Result of FASTA (omim) for
pFN21AE4493
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4493, 513 aa
1>>>pF1KE4493 513 - 513 aa - 513 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9507+/-0.000303; mu= 16.6315+/- 0.019
mean_var=102.1660+/-20.322, 0's: 0 Z-trim(120.5): 154 B-trim: 189 in 2/53
Lambda= 0.126888
statistics sampled from 35657 (35845) to 35657 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.42), width: 16
Scan time: 8.250
The best scores are: opt bits E(85289)
NP_001027539 (OMIM: 605123) kunitz-type protease i ( 513) 3652 678.8 1e-194
NP_003701 (OMIM: 605123) kunitz-type protease inhi ( 513) 3652 678.8 1e-194
XP_011520260 (OMIM: 605123) PREDICTED: kunitz-type ( 471) 2228 418.1 2.9e-116
NP_857593 (OMIM: 605123) kunitz-type protease inhi ( 529) 2153 404.4 4.3e-112
XP_006720720 (OMIM: 605123) PREDICTED: kunitz-type ( 529) 2153 404.4 4.3e-112
XP_011520259 (OMIM: 605123) PREDICTED: kunitz-type ( 487) 2138 401.6 2.7e-111
NP_006519 (OMIM: 600033) tissue factor pathway inh ( 235) 362 76.2 1.2e-13
NP_001257932 (OMIM: 600033) tissue factor pathway ( 224) 334 71.1 3.9e-12
NP_066925 (OMIM: 270420,605124) kunitz-type protea ( 252) 259 57.4 5.8e-08
NP_001159575 (OMIM: 270420,605124) kunitz-type pro ( 195) 253 56.2 1e-07
NP_001129602 (OMIM: 104300,104760,605714) amyloid ( 714) 220 50.6 1.8e-05
NP_001191230 (OMIM: 104300,104760,605714) amyloid ( 752) 220 50.7 1.9e-05
NP_000475 (OMIM: 104300,104760,605714) amyloid bet ( 770) 220 50.7 1.9e-05
NP_001315613 (OMIM: 104776) amyloid-like protein 2 ( 700) 214 49.5 3.8e-05
NP_001315615 (OMIM: 104776) amyloid-like protein 2 ( 730) 214 49.5 3.9e-05
NP_001135748 (OMIM: 104776) amyloid-like protein 2 ( 751) 214 49.6 4e-05
NP_001230228 (OMIM: 104776) amyloid-like protein 2 ( 761) 214 49.6 4e-05
NP_001633 (OMIM: 104776) amyloid-like protein 2 is ( 763) 214 49.6 4e-05
NP_006278 (OMIM: 152310) tissue factor pathway inh ( 304) 208 48.1 4.3e-05
XP_011510011 (OMIM: 152310) PREDICTED: tissue fact ( 304) 208 48.1 4.3e-05
XP_006712783 (OMIM: 152310) PREDICTED: tissue fact ( 304) 208 48.1 4.3e-05
XP_005246876 (OMIM: 152310) PREDICTED: tissue fact ( 304) 208 48.1 4.3e-05
NP_001316169 (OMIM: 152310) tissue factor pathway ( 304) 208 48.1 4.3e-05
NP_001316170 (OMIM: 152310) tissue factor pathway ( 304) 208 48.1 4.3e-05
NP_001316168 (OMIM: 152310) tissue factor pathway ( 304) 208 48.1 4.3e-05
NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 209 48.7 8e-05
XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 209 48.7 8.1e-05
NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 209 48.7 8.3e-05
NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 209 48.7 8.3e-05
NP_001305870 (OMIM: 152310) tissue factor pathway ( 251) 201 46.8 9e-05
NP_001027452 (OMIM: 152310) tissue factor pathway ( 251) 201 46.8 9e-05
NP_001257933 (OMIM: 600033) tissue factor pathway ( 186) 198 46.1 0.00011
NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobuli ( 548) 198 46.5 0.00024
NP_001191231 (OMIM: 104300,104760,605714) amyloid ( 733) 194 45.9 0.00049
NP_001129488 (OMIM: 104300,104760,605714) amyloid ( 746) 194 45.9 0.0005
NP_958816 (OMIM: 104300,104760,605714) amyloid bet ( 751) 194 45.9 0.0005
XP_011541265 (OMIM: 104300,602005) PREDICTED: sort (2176) 200 47.4 0.00052
NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglob ( 483) 191 45.2 0.00053
NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 193 45.7 0.00053
NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobuli ( 576) 191 45.3 0.0006
XP_016858793 (OMIM: 120250,158810,254090,616411) P (2375) 198 47.0 0.00072
XP_005246123 (OMIM: 120250,158810,254090,616411) P (2770) 198 47.1 0.00081
XP_006712316 (OMIM: 120250,158810,254090,616411) P (3010) 198 47.1 0.00086
XP_011508876 (OMIM: 120250,158810,254090,616411) P (3176) 198 47.1 0.0009
NP_004360 (OMIM: 120250,158810,254090,616411) coll (3177) 198 47.1 0.0009
NP_476507 (OMIM: 120250,158810,254090,616411) coll (2570) 188 45.2 0.0027
NP_065131 (OMIM: 609031) eppin isoform 1 precursor ( 133) 170 40.9 0.0029
NP_476508 (OMIM: 120250,158810,254090,616411) coll (2971) 188 45.3 0.003
XP_016858792 (OMIM: 120250,158810,254090,616411) P (2971) 188 45.3 0.003
XP_005246122 (OMIM: 120250,158810,254090,616411) P (2977) 188 45.3 0.003
>>NP_001027539 (OMIM: 605123) kunitz-type protease inhib (513 aa)
initn: 3652 init1: 3652 opt: 3652 Z-score: 3616.6 bits: 678.8 E(85289): 1e-194
Smith-Waterman score: 3652; 100.0% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
430 440 450 460 470 480
490 500 510
pF1KE4 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::
NP_001 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
490 500 510
>>NP_003701 (OMIM: 605123) kunitz-type protease inhibito (513 aa)
initn: 3652 init1: 3652 opt: 3652 Z-score: 3616.6 bits: 678.8 E(85289): 1e-194
Smith-Waterman score: 3652; 100.0% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
430 440 450 460 470 480
490 500 510
pF1KE4 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::
NP_003 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
490 500 510
>>XP_011520260 (OMIM: 605123) PREDICTED: kunitz-type pro (471 aa)
initn: 2388 init1: 2200 opt: 2228 Z-score: 2208.3 bits: 418.1 E(85289): 2.9e-116
Smith-Waterman score: 3218; 91.8% identity (91.8% similar) in 513 aa overlap (1-513:1-471)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
::::::::::::: :: :::
XP_011 RGVQGPSMERRHP--------------------------DT----------------SGF
310
370 380 390 400 410 420
pF1KE4 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE4 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
380 390 400 410 420 430
490 500 510
pF1KE4 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::
XP_011 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
440 450 460 470
>>NP_857593 (OMIM: 605123) kunitz-type protease inhibito (529 aa)
initn: 2318 init1: 2130 opt: 2153 Z-score: 2133.4 bits: 404.4 E(85289): 4.3e-112
Smith-Waterman score: 3610; 97.0% identity (97.0% similar) in 529 aa overlap (1-513:1-529)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340
pF1KE4 RGVQG----------------PSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
::::: :::::::::::::::::::::::::::::::::::::::
NP_857 RGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
430 440 450 460 470 480
470 480 490 500 510
pF1KE4 AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_857 AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
490 500 510 520
>>XP_006720720 (OMIM: 605123) PREDICTED: kunitz-type pro (529 aa)
initn: 2318 init1: 2130 opt: 2153 Z-score: 2133.4 bits: 404.4 E(85289): 4.3e-112
Smith-Waterman score: 3610; 97.0% identity (97.0% similar) in 529 aa overlap (1-513:1-529)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340
pF1KE4 RGVQG----------------PSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
::::: :::::::::::::::::::::::::::::::::::::::
XP_006 RGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
430 440 450 460 470 480
470 480 490 500 510
pF1KE4 AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
490 500 510 520
>>XP_011520259 (OMIM: 605123) PREDICTED: kunitz-type pro (487 aa)
initn: 3238 init1: 2130 opt: 2138 Z-score: 2119.1 bits: 401.6 E(85289): 2.7e-111
Smith-Waterman score: 3192; 91.2% identity (92.6% similar) in 513 aa overlap (1-513:1-487)
10 20 30 40 50 60
pF1KE4 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RGVQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGF
::::: . : :.: .: :. :. . . ::::
XP_011 RGVQGGPL----------------RGSSGAQA-TF------PQGPSMERR---HPDTSGF
310 320 330
370 380 390 400 410 420
pF1KE4 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQ
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFH
400 410 420 430 440 450
490 500 510
pF1KE4 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
:::::::::::::::::::::::::::::::::
XP_011 GHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
460 470 480
>>NP_006519 (OMIM: 600033) tissue factor pathway inhibit (235 aa)
initn: 364 init1: 176 opt: 362 Z-score: 366.3 bits: 76.2 E(85289): 1.2e-13
Smith-Waterman score: 362; 34.0% identity (54.8% similar) in 197 aa overlap (243-431:29-215)
220 230 240 250 260 270
pF1KE4 LKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTE
: .. . :: : ::. . :.:::
NP_006 MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYT
10 20 30 40 50
280 290 300 310 320
pF1KE4 QICKSFVYGGCLGNKNNYLREEECILACRGVQG-PSMERRH----PVCSGTCQPTQFRCS
: :..:.:::: :: ::. : : :: .. :.. : . : :. . : :
NP_006 QSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLS
60 70 80 90 100 110
330 340 350 360 370 380
pF1KE4 NGCCIDSFLE--CDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCK
. : ..:. : . :::.: :: ..: :: : . : :::.
NP_006 SMTC-EKFFSGGCHRNRIENRFPDEATCM----GFCAPKKI--PS---FCYSPKDEGLCS
120 130 140 150 160
390 400 410 420 430 440
pF1KE4 ESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESC-RGISKKDVFGLRREIPIPS
.. :.:.:: . : ::: :: :: ::: ...: ..: ....::
NP_006 ANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIR
170 180 190 200 210 220
450 460 470 480 490 500
pF1KE4 TGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHL
NP_006 KIRKKQF
230
>>NP_001257932 (OMIM: 600033) tissue factor pathway inhi (224 aa)
initn: 352 init1: 175 opt: 334 Z-score: 338.9 bits: 71.1 E(85289): 3.9e-12
Smith-Waterman score: 352; 32.2% identity (53.2% similar) in 205 aa overlap (235-431:10-204)
210 220 230 240 250 260
pF1KE4 PNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFP
.. . :. : . : ::. .
NP_001 MDPARPLGLSILLLFLTEAALGDAAQEPTDYGPCRALLL
10 20 30
270 280 290 300 310
pF1KE4 RWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQG-PSMERRH----PVCSGTC
:.::: : :..:.:::: :: ::. : : :: .. :.. : . : :.
NP_001 RYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGST
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE4 QPTQFRCSNGCCIDSFLE--CDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVD
. : :. : ..:. : . :::.: :: ..: :: : .
NP_001 EKYFFNLSSMTC-EKFFSGGCHRNRIENRFPDEATCM----GFCAPKKI--PS---FCYS
100 110 120 130 140
380 390 400 410 420 430
pF1KE4 LPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESC-RGISKKDVFGL
: :::. .. :.:.:: . : ::: :: :: ::: ...: ..: ....::
NP_001 PKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPK
150 160 170 180 190 200
440 450 460 470 480 490
pF1KE4 RREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVS
NP_001 LRFASRIRKIRKKQF
210 220
>>NP_066925 (OMIM: 270420,605124) kunitz-type protease i (252 aa)
initn: 430 init1: 259 opt: 259 Z-score: 264.0 bits: 57.4 E(85289): 5.8e-08
Smith-Waterman score: 404; 31.3% identity (55.1% similar) in 265 aa overlap (244-507:32-248)
220 230 240 250 260 270
pF1KE4 KEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQ
.. .:.::.:. :::::.:.:::.:. :.
NP_066 AQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDG
10 20 30 40 50 60
280 290 300 310 320 330
pF1KE4 ICKSFVYGGCLGNKNNYLREEECILACRGVQGPSMERRHPVCSGTCQPTQFRCSNGCCID
:. :::::: ::.:::: .:::. : : : . : .. :
NP_066 SCQLFVYGGCDGNSNNYLTKEECLKKCATV--------------TENATGDLATSRNAAD
70 80 90 100
340 350 360 370 380 390
pF1KE4 SFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYY
: ..:. : .: : ..: . : .. .:. :: :. :.::::.
NP_066 S-----SVPSAPRRQDS---EDHSSDM-------FNYEE-YCTANAVTGPCRASFPRWYF
110 120 130 140 150
400 410 420 430 440 450
pF1KE4 NPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVA
. . : : :::: ::::... :. :. : : ... :.: ..: . ..
NP_066 DVERNSCNNFIYGGCRGNKNSYRSEEACMLRC--------FRQQENPPLPLGSKVVVLAG
160 170 180 190 200
460 470 480 490 500 510
pF1KE4 VFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTV-STTEDTEHLVYNHTTRP
.:... :. . : . : ... :.. : :: :. .: :.:: :
NP_066 LFVMVLILFLGASMVY-LIRVARRN---------QERALRTVWSSGDDKEQLVKNTYVL
210 220 230 240 250
pF1KE4 L
>>NP_001159575 (OMIM: 270420,605124) kunitz-type proteas (195 aa)
initn: 411 init1: 240 opt: 253 Z-score: 259.6 bits: 56.2 E(85289): 1e-07
Smith-Waterman score: 253; 40.2% identity (69.0% similar) in 87 aa overlap (223-308:52-135)
200 210 220 230 240 250
pF1KE4 RGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLA
.: :. . .:. . . ... :.:: :
NP_001 LSGVLAADRERSIHENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNY---EEYCTA
30 40 50 60 70
260 270 280 290 300 310
pF1KE4 SNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC-RGVQGPSMERR
. .: ::.::::::.: .. :..:.:::: ::::.: :: :.: : : ..: .
NP_001 NAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLG
80 90 100 110 120 130
320 330 340 350 360 370
pF1KE4 HPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSD
NP_001 SKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL
140 150 160 170 180 190
513 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:35:07 2016 done: Mon Nov 7 18:35:08 2016
Total Scan time: 8.250 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]