FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6328, 440 aa 1>>>pF1KE6328 440 - 440 aa - 440 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1129+/-0.000524; mu= 2.3745+/- 0.032 mean_var=135.1776+/-28.630, 0's: 0 Z-trim(110.7): 290 B-trim: 828 in 1/53 Lambda= 0.110312 statistics sampled from 18764 (19144) to 18764 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.224), width: 16 Scan time: 7.970 The best scores are: opt bits E(85289) NP_002535 (OMIM: 164345) oligodendrocyte-myelin gl ( 440) 2865 468.3 1.8e-131 NP_000164 (OMIM: 153670,177820,231200,258660,60667 ( 652) 273 55.8 3.8e-07 NP_079269 (OMIM: 610870) leucine-rich repeat trans ( 518) 266 54.7 6.8e-07 NP_001269857 (OMIM: 610870) leucine-rich repeat tr ( 519) 266 54.7 6.8e-07 NP_001128217 (OMIM: 610870) leucine-rich repeat tr ( 590) 266 54.7 7.6e-07 NP_001269853 (OMIM: 610870) leucine-rich repeat tr ( 590) 266 54.7 7.6e-07 NP_001317299 (OMIM: 610870) leucine-rich repeat tr ( 591) 266 54.7 7.6e-07 XP_016876621 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_016876620 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_005267547 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_016876622 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_016876623 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 NP_001333072 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06 XP_016876619 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 NP_037363 (OMIM: 604807) leucine-rich repeat trans ( 660) 252 52.5 3.9e-06 NP_001333073 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06 XP_016876618 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_016876624 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 XP_011534913 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 252 52.5 3.9e-06 NP_001333075 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06 NP_001333074 (OMIM: 604807) leucine-rich repeat tr ( 660) 252 52.5 3.9e-06 XP_011543185 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 244 51.2 9.7e-06 NP_037412 (OMIM: 604806) leucine-rich repeat trans ( 674) 244 51.2 9.7e-06 XP_005273918 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 244 51.2 9.7e-06 XP_005270514 (OMIM: 608661) PREDICTED: podocan iso ( 613) 241 50.7 1.2e-05 NP_001186009 (OMIM: 608661) podocan isoform 2 [Hom ( 642) 241 50.7 1.3e-05 NP_001186010 (OMIM: 608661) podocan isoform 2 [Hom ( 642) 241 50.7 1.3e-05 XP_016855783 (OMIM: 608661) PREDICTED: podocan iso ( 652) 241 50.7 1.3e-05 NP_714914 (OMIM: 608661) podocan isoform 1 [Homo s ( 661) 241 50.7 1.3e-05 XP_011518513 (OMIM: 605247) PREDICTED: p53-induced ( 893) 229 48.9 6.5e-05 NP_665894 (OMIM: 605247) p53-induced protein with ( 893) 229 48.9 6.5e-05 XP_011518512 (OMIM: 605247) PREDICTED: p53-induced ( 910) 229 48.9 6.6e-05 NP_665893 (OMIM: 605247) p53-induced protein with ( 910) 229 48.9 6.6e-05 XP_011518511 (OMIM: 605247) PREDICTED: p53-induced ( 920) 229 48.9 6.7e-05 XP_005253062 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05 XP_005253064 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05 XP_005253063 (OMIM: 605247) PREDICTED: p53-induced ( 934) 229 48.9 6.8e-05 XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 218 47.0 9e-05 NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 221 47.5 0.0001 XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 221 47.5 0.0001 NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 221 47.5 0.0001 NP_056379 (OMIM: 610868) leucine-rich repeat trans ( 516) 219 47.2 0.00012 XP_011513028 (OMIM: 608195) PREDICTED: leucine-ric ( 524) 218 47.0 0.00014 NP_060684 (OMIM: 608195) leucine-rich repeat-conta ( 524) 218 47.0 0.00014 NP_078788 (OMIM: 607180) leucine-rich repeat-conta ( 371) 215 46.5 0.00014 XP_011532412 (OMIM: 607180) PREDICTED: leucine-ric ( 371) 215 46.5 0.00014 XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 224 48.1 0.00015 XP_016857383 (OMIM: 614453) PREDICTED: leucine-ric (1438) 224 48.1 0.00017 XP_016857382 (OMIM: 614453) PREDICTED: leucine-ric (1472) 224 48.1 0.00018 XP_016857381 (OMIM: 614453) PREDICTED: leucine-ric (1490) 224 48.1 0.00018 >>NP_002535 (OMIM: 164345) oligodendrocyte-myelin glycop (440 aa) initn: 2865 init1: 2865 opt: 2865 Z-score: 2481.3 bits: 468.3 E(85289): 1.8e-131 Smith-Waterman score: 2865; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440) 10 20 30 40 50 60 pF1KE6 MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 NLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 QILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 WMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 MVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVAN 370 380 390 400 410 420 430 440 pF1KE6 AWKVNASFLLLLNVVVMLAV :::::::::::::::::::: NP_002 AWKVNASFLLLLNVVVMLAV 430 440 >>NP_000164 (OMIM: 153670,177820,231200,258660,606672) p (652 aa) initn: 151 init1: 90 opt: 273 Z-score: 249.2 bits: 55.8 E(85289): 3.8e-07 Smith-Waterman score: 312; 26.4% identity (54.0% similar) in 439 aa overlap (12-417:3-427) 10 20 30 40 50 pF1KE6 MEYQILKMSLCLFILLFLTPGILCICPLQCICTE--RHRHVDCSGRNLSTLPSGLQENII :..::.: :. : :. : .. : .:.:. :::..:: : .. NP_000 MPLLLLLLLLPSPLHPHPI-CEVSKVASHLEVNCDKRNLTALPPDLPKDTT 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 HLNLSYNHFTDLH-NQLTQYTNLRTLDISNNRLESLPAH--LPRSLWNMSAANNNIK--- :.:: : . . : :: : :... .: .: . :: : ... ..:... NP_000 ILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLP-VLGTLDLSHNQLQSLP 60 70 80 90 100 120 130 140 150 160 pF1KE6 LLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSL---EVLNLSSNKLWTVPTNM--PS :: .. : : :::: : : .. : ..::.: . : :..:.: :.: .. :. NP_000 LLGQTLPA----LTVLDVSFNRLTSLPL--GALRGLGELQELYLKGNELKTLPPGLLTPT 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 -KLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNR ::. ..:.::.::.. : : .: :: : :..:.. :: : . . : :..: NP_000 PKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHL-LPFAFLHGNP 170 180 190 200 210 220 230 240 250 260 270 pF1KE6 WSCDHKQNITYLLKWMMETKAHVI----GTPC---STQISSLKEHN-----MYPTPSGFT : :. . : :. .:.... .: :. .....:.. : .: :. NP_000 WLCNCE--ILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGC 230 240 250 260 270 280 280 290 300 310 320 pF1KE6 SSLFTVSGMQTVD-----TINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDK .: . . : .. .: . :.:.: . .: : .: : .:. ... NP_000 PTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHT--TPWGLFYSWSTASLDSQM 290 300 310 320 330 330 340 350 360 370 380 pF1KE6 AFVPYPEDTSTETINSHEAA-AATLTIHLQDGMVTNTSLTSSTKSSPTPMTLS-ITSGMP .: . ::. .. . ..:.:... ..: :.:. .:.: : . : NP_000 PSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTP-KSTTEPTPSPTTSEPVPEPAP 340 350 360 370 380 390 390 400 410 420 430 440 pF1KE6 NNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV : . : : : : . . :: :. NP_000 NMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPT 400 410 420 430 440 450 >>NP_079269 (OMIM: 610870) leucine-rich repeat transmemb (518 aa) initn: 236 init1: 153 opt: 266 Z-score: 244.8 bits: 54.7 E(85289): 6.8e-07 Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503) 30 40 50 60 70 80 pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI :. .:.::::.. :... :. .:: : : NP_079 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII 110 120 130 140 150 160 90 100 110 120 130 pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV .: :...: .. .. :.. . : .. :... : .:: : . .:.. :. NP_079 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH . . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: . NP_079 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS : : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. : NP_079 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES 290 300 310 320 330 260 270 280 290 300 310 pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF :.: . .: . : . . : .:.:.: : : : : ::. : : NP_079 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF 340 350 360 370 380 390 320 330 340 350 360 370 pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK ....: : : . .: .: :. : .. :. :..... :. .:. . : : NP_079 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK 400 410 420 430 440 380 390 400 410 420 430 pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL :. : :. : : .. .. .: .: .. : : : . .::.: NP_079 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT 450 460 470 480 490 500 440 pF1KE6 LNVVVMLAV NP_079 YTISGSRECEV 510 >>NP_001269857 (OMIM: 610870) leucine-rich repeat transm (519 aa) initn: 236 init1: 153 opt: 266 Z-score: 244.8 bits: 54.7 E(85289): 6.8e-07 Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:135-504) 30 40 50 60 70 80 pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI :. .:.::::.. :... :. .:: : : NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII 110 120 130 140 150 160 90 100 110 120 130 pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV .: :...: .. .. :.. . : .. :... : .:: : . .:.. :. NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH . . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: . NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS : : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. : NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES 290 300 310 320 330 260 270 280 290 300 310 pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF :.: . .: . : . . : .:.:.: : : : : ::. : : NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF 340 350 360 370 380 390 320 330 340 350 360 370 pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK ....: : : . .: .: :. : .. :. :..... :. .:. . : : NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK 400 410 420 430 440 380 390 400 410 420 430 pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL :. : :. : : .. .. .: .: .. : : : . .::.: NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT 450 460 470 480 490 500 440 pF1KE6 LNVVVMLAV NP_001 YTISGSRECEV 510 >>NP_001128217 (OMIM: 610870) leucine-rich repeat transm (590 aa) initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07 Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503) 30 40 50 60 70 80 pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI :. .:.::::.. :... :. .:: : : NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII 110 120 130 140 150 160 90 100 110 120 130 pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV .: :...: .. .. :.. . : .. :... : .:: : . .:.. :. NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH . . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: . NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS : : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. : NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES 290 300 310 320 330 260 270 280 290 300 310 pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF :.: . .: . : . . : .:.:.: : : : : ::. : : NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF 340 350 360 370 380 390 320 330 340 350 360 370 pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK ....: : : . .: .: :. : .. :. :..... :. .:. . : : NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK 400 410 420 430 440 380 390 400 410 420 430 pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL :. : :. : : .. .. .: .: .. : : : . .::.: NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT 450 460 470 480 490 500 440 pF1KE6 LNVVVMLAV NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR 510 520 530 540 550 560 >>NP_001269853 (OMIM: 610870) leucine-rich repeat transm (590 aa) initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07 Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:134-503) 30 40 50 60 70 80 pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI :. .:.::::.. :... :. .:: : : NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII 110 120 130 140 150 160 90 100 110 120 130 pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV .: :...: .. .. :.. . : .. :... : .:: : . .:.. :. NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH . . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: . NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS : : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. : NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES 290 300 310 320 330 260 270 280 290 300 310 pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF :.: . .: . : . . : .:.:.: : : : : ::. : : NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF 340 350 360 370 380 390 320 330 340 350 360 370 pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK ....: : : . .: .: :. : .. :. :..... :. .:. . : : NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK 400 410 420 430 440 380 390 400 410 420 430 pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL :. : :. : : .. .. .: .: .. : : : . .::.: NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT 450 460 470 480 490 500 440 pF1KE6 LNVVVMLAV NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR 510 520 530 540 550 560 >>NP_001317299 (OMIM: 610870) leucine-rich repeat transm (591 aa) initn: 200 init1: 153 opt: 266 Z-score: 243.9 bits: 54.7 E(85289): 7.6e-07 Smith-Waterman score: 295; 26.7% identity (55.2% similar) in 386 aa overlap (56-427:135-504) 30 40 50 60 70 80 pF1KE6 CPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDI :. .:.::::.. :... :. .:: : : NP_001 AFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE--QFKGLRKLII 110 120 130 140 150 160 90 100 110 120 130 pF1KE6 ---SNNRLESLPAHLPRSLWNMSAAN---NNIKLLDKSDTAYQWNLKYLDVSKNMLEKVV .: :...: .. .. :.. . : .. :... : .:: : . .:.. :. NP_001 LHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE6 LIK-NTLRSLEVLNLSSNKLWTVPTNMP---SKLHIVDLSNNSLTQILPGTLINLTNLTH . . : .:. . :. :.. .. .. :.:: .:::.:.. : :::. : :: . NP_001 FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 230 240 250 260 270 280 200 210 220 230 240 250 pF1KE6 LYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCS : : .::.: : ... . ..: ::: .: : :. ..: :. :. . : :. : NP_001 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS--RSICPLFYWLKNFK----GNKES 290 300 310 320 330 260 270 280 290 300 310 pF1KE6 TQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQP-KVTKIPKQYRTKETTF :.: . .: . : . . : .:.:.: : : : : ::. : : NP_001 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPR-----PTIF 340 350 360 370 380 390 320 330 340 350 360 370 pF1KE6 GATLSKDTTFT-STDKAF-VPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTK ....: : : . .: .: :. : .. :. :..... :. .:. . : : NP_001 KPDVTQSTFETPSPSPGFQIPGAEQEY-EHVSFHKIIAGSVALFLSVAMIL-LVIYVSWK 400 410 420 430 440 380 390 400 410 420 430 pF1KE6 SSPTPMT-LSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLL :. : :. : : .. .. .: .: .. : : : . .::.: NP_001 RYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYK-PTNSETMDISVNGSGPCT 450 460 470 480 490 500 440 pF1KE6 LNVVVMLAV NP_001 YTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGR 510 520 530 540 550 560 >>XP_016876621 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa) initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06 Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453) 50 60 70 80 90 100 pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN .:. : .:.:.: :.:. :: .: .. . . XP_016 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE 130 140 150 160 170 180 110 120 130 140 150 160 pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT : : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: : XP_016 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP 190 200 210 220 230 240 170 180 190 200 210 220 pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT ..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...: XP_016 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT 250 260 270 280 290 300 230 240 250 260 270 pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS :: : :: .: .. .:. . .. .: : :. :. .. .: :: .. : XP_016 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS 310 320 330 340 350 280 290 300 310 320 330 pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY :. :. : : .::: . .::. :. : : : . . XP_016 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI 360 370 380 390 400 340 350 360 370 380 390 pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP :. . : .. . :.::. :..::. : : : :. ..: XP_016 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG 410 420 430 440 450 460 400 410 420 430 440 pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV XP_016 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN 470 480 490 500 510 520 >>XP_016876620 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa) initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06 Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453) 50 60 70 80 90 100 pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN .:. : .:.:.: :.:. :: .: .. . . XP_016 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE 130 140 150 160 170 180 110 120 130 140 150 160 pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT : : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: : XP_016 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP 190 200 210 220 230 240 170 180 190 200 210 220 pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT ..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...: XP_016 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT 250 260 270 280 290 300 230 240 250 260 270 pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS :: : :: .: .. .:. . .. .: : :. :. .. .: :: .. : XP_016 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS 310 320 330 340 350 280 290 300 310 320 330 pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY :. :. : : .::: . .::. :. : : : . . XP_016 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI 360 370 380 390 400 340 350 360 370 380 390 pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP :. . : .. . :.::. :..::. : : : :. ..: XP_016 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG 410 420 430 440 450 460 400 410 420 430 440 pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV XP_016 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN 470 480 490 500 510 520 >>XP_005267547 (OMIM: 604807) PREDICTED: leucine-rich re (660 aa) initn: 190 init1: 106 opt: 252 Z-score: 231.0 bits: 52.5 E(85289): 3.9e-06 Smith-Waterman score: 255; 26.3% identity (55.5% similar) in 319 aa overlap (79-383:160-453) 50 60 70 80 90 100 pF1KE6 LPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAAN .:. : .:.:.: :.:. :: .: .. . . XP_005 AQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE 130 140 150 160 170 180 110 120 130 140 150 160 pF1KE6 NNIKLLDKSDTAYQ--WNLKYLDVSKNMLEKVVLIKNT---LRSLEVLNLSSNKLWTVPT : : .. :: :.: .:. : :. :.: . . ..: : .:. ... :.: : XP_005 NRIAVI--SDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP 190 200 210 220 230 240 170 180 190 200 210 220 pF1KE6 NMPSKLHIVDL--SNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEIT ..:. :.. : ..:....: .. :: .: .: . ::.. .. . ::.: .:...: XP_005 DLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLT 250 260 270 280 290 300 230 240 250 260 270 pF1KE6 LYNNRWSCDHKQNITYLLKWM--METKAHVIGTPCS--TQISSL--KEHNMYPTPSGFTS :: : :: .: .. .:. . .. .: : :. :. .. .: :: .. : XP_005 ARNNPWFCD--CSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNM-----NLLS 310 320 330 340 350 280 290 300 310 320 330 pF1KE6 SLFTVSGMQTVDTINSL-SVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY :. :. : : .::: . .::. :. : : : . . XP_005 CPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY-----------TPPTPTTSKLPTI 360 370 380 390 400 340 350 360 370 380 390 pF1KE6 PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMP :. . : .. . :.::. :..::. : : : :. ..: XP_005 PDWDGRERVTPPISERIQLSIHF----VNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGG 410 420 430 440 450 460 400 410 420 430 440 pF1KE6 QQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV XP_005 IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSN 470 480 490 500 510 520 440 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:09:12 2016 done: Tue Nov 8 12:09:13 2016 Total Scan time: 7.970 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]