSKKNLRRL ::::::::::::::::::::::::::: NP_036 DGKLLKASCKIGPLPGTKKSKKNLRRL 430 440 >>NP_001135994 (OMIM: 606013) F-box only protein 5 isofo (401 aa) initn: 2666 init1: 2666 opt: 2666 Z-score: 2710.2 bits: 510.5 E(85289): 3.2e-144 Smith-Waterman score: 2666; 99.8% identity (100.0% similar) in 401 aa overlap (47-447:1-401) 20 30 40 50 60 70 pF1KE3 CSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTP :::::::::::::::::::::::::::::: NP_001 MKCDFNCNHVHSGLKLVKPDDIGRLVSYTP 10 20 30 80 90 100 110 120 130 pF1KE3 AYLEGSCKDCIKDYERLSCIGSPIVSPRIVELETESKRLHNKENQHVQQTLNSTNEIEAL ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: NP_001 AYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEAL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 ETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLH 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 FEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLR 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 HVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 EYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLK 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE3 ACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPG 340 350 360 370 380 390 440 pF1KE3 TKKSKKNLRRL ::::::::::: NP_001 TKKSKKNLRRL 400 >>NP_001025031 (OMIM: 609110) F-box only protein 43 [Hom (708 aa) initn: 518 init1: 258 opt: 356 Z-score: 365.0 bits: 77.4 E(85289): 1.4e-13 Smith-Waterman score: 535; 31.4% identity (60.9% similar) in 379 aa overlap (80-447:352-708) 50 60 70 80 90 100 pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE ::: .. .. .. .:. : . : . NP_001 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL--- 330 340 350 360 370 110 120 130 140 150 160 pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF .:.:: . ..: :. :. : ... . .. . . :..:: :.: .. NP_001 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES 380 390 400 410 420 170 180 190 200 210 220 pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF :: ..... .. : .:. : : : . :..:. . . .. : :: . NP_001 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC 430 440 450 460 470 480 230 240 250 260 270 280 pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDK : ..::.:::.: .:::.:: :.:.:.:: .: .:. .: .: ::: .:..:. .:: NP_001 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCSVWKVSRNWREIVVQDK 490 500 510 520 530 540 290 300 310 320 330 340 pF1KE3 GA---FQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLS .: ..: .. .:. :.:: .. :. : ::: .: . ... . :: NP_001 NANRRRKFYITQLKTDSEGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLS 550 560 570 580 590 600 350 360 370 380 390 pF1KE3 NQGD------QKGSTY--SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKR :. ... :. :...:. .::::: .:.:: : ::.:::::. : .:. :.: NP_001 PWGEVLTPLASSSVTHLSSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSR 610 620 630 640 650 660 400 410 420 430 440 pF1KE3 EGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL .::::.:. ::: :: ...:: : : . :::. .::.::.:: NP_001 TACGFDFCVLCLCAYHGSEECSRGAA-KPRNRKDALPGSAQSKRNLKRL 670 680 690 700 >>XP_011515292 (OMIM: 609110) PREDICTED: F-box only prot (717 aa) initn: 462 init1: 258 opt: 356 Z-score: 364.9 bits: 77.4 E(85289): 1.4e-13 Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:318-717) 50 60 70 80 90 100 pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE ::: .. .. .. .:. : . : . XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL--- 290 300 310 320 330 340 110 120 130 140 150 160 pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF .:.:: . ..: :. :. : ... . .. . . :..:: :.: .. XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES 350 360 370 380 390 170 180 190 200 210 220 pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF :: ..... .. : .:. : : : . :..:. . . .. : :: . XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC 400 410 420 430 440 230 240 250 260 270 pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI----------------- : ..::.:::.: .:::.:: :.:.:.:: .: .:. .: XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE 450 460 470 480 490 500 280 290 300 pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT .: ::: .:..:. .::.: ..: .. . XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS 510 520 530 540 550 560 310 320 330 340 350 pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY- :. :.:: .. :. : ::: .: . ... . :: :. ... :. XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL 570 580 590 600 610 620 360 370 380 390 400 410 pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT :...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: :: XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG 630 640 650 660 670 680 420 430 440 pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL ...:: : : . :::. .::.::.:: XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL 690 700 710 >>XP_011515291 (OMIM: 609110) PREDICTED: F-box only prot (717 aa) initn: 462 init1: 258 opt: 356 Z-score: 364.9 bits: 77.4 E(85289): 1.4e-13 Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:318-717) 50 60 70 80 90 100 pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE ::: .. .. .. .:. : . : . XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL--- 290 300 310 320 330 340 110 120 130 140 150 160 pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF .:.:: . ..: :. :. : ... . .. . . :..:: :.: .. XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES 350 360 370 380 390 170 180 190 200 210 220 pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF :: ..... .. : .:. : : : . :..:. . . .. : :: . XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC 400 410 420 430 440 230 240 250 260 270 pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI----------------- : ..::.:::.: .:::.:: :.:.:.:: .: .:. .: XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE 450 460 470 480 490 500 280 290 300 pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT .: ::: .:..:. .::.: ..: .. . XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS 510 520 530 540 550 560 310 320 330 340 350 pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY- :. :.:: .. :. : ::: .: . ... . :: :. ... :. XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL 570 580 590 600 610 620 360 370 380 390 400 410 pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT :...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: :: XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG 630 640 650 660 670 680 420 430 440 pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL ...:: : : . :::. .::.::.:: XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL 690 700 710 >>XP_011515289 (OMIM: 609110) PREDICTED: F-box only prot (751 aa) initn: 462 init1: 258 opt: 356 Z-score: 364.6 bits: 77.4 E(85289): 1.4e-13 Smith-Waterman score: 439; 28.2% identity (54.7% similar) in 422 aa overlap (80-447:352-751) 50 60 70 80 90 100 pF1KE3 DFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELE ::: .. .. .. .:. : . : . XP_011 PEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHL--- 330 340 350 360 370 110 120 130 140 150 160 pF1KE3 TESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENF .:.:: . ..: :. :. : ... . .. . . :..:: :.: .. XP_011 GRSRRLSTLREQSSQS--------ETEEEKQIVHPDSEKRAAAASAISE---GQLSSDES 380 390 400 410 420 170 180 190 200 210 220 pF1KE3 GDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNF :: ..... .. : .:. : : : . :..:. . . .. : :: . XP_011 GD----LTFSLKNLSKTPALQLVHEL-FMKSKRKRLQENSGH--EFLEQGDGEKIAVLQC 430 440 450 460 470 480 230 240 250 260 270 pF1KE3 RLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLI----------------- : ..::.:::.: .:::.:: :.:.:.:: .: .:. .: XP_011 ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCRTIRRQDPWECRGNEGE 490 500 510 520 530 540 280 290 300 pF1KE3 --------------------------NVSKVSTTWKKILEDDKGA---FQLYSKAIQRVT .: ::: .:..:. .::.: ..: .. . XP_011 KSCGTGFLQDDGYGGACGKLVSLFLDSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDS 550 560 570 580 590 600 310 320 330 340 350 pF1KE3 ENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGD------QKGSTY- :. :.:: .. :. : ::: .: . ... . :: :. ... :. XP_011 EGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHL 610 620 630 640 650 660 360 370 380 390 400 410 pF1KE3 -SRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHT :...:. .::::: .:.:: : ::.:::::. : .:. :.: .::::.:. ::: :: XP_011 SSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHG 670 680 690 700 710 720 420 430 440 pF1KE3 TKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL ...:: : : . :::. .::.::.:: XP_011 SEECSRGAA-KPRNRKDALPGSAQSKRNLKRL 730 740 750 447 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:54:36 2016 done: Sun Nov 6 08:54:37 2016 Total Scan time: 8.060 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]